[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"light-therapy-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:light-therapy-complications":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100572331","assessing-the-efficacy-of-photodynamic-therapy-for-preventing-surgical-site-infections-100572331",false,"NCT06731881","Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections","Leveraging Photodynamic Therapy to Inhibit Microorganisms - Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections in Nasal Surgery Patients: A Pilot Study","LIGHT","Inclusion Criteria:\n\n* Patients ≥ 16 years\n* Patients scheduled to undergo elective:\n\n  * Endoscopic Sinus Surgery (ESS) with or without adjunctive Septoplasty and\u002For Turbinoplasty\n  * Septoplasty with or without adjunctive Turbinoplasty\n  * Closed Septoplasty with or without adjunctive Turbinoplasty\n* Judged by the Investigator as suitable for participation in the study without safety concerns based on medical history and physical examination\n* Willing and able to provide written informed consent prior to participation in the clinical investigation\n* Willing and able to comply with all study related procedures\n\nExclusion Criteria:\n\n-• Patients undergoing open septorhinoplasty, anterior or septal biopsies, or post cautery\n\n* Congenital or acquired immunodeficiency, bone marrow disease, diabetes, autoimmune conditions requiring immunosuppressive treatment, any immunosuppressive medication at the time of consent or within the last 4 weeks before randomisation\n* Primary or secondary ciliary dyskinesia, cystic fibrosis\n* Patients who have received antibiotics within a week before randomisation\n* Patients who receive prophylactic antibiotics or antibiotics prior to discharge\n* Systemic steroid treatment less than 4 weeks before randomisation\n* History of frequent nose bleeds, or a condition that increases the risk of excessive bleeding\n* Undergoing active cancer treatment at time of consent\u002F or planning to start cancer treatment within trial period or completed cancer treatment within the last 4 weeks\n* Any disease, condition (medical or surgical), or drug or alcohol abuse, which, in the opinion of the investigator, might compromise the study results, or would place the patient at increased risk of infection\n* Previously treated with radiation on the face, head, or neck regions\n* Female patients who are pregnant or breastfeeding at the time of consent\n* Received a study drug in a clinical trial for an investigational drug within the previous 30 days from consent, or 5 half-lives, whichever is longer\n* Used antimicrobial wash or wipes within 7 days of randomisation or during the study period\n* Patients with allergies \u002F hypersensitivity to methylene blue, polymethyl methacrylate (PMMA), or to chlorhexidine gluconate (CHG)","ALL","16 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a randomised, unblinded interventional device proof of concept pilot trial in which patients undergoing nasal surgery will be selected for either photodisinfection therapy (PDT) with the Steriwave™ ND System, or control with nares swabbed with 'photosensitizer formulation' preoperatively.\n\nThis trial will primarily assess the safety and efficacy of nasal photodisinfection treatment in decreasing post-operative events in patients undergoing nasal surgery. After signing informed consent, and before surgery, participants will receive a baseline culture of the anterior nares to determine nasal bacterial colonization and will have a flexible nasendoscopy to determine their Lund-Kennedy (LK) endoscopic score. Subjects will then be randomised to nasal PDT (which includes two applications of 'photosensitizer formulation' \\[0.01% methylene blue with 0.25% chlorhexidine solution\\], two minutes apart), along with light therapy, or control with nares swabbed twice with 'photosensitizer formulation' with two minutes in between (no light therapy). Following treatment, participants will be re-cultured (2 weeks after the surgery ± 7 days) and reviewed for antibiotic use and surgical site infection (SSI) using LK endoscopic scoring. At 30 days, all participants will be followed up by telephone to review if they received antibiotics for presumed postoperative infection. Standard post-operative care will be provided according to the type of surgery performed. Any required interventions post-operatively will be documented.",[27,28,29],"Surgery","Nasal Disease","Light; Therapy, Complications",[31,32,33,34],"nasal surgery","nasal photodisinfection","decolonisation","surgical site infection","RECRUITING","2026-06-10",{"date":38,"type":39},"2026-06-11","ACTUAL",{"date":41,"type":39},"2025-06-04",{"date":43,"type":21},"2026-06-30",{"name":45,"class":46},"Guy's and St Thomas' NHS Foundation Trust","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100564604","optimizing-light-exposure-for-myopia-prevention-and-control-lightspan-100564604","NCT06631339","Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)","LightSPAN","Inclusion Criteria:\n\n* Subject must meet all the inclusion criteria below to participate in this study.\n\n  1. Written Informed Consent form from parent \u002F legal guardian and assent from child subject has been obtained\n  2. Is between 7 to 10 years of age at start of study intervention which is 2 January 2025 or 1 January 2026\n  3. Studying in either Primary 2 or 3 classes of the participating school(s) in academic year 2025 or 2026.\n  4. Presenting visual acuity or best corrected visual acuity (BCVA) better or equal to LogMAR 0.2 (equivalent to Snellen 6\u002F9 or better) in each eye\n  5. Normal Intraocular pressure (not more than 21mmHg)\n  6. No ocular conditions (e.g., optic nerve disease, glaucoma, retinal diseases) except for refractive error.\n  7. No ocular conditions affecting the accuracy of the ophthalmic examinations\n  8. In good general health with no significant systemic diseases that may affect eye health\n\n     Exclusion Criteria:\n* All subjects meeting any of the exclusion criteria at baseline will be excluded from participation.\n\n  1. Previous or ongoing myopia control treatment (including but not limited to orthokeratology, atropine, pirenzepine, myopia control spectacle and contact lenses, light therapy)\n  2. Ongoing participation in other myopia prevention and control research trials\n  3. Any systemic or neurologic diseases (e.g. cancer, epilepsy, Kawasaki disease) known to affect eye health or make the participant vulnerable to the ophthalmic examinations (e.g., light flash)\n  4. Any other conditions precluding adherence to the protocol including unwillingness to refrain from myopia control treatment for the duration of the study",true,"7 Years","10 Years",{"count":59,"type":21},396,[24],"The goal of this clinical trial is to evaluate whether the optimization of daily exposure to light in primary school children can lead to better myopia prevention and control. The trial also aims to better understand the impact of light exposure on sleep and cognitive performance in children.\n\nThis trial has 3 arms namely, (1) a technical intervention arm, (2) a digital intervention arm, and (3) a control arm.\n\n1. technical intervention - which involves changing of classroom lighting in primary schools to ceiling lights that mimic the spectral composition of sunlight and fluctuates in intensity. Parents of children within that arm will have a sham smart-phone application (s-LightUP)\n2. digital intervention - which involves standard classroom lighting and giving parents an interventional smart-phone application (i-LightUP) that will be coupled with their child's light and activity sensor (wrist worn device ). The interventional app will provide individually tailored recommendation based on their children's behaviour (data feedback that is collected from the light and activity monitoring watch). The interventional app would then send reminder prompts\u002Fnotifications to encourage parents help their children achieve required amounts of myopia-preventive light quantum target set per day.\n3. Standard care or control group which involves standard classroom lighting and parents having a sham smart-phone application (s-LightUP)\n\nParticipants will:\n\n* be randomised to receive either no intervention (control group), technical intervention (light intervention that mimics sunlight) or digital intervention (parents having an app that syncs with child's light and activity sensor which will provide feedback to parents to encourage and recommends increment of outdoor activities and hours).\n* have their myopia progression monitored every 6 monthly and cognitive assessment done once every 3 months over a year.\n* wear the light and activity sensor watches throughout the 1-year study period as much as possible (minimum 1 week per month) except for wet water activities such as swimming, diving and showering for research data collection purpose.",[63,29,64,65,66],"Myopia","Myopia Progression","Short-Sighted","Myopia; Refractive Error",[68,69,63,70,71,72,73,74,75,76,77,78,79,80],"Light Exposure","Digital Intervention","Myopia Prevention","Cognition","Light Intervention","Behaviour changing phone application","Classroom","School-based","School","Singapore","Primary School","Light therapy","Myopia-control","2025-09-21",{"date":83,"type":39},"2025-09-23",{"date":85,"type":39},"2024-10-21",{"date":87,"type":21},"2027-01-26",{"name":89,"class":46},"National University of Singapore",5]