[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lmna-lamin-nuclear-a-related-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lmna-lamin-nuclear-a-related-disorders":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100624622","identification-of-women-with-severe-insulin-resistant-syndromes-of-genetic-origin-among-patients-with-classic-polycystic-ovary-syndrome-pcos-100624622",false,"NCT07412028","Identification of Women With Severe Insulin Resistant Syndromes of Genetic Origin Among Patients With \"Classic\" Polycystic Ovary Syndrome (PCOS)","ANDROLIPO","Inclusion Criteria:\n\n* Women aged ≥ 18 years and \\\u003C 45 years ;\n* Discontinuation of estrogen-progestin therapyfor at least 3 months ;\n* Signed informed consent ;\n* Social security affiliation.\n\nCase (n=25):\n\n\\- Patient with a lipodystrophic syndrome due to a known pathogenic variant of the LMNA gene.\n\nControl (n=50), :\n\n\\- patient consulting for polycystic ovary syndrome (PCOS according to the Rotterdam criteria) in day hospital matched on age +\u002F-5 years and BMI+\u002F-5 kg\u002Fm2.\n\nExclusion Criteria:\n\n* \\- Severe renal insufficiency (GFR \\\u003C 30 ml\u002Fmin) ;\n* Hepato-cellular insufficiency (TP \\\u003C 50%) ;\n* Taking corticosteroids or antiretrovirals ;\n* Menopausal women ;\n* Taking estrogen-progestin therapy;\n* Diabetic patients on insulin : type 1 diabetes or pancreatectomised patients\n* Other known causes of hyperandrogenism (21-hydroxylase block, Cushing's syndrome, ovarian tumor).\n* Pregnant woman\n* Breastfeeding woman","FEMALE","18 Years","45 Years",{"count":20,"type":21},81,"ESTIMATED","INTERVENTIONAL",[24],"NA","Diagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+\u002F- 5 years) and Body mass index (+\u002F- 5kg\u002Fm2).",[27,28,29],"Polycystic Ovary Syndrome","Familial Partial Lipodystrophy","LMNA (LaMin Nuclear A) Related Disorders",[27,28,31],"LMNA related disorders","NOT_YET_RECRUITING","2026-02-13",{"date":35,"type":36},"2026-02-17","ACTUAL",{"date":38,"type":21},"2026-02",{"date":40,"type":21},"2027-09",{"name":42,"class":43},"Assistance Publique - Hôpitaux de Paris","OTHER"]