[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"locomotion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:locomotion":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,61],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":60},"100621832","spinal-stimulation-with-gait-training-to-improve-lower-limbs-motor-recovery-in-spinal-cord-injury-100621832",false,"NCT07375745","Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury","Combined Gait Training and Transcutaneous Spinal Cord Stimulation to Enhance Lower Limbs Motor Recovery After Subacute SCI","CIMELocomotion","Inclusion Criteria:\n\n* paraplegic or quadriplegic participants with a subacute spinal cord injury (sSCI), defined as the stage of spinal cord damage occuring between 1 week and 6 months post-injury\n* above 16 years old\n* have a lesion between C1 - L2\n* be considered as AIS A to D\n* be able to stay at least 10 minutes standing with or without assistance\n* can provide informed consent (no cognitive deficits by MoCA)\n* be able to follow instructions in French or English\n\nExclusion Criteria:\n\n* pacemaker\n* active cancer on stimulation site or metastatic cancer\n* unhealed wound, scar or pain which makes positioning of the electrodes impossible\n* participants with specific contraindications to TMS (epilepsy, non-union cranial fracture and increased intracranial pressure) will be able to participate in the study, but will not receive TMS\n* chronic and severe neuropathic pain\n* pharmacology or implants that may impede with rehabilitation or spinal stimulation\n* pregnancy","ALL","16 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\\\u003C 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation. Standard care in rehabilitation centers relies on activity-based therapy (ABT), which uses intensive, task-specific training to promote recovery. Although ABT can improve mobility, its effects are often limited due to the nature of SCI and the indirect activation of neural circuits.\n\nRecent findings suggest that adding transcutaneous spinal cord stimulation (tSCS) to ABT in chronic SCI (\\> 12 months) can enhance lower-limb motor recovery. This study will evaluate whether combining tSCS with gait training is safe and feasible in individuals with subacute SCI and whether it improves lower-limb motor outcomes compared with gait training alone.\n\nThe investigators hypothesize that pairing gait training with tSCS early after injury will be safe and feasible and that tSCS delivered during gait training will augment leg muscle activation and lead to greater functional improvements. The study will also assess the feasibility, safety and tolerability of implementing this combined intervention in a intensive functional rehabilitation setting.",[27,28,29,30,31],"Spinal Cord Injury","Spinal Cord Injury Subacute","Locomotion","Gait Disorder, Sensorimotor","Gait Disorders",[27,33,29,34,35,36,37,38,39,40,41,42,43,44,45,46,47],"Neuromodulation","tSCS","Non-invasive","Transcutaneous","Gait","Transcranial Magnetic Stimulation","Subacute","Artificial Intelligence","AI","Lower Limb","Gait training","Walking","Transcutaneous spinal stimulation","Tonic stimulation","Combined gait training and neuromodulation","NOT_YET_RECRUITING","2026-03-04",{"date":51,"type":52},"2026-03-06","ACTUAL",{"date":54,"type":21},"2026-07-01",{"date":56,"type":21},"2029-07",{"name":58,"class":59},"Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal","OTHER",1,{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":4,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":17,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":60},"100599509","sensor-ankle-brace-for-special-operations-rehabilitation-100599509","NCT07085416","Sensor Ankle Brace for Special Operations Rehabilitation","Inclusion Criteria for both cohorts:\n\n* Healthy adults: ages 18 - 40 years\n* considered \"healthy to exercise\" as determined by the physical activity readiness questionnaire (PAR-Q)\n\nAdditional Inclusion Criteria specific to cohort 2 only:\n\n* Classified as \"moderate\" or \"high\" activity level as defined by the scoring criteria of the International Physical Activity Questionnaire - Short Form (IPAQ)\n* Comfortably fit into combat boots provided by the laboratory (Men's sizes 8, 9, 10, 11, 12 and Women's sizes 6, 7, 8, 9, 10 will be purchased, and so participants with foot lengths of 22.54-29.27.8 cm are expected to fit in the boots provided).\n\nExclusion Criteria for both cohorts:\n\n* Smoking tobacco on a regular basis\n* Previous lower back or lower limb surgery (including the joints of the pelvis and lower limbs)\n* Musculoskeletal injury sustained within the 12-weeks prior to enrollment . A musculoskeletal injury is defined as musculoskeletal pain causing a reduction or stoppage of normal physical activity for at least 3 days within a 7-day period, and have not returned to their normal physical activity and exercise without pain for at least the last 6-weeks.\n* Pregnant (women only)\n* Current or history of an unresolved musculoskeletal, neurological, cardiovascular, pulmonary\u002Frespiratory, metabolic, renal condition, disease, or problem.\n* Torn anterior or posterior cruciate ligament (ACL or PCL).\n* Any other disease or problems that may affect movement or the ability to exercise even at a low intensity.\n\nAdditional Exclusion Criteria specific to cohort 2 only:\n\n* Identification of Functional Ankle Instability (IDFAI) score of \\\u003C11.\n* unable to comfortably perform the drop landing condition.\n* Feet are too large or too small to fit comfortably in the combat boots provided.",true,"18 Years","40 Years",{"count":71,"type":21},60,[24],"The primary purpose of this study is to conduct a clinical trial to test a prototype device for feasibility and not health outcomes. To do this, the investigators will evaluate the performance of commercially available inertial measurement unit sensors incorporated into an existing ankle brace (\"sXAB\") by TayCo Brace, Inc. We will compare the gait metrics calculated from the sensors incorporated into the brace with gold-standard equipment that is used in research and clinical settings to determine whether the sXAB performs adequately in terms of measurement or technical feasibility prior to further clinical evaluation. The sensors in the ankle brace will be validated in the lab, first on healthy subjects walking in standard tennis shoes\u002Fsneakers (protocol 1), and secondarily in the lab on healthy subjects wearing combat boots performing walking, running, jumping, and stair climbing (protocol 2). These movements were selected because they simulate key movements performed during operational activities. Protocol 1 will take place first, then aspects of the sXAB will be evaluated and implemented, then protocol 2 will take place. Participants completing protocol 1 are eligible to complete protocol 2. The study includes two cohorts of participants completing different functional tasks. All participants experience both conditions: with an ankle brace and without an ankle brace. Comparisons are made within-subject between brace and no-brace conditions. It is hypothesized that the sensor-enabled ankle brace will measure gait metrics with a high degree of accuracy (within 5%) when compared against the gold-standard lab equipment (i.e., motion capture and research-grade inertial measurement units).",[37,75,76,77,29],"Balance","Biomechanical Data","Postural Control",[79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95],"adult","gait","gait analysis","humans","ankle brace","motion capture","sensor validation","wearable electronic devices","wearable sensors","inertial measurement unit","IMU","locomotion","running","walking","landing","stair ascent","stair descent","RECRUITING","2025-10-21",{"date":99,"type":52},"2025-10-23",{"date":101,"type":52},"2025-10-16",{"date":103,"type":21},"2026-06-18",{"name":105,"class":59},"Indiana University"]