[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"living-donor-kidney-transplantation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:living-donor-kidney-transplantation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100358144","phase-1-tli-tbi-atg--hematopoietic-stem-cell-transplantation-and-recipient-t-regs-therapy-in-living-donor-kidney-transplantation-100358144",false,"NCT03943238","TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation","Phase 1 Study of Total Lymphoid Irradiation, Total Body Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+, T-cell and Recipient T Regulatory Cell Transfusion in Human Leukocyte Antigen Mismatched Living Donor Kidney Transplantation","Inclusion Criteria:\n\n1. All consenting adults who are 18 to 65 years, living donor renal transplant recipients at Stanford University Medical Center or Northwestern Medicine who have a haplotype matched (minimum single Human Leukocyte Antigen - DR locus (HLA-DR) and HLA-A or B match) living related or unrelated donor.\n2. Patients who agree to participate in the study and sign an Informed Consent.\n3. Patients who have no known contraindication to administration of rabbit ATG or radiation.\n4. Males and females of reproductive potential who agree to practice a reliable form of contraception for at least 1 year posttransplant\n\nExclusion Criteria:\n\n1. Previous treatment with rabbit ATG or a known allergy to rabbit proteins.\n2. History of malignancy with the exception of non-melanoma skin malignancies.\n3. Pregnant women or nursing mothers.\n4. Serological evidence of HIV, Hepatitis B surface antigen positive (HBsAg+), or Hepatitis C infection. Epstein Barr Virus (EBV) positive to EBV negative.\n5. Leukopenia (with a white blood cell count \\\u003C 3000\u002Fmm3) or thrombocytopenia (with a platelet count \\\u003C 100,000\u002Fmm3).\n6. Panel Reactive Antibody (PRA) greater than 80% or demonstration of historic and\u002For current donor specific antibody (DSA)\n7. Prior organ transplantation\n8. High risk of primary kidney disease recurrence\n9. Advanced coronary or vascular disease.","ALL","18 Years","65 Years",{"count":20,"type":21},22,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","This study will determine whether a preparatory regimen including total lymphoid irradiation (TLI), total body irradiation (TBI), anti-thymocyte globulin (ATG) and infusion of the donor hematopoietic stem cells when given along with recipient regulatory T cells (Tregs) will allow for eventual discontinuation of anti-rejection drugs after living donor kidney transplantation.",[27],"Living Donor Kidney Transplantation",[29,30,31,32],"kidney transplant","Immunological Tolerance","Tregs","Stem cells","RECRUITING","2026-06-29",{"date":36,"type":37},"2026-07-01","ACTUAL",{"date":39,"type":37},"2020-02-01",{"date":41,"type":21},"2029-12-01",{"name":43,"class":44},"Stanford University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100572557","storytelling-to-promote-living-donor-kidney-transplant-100572557","NCT06734819","Storytelling to Promote Living Donor Kidney Transplant","Effectiveness of Digital Storytelling in Increasing Living Kidney Donor Recruitment in Canada","LDKT Stories","Inclusion Criteria:\n\n* Waitlisted and newly referred kidney transplant candidates at the Vancouver Kidney Transplant Program\n* 18 years of age or older\n* Able to provide informed consent\n* English literate\n\nExclusion Criteria:\n\n* Inability to understand English and provide informed consent\n* Transplant candidates excluded from transplantation based on clinical criteria or other contraindications for transplant\n* Unwilling to disclose information on race or ethnicity",{"count":54,"type":21},80,[56],"NA","This study will examine the effectiveness of first-person storytelling in encouraging patients with end-stage renal disease to pursue Living Donor Kidney Transplant (LDKT). The Living Donation Storytelling Library LDSP is a library of videos from donors and recipients sharing their transplant stories, serving as a narrative-based transplant education resource. This study will investigate if exposure to the LDSP changes patient readiness and motivation to pursue LDKT to ultimately increase the number of donor inquiries and donor evaluations. This study will also test if the LDSP serves as a health-literate and culturally safe education approach that can effectively support racialized communities who have a disproportionately higher need for LDKT.",[27,59,60,61],"Health Equity","Patient Education","Narrative Medicine",[27,59,60,61,63],"Digital Storytelling","NOT_YET_RECRUITING","2024-12-14",{"date":67,"type":37},"2024-12-18",{"date":69,"type":21},"2024-12",{"date":71,"type":21},"2025-12",{"name":73,"class":44},"University of British Columbia",1]