[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"locally-recurrent-prostate-carcinoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:locally-recurrent-prostate-carcinoma":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100442721","early-phase-1-immunological-effects-of-vitamin-d-replacement-among-blackafrican-american-prostate-cancer-patients-100442721",false,"NCT05045066","Immunological Effects of Vitamin D Replacement Among Black\u002FAfrican American Prostate Cancer Patients","MC210501 Differences in Immunological Effects of Vitamin D Replacement Among Black\u002F African American (AA) Prostate Cancer Patients With Localized Versus Metastatic Disease","Inclusion Criteria:\n\n* Pre-Registration:\n\n  * African American males, age \\>= 18 years\n  * Patients with a previous history of localized or metastatic or locally recurrent prostate cancer\n* Registration:\n\n  * Patients with Vitamin D levels below 30 ng\u002Fml\n\nExclusion Criteria:\n\n* Pre-Registration:\n\n  * Known hypersensitivity to vitamin D\n  * End stage renal failure on dialysis\n  * Liver cirrhosis\n  * Currently taking a vitamin D or multivitamin supplement, that has more than 400 IU\u002F10mcg of vitamin D daily for the past month\n  * Legal inability or restricted legal ability, medical or psychological conditions not allowing proper study completion or informed consent signature\n  * Chemotherapy or surgery or radiation within the last 3 weeks prior to blood collection\n  * History of hypercalcemia\n* Registration:\n\n  * Chemotherapy or surgery or radiation within the last 3 weeks prior to blood collection","MALE","18 Years",{"count":19,"type":20},220,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","This early phase I is to find out how common vitamin D insufficiency is among African American patients with a history of prostate cancer that has not spread to other parts of the body (localized) or has spread to other places in the body (metastatic) and how vitamin D insufficiency affects the immune system. This study also aims to find out if replacing vitamin D results in normalization of the immune function. Information from this study may benefit prostate cancer patients by identifying vitamin D insufficiency which in several studies had been found to contribute to more aggressive prostate cancers.",[26,27,28,29],"Localized Prostate Carcinoma","Stage IV Prostate Cancer AJCC v8","Locally Recurrent Prostate Carcinoma","Metastatic Prostate Carcinoma","RECRUITING","2026-06-04",{"date":33,"type":34},"2026-06-08","ACTUAL",{"date":36,"type":34},"2021-12-29",{"date":38,"type":20},"2029-08-31",{"name":40,"class":41},"Mayo Clinic","OTHER",2]