[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"living-donors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:living-donors":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100623447","the-effects-of-transversalis-fascia-plane-block-on-opioid-consumption-in-patients-undergoing-hand-assisted-laparoscopic-donor-nephrectomy-a-randomized-controlled-prospective-study-100623447",false,"NCT07396753","The Effects of Transversalis Fascia Plane Block on Opioid Consumption in Patients Undergoing Hand-Assisted Laparoscopic Donor Nephrectomy: A Randomized Controlled Prospective Study","Inclusion Criteria:\n\n* Approved by the transplant committee for living kidney donation\n* Scheduled for hand-assisted laparoscopic donor nephrectomy (HALDN)\n* Able to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Known allergy to any medications used in the study (e.g., local anesthetics, opioids)\n* Chronic opioid use or use of opioid receptor agonists\n* Inability to communicate effectively (e.g., cognitive impairment, language barrier)\n* Chronic organ failure or major organ dysfunction\n* Refusal or inability to provide informed consent\n* Foreign nationality (if follow-up or consent is restricted)\n* American Society of Anesthesiologists (ASA) physical status ≥ III","ALL","18 Years","80 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to evaluate whether a regional anesthesia technique called the transversalis fascia plane block (TFPB) can improve pain control after hand-assisted laparoscopic donor nephrectomy (HALDN), a minimally invasive surgery performed in living kidney donors.\n\nAlthough HALDN is less invasive than open surgery, patients often experience significant pain after the operation, mainly due to the surgical incisions in the lower abdomen and trocar entry sites. Poorly controlled pain can delay recovery and increase the need for opioid pain medications, which may cause side effects such as nausea, vomiting, itching, and sedation.\n\nThe transversalis fascia plane block is an ultrasound-guided regional anesthesia technique in which a local anesthetic is injected into a specific tissue plane in the lower abdominal wall. This injection temporarily blocks pain signals from nerves supplying the lower abdomen and groin area. The technique has been shown to reduce pain and opioid use after various lower abdominal surgeries and is considered minimally invasive and safe when performed under ultrasound guidance.\n\nIn this study, patients undergoing HALDN will be randomly assigned to one of two groups. One group will receive standard general anesthesia only, while the other group will receive general anesthesia plus a transversalis fascia plane block using a local anesthetic (bupivacaine). All patients will receive the same standard pain treatment after surgery, including paracetamol and patient-controlled morphine.\n\nThe main goal of the study is to compare the amount of opioid pain medication used during the first 24 hours after surgery between the two groups. Secondary outcomes include pain scores measured using the Numeric Rating Scale (NRS), the frequency of opioid-related side effects, and patient satisfaction with pain control.\n\nThe results of this study may help determine whether adding the transversalis fascia plane block to standard anesthesia can provide better pain relief, reduce opioid consumption, and improve comfort and recovery in living kidney donors.",[26,27,28,29,30,31],"Postoperative Pain","Analgesics, Opioid","Pain Management","Anesthesia Regional","Living Donors","Nephrectomy,Kidney Donation",[33,34,35,36],"Hand-assisted laparoscopic donor nephrectomy","Transversalis fascia plane block","Regional anesthesia","Opioid consumption","RECRUITING","2026-02-02",{"date":40,"type":41},"2026-02-09","ACTUAL",{"date":43,"type":41},"2025-07-25",{"date":45,"type":20},"2026-03-03",{"name":47,"class":48},"Koç University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":5},"100532265","multiparametric-mri-in-a-prospective-cohort-of-living-kidney-donors-recipients-and-healthy-controls-correlations-with-markers-of-renal-function-fibrosis-and-ageing-100532265","NCT06210555","Multiparametric MRI in a Prospective Cohort of Living Kidney Donors, Recipients, and Healthy Controls: Correlations With Markers of Renal Function, Fibrosis and Ageing","MpRenal","Living kidney donors and transplant recipients:\n\nInclusion Criteria:\n\n* Approved as a living kidney donor or recipient of a kidney from a living donor.\n* Able to cooperate to an MRI examination\n\nExclusion Criteria:\n\n* Contraindications to MRI due to incompatible foreign objects.\n* Severe claustrophobia\n\nHealthy controls:\n\nInclusion Criteria:\n\n* Office BP \\\u003C 140\u002F90 mmHg. (use of 1 antihypertensive drug allowed)\n* Normal eGFR. (CKD-EPI)\n* Urine albumin-to-creatinine ratio \\\u003C 30 mg\u002Fg.\n* Dipstick negative for hematuria and proteinuria.\n* Able to cooperate to an MRI examination.\n\nExclusion Criteria:\n\n* Contraindications to MRI due to incompatible foreign objects.\n* Severe claustrophobia.\n* Pregnancy.\n* Condition(s) that would exclude living kidney donation.",true,{"count":59,"type":20},96,"OBSERVATIONAL","Development of renal fibrosis is the irreversible culmination of various renal diseases and independently predicts adverse outcomes. Currently renal fibrosis can only be diagnosed by performing a renal biopsy. The procedure is invasive and is limited by sampling bias.\n\nIn recent years there has been a significant development in magnetic resonance imaging (MRI) based techniques. MRI can provide highly detailed anatomical images. Other MRI measures allow quantitative measurements of perfusion, oxygenation, tissue stiffness and diffusion of water molecules within tissue. The combination of several MRI techniques sensitive to different biophysical tissue properties in a single scan session is referred to as multiparametric MRI (mpMRI).\n\nEmerging evidence suggests that mpMRI could represent a method for indirect characterization of renal microstructure and extent of fibrosis. So far, studies performed in living kidney donors and recipients have been mostly cross-sectional. For mpMRI to transition to the clinical setting there is a need for validation of MRI-based measures with currently used reference methods for quantifying renal function and fibrosis.\n\nThe aim of this longitudinal observational study in a cohort of living kidney donors, recipients and healthy controls is to investigate the utility of repeated mpMRI over a period of 2 years. MRI-based measures will be compared to current reference methods for quantifying renal function and fibrosis.\n\nThe investigators hypothesize that there will be significant correlations between MRI-based measures, renal function determined by precise measurement of glomerular filtration rate and extent of fibrosis determined by renal biopsy. MRI-based measures are expected to be predictive of renal function decline and development of renal fibrosis.\n\nThis study could provide valuable data that will be helpful in moving the field of renal mpMRI forward, with the goal of providing a novel and non-invasive method for the diagnosis of renal pathology.",[63,64,30,65,66],"Kidney Transplantation","Multiparametric Magnetic Resonance Imaging","Renal Fibrosis","Senescence",[68,69,70,71,72],"MRI","Multiparametric","Renal transplantation","Fibrosis","Kidney donor","2025-07-23",{"date":75,"type":41},"2025-07-28",{"date":77,"type":41},"2024-10-29",{"date":79,"type":20},"2029-08-01",{"name":81,"class":48},"Patrick Schjelderup"]