[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lignocaine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lignocaine":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100640579","phase-4-dexmedetomidine-vs-lignocaine-for-reducing-intubation-induced-hemodynamic-responses-in-cardiac-surgery-a-randomized-controlled-trial-100640579",false,"NCT07611890","Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial","Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial","Inclusion Criteria:\n\nAmerican Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events\n\nExclusion Criteria:\n\n1. Patients with known hypersensitivity to dexmedetomidine and Lignocaine.\n2. Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).\n3. Pregnant or lactating women.\n4. Patients with a history of airway anomalies or difficult intubation.","ALL","18 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.",[27,28,29],"Laryngoscopic Stress Response","Dexmedetomidine","Lignocaine",[31,28,29,32],"Laryngoscopic stress response","Cardiac surgery","RECRUITING","2026-05-21",{"date":36,"type":37},"2026-05-28","ACTUAL",{"date":34,"type":37},{"date":40,"type":21},"2026-08-21",{"name":42,"class":43},"Rawalpindi Institute of Cardiology","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":52,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":44},"100559757","lignocaine-vs-bupivacaine-infiltration-for-postpartum-perineal-pain-after-vaginal-delivery-with-episiotomy-in-primigravidae-100559757","NCT06568289","Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae","Lignocaine vs Bupivacaine Infiltration for Postpartum Perineal Pain After Vaginal Delivery With Episiotomy in Primigravidae: A Prospective Randomized, Double-Blind, Clinical Trial","Inclusion Criteria:\n\n* Primigravidae with the full term undergoing vaginal delivery with episiotomy.\n* Pregnancies and singleton vertex cephalic fetuses.\n* In the active phase of the first stage of labor.\n\nExclusion Criteria:\n\n* Patients with history of drug allergies to study drugs as this will increase the risk of complications.\n* Patients undergoing vaginal delivery under epidural or spinal anesthesia as they will affect post-operative pain and interfere with assessment of efficacy of local infiltration of the study drugs.\n* Evidence of local infection at site of injection as this will interfere with the action of the study drug and will increase the risk of complications.\n* Inability to cooperate as this will affect our assessment.\n* Patient's refusal.\n* Any intraoperative complications that will affect our outcome criteria (bleeding, organ injury) as they will affect patient's vital data and affect our assessment.\n* Neurological comorbidities (chronic pain disorder, chronic systemic disease, neurological disorder, neuropathic pain) as they will need more analgesia.\n* Drug abuse as they will be tolerant to the used analgesics.","FEMALE","40 Years",{"count":55,"type":21},60,[57],"NA","In this study, we will compare the effect and safety of lignocaine versus bupivacaine infiltration for postpartum perineal pain after vaginal delivery with episiotomy in primigravidae.",[29,60,61,62,63,64],"Bupivacaine","Postpartum Perineal Pain","Vaginal Delivery","Episiotomy","Primigravidae","2024-08-22",{"date":67,"type":37},"2024-08-23",{"date":69,"type":37},"2024-03-01",{"date":71,"type":21},"2024-09-01",{"name":73,"class":43},"Ain Shams University"]