[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lobectomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lobectomy":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,39,65,91,115,140,169,188,219,248,274,301],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100641522","evaluating-the-association-of-force-feedback-with-outcomes-after-lung-resection-using-the-da-vinci-multiport-system-100641522",false,"NCT07660900","Evaluating the Association of Force Feedback With Outcomes After Lung Resection Using the da Vinci Multiport System","Inclusion Criteria:\n\n* Ages 18 years or older\n* Undergoing robotic-assisted anatomic lung resection (lobectomy or segmentectomy) at The Ohio State University Wexner Medical Center\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old\n* Subject is pregnant or suspected to be pregnant or breastfeeding\n* ECOG Performance status \\> 2\n* Do not qualify for ERAS protocol\n* Undergoing an emergent procedure\n* Undergoing non-anatomic lung resection\n* Undergoing pneumonectomy\n* Previous ipsilateral thoracic surgery (open, video-assisted thoracoscopic or robotic)\n* Planned to undergo major concomitant surgery for the treatment of a different medical condition than was originally planned\n* Non-English speaking","ALL","18 Years",{"count":18,"type":19},270,"ESTIMATED","OBSERVATIONAL","The purpose of this research is to study patient outcomes based on the use of Force Feedback instruments during robotic-assisted lung resection. Force Feedback technology describes the physical forces a surgeon senses when pushing and pulling structures inside the body during robotic-assisted surgery.",[23,24,25],"Lobectomy","Segmentectomy","Force Measurement","RECRUITING","2026-06-16",{"date":29,"type":30},"2026-06-22","ACTUAL",{"date":32,"type":30},"2025-09-05",{"date":34,"type":19},"2027-12-31",{"name":36,"class":37},"Ohio State University","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":38},"100641875","pre-incisional-infiltration-with-ropivacaine-plus-diprospan-for-relieving-postoperative-pain-after-thoracoscopic-surgery-100641875","NCT07626489","Pre-incisional Infiltration With Ropivacaine Plus Diprospan for Relieving Postoperative Pain After Thoracoscopic Surgery","The Efficacy and Safety of Pre-incisional Infiltration With Ropivacaine Plus Diprospan in Patients Undergoing Video-assisted Thoracoscopic: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Video-assisted thoracoscopic surgery for wedge resection, segmentectomy and lobectomy of the lungs under general anesthesia;\n2. 8 to 64 years old\n3. American Society of Anesthesiologists (ASA) physical status of I-III\n4. Patients must be able to understand the nature and potential personal consequences of the clinical trial and cooperate with follow-up investigations\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of allergies to experimental drugs such as opioids or steroids;\n2. Alcohol abuse; Long term use of opioid drugs (exceeding 2 weeks or 3 days per week for more than 1 month); Suspected use of sedatives and analgesics; Use analgesic drugs within 24 hours before surgery; Patients undergoing steroid therapy;\n3. Serious neurological disorders, severe liver and kidney dysfunction, heart failure, etc;\n4. Unable to use pain assessment scale;\n5. Pregnant or lactating patients.","64 Years",{"count":48,"type":19},100,"INTERVENTIONAL",[51],"NA","Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%. Inadequate postoperative analgesia may trigger a series of adverse physiological stress responses, increase the occurrence of postoperative complications, and affect the rehabilitation process. If acute pain is not managed promptly and sufficiently, nearly one-quarter of patients may develop chronic pain, impacting normal life and sleep quality after discharge. Acute pain after VATS is mainly caused by the release of inflammatory mediators after soft tissue injury at the surgical site, which activates peripheral pain receptors and leads to abnormal action potentials transmitted along A δ and C fibers. Inflammatory mediators released from the soft tissues around incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization.\n\nIncisional infiltration is the simplest, safest, and most effective anesthesia method for preventing incision pain after VATS, but even using long-acting local anesthetics, the effectiveness of postoperative analgesia can only last for a relatively short period of time. To improve the efficiency of local incision infiltration in postoperative analgesia, at least two issues need to be addressed: prolonging the duration of analgesia and reducing inflammation of nerve surrounding tissues. Numerous studies have shown that glucocorticoids not only can achieve anti-inflammatory and analgesic effects by inhibiting inflammatory cytokines and inflammatory responses but also can prolong the duration of action of local anesthetics. Preemptive incisional infiltration using local anesthetics with corticosteroids which have potent local anti-inflammatory properties may play a key role in preventing or reducing postoperative pain. The objective of this trial is to determine whether preemptive incisional infiltration with ropivacaine plus diprospan is superior to ropivacaine alone in relieving postoperative pain for adults undergoing VATS. The investigators also compare the effects of the two intervention measures on postoperative pain management, patient safety, and recovery quality.",[54,55,24,23,56],"Video-assisted Thoracoscopic Surgery (VATS)","Wedge Resection","Infiltration Anesthesia",{"date":58,"type":30},"2026-06-17",{"date":60,"type":19},"2026-05-30",{"date":62,"type":19},"2028-05-30",{"name":64,"class":37},"Beijing Tiantan Hospital",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":49,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":38},"100642769","acute-effects-of-visual-feedback-assisted-inspiratory-muscle-training-after-lobectomy-100642769","NCT07646288","Acute Effects of Visual Feedback-Assisted Inspiratory Muscle Training After Lobectomy","Evaluation of the Acute Effects of Respiratory Muscle Strength Training With Visual Feedback in Lung Cancer Patients Undergoing Lobectomy","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being clinically stable,\n* Being a lung cancer patient scheduled for lobectomy,\n* Being between 18 and 75 years of age,\n* Being able to cooperate with the tests to be performed.\n\nExclusion Criteria:\n\n* Presence of any orthopedic or neurological problem that prevents walking,\n* History of any surgery involving the thoracic wall,\n* Having diseases that may affect respiratory parameters, such as severe heart failure or severe chronic obstructive pulmonary disease (COPD).","75 Years",{"count":74,"type":19},40,[51],"This study aims to evaluate the acute effects of inspiratory muscle training performed with and without a mobile application providing visual feedback on exercise motivation, patient adherence, dyspnea perception, usability, and patient satisfaction in lung cancer patients undergoing lobectomy via video-assisted thoracic surgery. Participants will perform conventional inspiratory muscle training without visual feedback in the morning on postoperative day 1 after transfer to the ward. After at least two hours of rest, the same exercise protocol will be repeated with a smart adaptor connected to a mobile application to provide visual feedback. Inspiratory muscle training will be performed using a threshold-loading device at 40% of maximal inspiratory pressure, with three sets of ten breaths. Outcomes will be assessed before and\u002For after each session as appropriate.",[78,79,80,81,23],"VATS","Respiratory Muscles","Exercise Training","Lung Cancer (NSCLC)","2026-06-11",{"date":84,"type":30},"2026-06-15",{"date":86,"type":30},"2025-12-01",{"date":88,"type":19},"2027-03-01",{"name":90,"class":37},"Hacettepe University",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":46,"enrollmentInfo":98,"targetDuration":4,"studyType":49,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":4},"100642646","the-efficacy-and-safety-of-loxoprofen-sodium-patch-in-relieving-postoperative-pain-after-thoracoscopic-surgery-100642646","NCT07591220","The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery","The Efficacy and Safety of Incisional Preemptive Analgesia Using Loxoprofen Sodium Patch in Patients Undergoing Thoracoscopic Surgery: a Multi-center Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Patients scheduled for elective Video-assisted thoracoscopic surgery for wedge resection, segmentectomy and lobectomy of the lungs under general anesthesia;\n2. 8 to 64 years old;\n3. American Society of Anesthesiologists (ASA) physical status of I-III;\n4. Patients must be able to understand the nature and potential personal consequences of the clinical trial and cooperate with follow-up investigations\n5. signing of the informed consent form.\n\nExclusion Criteria:\n\n1. History of chronic pain syndrome of any cause and mental illness;\n2. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery;\n3. History of hypertension (Grade 3, extremely high risk);\n4. Pregnancy or breastfeeding;\n5. Extreme body mass index (BMI) (\\\u003C 15 or \\> 35);\n6. Participation in another interventional trial that interferes with the intervention or outcome of this trial;\n7. Digestive system diseases (such as peptic ulcers, gastric bleeding);\n8. Patients with coronary artery disease;\n9. Patients with renal impairment (serum creatinine \\> 176 µmol\u002FL) and abnormal liver function(alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) \\> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN);\n10. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran;\n11. Patients with a history of allergy to anyone of the study drugs;",{"count":99,"type":19},156,[51],"Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%. Inadequate postoperative analgesia may trigger a series of adverse physiological stress responses, increase the occurrence of postoperative complications, and affect the rehabilitation process. If acute pain is not managed promptly and sufficiently, nearly one-quarter of patients may develop chronic pain, impacting normal life and sleep quality after discharge. Acute pain after VATS is mainly caused by the release of inflammatory mediators after soft tissue injury at the surgical site, which activates peripheral pain receptors and leads to abnormal action potentials transmitted along A δ and C fibers. Inflammatory mediators released from the soft tissues around incisions not only significantly alters the chemical microenvironment at the peripheral terminals of nociceptors, directly inducing pain, but also sensitizes afferent fibers, contributing to peripheral sensitization. Therefore, drugs with potent local anti-inflammatory properties such as Loxoprofen Sodium may play a key role in preventing or reducing postoperative pain. The investigators conducted a multicenter, prospective, randomized controlled clinical study to explore the use of Loxoprofen Sodium Patch for preoperative local incision analgesia in VATS patients. The investigators aim to observe whether this method can effectively alleviate postoperative incision pain, reduce the dosage of postoperative analgesics and the side effects caused using postoperative analgesics, improve patient satisfaction, and provide new ideas for postoperative analgesia in VATS patients, promoting rapid recovery after VATS.",[54,103,104,105,55,24,23],"Loxoprofen Sodium Patch","Local Incision","Postoperative Pain","NOT_YET_RECRUITING","2026-06-07",{"date":109,"type":30},"2026-06-10",{"date":111,"type":19},"2026-06-01",{"date":113,"type":19},"2028-04-30",{"name":64,"class":37},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":49,"phases":125,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":138,"locationsCount":4},"100626018","the-effects-of-benson-and-progressive-relaxation-techniques-on-pain-and-sleep-in-lobectomy-100626018","NCT07430176","The Effects of Benson and Progressive Relaxation Techniques on Pain and Sleep in Lobectomy.","THE EFFECT OF BENSON AND PROGRESSİVE RELAXATİON TECHNİQUES ON PAİN AND SLEEP QUALİTY İN LOBECTOMY PATİENS","Inclusion Criteria:\n\n* Patients aged 18 and over, Patients undergoing planned lobectomy surgery for the first time, Patients without diagnosed sleep problems, Patients who volunteer to participate in the study, Patients whose cognitive level is suitable for progressive relaxation and Benson exercises, Patients without visual, hearing, or speech problems will be included in the study.\n\nExclusion Criteria:\n\n* Patients with mental health issues, those who are not volunteers to participate in the study, and patients undergoing emergency surgery will not be included.",true,{"count":124,"type":19},160,[51],"During lobectomy surgical treatment, thoracotomy is performed on patients, and post-thoracotomy pain is observed. Pain is one of the most common problems in patients and causes serious morbidity. As a result of the pain experienced, changes in sympathetic activity and the release of catecholamines as a result of the stress response lead to many complications, primarily in the cardiovascular, urinary, gastrointestinal, and nervous systems. In addition, pain can cause sleep problems in the patient due to the stress response, and the healing process is negatively affected. The aim of this research is to evaluate the effects of Benson relaxation technique and progressive muscle relaxation exercises on the pain levels and sleep quality of patients who have undergone lobectomy, in relation to the pain and sleep problems experienced in the postoperative period. The main aim of the study is to reveal the effectiveness of these two relaxation techniques in reducing pain and improving sleep quality in the postoperative care process, and to develop recommendations for clinical applications based on the findings obtained.",[23,128,129],"Lobectomy Patient","Sleep",[131],"lobectomy, pain, sleep quality, benson exercises, progressive relaxation exercises.","2026-04-15",{"date":134,"type":30},"2026-04-16",{"date":136,"type":19},"2026-04-20",{"date":84,"type":19},{"name":139,"class":37},"Cagla Toprak",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":148,"targetDuration":150,"studyType":20,"phases":4,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":168},"100631915","simplified-exercise-based-risk-assessment-in-lung-cancer-100631915","NCT07506889","Simplified Exercise-based Risk Assessment in Lung Cancer","EXercise-based Evaluation of Ventilatory Efficiency for enHanced Risk Assessment in Lungcancer trEatment Using End-tidal CO2: a Multicenter, Prospective Study","EXHALE-CO2","Inclusion Criteria:\n\n* Lung Cancer Diagnosis\n* Age of at least 18 years\n\nExclusion Criteria:\n\n* Not able to perform cycle ergometer exercise\n* Not able to understand spoken or written Swedish",{"count":149,"type":19},500,"1 Year","Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.",[153,23,154,155,156,157],"Lung Cancer (Diagnosis)","Surgery Complications","Neoadjuvant Chemoimmunotherapy","End-Tidal Carbon Dioxide","Exercise","2026-04-02",{"date":160,"type":30},"2026-04-08",{"date":162,"type":19},"2026-04-01",{"date":164,"type":19},"2029-12",{"name":166,"class":167},"Linkoeping University","OTHER_GOV",5,{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":72,"enrollmentInfo":176,"targetDuration":4,"studyType":49,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":181,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":38},"100622669","tegileridine-combined-with-intercostal-nerve-block-after-thoracoscopic-lung-resection-100622669","NCT07386626","Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection","Study on the Analgesic Effect of Tegileridine Combined With Intercostal Nerve Block After Thoracoscopic Lung Resection","Inclusion Criteria:\n\n* Age range: 18 to 75 years old;\n* Patients undergoing elective thoracoscopic lobectomy or segmentectomy;\n* ASA classification levels I-III;\n* BMI 18 \\~ 30 kg\u002Fm2。\n* Voluntarily participate and sign an informed consent form.\n\nExclusion Criteria:\n\n* Patients with preoperative alcohol dependence and long-term use of analgesic drugs are receiving analgesic treatment for other acute and chronic pain;\n* Pregnant or lactating women;\n* Allergies or other contraindications to the anesthetics, analgesics, and antiemetic drugs used in the study;\n* Patients with severe sleep apnea syndrome or acute or severe bronchial asthma;\n* Suffering from mental and neurological disorders or cognitive impairment, known or suspected gastrointestinal obstruction, severe liver and kidney dysfunction (Child Pugh score C), chronic obstructive pulmonary disease or severe cardiovascular disease, etc;\n* Researchers consider participants who are not suitable to participate in this study and those who refuse to participate.",{"count":177,"type":19},118,[51],"Combining tegileridine PCIA with ICNB targeting peripheral nerves, may constitute an ideal analgesic model with complementary advantages. Thus potentially achieving the analgesic goal of \"early pain relief, stable throughout the process, and rapid recovery,\" and may have a positive impact on reducing CPSP.",[23],{"date":160,"type":30},{"date":183,"type":30},"2026-03-18",{"date":185,"type":19},"2027-01-31",{"name":187,"class":37},"Tongji Hospital",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":194,"eligibilityCriteria":195,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":196,"enrollmentInfo":197,"targetDuration":4,"studyType":49,"phases":199,"briefSummary":200,"conditions":201,"keywords":203,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":218},"100597184","toetva-technique-compared-with-anterior-cervical-thyroidectomy-ac-in-terms-of-efficacy-and-safety-100597184","NCT07055191","TOETVA Technique Compared With Anterior Cervical Thyroidectomy (AC) in Terms of Efficacy and Safety","Prospective Randomized Multicenter Trial Comparing the Efficacy and Safety of the Transoral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA) Versus Anterior Cervical Thyroidectomy (AC)","THYRORAL","Inclusion Criteria:\n\n* Patients with a surgical indication for lobectomy or thyroidectomy\n* Estimated thyroid volume measured by ultrasonography of less than 60 mL\n* Nodules suspected to be malignant measuring less than 4 cm\n* Patient aged between 18 and 65 years old\n* Patient who has benefited from an endocrinological evaluation, with a favorable opinion for TOETVA or AC Patient who understands and accepts the need for follow-up\n* Patient who agrees to be included in the study and who signs the informed consent form\n* Patient affiliated to a healthcare insurance plan\n\nExclusion Criteria:\n\n* Patients refusing an alternative to AC or refusing AC\n* History of cervical surgery\n* Associated parathyroid surgery\n* Identification of malignant lymph nodes\n* Presence of a severe and evolutive life threatening pathology\n* Patients with unstable psychiatric disorder, under supervision or guardianship\n* Patient who does not understand French\u002F is unable to give consent\n* Patient not affiliated to a French or European healthcare insurance\n* Patient who has already been included in a trial which has a conflict of interests with the present study\n* Pregnant or breast-feeding patient\n* Patient incarcerated","65 Years",{"count":198,"type":19},616,[51],"Nearly 50,000 thyroidectomies are performed in France each year for benign and malignant pathologies. Each one affects the life of the patient and represents, for some, suffering, symbolized by the stigma of the operation. The consequences of these scars vary according to the patient, their experience and their culture. For example, cervicotomies are particularly badly accepted in Asia since they are supposed to interrupt the fertility meridian. In France, increasing attention is being paid to the global management of a person with some disease. As a disease state may be transitory, the medical team must consider the situation \"after the illness\" and plan a return to normality. In particular, alternative approaches to cervicotomy have been developed, in which the scar is in a less visible location, at the cost of a more extensive dissection. These techniques include the transaxillary approach, the bi-areolar biaxillary approach and the retroauricular approach. Such procedures, initially developed as an endoscopic approach, have become progressively robotically assisted, to help with the ergonomics of the procedure. Even though robotic assistance initially helped to spread use of these techniques, it has, over time, limited them, first because of higher cost, and second because of the high learning curve (50 to 75 cases). Finally, the transaxillary approach, which is the most commonly performed, has an inherent problem due to the decreased visibility of the noble structures on the contralateral side, leading to frequent subtotal resection.\n\nSince 2014, the Transoral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA) has been developed as an alternative to these robot-assisted procedures. Because this technique offers the surgeon similar access to the anatomical structures on both sides of the trachea and makes it possible to identify the noble structures to be preserved, TOETVA is currently undergoing a more widespread use in France and worldwide and more candidates for are being offered the procedure. TOETVA reduces the need for dissection to reach the thyroid gland. Moreover, this procedure does not require any special equipment, even if robotic assistance has been used in transoral thyroidectomy.\n\nJust like the electric light was not developed from the continuous improvement of candles, entirely new approaches are sometimes necessary in surgery. The Scientific Committee of the French Association of Endocrine Surgery is convinced that TOETVA, will become more widely used in France, even if this technique is a major departure from the standard approach. However, it is technically more demanding and must, therefore, be evaluated and supervised. This will require a safety study and a comparison with the current reference procedure, the anterior cervical thyroidectomy (AC). The investigators assume, based on our initial experience, that the use of endoscopic equipment and its magnification will allow good visualization of the noble elements (recurrent nerve and parathyroid glands) and that the complication rate of TOETVA will not be higher than that of the reference approach.\n\nThe investigators propose to evaluate, through a prospective randomized study, an innovative endocrine surgical technique that has started to be used worldwide. Although this study is in line with the objectives of an evaluation of the pertinence of care by the health authorities, it would be the first assessment of this innovative surgical technique in thyroid surgery. To our knowledge, after an extensive bibliographic search, no prospective multicenter randomized trial comparing TOETVA to AC has yet been performed, even if many cohorts of patients have been reported to have benefited from this approach6.\n\nIn this trial, any change to the quality of life will be extensively evaluated. The use of validated scores to quantify pain and quality of life will provide objective information and make it possible to determine the impact of the presence or absence of a scar.",[23,202],"Thyroidectomy",[204,205,206,207,208],"Endocrinology","thyroidectomy","mini-invasive","TransOral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA)","Anterior Cervical thyroidectomy (AC)","2026-01-15",{"date":211,"type":30},"2026-01-16",{"date":213,"type":30},"2025-11-07",{"date":215,"type":19},"2028-11",{"name":217,"class":37},"University Hospital, Lille",10,{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":15,"minAge":226,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":49,"phases":228,"briefSummary":229,"conditions":230,"keywords":236,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":38},"100555754","auricular-acupressure-in-prehabilitation-100555754","NCT06516198","Auricular Acupressure in Prehabilitation","A Pilot Study of the Utility of Auricular Acupressure in Enhancing Prehabilitation Benefits in Candidates for Thoracic Surgery.","Inclusion Criteria\n\n* Being considered for major lung surgery\n* Surgery is not scheduled for at least 2 weeks\n* Age ≥ 50 years\n* Able to understand English at a 4th grade level\n* No known contraindications to prehabilitation (strength, endurance, balance exercises)\n* Able to provide informed consent for participation\n* Has an adult care partner who will be available and capable of placing seeds\n* Has access to smart phone for communication and image sharing\n* Underwent frailty screening (given any score)\n* Able to perform spirometry testing in clinic\n\nExclusion Criteria:\n\n* Allergy to Vaccaria seeds\n* Medical condition affecting either ear preventing use of auricular acupressure such as eczema, frostbite, sunburn","50 Years",{"count":74,"type":19},[51],"Complementary medicine is recognized for its ability to enhance appetite, increase energy, reduce anxiety, decrease pain, and improve sleep, among many other benefits. Acupuncture is among the most frequent types of complementary medicine practiced in the US, and Medicare currently includes back pain as a reimbursable indication for this therapy. Acupuncture-related therapies may enhance efforts at prehabilitation in candidates for major lung resection.",[231,232,233,234,55,24,23,235],"Frailty","Thoracic","Prehabilitation","Lung Surgery","Pneumonectomy; Status",[237,238],"accupressure","vaccaria seeds","2025-12-02",{"date":241,"type":30},"2025-12-09",{"date":243,"type":30},"2025-07-21",{"date":245,"type":19},"2027-06-20",{"name":247,"class":37},"University of Chicago",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":49,"phases":258,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":38},"100536967","phase-4-stellate-ganglion-block-100536967","NCT06271707","Stellate Ganglion Block","Left Sided Stellate Ganglion Blocks Impact on the Rate of Post-operative Atrial Fibrillation in Patients Undergoing Thoracic Surgery: A Pilot Study","Inclusion Criteria:\n\n* Patients undergoing esophagectomy, pneumonectomy, or lobectomy aged 18-85.\n\nExclusion Criteria:\n\n* Patients who have an exclusion to regional anesthesia.\n* Patients who have exclusion to stellate blockade.\n* Patients who are pregnant assessed via self-report or pregnancy test if they have taken one","85 Years",{"count":257,"type":19},48,[259],"PHASE4","The purpose of this study is to determine if the addition of an ultrasound guided left sided stellate ganglion block with bupivacaine in patients undergoing esophagectomy, pneumonectomy, or lobectomy will result in lower rates of postoperative atrial fibrillation as compared to standard of care.",[262,263,23],"Esophagectomy","Pneumonectomy",[262,263,23,252],"2025-08-27",{"date":267,"type":30},"2025-09-04",{"date":269,"type":30},"2025-05-19",{"date":271,"type":19},"2027-07-15",{"name":273,"class":37},"University of Minnesota",{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":284,"conditions":285,"keywords":287,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":300},"100479664","personalized-postoperative-pain-management-following-thoracic-surgery-in-adults-100479664","NCT05525923","Personalized Postoperative Pain Management Following Thoracic Surgery in Adults","Pharmacogenetics and Pharmacokinetics of Oxycodone to Personalize Postoperative Pain Management Following Thoracic Surgery in Adults","Inclusion Criteria:\n\n* \\>18 years\n* American Society of Anesthesiologists (ASA) Physical Status 1, 2, 3\n* Undergoing thoracic surgery (TS; pneumonectomy, lobectomy and segmentectomy)\n\nExclusion Criteria:\n\n* Children (\\\u003C18 years)\n* Pregnant women\n* American Society of Anesthesiologists (ASA) Physical Status 4 or above\n* Non-English speaking\n* Outpatient surgery\n* Concomitant additional surgical procedures\n* Significant liver and kidney dysfunction\n* Significant cardiorespiratory compromise\n* Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)","99 Years",{"count":283,"type":19},200,"The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone, in adults following thoracic surgery. Major inpatient thoracic surgeries (TS) for lung disease are common and extremely painful surgeries and are associated with sever post-surgical pain, high incidence of chronic post-surgical pain (CPSP), excess opioid use, costly immediate postoperative opioid adverse events (AEs), and long hospital stays. This study is aiming to develop proactive risk prediction algorithms for precision surgical pain relief in adult TS patients through comparison of actual clinical outcomes with standard of care to predicted outcomes based on personalized risk assessments.",[286,263,23,24],"Thoracic Surgery",[288,289],"Pain Management","Opioid Use","2025-04-28",{"date":292,"type":30},"2025-05-01",{"date":294,"type":30},"2023-11-30",{"date":296,"type":19},"2028-03-01",{"name":298,"class":299},"OpalGenix, Inc","INDUSTRY",4,{"id":302,"slug":303,"hasResults":11,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":49,"phases":310,"briefSummary":312,"conditions":313,"keywords":320,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":38},"100562399","phase-1-reinforced-and-non-reinforced-staple-lines-in-fissureless-lobectomy-100562399","NCT06602661","Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy","A Prospective Randomized Study of Reinforced Vs Non-reinforced Staple Lines in Fissureless Lobectomy","Inclusion Criteria:\n\n* Patients aged 18 and over.\n* Patients undergoing fissureless lobectomy for lung carcinoma.\n\nExclusion Criteria:\n\n* Patients suitable for sub lobar resections.\n* Patients undergoing lobectomy for indications other than lung cancer.\n* Patients with a history of pleural adhesions.\n* Patients with previous lung resection on the same side.",{"count":309,"type":19},65,[311],"PHASE1","Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs. Reinforced staplers are designed to make the staple line stronger and reduce the risk of PAL. However, investigators don't know if they are better than standard staplers, especially in a specific type of lung surgery called fissureless lobectomy for lung cancer. This study aims to find out if reinforced staplers are more effective at reducing PAL and its complications compared to non-reinforced staplers.\n\nReinforced staplers have been used in lung surgeries and have shown to reduce PAL. For example, staplers with special materials like polyglycolic acid (PGA) sheets have shown lower air leakage and fewer days with chest tubes. Other materials like expanded polytetrafluoroethylene (ePTFE) sleeves have also been used to manage air leaks in different types of lung surgeries. However, their effectiveness in fissureless lobectomy has not been studied yet.",[314,315,316,317,318,23,128,319,78],"Lung","Lung Adenocarcinoma","Lung Adenosquamous Carcinoma","Lung Cancer, Non-Small Cell","Lung Carcinoma","Lobectomy by Video-thoracoscopies",[321,322,323,324,325,318,326,327,328,329,330,331,332,333,334,335,336,337,338,339],"Prospective Randomized Study","Fissureless Lobectomy","Prolonged Air Leak (PAL)","Pulmonary Resections","Hospital Length of Stay (LOS)","Echelon 3000 stapler","Endopath Stapler Line Reinforcement","Video-Assisted Thoracoscopic Surgery (VATS)","Postoperative Outcomes","Intraoperative Characteristics","Randomized Control Trial (RCT)","Surrey Memorial Hospital (SMH)","Surrey Thoracic Surgery Group (STSG)","Digital Drainage System (Thopaz)","Chest Tube Duration","Hospital Readmission","Patient Outcomes","Bioabsorbable Buttress Material","Polyglactin and Polydioxanone","2024-09-17",{"date":342,"type":30},"2024-09-19",{"date":344,"type":19},"2025-01-01",{"date":346,"type":19},"2028-01",{"name":348,"class":37},"Surrey Thoracic Surgery Group"]