[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"local-anesthetic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:local-anesthetic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,73,98],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100570979","phase-1-laparoscopic-assisted-transversus-abdominus-plane-block-versus-intraperitoneal-irrigation-of-local-anesthetic-for-patients-undergoing-laparoscopic-cholecystectomy-100570979",false,"NCT06714279","Laparoscopic-Assisted Transversus Abdominus Plane Block Versus Intraperitoneal Irrigation of Local Anesthetic for Patients Undergoing Laparoscopic Cholecystectomy","Laparoscopic-Assisted Transversus Abdominus Plane Block Versus Intraperitoneal Irrigation of Local Anesthetic for Patients Undergoing Laparoscopic Cholecystectomy - A Prospective, Randomised Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18 years or older will be considered for recruitment into this study if they are indicated to undergo elective laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* Patients failing to meet the above inclusion criteria.","ALL","18 Years",{"count":19,"type":20},144,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","This study is being performed to investigate whether the administration of local anaesthetic into the muscles in the abdomen or onto squirting the local anaesthetic onto the liver following keyhole gallbladder surgery is more beneficial in reducing pain post-operatively.\n\nKeyhole gallbladder surgery is typically performed under general anaesthesia (or while the patient is 'fully asleep'), however doctors use other pain relief types to reduce pain after the operation. One of these options is local anaesthetic, which involves the injection of an medication into or onto the part of the body which has been operated on. The reason for doing this is to reduce the pain felt by the patient in the part if the body where the operation occurred. The best way of using these medications remain unclear.\n\nThe local anaesthetic being used in the study is fully approved for use in Ireland and the drug itself is not being tested. In other words, the drug is not an experimental drug. Local anaesthetic drugs are given in different ways in patients who have just had the keyhole surgery on their gall bladder (this is the surgery that you are about to have).\n\nTherefore, the aim of this study is to compare two ways of giving patients these local anaesthetic medications following key-hole gallbladder surgery. These include (1) injecting the medication into the skin at the surgical wounds and squirting it onto the liver (where the gallbladder has been removed from), or (2) injecting the medication into the skin at the surgical wounds and into the muscles in the abdomen (known formally as a transversus abdominus plane block).",[26,27,28],"Laparoscopic Cholecystectomy","TAP Block","Local Anesthetic",[30,31,32,33],"Laparoscopic cholecystectomy","TAP block","Transversus abdominus plane block","Local anesthetic","RECRUITING","2025-08-09",{"date":37,"type":38},"2025-08-14","ACTUAL",{"date":40,"type":38},"2025-03-12",{"date":42,"type":20},"2026-06",{"name":44,"class":45},"Royal College of Surgeons, Ireland","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":46},"100544989","chloroprocaine-1-versus-ropivacaine-075-during-cesarean-section-100544989","NCT06376058","Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section","Intrathecal Use of Chloroprocaine 1% and Ropivacaine 0,75% During Elective Cesarean Section. A Comparative Study","annie-mariana","Inclusion Criteria:\n\n* adult parturients, American Society of Anesthesiologists (ASA) I-II,\n* singleton gestation\\>37 weeks\n* elective cesarean section\n\nExclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) \\> III\n* age \\\u003C 18 years\n* singleton gestation \\\u003C37 weeks\n* Body Mass Index (BMI) \\>40 kg\u002Fm2\n* Body weight \\\u003C50 kg\n* Body weight\\>100 kg\n* height\\\u003C150 cm\n* height\\>180 cm\n* multiple gestation\n* emergency delivery\n* fetal abnormality\n* fetal distress\n* pregnancy-induced pathology such as preeclampsia, eclampsia, premature labor, placental abnormalities\n* pregnancy- induced diseases such as hepatic failure, pseudocholinesterase deficiency, neuromuscular diseases\n* lack of informed consent\n* contraindication for regional anesthesia such as thrombocytopenia, coagulation abnormalities, allergy to local anesthetics","FEMALE","48 Years",{"count":58,"type":20},60,[60],"NA","This will be a prospective randomized study, aiming at comparing an intrathecal fixed dose of chloroprocaine 1% versus an intrathecal fixed dose of ropivacaine 0.75% in elective cesarean sections",[63,28],"Cesarean Section","2025-07-20",{"date":66,"type":38},"2025-07-22",{"date":68,"type":38},"2024-01-10",{"date":70,"type":20},"2026-01-10",{"name":72,"class":45},"Aretaieion University Hospital",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100577692","phase-4-age-based-and-weight-based-bupivacaine-dosing-for-pediatric-spinal-anesthesia-for-elective-infra-umbilical-surgeries-100577692","NCT06801600","Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries","A Comparative Study Between Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia in Children Undergoing Elective Infra-Umbilical Surgeries: A Randomized Double-Blinded Controlled Trial","Inclusion Criteria:\n\n* ASA I and II\n* Both genders\n* Elective infra-umbilical surgeries with anticipated duration ≤ 90 minutes.\n\nExclusion Criteria:\n\n* Guardian refusal.\n* Children with major congenital heart disease, including septal defects.\n* Patients with neuromuscular disorders or high intracranial pressure.\n* Children with spinal deformities or morbid obesity (BMI above the 99th percentile).\n* Children with a history or family history of coagulation disorders.\n* Children with local infection at the site of skin puncture for spinal anesthesia.\n* Children with known allergy to bupivacaine.\n* Surgeries requiring head down (Trendelenburg) or prone position.\n* Unexpected prolongation of surgery \\> 90 minutes.","1 Year","6 Years",{"count":58,"type":20},[84],"PHASE4","Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA). Spinal anesthesia in infants has been linked to a lower incidence of hypotension, hypoxia, bradycardia, and postoperative apnea in comparison to general anesthesia (GA); ensuring a high level of cardiovascular and respiratory stability.\n\nAdditionally, SA has been linked to lower operating room time, post-anesthesia care unit, hospital length of stay, corticosteroid administration, narcotic requirements, postoperative emesis, and cardiopulmonary complications in comparison to GA.\n\nA reduction in systemic blood pressure frequently accompanies neuraxial blocks in adults, necessitating intervention. Nevertheless, spinal, caudal, or epidural blocks administered to children under six years old are not associated with any substantial alterations in blood pressure. In children aged 6 to 10, there is a linear decrease in blood pressure that will reach a plateau at approximately a 30% decrease in those beyond the age of 10. Conversely, younger children require no additional precautions.\n\nBupivacaine, has a narrow therapeutic index in children, and its dosing requires careful consideration to strike a balance between effective anesthesia and the risk of toxicity. The traditional method of dosing bupivacaine in pediatric spinal anesthesia is based on the child's body weight. This weight-based dosing considers the assumption that children's drug clearance correlates with their body mass. However, this approach might not account for the maturational changes in drug handling by pediatric patients or the variability in spinal column length and cerebrospinal fluid volumes, not always proportional to weight but may evolve with age.\n\nEmerging evidence suggests that age-based dosing may be more effective. It hypothesizes that developmental pharmacokinetics, including changes in body composition, organ function, and drug-receptor differences, can influence bupivacaine metabolism and action more significantly than body mass alone. By accounting for the age-related anatomical and physiological changes, age-based dosing could result in more precise and effective anesthesia with a decreased risk of adverse outcomes.\n\nTo the authors knowledge, there is no study comparing age-based and weight-based bupivacaine dosing for pediatric spinal anesthesia in children undergoing elective infra-umbilical surgery.",[87,28,88],"Spinal Anesthesia","Bupivacaine","NOT_YET_RECRUITING","2025-01-25",{"date":92,"type":38},"2025-01-30",{"date":92,"type":20},{"date":95,"type":20},"2025-06-05",{"name":97,"class":45},"Cairo University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":21,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100567656","mixed-local-for-sciatic-block-100567656","NCT06671028","Mixed Local for Sciatic Block","Ropivacaine Versus Ropivacaine With Lidocaine Mixture in Poplitial-Sciatic Nerve Block for Below Knee Surgeries- A Randomized, Single Center Study","Inclusion Criteria:\n\n* Adult patients (≥18 years old)\n* Scheduled for elective below-knee surgeries such as ankle arthroscopy, lower limb fracture fixation, toe surgeries, etc\n* Capable of providing informed consent\n\nExclusion Criteria:\n\n* History of allergic reaction to local anesthetics\n* Pre-existing neurological disorders affecting lower limbs\n* Significant renal or hepatic impairment\n* Pregnancy or breastfeeding\n* Less than 60kg\n* Inability to provide informed consent",{"count":106,"type":20},110,[60],"Choice of local anesthetics is the major determinant of the characteristics of a peripheral nerve block. Short acting local anesthetics while provides faster onset suffer from shorter duration. On the other hand, long acting local anesthetics while provides long duration suffered from long onset time. The ideal local anesthetics should provide faster nerve block onset while providing reasonable duration to provide sustained postoperative analgesia. Mixing short and long acting local anesthetics for nerve blocks may appear to be the solution however previous published studies have demonstrated similar onset time to long acting local anesthetics and with reduced duration. Recently, the London Health Sciences Centre established an ambulatory surgical centre. Fast onset peripheral nerve block is desirable. Previous studies have not looked at popliteal sciatic block and anecdotally we feel addition of short acting local anesthetics appear to speed up onset. We are therefore interested in conducting a randomize trial to determine whether mixing short and long acting local anesthetics can speed up onset of surgical quality block.",[110,28],"Regional Anesthesia","2024-10-31",{"date":113,"type":38},"2024-11-04",{"date":115,"type":20},"2025-01-01",{"date":117,"type":20},"2027-07-01",{"name":119,"class":45},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's"]