[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ligament-knee-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ligament-knee-injury":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100464113","optimized-rehabilitation-after-anterior-cruciate-ligament-before-returning-to-sport-100464113",false,"NCT05323474","Optimized Rehabilitation After Anterior Cruciate Ligament Before Returning to Sport","Optimized Rehabilitation After Anterior Cruciate Ligament Reconstruction at the First Step of Return to Sport","ORACL-Run","Inclusion Criteria:\n\n* Affiliation to the French Social Security system\n* Patient who has had an ACL reconstruction regardless of the standard surgical technique used\n* Patient with a sports activity, pivot and\u002For contact (e.g. soccer, basketball, handball, rugby, judo...) and practiced in competition (Tegner sports activity scores \\>7 and Marx scores \\>11 before the accident.\n* Patient wishing to return to competitive sport\n* Consent signed by the patient\n\nExclusion Criteria:\n\n* Contralateral or bilateral involvement or operated on for a re-injury of the ACL\n* Patients with a medical contraindication to the performance of one of the tests\n* Patients suffering from a neurological (motor and\u002For sensitive), vestibular or rheumatic pathology\n* Patient performing rehabilitation with a physiotherapist who does not wish to participate in the study.\n* Pregnant or breastfeeding woman\n* Patient under guardianship or curators","ALL","18 Years","25 Years",{"count":21,"type":22},432,"ESTIMATED","INTERVENTIONAL",[25],"NA","Following reconstruction of the anterior cruciate ligament (ACL), a standardized rehabilitation protocol is carried out by a physiotherapist. In France, a well-established rehabilitation consensus guides the first phase of 3 months postoperatively and patient compliance is generally excellent. The next phase should allow a return to sport (RTS) following a continuum depending on the objectives of the sport's patient, starting with a return to running activities (RTR) and a preparatory phase for a RTS which may be authorized at 6 months post-op.\n\nThis multicentre randomized control trial aims to evaluate the effectiveness of an individualized and optimized rehabilitation program guided by monthly assessments carried out by physiotherapists from the 3rd to the 6th month postoperatively to reduce the risk of new ACL injuries (operated or healthy knee), compared to standard management.",[28,29],"Ligament Knee Injury","Anterior Cruciate Ligament Rupture",[31,32,33,34,35,36],"Physiotherapy","Rehabilitation","Orthopedic surgery","Knee joint","Ligament","Anterior Cruciate Ligament Reconstruction","RECRUITING","2026-04-21",{"date":40,"type":41},"2026-04-24","ACTUAL",{"date":43,"type":41},"2022-11-14",{"date":45,"type":22},"2029-12",{"name":47,"class":48},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",8,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100554933","combined-intra--and-extra-articular-acl-reconstruction-versus-isolated-intra-articular-acl-reconstruction-100554933","NCT06505525","Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction","Combined Intra- and Extra-articular ACL Reconstruction Versus Isolated Intra-articular ACL Reconstruction: Prospective Multicenter Randomized Clinical Trial With Hamstring Autograft","Inclusion Criteria\n\nPatients from the hospital's demand (emergency care and outpatient care) and from CROSS (Center for Regulation of Health Service Offers) who present one or more risk factors will be included:\n\n* Age (Female 14 years - 25 years and Male 16 years - 25 years);\n* Pivot-shift test \\> 2;\n* Chronic ACL injury (\\>12 months);\n* Athlete (Tegner Scale ≥ 7);\n* Tibial slope \\> 12 degrees;\n* Recurvatum \\> 5 degrees and \\\u003C 15 degrees (asymmetric);\n* Ligamentous Hypermobility (Beighton Scale \\> 5).\n\nNon-Inclusion Criteria\n\n* Individuals over 40 years of age will not be included;\n* ACL revision;\n* PCL injury (grade 2 and 3);\n* MCL injury (grade 2 and 3) or (grade 1 with valgus aligned axis);\n* CPL injury (grade 2 and 3 according to Fanelli classification);\n* Recurrent patellar dislocation;\n* Severe chondral lesion (ICRS grade 3 and 4) larger than 1cm2;\n* Previous ipsilateral knee surgery;\n* Kellgren Lawrence grade 3 or more;\n* Autoimmune\u002Frheumatologic inflammatory disease;\n* Contralateral knee ligament injury;\n* Malalignment \\> 5 degrees clinical asymmetry between limbs or symmetric \\> 10 degrees axis deviation to varus (corresponding to \\> 4 degrees varus between the anatomical axis of the femur and the anatomical axis of the tibia in the clinical examination) or \\> 10 degrees axis deviation to valgus (corresponding to \\> 16 degrees valgus between the anatomical axis of the femur and the anatomical axis of the tibia in the clinical examination);\n* Graft diameter \\\u003C 7 mm;\n* BMI \\> 35 or \\\u003C 18;\n* Active or undergoing treatment for malignant neoplasia;\n* Pregnancy or suspected pregnancy;\n* Psychiatric disorders.\n\nExclusion Criteria\n\nLeave of absence from work due to disability or reduced income assistance (worker's compensation) whenever one of the investigators considers that the participant may be simulating a worse health condition than reality in order to receive financial assistance with work leave.","14 Years","40 Years",{"count":60,"type":22},146,[25],"Abstract\n\nIntroduction: Autologous hamstring tendons are the most commonly used grafts in ACL reconstruction worldwide. There are several ways to prepare the graft using these tendons. One can prioritize increasing the diameter of an isolated intra-articular graft or alternatively, using one graft limb as an extra-articular reinforcement via the anterolateral ligament (ALL) reconstruction, with both options aiming to reduce the re-rupture rate relative to traditional quadrupled hamstring grafts.\n\nObjective: To compare, through a prospective and randomized clinical trial, intra and extra-articular ACL reconstruction with ALL using hamstring autograft versus isolated anatomical ACL reconstruction using quintuple or sextuple hamstring autograft.\n\nMethods: 146 patients will be randomized into two groups of 73 patients. Patients included in the study will be evaluated preoperatively and after surgery at 3, 6, 9, 12, and 24 months postoperatively. The primary outcomes will be clinical failure rate and graft rerupture rate. Secondary outcomes will include functional capacity assessed through IKDC, Lysholm KOOS, and Tegner scores, pain using the VAS, as well as stability assessed by digital rolimeter and objective IKDC. Kinesiophobia and anxiety will be measured using the Tampa scale and Anxiety and Depression scale.\n\nKeywords: Rupture, Anterior Cruciate Ligament, Anterior Cruciate Ligament Reconstruction",[29,28],[65,66,36],"Rupture","Anterior Cruciate Ligament","2025-03-29",{"date":69,"type":41},"2025-04-03",{"date":71,"type":41},"2022-08-01",{"date":73,"type":22},"2027-06-01",{"name":75,"class":48},"Federal University of São Paulo"]