[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"local-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:local-anesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,86,118,141,171,199,232,267,292,313],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100638497","comparison-of-anesthetic-efficacy-and-safety-between-inferior-alveolar-nerve-block-and-the-infiltrative-technique-for-the-treatment-of-peri-implant-diseases-in-posterior-mandibular-implants-100638497",false,"NCT07590037","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants","Comparison of Anesthetic Efficacy and Safety Between Inferior Alveolar Nerve Block and the Infiltrative Technique for the Treatment of Peri-implant Diseases in Posterior Mandibular Implants: A Triple-blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years) requiring surgical treatment of peri-implantitis in the posterior mandibular sector.\n* Patients without relevant systemic disease (ASA II or lower).\n* Sufficient intellectual capacity to understand the study and informed consent and to complete the questionnaires adequately.\n\nExclusion Criteria:\n\n* Pregnant patients.\n* Patients with allergy or hypersensitivity to articaine or epinephrine.\n* Patients with uncontrolled systemic diseases.\n* Patients with coagulation disorders or medication that alters coagulation.\n* Patients who may be able to recognize the anesthetic technique used, such as dentists.\n* Drugs or systemic diseases (ASA III or higher) that contraindicate surgical intervention or the use of anesthetics and\u002For vasoconstrictors.\n* Patients with relative or absolute contraindication to conventional analgesic or anti-inflammatory regimens.",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This triple-blind randomized clinical trial aims to compare the anesthetic efficacy and safety of two local anesthesia techniques for the surgical treatment of peri-implantitis in posterior mandibular implants: inferior alveolar nerve block (IANB) and infiltrative anesthesia with 4% articaine and epinephrine 1:100,000.\n\nPeri-implantitis is an inflammatory disease affecting the tissues around dental implants, characterized by progressive bone loss and clinical signs of inflammation. When non-surgical therapy is insufficient, surgical treatment is required, usually involving flap elevation, debridement of granulation tissue, implant surface decontamination, and, depending on the defect, resective, regenerative, or combined surgery.\n\nEffective local anesthesia is essential in these procedures, especially in the posterior mandible, where dense bone may limit anesthetic diffusion. IANB is the conventional technique for achieving profound mandibular anesthesia, but it may fail due to anatomical variations, accessory innervation, or technical difficulty. Infiltrative anesthesia has been proposed as an alternative, particularly with articaine because of its high diffusion capacity, although its predictability in complex mandibular surgery remains uncertain.\n\nThe main objective is to compare the efficacy of IANB and infiltrative anesthesia, measured by the need for re-anesthesia during surgery. Secondary objectives include assessing safety, intraoperative discomfort, postoperative pain, duration of anesthesia, patient satisfaction, and adverse events.\n\nAdult patients requiring surgical treatment for peri-implantitis in posterior mandibular implants at the Dental Hospital of the University of Barcelona will be included. Eligible participants must be ≥18 years old, medically fit for surgery, and able to understand the study and complete the questionnaires. Exclusion criteria include pregnancy, allergy to articaine or epinephrine, uncontrolled systemic disease, coagulation disorders or anticoagulant medication, ASA III or higher status, and contraindications to conventional analgesic or anti-inflammatory medication.\n\nParticipants will be randomly assigned to either the IANB group or the infiltrative anesthesia group. Randomization will be performed using a computer-generated sequence placed in opaque, sequentially numbered envelopes. The patient, surgeon, outcome assessor, and statistician will remain blinded to group allocation.\n\nThe study includes three visits. At the first visit, eligibility will be assessed and informed consent obtained. At the second visit, surgery will be performed after the assigned anesthetic technique. Patients will record pain using visual analogue scales at injection, during surgery, 2 h, 6 h, 12 h, 24 h, and daily until day 7, as well as rescue medication use and sick leave. At the third visit, 7-9 days after surgery, postoperative healing, complications, adverse events, pain diary, and patient satisfaction will be assessed.\n\nThe primary outcome is anesthetic efficacy, defined as absence of need for re-anesthesia. Secondary variables include demographic factors, systemic disease, medication, smoking, dental anxiety, type and duration of surgery, surgeon experience, number and position of implants, intraoperative and postoperative pain, duration of anesthesia, adverse events, complications, and patient-reported experience measures.\n\nData will be analyzed using Stata\u002FIC 15.1. Quantitative variables will be described using means and standard deviations or medians and interquartile ranges, depending on normality. Qualitative variables will be presented as frequencies and percentages. Group comparisons will use appropriate statistical tests, with significance set at p \\\u003C 0.05.\n\nAs a pilot exploratory trial, the study will include 30 patients, 15 per group. Its aim is to assess feasibility, estimate preliminary event rates, and generate data for future confirmatory trials. The study will follow the Declaration of Helsinki and applicable data protection regulations. Participation will be voluntary, anonymous, and based on written informed consent.",[27,28,29],"Local Anesthesia","Dental Implants","Periimplantitis",[31,32,33,34,35],"dental implants","articaine","periimplantitis","block nerve","local anesthesia","NOT_YET_RECRUITING","2026-05-19",{"date":39,"type":40},"2026-05-22","ACTUAL",{"date":42,"type":21},"2026-09",{"date":44,"type":21},"2027-12",{"name":46,"class":47},"University of Barcelona","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":48},"100416909","the-effect-of-music-therapy-under-ultrasound-guided-manual-vacuum-aspiration-100416909","NCT04708808","The Effect of Music Therapy Under Ultrasound Guided Manual Vacuum Aspiration","The Efficacy of Music as an Adjunct Analgesic in Reducing Pain and Anxiety During Ultrasound-guided Manual Vacuum Aspiration (USG-MVA): A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women 18 years old or above\n* hospitalized for termination of first trimester pregnancy under local anaesthesia\n\nExclusion Criteria:\n\n* being a minor or adult protected by law\n* not feasible for MVA procedure\n* Partial or total hearing impairment\n* on anxiolytics and analgesics before arriving at the hospital\n* refusal to participate","FEMALE",{"count":58,"type":21},176,[24],"Manual vacuum aspiration (MVA) is one of the surgical treatment options for managing early pregnancy loss. When compared to traditional surgical method; MVA is safer, more cost-effective, due to its shorter hospitalisation period and not undergo the risk of general anaesthesia. The MVA procedure is performed under local anaesthesia and analgesics is given prior the procedure. However, majority of patients still complaint significant pain during the procedure.\n\nIn our previous study, the investigator found women had high anxiety and stress levels when undergo miscarriage and the operation. Pain perception may further be affected by one's psychological state at the time of the procedure. Therefore reducing the patient's anxiety during the USG-MVA may further improve the patient's pain control and overall acceptance of the procedure.\n\nMusic can act as a distracter and has a calming effect which turn the patient's attention away from negative stimuli. Yet, there has been no RCTs to investigate the beneficial effect of music therapy in pain control or reducing anxiety levels during USG-MVA.\n\nThe investigator hypothesis the intervention of music therapy to our current pain control will reduce the pain and anxiety levels experienced by our patients during USG-MVA. Thus, there is a need to conduct an RCT to test our hypothesis.\n\nThe study is conducted in an university affilated hospital for women undergo the USG-MVA procedure. The primary outcome is to evaluate in between group difference in the pain intensity after the USG-guided MVA procedure. The secondary outcome is to evaluate the difference in anxiety level . Case is randomized to music and non music group, Bluetooth headphone are provided during the procedure and case can choose their favourite songs. The outcome are measured by the self rated instrument: Visual analogue scale and the STAI trait anxiety score and the physiological measure salivary alpha amylase (sAA )score. The pain score and the anxiety level is measured pre operatively, immediate after the procedure and 2 hours post operatively. The SPSS-26 will be used for statistics analysis.",[62,63,64,27,65],"First Trimester Abortion","Surgical Abortion","Music Intervention","Pain",[67,68,69,70,71,72,73,74,75],"music","termination of pregnancy","suction curettage","evacuation of gestational product","anxiety","abortion","pain","surgical abortion","aspiration abortion","RECRUITING","2026-05-03",{"date":79,"type":40},"2026-05-07",{"date":81,"type":40},"2021-11-16",{"date":83,"type":21},"2027-12-30",{"name":85,"class":47},"Chinese University of Hong Kong",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":16,"sex":17,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":103,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":48},"100627534","ai-avatar-video-vs-tell-show-do-for-reducing-anxiety-and-improving-cooperation-in-children-during-local-anesthesia-100627534","NCT07449884","AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia","Artificial Intelligence-driven Avatar-based Video vs. Tell-show-do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Inclusion Criteria:\n\n  * Children aged 5 to 7 years\n  * Medically healthy (ASA I)\n  * Cooperative behavior during dental examination\n  * No known allergy to local anesthetics\n  * Require non-urgent dental treatment under local anesthesia\n  * First-time experience receiving local anesthesia\n  * Able to understand and communicate\n\nExclusion Criteria:\n\n* History of epilepsy\n* Diagnosed anxiety or behavioral disorders\n* Cognitive or developmental delay\n* Hearing or visual impairment\n* Previous experience with dental anesthesia\n* Require inferior alveolar nerve block anesthesia\n\nExclusion Criteria:\n\n\\-","5 Years","7 Years",{"count":96,"type":21},70,[24],"This randomized clinical trial aims to compare two behavior guidance techniques used to reduce anxiety in children during local anesthesia injections in dental treatment. The study evaluates the traditional Tell-Show-Do (TSD) technique versus an artificial intelligence (AI)-driven, avatar-based video method called the \"Mini Dentist.\"\n\nChildren aged 5 to 7 years who require local anesthesia for routine dental treatment will be randomly assigned to one of two groups. The control group will receive the conventional Tell-Show-Do explanation from the pediatric dentist. The experimental group will watch a short animated video featuring an AI-generated avatar that explains and demonstrates the procedure in a child-friendly manner before the injection.\n\nAnxiety and behavior will be assessed using heart rate monitoring, behavioral observation (FLACC scale), and a self-reported pain scale (Wong-Baker FACES). The goal is to determine whether the AI-based method improves cooperation and reduces anxiety compared to the traditional approach.\n\nParticipation is voluntary, and all procedures follow ethical research standards.",[100,101,27,102],"Anxiety","Fear","Pediatric Dentistry",[104,105,106,107,108],"Artificial intelligence","Child behavior","Dental anxiety","Local anesthesia.","Randomized Controlled trial","2026-03-24",{"date":111,"type":40},"2026-03-30",{"date":113,"type":40},"2026-02-16",{"date":115,"type":21},"2027-05-30",{"name":117,"class":47},"Saint-Joseph University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":48},"100542689","effect-of-virtual-reality-on-patients-comfort-during-cardiac-electronic-device-implantation-100542689","NCT06346132","Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation.","Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation: a Randomized, Controlled Trial.","Inclusion Criteria:\n\n* Patients over 18 year old,\n* Patients who signed the consent form and accepted to participate to the trial,\n* New cardiac electronic device implantation or cardiac electronic device battery change,\n* Surgical procedure planned in ambulatory care.\n\nExclusion Criteria:\n\n* Communication limitations,\n* Surgical procedure planned in sedation or narcosis,\n* Severe sensorial deficits (visual, auditory),\n* Claustrophobia,\n* Known motion sickness,\n* Patient isolated or with contact precautions,\n* Known or anticipated psychiatric diseases,\n* Patient known for epilepsia,\n* Opened scar and or ongoing infection at the level of the face and\u002For eyes,\n* Patient evaluated non suitable for the study by the surgeon, cardiologist or anesthetist.",{"count":126,"type":21},150,[24],"The purpose of this study is to assess the effect on patient's comfort of a virtual reality experience during a procedure of cardiac electronic device implantation under local anesthesia.",[130,131,27,65],"Virtual Reality","Medical Device","2026-03-18",{"date":134,"type":40},"2026-03-20",{"date":136,"type":40},"2024-03-29",{"date":138,"type":21},"2026-12-31",{"name":140,"class":47},"Schlotterbeck Hervé",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":48},"100621205","lavender-vs-bitter-orange-aromatherapy-to-reduce-anxiety-and-pain-in-pediatric-local-anesthesia-100621205","NCT07367594","Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia","Comparative Evaluation of the Effect of Lavender Versus Bitter Orange Essential Oils Aromatherapy on Decreasing Dental Anxiety and Pain of Children During Administration of Local Anesthetic: (A Randomized Clinical Trial)","Inclusion Criteria:\n\n* Children with the age range of 6-12 years\n* Any dental procedure that requires injection of local anesthesia.\n* Cooperative patients.(according to Frankl's classification class 1 and 2)\n* Parents or guardians willing to participate in the study.\n* Healthy child\n\nExclusion Criteria:\n\n* Children with complicated systemic disease.\n* Uncooperative patients. .(according to Frankl's classification class 3 and 4)\n* Children with severe cognitive impairment or developmental disorders\n* Children with respiratory tract infections.\n* Children experiencing dental pain such as (acute pain or hyperemia).","6 Years","12 Years",{"count":151,"type":21},26,[24],"This randomized controlled clinical trial aims to evaluate and compare the effectiveness of lavender essential oil and bitter orange essential oil aromatherapy in reducing dental anxiety and pain in children during the administration of local anesthesia. Children aged 6-12 years undergoing dental procedures requiring local anesthetic infiltration will be randomly assigned to lavender aromatherapy, bitter orange aromatherapy, or placebo (empty inhaler). Dental anxiety will be assessed using pulse rate and blood pressure measurements, while pain will be evaluated using the FLACC behavioral pain scale. The findings are expected to provide evidence on the role of aromatherapy as a non-pharmacological, safe, and cost-effective behavior guidance method in pediatric dentistry.",[155,27],"Dental Anxiety",[157,158,159,160,161],"aromatherapy","local anesthesia injection","lavender essential oil","bitter orange essential oil","dental anxiety","2026-01-26",{"date":164,"type":40},"2026-01-28",{"date":166,"type":21},"2026-02",{"date":168,"type":21},"2026-04-01",{"name":170,"class":47},"October University for Modern Sciences and Arts",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":16,"sex":17,"minAge":94,"maxAge":149,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":185,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":48},"100603238","effect-of-ai-supported-child-friendly-communication-on-dental-anxiety-in-pediatric-patients-100603238","NCT07133919","Effect of AI-Supported Child-Friendly Communication on Dental Anxiety in Pediatric Patients","Evaluation of the Effect of Traditional Behavior Management Techniques and AI-Assisted Child-Friendly Communication on Dental Anxiety in Pediatric Dental Anesthesia Applications","Inclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who have read and signed the informed consent form and agreed to participate in the study\n* Systemically healthy children aged 6-12 years in the mixed dentition period\n* Children requiring restorative dental procedures (including pulpotomy, pulp capping, or composite restorations) on mandibular teeth under inferior alveolar nerve block local anesthesia\n* Children who are attending their first dental visit and demonstrate behavior rated as 2 (negative) or 3 (positive) according to the Frankl Behavior Rating Scale (Categories: 1 - definitely negative; 2 - negative; 3 - positive; 4 - definitely positive) Behaviors will be categorized as positive (+) or negative (-) based on the Frankl Behavior Rating Scale (Wright's modification)\n* Children receiving local anesthesia for the first time\n\nExclusion Criteria:\n\n* Children volunteers and their parents\u002Flegal guardians who read the informed consent form but declined to participate in the study\n* Children with systemic diseases requiring continuous medication\n* Children with mental or cognitive impairments, as well as those with visual or hearing disabilities\n* Children who, after oral prophylaxis at the first visit, exhibit \"definitely negative\" (Frankl 1) or \"definitely positive\" (Frankl 4) behavior according to the Frankl Behavior Rating Scale\n* Children with previous experience of local anesthesia",{"count":179,"type":21},60,[24],"This study compares the effects of traditional behavior management techniques and AI-assisted child-friendly communication on dental anxiety, physiological stress, and pain perception during local anesthesia in healthy children aged 6-12. The aim is to evaluate the effectiveness of AI-supported communication tools in reducing anxiety and improving comfort in pediatric dental treatments, potentially enhancing clinical outcomes and advancing technology use in pediatric dentistry.",[183,27,184,155],"Caries, Dental","Inferior Alveolar Nerve Block",[186,161,187,188,189],"dental anesthesia","pediatric dentistry","pediatric patients","inferior alveolar nerve block","2025-12-22",{"date":192,"type":40},"2025-12-24",{"date":194,"type":40},"2025-10-15",{"date":196,"type":21},"2026-01",{"name":198,"class":47},"Çanakkale Onsekiz Mart University",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":56,"minAge":18,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":208,"briefSummary":209,"conditions":210,"keywords":215,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":4},"100606655","hysteroscopy-anesthesia-for-relief-of-pain-100606655","NCT07178379","Hysteroscopy Anesthesia for Relief of Pain","HARP Trial: Hysteroscopy Anesthesia for Relief of Pain","HARP","Inclusion Criteria\n\n* Age ≥ 18 years: To ensure that participants are legal adults and able to provide informed consent.\n* Indication for office-based diagnostic hysteroscopy: The patient must be scheduled for a diagnostic hysteroscopy, either for uterine cavity evaluation or diagnostic purposes.\n* Simple procedures like uterine polypectomies involving 1, 2, or more than 3 polyps or endometrial biopsy\n* No previous hysteroscopies\n\nExclusion Criteria\n\n* Age \\\u003C 18 years\n* Known allergy to any local anesthetic\n* General contraindications to hysteroscopy including pregnancy (established via interview, last menstrual period, contraceptive use, or pregnancy test), active infection (e.g., pyometra or recent pelvic inflammatory disease), recent uterine perforation, etc.\n* Complex procedures like myomectomy with morcellator\n* Failure to access the uterine cavity\n* Anatomic conditions preventing cavity access\n* Excessive procedure duration or fluid use (fluid deficit \\> 1000 cc)\n* Known uterine malformations\n* Waiting times exceeding 60 minutes\n* Use of analgesic medication prior to the procedure\n* Major complications related to the procedure including uterine perforation, creation of a false passage, or significant bleeding requiring interventions beyond standard care.\n* Incomplete delivery of informed consent or failure to complete the pre-procedure anxiety questionnaire.",{"count":96,"type":21},[24],"This randomized clinical trial aims to evaluate the effect of local anesthesia on pain perception in patients undergoing outpatient diagnostic hysteroscopy. Although generally well tolerated, pain during hysteroscopy remains a leading cause of procedural failure and patient discomfort. Current evidence on the effectiveness of local anesthetic techniques is limited, with considerable variability in study designs, patient populations, and outcomes measured.\n\nThis study will compare pain levels between two groups: one receiving local anesthetic infiltration (3% mepivacaine into the uterosacral ligaments), and the other undergoing a placebo-like intervention (saline irrigation without injection). Pain will be assessed using a standardized Visual Analog Scale (VAS).\n\nThe primary objective is to determine whether local anesthesia significantly reduces pain perception during the procedure. Secondary objectives include evaluating which patient or procedural variables may influence pain (e.g., parity, uterine position, BMI, operator experience) and whether local anesthesia impacts the need for post-procedural analgesia or complication rates.\n\nPatients will be randomly assigned in a 1:1 ratio using a simple randomization method. Although the study design does not allow for double blinding, efforts will be made to minimize expectation bias-patients will not be explicitly informed whether they are receiving anesthesia or not, and the placebo group will receive simulated intervention. The principal investigator and the statistician will be blinded to the treatment allocation during data analysis.\n\nInclusion criteria are: age ≥ 18 years, indication for office-based diagnostic hysteroscopy or minor operative procedures (e.g., polypectomy or biopsy), and no previous hysteroscopy experience. Exclusion criteria include known anesthetic allergy, complex procedures (e.g., myomectomy), anatomic uterine malformations, severe complications, or lack of consent.\n\nA total sample size of 58 patients (29 per group) has been calculated based on an expected clinically relevant VAS difference of 1.5 points and a standard deviation of 2.0. To account for possible dropouts, up to 70 patients may be enrolled.\n\nThe results of this trial will provide higher quality evidence on whether local anesthesia should be routinely recommended in outpatient hysteroscopy and may support cost-effectiveness studies in the future.",[211,212,27,213,214],"Pain Management","Outpatient Hysteroscopy","Procedural Pain Relief","Gynecologic Procedure",[216,217,218,219,220,221,222],"hysteroscoy","outpatient hysteroscopy","pain assessment","visual analog scale","localanesthesia","ambulatory surgery","randomized controlled trial","2025-09-10",{"date":225,"type":40},"2025-09-17",{"date":227,"type":21},"2025-09-06",{"date":229,"type":21},"2025-12-31",{"name":231,"class":47},"Maimónides Biomedical Research Institute of Córdoba",{"id":233,"slug":234,"hasResults":11,"nctId":235,"briefTitle":236,"officialTitle":237,"acronym":4,"eligibilityCriteria":238,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":247,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":266},"100602995","intraligamentary-vs-inferior-alveolar-nerve-block-for-pulpitis-a-randomized-clinical-trial-100602995","NCT07130760","Intraligamentary vs Inferior Alveolar Nerve Block for Pulpitis: A Randomized Clinical Trial","Is Intraligamentary Injection the Anesthesia of Choice for Symptomatic Irreversible Pulpitis in Mandibular Molars? A Multicenter Randomized Comparative Trial.","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Presenting with symptomatic irreversible pulpitis in a mandibular molar\n* Vital response to cold testing\n* Ability to understand and provide informed consent\n* Available for follow-up and data collection\n\nExclusion Criteria:\n\n* Known allergy to lidocaine or epinephrine\n* Pregnancy or breastfeeding\n* Use of analgesics or anti-inflammatory drugs in the previous 6 hours\n* Non-vital or previously treated teeth\n* Significant systemic disease (ASA III or above)\n* History of psychiatric or neurological disorders affecting pain perception",{"count":240,"type":21},52,[24],"This multicenter randomized trial compares the clinical effectiveness of intraligamentary injection versus inferior alveolar nerve block (IANB) in patients with symptomatic irreversible pulpitis in mandibular molars. The goal is to determine which technique provides better pain control during endodontic treatment.",[244,245,246,27],"Symptomatic Irreversible Pulpitis (SIP)","Dental Pain","Inferior Alveolar Nerve Block Failure",[248,249,250,251,252,253,254,255,256],"Inferior alveolar nerve block","Pulpitis Mandibular molars","Emergency dental treatment","Symptomatic irreversible pulpitis","Randomized clinical trial","Endodontics","Dental pain","Local anesthesia","Intraligamentary anesthesia","2025-08-16",{"date":259,"type":40},"2025-08-19",{"date":261,"type":40},"2025-06-20",{"date":263,"type":21},"2027-07",{"name":265,"class":47},"Aula Dental Avanzada",2,{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":290,"locationsCount":48},"100590569","rct-of-minimalist-vs-standard-procedure-for-laac-in-nvaf-patients-100590569","NCT06969118","RCT of Minimalist vs Standard Procedure for LAAC in NVAF Patients","A Multi-center, Randomized, Controlled Study Comparing Minimalist Procedure With Standard Procedure for Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation","Inclusion Criteria:\n\n1. Age 18 - 85 years old, all genders;\n2. Subjects who can understand the purpose of the trial, participate voluntarily and sign the informed consent form, and are willing to complete the follow-up according to the protocol requirements;\n3. Indications for left atrial appendage closure: non-valvular atrial fibrillation patients with CHA2DS2-VAS2 score ≥2 and HAS-BLED score ≥3, or who are unable or unwilling to receive long-term oral anticoagulants;\n4. Life expectancy ≥1 year;\n\nExclusion Criteria:\n\n1. Preoperative TEE\u002Fheart CT\u002Fintracardiac ultrasound suggested thrombus in the left atrial appendage\u002Fleft atrium;\n2. Patients with severe renal insufficiency (creatinine ≥200 μmol\u002FL, creatinine clearance \\\u003C30 ml\u002Fmin);\n3. Liver disease patients with coagulation abnormalities and clinically relevant bleeding risks, including liver cirrhosis patients reaching Child Pugh stages B and C;\n4. Severely decreased platelet count at baseline: PLT ≤50\\*10\\^9\u002FL;\n5. Patients with severe preoperative cardiac insufficiency (LVEF \\\u003C35%; clinical manifestations are uncontrolled class IV heart failure);\n6. Combined with other severe cardiac valvular diseases or other structural abnormalities that require surgical treatment on an elective day; or severe coronary heart disease that requires intervention within a fixed period;\n7. Patients who have lesions or conditions with a significant risk of major bleeding, such as current or recent gastrointestinal ulcers, malignant tumors with a high risk of bleeding, recent brain or spinal injuries, recent brain, spinal or ophthalmic procedure, recent intracranial hemorrhage, known or suspected esophageal varices, arteriovenous malformations, vascular aneurysms, or major intraspinal or intracerebral vascular malformations;\n8. Patients with concurrent diseases (other than atrial fibrillation) that require anticoagulant therapy (such as after mechanical valve replacement, and spontaneous or recurrent venous thromboembolism);\n9. Patients who are in clinical trials of other drugs or medical devices and have not completed it yet;\n10. Patients who are considered ineligible to participate in the clinical trial by the investigator.","85 Years",{"count":276,"type":21},200,[24],"Percutaneous left atrial appendage closure (LAAC) is an effective strategy for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). Standard procedure requires general anesthesia, transesophageal echocardiography (TEE) guidance. With the experience accumulation, LAAC can be successfully completed in many centers under local anesthesia, the guidance of X-ray and transthoracic echocardiography (TTE), also known as minimalist procedure. Our center was one of the earliest to carry out minimalist procedure worldwide. At present, expert consensus suggests that minimalist procedure is feasible in experienced centers, but the relevant evidence is insufficient. Some single-arm studies have shown that minimalist procedure is safe and effective. However, there is currently a lack of direct evidence to compare the strengths and weaknesses of these two LAAC procedures. The goal of the study was to compare the effectiveness and safety of minimalist procedure and standard procedure for LAAC in patients with NVAF.",[280,281,282,27],"Atrial Fibrillation","Left Atrial Appendage Occlusion","General Anesthesia","2025-05-06",{"date":285,"type":40},"2025-05-13",{"date":287,"type":21},"2025-06-01",{"date":289,"type":21},"2027-06-01",{"name":291,"class":47},"Shanghai Zhongshan Hospital",{"id":293,"slug":294,"hasResults":11,"nctId":295,"briefTitle":296,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":299,"phases":4,"briefSummary":300,"conditions":301,"keywords":302,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":4},"100546519","result-of-use-of-wide-awake-local-anaesthesia-in-fixation-of-ankle-fractures-100546519","NCT06395987","Result Of Use Of Wide Awake Local Anaesthesia In Fixation Of Ankle Fractures","Inclusion Criteria:\n\n* All adult patients with unstable ankle fracture who need fixation presenting to the Trauma Unit of Assiut University Hospital with the following criteria:\n\n  1. Age ≥ 18 years.\n  2. Isolated ankle fracture in one or both lower limbs.\n\nExclusion Criteria:\n\n1. patients\\\u003C 18 years.\n2. Patients with uncontrolled diabetes mellitus.\n3. open fractures.\n4. Associated fractures in the lower limbs(Spinal anaesthesia will be more suitable in multiple fractures)\n5. Fractures managed by closed contact casting.\n6. Patients with dementia and psychological disease.",{"count":179,"type":21},"OBSERVATIONAL","to assess the success of wide-awake local anaesthesia In fixation of ankle fractures",[27],[303],"Wide_awake","2024-12-04",{"date":306,"type":40},"2024-12-05",{"date":308,"type":21},"2025-01-16",{"date":310,"type":21},"2025-07-16",{"name":312,"class":47},"Assiut University",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":17,"minAge":320,"maxAge":148,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":327,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":4},"100508619","can-caudal-dexmedetomidine-provide-effective-analgesia-100508619","NCT05902780","Can Caudal Dexmedetomidine Provide Effective Analgesia?","Can Caudal Dexmedetomidine Provide Effective Analgesia During Pediatric Inguinoscrotal Surgery?","Inclusion Criteria:\n\n* ASA-I and ASA-II pediatric patients (age :1-6 years old)\n* Inguinoscrotal surgeries\n\nExclusion Criteria:\n\n* Patient's parent's refusal\n* Unable to give consent\n* Known allergy to the study medications\n* Coagulopathies or on anticoagulant medications\n* ASA-III or ASA-IV","1 Year",{"count":322,"type":21},50,[24],"The goal of this clinical trial is to evaluate if caudal dexmedetomidine can provide effective analgesia during inguinoscrotal surgeries in pediatrics, if used caudally alone (and not as an adjunct to caudal bupivacaine).\n\nThe main question it aims to answer is:\n\n* Can caudal dexmedetomidine provide effective analgesia? Participants will be pediatrics aged from 1 to 6 years ASA-I and ASA-II undergoing inguinoscrotal surgeries.\n\n  \\- A total of 50 pediatric patients who will undergo inguinoscrotal surgery will be allocated randomly into 2 equal groups:\n* Group B (n =25): In this group, and after induction of general anesthesia, pediatric patients will receive a caudal injection of bupivacaine 0.125 % in a dose of 1ml\u002Fkg.\n* Group D (n =25): In this group, and after injection of general anesthesia, pediatric patients will receive a caudal injection of dexmedetomidine in a dose of 1.5 mcg\u002Fkg.",[326,27],"Anesthesia",[326,328,329,330,331],"Caudal","Epidural","Regional","postoperative pain","2024-02-12",{"date":334,"type":40},"2024-02-13",{"date":336,"type":21},"2024-09-01",{"date":338,"type":21},"2027-10-01",{"name":340,"class":47},"Benha University"]