[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"limb-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:limb-fracture":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100611174","chronic-pain-predictors-in-major-trauma-100611174",false,"NCT07237152","Chronic Pain Predictors in Major Trauma","Risk Factors for Chronic Limb Pain in Major Trauma Patients With Limb Injury","COPE: MT","Inclusion Criteria:\n\nAged ≥ 16 Polytrauma patient (multiple injuries affecting multiple body regions or organ systems) Admitted to a UK Major Trauma Centre Minimum of 1 radiologically confirmed traumatic limb fracture Have capacity to provide informed consent to participate in the study Have sufficient proficiency in English to provide the required data or be willing to use an approved interpreting service for data collection Recruited within 4 weeks of injury\n\nExclusion Criteria:\n\nNo traumatic limb fracture Patients with a primary or treatment amputation in relation to their limb injury Pathological limb fractures Prisoners No fixed abode","ALL","16 Years",{"count":20,"type":21},450,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about who is at risk of developing chronic pain in a major trauma population with at least one limb fracture.\n\nThe main question it aims to answer is: which risk factors predict which patients will experience chronic pain following traumatic limb injury.\n\nParticipants will answer a baseline questionnaire and two outcome questionnaires about their pain at 3 and 6 months after their injury.",[25,26],"Chronic Pain","Limb Fracture",[28,29,30,31],"chronic pain","limb fracture","risk factors","prediction model","NOT_YET_RECRUITING","2025-11-14",{"date":35,"type":36},"2025-11-19","ACTUAL",{"date":38,"type":21},"2025-12",{"date":40,"type":21},"2027-10",{"name":42,"class":43},"University of Nottingham","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":22,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100371178","an-international-multicenter-prospective-registry-on-post-traumatic-long-bones-defects-100371178","NCT04112992","An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects","An International, Multicenter, Prospective Registry to Investigate Treatment Options and Their Outcomes on Post-traumatic Long Bones Defects","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Skeletally mature\n* Post traumatic bone defect \\> 2 cm either\n\n  * initially after injury or\n  * after surgical debridement\n* Informed consent obtained, i.e.:\n\n  * Ability to understand the content of the patient information\u002FICF\n  * Willingness and ability to participate in the clinical investigation according to the registry plan\n  * Signed and dated EC\u002FIRB approved written informed consent OR\n  * Written consent provided according to the IRB\u002FEC defined and approved procedures for patients who are not able to provide independent written informed consent\n\nExclusion Criteria:\n\n* Any oblique defect that has less than 8cm expansion when adding the defect size of all four cortices\n* Any not medically managed severe systemic disease\n* Pregnancy\n* Prisoners\n* Participation in any other medical device or medicinal product registry within the previous 3 months that could influence the results of the present registry","18 Years",{"count":54,"type":21},600,"1 Year","Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group.\n\nReports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations.\n\nIn a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.",[26,58],"Bone Loss",[60],"long bone defect","RECRUITING","2025-08-28",{"date":64,"type":36},"2025-08-29",{"date":66,"type":36},"2024-07-03",{"date":68,"type":21},"2029-03-30",{"name":70,"class":43},"AO Innovation Translation Center",21]