[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lipid-induced-insulin-resistance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lipid-induced-insulin-resistance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100530967","overfeeding-induced-fat-tissue-stimulation-100530967",false,"NCT06193668","Overfeeding Induced Fat-tissue Stimulation","Short-term High-fat Overnutrition Induces Insulin Resistance in White Adipose Tissue","OVID_FASTI","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* BMI \\\u003C 29 kg\u002Fm2\n* Sport inactive (\\\u003C1x \u002Fweek)\n* Capacity to consent\n\nExclusion Criteria:\n\n* Diabetes mellitus disease\n* Acute coronary heart syndrome (myocardial infarction, unstable angina pectoris, stroke or transient ischemic attack in the last 3 months before study participation)\n* Acute infectious disease\n* Taking blood glucose-lowering drugs\n* Diseases or drugs affecting the immune system and allergies to drugs used in the study\n* Drugs with potential metabolic effects\n* Chronic liver disease (hepatitis, gallbladder disease, elevated liver enzymes (ALT \\> 300 U\u002FL))\n* Chronic inflammatory bowel diseases\n* Rheumatic diseases\n* Hyper- or hypothyroidism of the thyroid gland\n* Renal insufficiency, administration of iodine-containing contrast media in the last 2 days\n* Chronic lung diseases\n* cancerous diseases\n* Addictive diseases, psychiatric diseases\n* Pregnancy, breastfeeding\n* Shift workers\n* Anemia (Hb \\\u003C12 g\u002Fdl)\n* Disorders of hemostasis\n* Regular use of antithrombotic drugs\n* Alcohol consumption, smoking\n* Conditions that do not permit an MRI examination",true,"ALL","18 Years","40 Years",{"count":22,"type":23},32,"ESTIMATED","INTERVENTIONAL",[26],"NA","Type 2 diabetes is the most common metabolic disease worldwide, characterized by hyperglycemia, decreased whole body insulin sensitivity, and white adipose tissue (WAT) dysfunction. A key factor in its development is chronic overnutrition, usually with a high-fat diet (HFD), leading to disturbances of glucose and lipid metabolism. However, the mechanism of short-term HFD-induced tissue-specific insulin resistance remains poorly understood. This project aims to further unravel the underlying mechanisms of short-term HFD overnutrition-mediated WAT insulin resistance. The model described here corresponds to a randomized, single- blinded parallel-grouped trial, consisting of two interventions: a macronutrient-balanced diet and or a hypercaloric diet over three weeks in order to investigate differences in interorgan fatty acid and glucose metabolism between the studied groups. Based on recent studies, the hypothesis is that 21-day hypercaloric HFD induces WAT insulin resistance via a diacylglycerol, novel protein kinase C-insulin receptor signaling model in both fasting and insulin-stimulated states.",[29],"Lipid-induced Insulin Resistance","RECRUITING","2024-02-29",{"date":33,"type":34},"2024-03-01","ACTUAL",{"date":36,"type":34},"2024-01-31",{"date":38,"type":23},"2030-12-31",{"name":40,"class":41},"German Diabetes Center","OTHER"]