[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ligament-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ligament-injury":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,107,132,163,199],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100643286","clap--compare-the-quality-of-3d-modeling-of-the-wrist-based-on-the-cone-beam-to-the-gold-standard-100643286",false,"NCT07632521","CLAP : Compare the Quality of 3D Modeling of the Wrist Based on the Cone Beam to the Gold Standard","CLAP: Single Center Prospective Study to Compare the Quality of 3D Modeling of the Wrist Based on the Cone Beam to the Gold Standard of CT SCAN in 6 Healthy Volunteers.","CLAP","Inclusion Criteria:\n\n* no clinical symptoms suggestive of a wrist ligament injury (e.g., pain, instability)\n* no contraindications to undergoing a CBCT scan (e.g., pregnancy, history of hypersensitivity to radiation).\n* Enrolled in or eligible for a French social security plan.\n* Signing of an informed consent form indicating that the subject understands the purpose and procedures required by the study and agrees to participate in the study and comply with the requirements and restrictions inherent to this study\n\nExclusion Criteria:\n\n* Pregnant women and breastfeeding mothers\n* Persons deprived of their liberty by a judicial or administrative decision; persons undergoing involuntary psychiatric treatment; persons admitted to a health or social care facility for purposes other than research\n* Adults subject to a legal protection measure (judicial protection, guardianship, or conservatorship) or who are unable to give consent",true,"ALL","18 Years","65 Years",{"count":5,"type":22},"ESTIMATED","INTERVENTIONAL",[25],"NA","Recent advances in personalized 3D modeling make it possible to consider personalized hand modeling based on cone-beam CT. The goal is to develop a personalized 3D modeling tool for use in routine clinical practice that reduces both the radiation dose to which patients are currently exposed during CT scans and the time required to process CT data (segmentation). the main, objective of the study is to compare the quality of 3D hand modeling based on cone-beam CT with the gold standard of computed tomography.\n\nThis prospective, single-center, interventional study will include 6 healthy volunteers.",[28,29],"Wrist Injuries","Ligament Injury",[31,32],"CT scan","cone-beam scan","NOT_YET_RECRUITING","2026-06-02",{"date":36,"type":37},"2026-06-08","ACTUAL",{"date":39,"type":22},"2026-06-01",{"date":41,"type":22},"2026-10-30",{"name":43,"class":44},"Centre Hospitalier Universitaire de Besancon","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100611443","phase-4-outcomes-from-hyperbaric-oxygen-hbo2-treatment-for-emerging-indications-100611443","NCT07240649","Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications","Emerging Indications for Hyperbaric Oxygen Treatment","Inclusion Criteria:\n\n* Patients referred for HBOT with an emerging indication\n\nExclusion Criteria:\n\n* Contraindication to hyperbaric oxygen treatment (untreated seizures, pneumothorax, significant pulmonary airspace pathology that might lead to pulmonary barotrauma, unmanageable confinement anxiety, chronic obstructive pulmonary disease with CO2 retention)\n* Pregnant persons",{"count":53,"type":22},100,[55],"PHASE4","This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric Oxygen Treatment. The study team aims to collect ongoing data on how well HBOT treats these emerging indications, and to add these data to the growing HBO Registry. The research team hypothesizes that HBOT will result in improvements of the condition of the various emerging indications.",[58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,29,96,97],"Post-COVID-19 Condition","Ulcerative Colitis","Crohn Disease","Calciphylaxis","Frostbite","Acute COVID-19","Pyoderma Gangrenosum","Pterygium","Hypospadias","Head Trauma","Pneumatosis Intestinalis","Ischemic Bowel","Raynaud Syndrome","Malignant Otitis Externa","Nonarteritic Anterior Ischemic Optic Neuropathy","Central Retinal Vein Occlusion","Femoral Head Necrosis","Invasive Fungal Infection","Chronic Anal Fissure","Vasculitic Ulcer","Graft-vs-Host Disease","Decubitus Ulcer","Greater Trochanteric Pain Syndrome","Rectovaginal Fistula","Pouchitis","Tinnitus","Clostridium Enterocolitis","Branch Retinal Artery Occlusion","Axonotmesis","Multiple Sclerosis","Inclusion Body Myositis","Epidermolysis Bullosa (EB)","Osteonecrosis","Ulcer Ischemic","Avascular Necrosis of Bone","Prosthesis Related Infections","Facial Filler Injections","Cystitis Chronic","Anastomosis, Leaking","Cartilage Injury","2026-05-01",{"date":100,"type":37},"2026-05-05",{"date":102,"type":22},"2026-08",{"date":104,"type":22},"2035-12",{"name":106,"class":44},"Jay C. Buckey Jr.",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":18,"minAge":114,"maxAge":20,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100606335","clinical-instrumental-evaluation-and-assessment-of-return-to-sports-activity-in-patients-surgically-treated-for-isolated-stener-like-lesions-of-the-medial-collateral-ligament-mcl-or-in-the-context-of-multiligament-injuries-and-articular-fractures-100606335","NCT07174219","Clinical-instrumental Evaluation and Assessment of Return to Sports Activity in Patients Surgically Treated for Isolated \"Stener-like\" Lesions of the Medial Collateral Ligament (MCL) or in the Context of Multiligament Injuries and Articular Fractures","STENER_MCL","Inclusion Criteria:\n\n* Patients of both male and female sex.\n* Patients who underwent surgical re-insertion of the distal insertion of the medial collateral ligament starting from 01\u002F01\u002F2020 and all patients scheduled for this type of surgical intervention until 12\u002F31\u002F2027;\n* Patients aged between 12 and 65 years at the time of surgery;\n* Patients who underwent isolated distal medial collateral ligament re-insertion surgery, as well as those who underwent the same procedure combined with other interventions on the same knee (e.g., multiligament injuries, reduction and osteosynthesis of bone fractures);\n* Patients who have given consent to participate in the study;\n* Patients who have undergone preoperative radiological investigations of the affected knee confirming the diagnosis of distal medial collateral ligament injury (MRI in the case of ligament injuries; X-ray and\u002For CT scan in the case of articular fractures).\n\nExclusion Criteria:\n\n* Previous fractures of the same limb treated surgically.\n* Patient age under 12 years at the time of surgery or patients over 65 years of age.\n* Patients who have not provided informed consent.\n* Patients who are no longer contactable.\n* Patients who have not engaged in sports activity in the 2 years prior to the surgical intervention.","12 Years",{"count":116,"type":22},43,"OBSERVATIONAL","The knee is a complex joint stabilized by four main ligaments: the anterior and posterior cruciate ligaments and the medial and lateral collateral ligaments. Multiligamentous knee injuries involve at least two ligaments and usually result from high-energy trauma, causing significant functional limitations.\n\nOne specific injury is the \"Stener-like\" lesion of the medial collateral ligament (MCL), characterized by an avulsion at its distal tibial insertion with interposition of tendons from the pes anserinus, which prevents natural healing. This lesion often occurs with other ligament or bone injuries and requires surgical treatment.\n\nDiagnosis is clinical, supported by MRI to confirm the distal lesion and tendon interposition. Despite its importance, literature on this injury is scarce, with only a few studies and case reports, often limited by small sample sizes and lack of standardized follow-up assessments.\n\nDue to the rarity and complexity of these injuries, there is a need for a comprehensive clinical study with standardized evaluations to improve understanding and develop standardized surgical treatments for isolated and associated Stener-like MCL lesions.",[29,120],"Knee Injuries","RECRUITING","2025-09-15",{"date":124,"type":37},"2025-09-16",{"date":126,"type":37},"2025-09-10",{"date":128,"type":22},"2030-08",{"name":130,"class":44},"Stefano Zaffagnini",1,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":162},"100335169","arthroscopic-versus-open-brostrom-for-ankle-instability-100335169","NCT03643926","Arthroscopic Versus Open Brostrom for Ankle Instability","Arthroscopic Versus Open Brostrom for Ankle Instability: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Individuals must be older than 18 and younger than 65 years of age, both genders;\n* Participants must be experiencing instability symptoms at the ankle over the last six months;\n* Clinical diagnosis of ankle instability, defined as the presence of at least one previous ankle sprain associated with a current instability sensation by the patient and the presence of a positive anterior drawer test; the previous lateral ligament injury must be confirmed by Magnetic Resonance Imaging (MRI) findings.\n\nExclusion Criteria:\n\n* Previous surgery involving the affected foot or ankle;\n* History or documented evidence of autoimmune or peripheral vascular diseases;\n* History or documented evidence of peripheral neuropathy (nervous compression syndrome, tarsal tunnel syndrome) or systemic inflammatory disease a (rheumatoid arthritis, spondylitis, Reiter Syndrome, etc.);\n* Associated injuries, such as osteochondral lesions, tendon ruptures and fractures.\n* Associated instability, such as syndesmotic and medial instability.\n* Cavovarus foot;\n* BMI over 35;\n* Previous infiltration in the ankle over the six months preceding the initial assessment;\n* Pregnancy;\n* Any condition that represents a contraindication of the proposed therapies;\n* Impossibility or incapacity to sign the informed Consent Form;\n* History or documented evidence of blood coagulation disorders (including treatment with anti-coagulants, but excluding aspirin);\n* Use of heart pacemaker;\n* Presence of infectious process (superficial on skin and cellular tissue, or deep in the bone) in the region to be treated;",{"count":140,"type":22},98,[25],"Background: Ankle sprains are among the most prevalent lesions in primary care. A substantial number of these ligament lesions will develop ankle instability and require a surgical procedure. The Brostrom-Gould technique is the standard surgical approach for this condition, providing excellent results over the years. Thru the last decades, the arthroscopic Brostrom has gain popularity and support by several studies. Yet, there is no consensus regarding the best procedure to treat ankle instability nowadays.\n\nHypothesis: The arthroscopic Brostrom technique will present better levels of pain and function when compared to the standard open approach.\n\nDesign: blinded, in parallel groups, multicentric, randomized, clinical trial.\n\nMaterials and Methods: 98 patients with a diagnosis of chronic ankle instability, referred from primary or secondary health care services, will be assessed and enrolled in this study. Participants will be divided in two groups (randomized by sequentially numbered identical envelopes, which will be administered serially to participants), one containing the open Brostrom repair technique and the other comprehending the arthroscopic Brostrom approach. The assessments will occur in 3, 6, 12, 24 and 48 weeks. Patients will be evaluated primarily by complications and secondarily the Cumberland Ankle Instability Tool (CAIT), American Orthopedic Foot and Ankle Society (AOFAS), the Visual Analogue Scale (VAS), the Foot Function Index (FFI) and the 36 Item Short Form Health Survey (SF-36). The investigators will use Comparison of Two Proportions via relative frequency analysis, the Pearson Correlation the Chi-Square test and the ANOVA for statistical analyses.\n\nDiscussion: This study intends to establish if the arthroscopic Brostrom technique can produce excellent and reliable results when treating chronic ankle instability. A shorter surgical time, a better cosmetic appearance and a smaller soft tissue injury would support the choice for this procedure if the outcomes could be compared to the open approach.",[144,145,29,146],"Ankle Sprains","Instability, Joint","Surgery",[148,149,150,151,152],"ankle","instability","brostrom","open","arthroscopic","2024-09-26",{"date":155,"type":37},"2024-09-27",{"date":157,"type":37},"2019-06-01",{"date":159,"type":22},"2027-12-05",{"name":161,"class":44},"Federal University of São Paulo",2,{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":182,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":131},"100315776","evaluation-of-outcomes-with-umbilical-cord-allograft-for-musculoskeletal-conditions-musculoskeletal-conditions-100315776","NCT03390920","Evaluation of Outcomes With Umbilical Cord Allograft for Musculoskeletal Conditions Musculoskeletal Conditions","Evaluation of Regenerative Medicine Outcomes With Umbilical Allograft for Musculoskeletal Conditions","Inclusion Criteria:\n\n1. Age 18 and over.\n2. Ability to attend follow up visits or at least converse on phone or complete email follow up forms.\n\n4\\) Competent to understand the study protocol and provide voluntary informed consent.\n\nExclusion Criteria:\n\n1. Active Infection\n2. Pregnancy, Lactating\n3. Clotting disorder",{"count":171,"type":22},200,[25],"The aim of the study is to determine the efficacy of an Amniotic Fluid Tissue Product for pain relief and functional improvements for all types of musculoskeletal conditions. The study is prospective, with outcome measures being obtained at numerous time points after the regenerative procedure.",[175,176,177,178,179,29,180,181],"Osteoarthritis","Tendinitis","Sports Injury","Degenerative Disc Disease","Degenerative Arthritis","Neuropathy","Pelvic Pain",[183,184,185,186,187,188],"regenerative medicine","arthritis","amniotic","stem cell","growth factor","cartilage","2021-09-10",{"date":191,"type":37},"2021-09-17",{"date":193,"type":22},"2022-01-01",{"date":195,"type":22},"2030-01-01",{"name":197,"class":198},"R3 Stem Cell","INDUSTRY",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":121,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":162},"100389236","danish-multicenter-scapholunate-ligament-study-100389236","NCT04348253","Danish Multicenter Scapholunate Ligament Study","Reconstruction of Chronic Scapholunate Ligament Injuries in the Wrist: A Randomized Controlled Trial Comparing The Berger Capsulodesis and Three-Ligament-Tenodesis (3LT)","Inclusion Criteria:\n\n* Age 18-60 years (both included).\n* Symptomatic SL instability (VAS score ³3, QDASH score ³ 20).\n* \\> 6 weeks since symptomatic hand trauma (chronic SL lesions).\n* SL gapping on radiographic stress views or SL gapping (³2mm) on static PA views.\n* Complete SL ligament lesion confirmed by wrist arthroscopy\n\nExclusion Criteria:\n\n* Geissler grade 1-3 SLL injury (evaluated by arthroscopy).\n* Concomitant complete luno-triquetral (LT) ligament injury (evaluated by arthroscopy).\n* Lesion of TFCC leading to DRUJ instability (evaluated by arthroscopy).\n* Radiocarpal or midcarpal arthritis evaluated by arthroscopy.\n* Previous fracture in carpus or intraarticular radius fracture with step off (³2 mm), disposing to posttraumatic arthritis.\n* Adverse effects after extra articular radial fractures (dorsal angulation ³10 grader).\n* Peroperatively non-reducible scaphoid flexion\u002FSL gap.\n* Terminal illness or severe medical illness: ASA score higher than or equal to 3.","60 Years",{"count":53,"type":22},[25],"Comparison of two surgical techniques commonly used for reconstruction of the scapholunate (SL) ligament. A randomized multicenter study.",[29,211],"Wrist Sprain","2020-04-15",{"date":214,"type":37},"2020-04-16",{"date":216,"type":37},"2018-08-01",{"date":218,"type":22},"2033-04-30",{"name":220,"class":44},"University of Aarhus"]