[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"local\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:local":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100633275","comparison-of-digital-intraosseous-and-manual-intraligamentary-anesthesia-in-children-100633275",false,"NCT07524569","Comparison of Digital Intraosseous and Manual Intraligamentary Anesthesia in Children","Comparison of Digital Intraosseous and Manual Intraligamentary Anesthesia in Children: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Subjects with American Society of Anesthesiologists score I (ASA I)\n* Subjects with Frankl's behavior rate III (positive) and IV (definitely positive),\n* Subjects with indication of similar restoration treatment on bilateral first -permanent mandibular molars\n* Subjects whose plaque index score of 0 (no plaque) and 1\n* Subjects whose gingival index score of 0\n\nExclusion Criteria:\n\n* Allergic to the local anesthetics or sulfites\n* Subjects with cholinesterase deficiency\n* Subjects who use drugs that may affect the assessment of pain, such as narcotic or non-narcotic analgesic, anti-inflammatory, anxiolytic, antipsychotic and antihistamine agents\n* Subjects who need to use sedatives or other medications during dental procedures",true,"ALL","6 Years","12 Years",{"count":21,"type":22},78,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to compare the effects of digital intraosseous anesthesia and manual intraligamentary anesthesia techniques on pain scores during the restorative treatment of permanent mandibular molars in pediatric patients. In addition, the techniques will be compared in terms of injection pain, anesthetic success, postoperative complications, and patient preferences. This randomized, controlled, crossover, single-blind, split-mouth study will be conducted on 78 children aged 6-12 years. Participants with bilateral permanent mandibular molars presenting enamel-dentin carious lesions will be included in the study.",[28,29],"Anesthesia","Local",[31,32,33],"intraligamentary anesthesia","paediatric dentistry","Digital Intraosseous Anesthesia","RECRUITING","2026-04-05",{"date":37,"type":38},"2026-04-13","ACTUAL",{"date":40,"type":22},"2026-04-01",{"date":42,"type":22},"2027-10",{"name":44,"class":45},"Izmir Katip Celebi University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":46},"100558695","local-vs-systemic-methotrexate-in-management-of-uterine-ectopic-pregnancy-100558695","NCT06554470","Local vs Systemic Methotrexate in Management of Uterine Ectopic Pregnancy","Local Versus Systemic Methotrexate in Management of Uterine Ectopic Pregnancy: A Randomized Trial","Inclusion Criteria:\n\n* Age from 20 to 40 years.\n* Women with uterine ectopic pregnancy (interstitial pregnancy, cervical pregnancy, or cesarean scar pregnancy).\n* Gestational age is less than 9 weeks, the embryo size is smaller than 10 mm, and the serum beta-human chorionic gonadotropin (β-hCG) levels are less than 10,000 mIU\u002FmL.\n\nExclusion Criteria:\n\n* Patients with basal beta hCG levels less than 1500 mIU\u002FMl.\n* Any contraindications to MTX as a hepatic disorder, renal disorder and thrombocytopenia\n* Diabetes mellitus.\n* Severe vaginal bleeding or hemodynamic changes or hemoperitoneum.\n* History of cancer.\n* Ascites.\n* Pleural effusion.","FEMALE","20 Years","40 Years",{"count":58,"type":22},34,[25],"This study aims to compare local and systemic methotrexate in the management of uterine ectopic pregnancy regarding the duration of beta human chorionic gonadotropin (hCG) clearance and need for further management options.",[29,62,63,64],"Systemic","Methotrexate","Uterine Ectopic Pregnancy","2024-08-15",{"date":67,"type":38},"2024-08-16",{"date":65,"type":38},{"date":70,"type":22},"2025-07-01",{"name":72,"class":45},"Tanta University"]