[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"loneliness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:loneliness":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,52,0,25,[9,48,80,108,142,171,197,224,245,268,296,323,348,376,416,443,468,490,520,539,567,592,620,647,668],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644029","social-prescribing-for-a-mindful-lifestyle-100644029",false,"NCT07669805","Social Prescribing for a Mindful Lifestyle","Inclusion Criteria:\n\n* People aged 55 years or older.\n* People with a Geriatric Depression Scale (GDS-15) score of 7-10 or a UCLA Loneliness Scale Version 3 score of 35-64.\n* People can understand the research process, meet the requirements of the research, and can sign the informed consent and participate in the project.\n\nExclusion Criteria:\n\n* People that are unable to cooperate with the project or follow-up.\n* According to the PI's judgment, people with severe or poorly controlled conditions include ongoing acute diseases, severe infections, severe abnormal laboratory tests, or serious medical conditions with the following systems: cardiovascular, pulmonary, hepatic, nervous, mental, metabolic, renal, musculoskeletal, gastrointestinal, etc.\n* People with severe depression, risk of self-harm, severe cognitive impairment (dementia), visual or hearing impairment, and disabilities that prevent the completion of the project and assessment.\n* People are currently or expected to join any other physical training courses or nutrition intervention plans during the project period.\n* Others are based on the judgment of the PI that participating in this project may adversely affect the safety of the subjects, hinder the progress of the experiment, or interfere with the evaluation of the outcomes of the project.","ALL","55 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to evaluate the effectiveness of an 8-week mindfulness lifestyle social prescribing program in community-dwelling older adults aged 55 and older. The main questions it aims to answer are:\n\nTo establish a mindfulness lifestyle social prescribing model applied to the psychological and social health promotion of middle-aged and older populations.\n\nTo evaluate the effectiveness of the intervention on improving depressive symptoms, loneliness, and quality of life in this population.\n\nParticipants will receive an 8-week group intervention program, with each weekly session lasting approximately 3 hours. The structured curriculum integrates mindfulness awareness, body scanning, mindfulness stretching, breathing training, healthy dietary education, and art practices (such as herbal therapy and leaf printing). Researchers will collect and evaluate data from pre- and post-intervention assessments to measure changes in depressive symptoms, loneliness risk, and overall quality of life.",[26,27,28],"Depression and\u002For Anxiety in the Mild-to-moderate Range","Loneliness","Social Isolation",[30,31,32,33,34],"Mindfulness","Older Adults","Lifestyle Medicine","Quality of Life","Social Prescribing","NOT_YET_RECRUITING","2026-06-21",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":20},"2026-07-01",{"date":43,"type":20},"2028-12-31",{"name":45,"class":46},"Buddhist Tzu Chi General Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100641745","student-precarity-and-psychiatry-100641745","NCT07618208","Student Precarity and Psychiatry","Impact of Precarity on the Emergence of Psychiatric Disorders and the Use of Care Among Students","PEPSY","Inclusion Criteria:\n\n* Student enrolled at Paris Sciences et Lettres University (PSL, 17,000 students) or the Faculty of Health Sciences at Paris Cité University (UPC, 28,000 students),\n* Aged 18 or over,\n* Fluent in French,\n* Affiliated to a health insurance.\n\nExclusion Criteria:\n\n* Applicants under the age of 18,\n* Not enrolled at PSL universities or the UPCS Faculty of Health,\n* Insufficient level of French.",true,"18 Years",{"count":59,"type":20},45000,"OBSERVATIONAL","Since the COVID-19 pandemic, mental health disorders have increased significantly, particularly among young people. In France, the proportion of young people aged 18 to 25 suffering from depression almost doubled between 2017 and 2021. This phenomenon particularly affects students, who are already identified as being at greater risk of mental health disorders than the general population. Medical students seem to be particularly vulnerable: in 2021, a national study showed very high rates of depression and suicidal thoughts in this population. The main factor associated with depression was the feeling of financial hardship.\n\nStudents often face multiple forms of insecurity. Financially, they have limited resources and struggle to cover their basic needs such as housing, food and healthcare. Socially, many experience significant isolation, particularly when they are away from their families or under pressure from their studies. All of this has a significant impact on their mental health. Unfortunately, many students do not seek help due to lack of time, resources, or awareness of support services. The 2021 study showed that only one-third of medical students suffering from depression received appropriate treatment.\n\nThe aim of our study is to assess the impact of precariousness on the onset of psychiatric disorders and on the use or non-use of healthcare services.\n\nOur study will involve nearly 45,000 students from PSL and UPC universities. It is based on a longitudinal cohort (via questionnaires) over three years. The aim is to identify precisely the different aspects of student precariousness (housing, transport, isolation, economic difficulties, etc.) and their link with psychological distress. The study will measure the extent of the phenomenon and identify modifiable factors that could be targeted by preventive measures. The results will enable us to better target preventive measures and propose concrete solutions to improve students' well-being and promote their success.",[63,64,65,27],"Depressive Disorder, Major","Generalized Anxiety Disorder","Suicidal Ideation",[67,68,69,70],"Students","Depression","Use of care","Precarity","2026-06-11",{"date":73,"type":39},"2026-06-15",{"date":75,"type":20},"2026-09",{"date":77,"type":20},"2028-11",{"name":79,"class":46},"Assistance Publique - Hôpitaux de Paris",{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":60,"phases":4,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100618546","lonely-in-depression-100618546","NCT07333027","Lonely in Depression","Effects of Loneliness in the Treatment of Depression","Inclusion Criteria:\n\n* primary diagnosis of depression according to ICD-10 (F32 or F33), as diagnosed by a physician or clinical psychologist in conjunction with the M.I.N.I. Mini-International Neuropsychiatric Interview diagnostic tools\n* inpatient elective or emergency admission to one of the two psychiatric clinics; - age over 18 years\n* sufficient understanding of spoken and written German\n* informed voluntary consent\n\nExclusion Criteria:\n\n* a current lack of capacity to provide consent (e.g., pronounced psychotic symptoms, stuporous depressive syndrome, and thought constriction to suicidality)\n* previous participation in the study\n* pregnancy or breastfeeding\n* inpatient stay of less than 7 days, even if the patients initially met the inclusion criteria.",{"count":88,"type":20},200,"3 Months","The goal of this prospective study is to better understand the link between loneliness and depression in the inpatient psychiatric treatment of depression. It aims to answer:\n\nDo lonely and not lonely persons benefit the same way from inpatient depression treatment? Is loneliness a clinical relevant factor in inpatient treatment of depression? What are the underlying biopsychosocial mechanisms?\n\nParticipants will be asked to do some\n\n* self-report questionnaires\n* clinical interview\n* biosampling (blood, saliva, stool) at three main measurement timepoints (1. begin of inpatient treatment, 2. day of discharge, 3. three months after discharge).",[92,27],"Depression Disorder",[94,95,96,97,98],"loneliness","depression","prospective","biosampling","clinical","RECRUITING",{"date":73,"type":39},{"date":102,"type":39},"2026-02-05",{"date":104,"type":20},"2027-09",{"name":106,"class":46},"Friedrich-Alexander-Universität Erlangen-Nürnberg",2,{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100642919","steps---stress-training-and-engagement-via-phone-based-systems-100642919","NCT07639697","STEPS - Stress Training and Engagement Via Phone-Based Systems","Mindfulness Training and Respiration Biosignal Feedback - Study 3","Inclusion Criteria:\n\n* Ages 18-30 years of Age\n* Fluent in English\n* Psychological distress\n* Interested in completing smartphone guided training sessions remotely for 14 days\n* Willing and able to wear physiological monitoring equipment\n* Willing to be randomized to one of three conditions\n* Located in the United States\n\nExclusion Criteria:\n\n* Currently pregnant\n* Current or previous diagnosis with psychosis or schizophrenia","30 Years",{"count":117,"type":20},300,[23],"This study will evaluate engagement, usability, and psychological outcomes associated with participation in smartphone-based stress management or mindfulness training program among young adults. The study will compare multiple versions of a digital training program delivered through the Equa mobile application.\n\nParticipants will be individually randomized to one of several app-based training programs using a stratified randomization procedure. Each program consists of guided daily lessons completed over a 14-day period and is designed to support stress management and well-being through structured skill development activities.\n\nPrimary objectives include evaluating user satisfaction and usability of the digital platform and assessing changes in mindfulness-related skills and mental distress over time.\n\nParticipants will:\n\nComplete surveys assessing demographics and psychological well-being at baseline, post-intervention, and one-month follow-up.\n\nComplete a 14-day smartphone-delivered training program consisting of guided lessons while physiological data are collected using wearable sensors.\n\nSome participants may receive additional in-app features designed to support personalized learning or engagement with training lessons.\n\nSome participants will complete brief questionnaires before and after selected lessons to assess short-term changes associated with lesson participation.",[121,122,123,124,27],"Psychological Distress","Mindfulness Skills","Usability Satisfaction","Program Engagement",[126,127,128,129,130,131],"young adults","mental health","well-being","mindfulness skills","psychological distress","stress management","2026-06-09",{"date":134,"type":39},"2026-06-10",{"date":136,"type":20},"2026-06-05",{"date":138,"type":20},"2027-07",{"name":140,"class":141},"Equa Health","INDUSTRY",{"id":143,"slug":144,"hasResults":12,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":56,"sex":16,"minAge":149,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":158,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":164,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":47},"100617518","community-based-social-connection-intervention-program-to-improve-cardiovascular-and-brain-health-100617518","NCT07319663","Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health","Quasi-experimental Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health in Older Adults Living in Rural Ecuador","Inclusion Criteria:\n\nAge 60 years or older Permanent resident of the community for at least one year Able to provide written informed consent Able to participate in community activities and home-based assessments No plans to relocate during the 12-month follow-up\n\nExclusion Criteria:\n\nSevere disability that prevents participation in study activities Diagnosed dementia, major psychiatric illness, or severe cognitive impairment History of stroke with significant functional limitation Terminal illness or medical condition that precludes follow-up\n\n\\-","60 Years",{"count":151,"type":20},500,[23],"This study evaluates the effectiveness of a community-based social connection intervention program (SCIP) designed to reduce social isolation and loneliness and improve cardiovascular and brain health among older adults living in rural Ecuador. Loneliness and social isolation are recognized risk factors for poor cardiovascular outcomes, cognitive decline, depression, and reduced quality of life. However, evidence from low- and middle-income countries, particularly in rural Latin American settings, remains limited. This protocol describes a quasi-experimental, longitudinal study conducted in three rural villages that have been part of a long-standing population-based cohort.\n\nThe intervention will be implemented in one community and compared with two similar communities that will continue receiving usual community activities. SCIP consists of three components: (1) monthly community activities and educational talks designed to promote social participation; (2) monthly peer-support group sessions facilitated by trained personnel; and (3) individualized home-based coaching delivered twice per month, incorporating principles of Social Cognitive Theory and Cognitive Behavioral Therapy. The program aims to strengthen social networks, enhance coping skills, and promote healthier behaviors.\n\nParticipants aged 60 years and older will be enrolled and followed for 12 months. Assessments will occur at baseline, 6 months, and 12 months. Primary outcomes include changes in social isolation (Lubben Social Network Scale-6) and loneliness (De Jong Gierveld Scale). Secondary outcomes include cardiovascular health (Life's Essential 8), sleep quality (Pittsburgh Sleep Quality Index), cognitive performance (Montreal Cognitive Assessment), depressive symptoms (DASS-21), and quality of life (SF-36). Exploratory outcomes include incident stroke, cardiovascular events, and mortality, monitored through ongoing community surveillance.\n\nThis study will generate evidence on the feasibility and impact of a culturally adapted, community-based intervention to promote social connection and healthy aging in a resource-limited rural setting. Findings may inform scalable public health strategies for older adults in similar contexts.",[155,27,156,157],"Social Isolation in Older Adults","Stroke","Cognitive Decline",[159,27,160,161,162,163],"Social isolation","Social support","Community Health Services","Rural population","Aged",{"date":71,"type":39},{"date":166,"type":39},"2026-06-01",{"date":168,"type":20},"2027-06-01",{"name":170,"class":46},"Universidad de Especialidades Espiritu Santo",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":56,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":21,"phases":182,"briefSummary":183,"conditions":184,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":192,"leadSponsor":194,"locationsCount":196},"100642586","using-virtual-reality-travel-to-reduce-loneliness-in-older-adults-100642586","NCT07644416","Using Virtual Reality Travel to Reduce Loneliness in Older Adults","Virtual Reality Travel (VRT) as a Loneliness Intervention for Older Adults: A Pilot Randomized Controlled Trial","VRT","Inclusion Criteria:\n\n* Adults aged 65 years or older\n* Express willingness to engage with VR technology\n\nExclusion Criteria:\n\n\\- No self-reported physical, sensory, neurological, or cognitive conditions that would make VR use unsafe or impractical (e.g., uncontrolled seizures, severe vertigo, or significant uncorrected vision\u002Fhearing impairments).","65 Years",{"count":181,"type":20},40,[23],"This study aims to investigate whether and how virtual reality travel (VRT) can reduce loneliness among older adults. It will utilize a mixed-methods research design that combines an randomly assigned experiment with follow-up semi-structured interviews.\n\nThis is a pilot study and it is essential to establish the feasibility and acceptability of the protocol, assess the tolerability of VR technology in this population prior to conducting a full-scale RCT, and generate preliminary effect size estimates to inform future sample size calculations.",[27,185,186,187],"Older Adults (65 Years and Older)","Virtual Reality","Leisure Activities","2026-06-08",{"date":190,"type":39},"2026-06-12",{"date":166,"type":20},{"date":193,"type":20},"2027-05-30",{"name":195,"class":46},"Indiana University",3,{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":56,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":21,"phases":205,"briefSummary":206,"conditions":207,"keywords":212,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":219,"completionDateStruct":220,"leadSponsor":222,"locationsCount":47},"100643409","music-breathing-in-enhancing-resilience-among-elders-at-risk-of-mental-health-problems-100643409","NCT07631845","Music Breathing in Enhancing Resilience Among Elders at Risk of Mental Health Problems","Effects of a Mindfulness-based Music Breathing Intervention in Enhancing Resilience Among Community-dwelling Elders at Risk of Mental Health Problems: A Pilot Randomised Controlled Trial","Inclusion Criteria:\n\n* Aged 65 years or above\n* Able to read Chinese and communicate in Cantonese\u002FMandarin.\n* Has mild to moderate anxiety and\u002For depressive symptoms, based on the - Hospital Anxiety and Depression Scale (HADS) (i.e., a score of 8 or higher on either the anxiety or depression subscale)\n\nExclusion Criteria:\n\n* Partcipants will be excluded if they have cognitive impairment, hearing loss, severe depression, known mental illness, or chronic illness.",{"count":181,"type":20},[23],"The goal of this pilot randomised controlled trial is to examine the effects of a mindfulness-based music breathing intervention in enhancing resilience (primary outcome), and in reducing anxiety, depressive symptoms, loneliness, and improving health-related quality of life (secondary outcomes) among community-dwelling older adults at risk of mental health problems.\n\nIt is hypothesised that compared with the control group, participants in the intervention group will report enhanced resilience, reduced anxiety, depressive symptoms, and loneliness, and improved health-related quality of life immediately post-intervention.",[208,209,210,27,211],"Resilience","Anxiety","Depressive Symptom","Health-related Quality of Life",[30,213,214,215,208,216],"Msuic","Breathing","Community-dwelling elders","Mental health","2026-06-07",{"date":134,"type":39},{"date":188,"type":39},{"date":221,"type":20},"2026-08-31",{"name":223,"class":46},"Chinese University of Hong Kong",{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":115,"enrollmentInfo":231,"targetDuration":4,"studyType":21,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":47},"100634743","evaluating-the-effectiveness-of-interventions-to-reduce-loneliness-in-chinese-young-adults-100634743","NCT07543653","Evaluating the Effectiveness of Interventions to Reduce Loneliness in Chinese Young Adults","Group-Based Positive Affect Intervention for Loneliness Reduction: A Randomized Controlled Trial in Chinese Young Adults","Inclusion Criteria:\n\n* aged 18 to 30 years\n* proficiency in Chinese (Cantonese or Mandarin)\n* experiencing loneliness (defined as a score of ≥ 6 on the 3-item UCLA Loneliness Scale)\n\nExclusion Criteria:\n\n* cognitive impairments\n* psychiatric disorders, learning disabilities, or active suicidal ideation\n* currently participating in other psychotherapy or psychosocial interventions aimed at enhancing well-being",{"count":232,"type":20},100,[23],"This study aims to evaluate the effectiveness of a group-based Positive Affect (PA) intervention compared to an active control condition, Social Skills Training (SST), in reducing loneliness among young adults in Hong Kong and mainland China. It further examines the psychological mechanisms underlying intervention effects, specifically the roles of positive affect and perceived social support as mediators, and rejection sensitivity as a moderator influencing both treatment responsiveness and outcome translation.",[27],"2026-05-14",{"date":238,"type":39},"2026-05-18",{"date":240,"type":39},"2026-03-31",{"date":242,"type":20},"2026-08",{"name":244,"class":46},"Education University of Hong Kong",{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":16,"minAge":252,"maxAge":57,"enrollmentInfo":253,"targetDuration":4,"studyType":21,"phases":255,"briefSummary":256,"conditions":257,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":4},"100638817","application-for-arts-based-social-prescribing-100638817","NCT07593443","Application for Arts-Based Social Prescribing","Member Engagement Application for Personalized Arts-based Social Prescriptions","Inclusion Criteria:\n\nParticipants must meet the following criteria:\n\n* Aged 15-18 years enrolled in Medicaid managed care\n* Positive screen for depression and\u002For anxiety (e.g., PHQ-2 or GAD-2 ≥ 3)\n* Currently own and easily operate a smartphone\n* Have a valid e-mail address checked regularly\n* English fluency, and\n* Have a stable treatment regimen for at least 30 days prior to baseline with no planned treatment changes.\n\nExclusion Criteria:\n\nParticipants will be excluded if they:\n\n* Endorse current suicidal ideation at study screening, defined as a response ≥ 1 (\"several days\") on Item 9 of the PHQ-9A\n* Initiate a new treatment regimen or plan on initiating a new treatment regimen (i.e., medication, psychotherapy, or mind-body interventions) at the time of enrollment.","15 Years",{"count":254,"type":20},230,[23],"The goal of this clinical trial is to learn if a personalized arts-based social prescribing program, Art Pharmacy, delivered through a mobile app (SocialRx App) can improve mental health and social connectedness in adolescents aged 15-18 with depression or anxiety enrolled in Medicaid managed care.\n\nThe main question it aims to answer is:\n\nCompared to stable treatment, does participation in the Art Pharmacy program through the SocialRx App improve depression, anxiety, social connectedness, and loneliness? Researchers will compare participants receiving the Art Pharmacy program and digital companion to those receiving stable treatment (no change to existing care) to evaluate its effects on mental health and social connectedness.\n\nParticipants will:\n\nBe randomly assigned to either the Art Pharmacy program delivered through the SocialRx App or a control group receiving stable treatment.\n\nComplete online surveys at baseline and follow-up time points (e.g., 3, 6, 9, and 12 months).\n\nIf assigned to the intervention group, Art Pharmacy, participants will receive monthly arts and cultural activity recommendations, attend activities, and interact with a care navigator delivered through the SocialRx App.",[258,209,27,259],"Depression in Adolescence","Social Connectedness","2026-05-13",{"date":238,"type":39},{"date":263,"type":20},"2026-05",{"date":265,"type":20},"2028-04",{"name":267,"class":141},"SocialRx Inc",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":12,"sex":16,"minAge":276,"maxAge":4,"enrollmentInfo":277,"targetDuration":4,"studyType":21,"phases":279,"briefSummary":280,"conditions":281,"keywords":283,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":292,"leadSponsor":294,"locationsCount":4},"100639882","creating-encounters-between-generations---together-instead-of-alone-gemse-100639882","NCT07581171","Creating Encounters Between Generations - Together Instead of Alone (GemsE)","Creating Encounters: Generations in Action - Together Instead of Alone (GemsE)","GemsE","Inclusion Criteria:\n\n* Older adults aged 60 years and older who are residents of Hamburg\n* Children and adolescents aged 12 to 21 years with at least one parent with a mental illness and who are residents of Hamburg\n* Sufficient German language proficiency\n* Ability and willingness to provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Children and adolescents with severe acute psychological symptoms requiring inpatient treatment, including acute suicidality, acute substance use, or acute psychotic symptoms\n* Older adults with acute psychological crises or untreated severe mental illness preventing reliable participation\n* Older adults with cognitive impairment or dementia preventing reliable participation in the intervention","12 Years",{"count":278,"type":20},80,[23],"Elderly people and children and young people (CYP) and from families with mentally ill parents are particularly affected by loneliness. The GemsE project is investigating whether intergenerational mentoring between seniors and children or young people helps to reduce loneliness and improve the mental well-being and quality of life of both groups. The aim of the study is to scientifically record the effect of these sponsorships and to find out how such encounters can be successfully organized.",[27,282,211],"Mental Well-being",[284,285,94,286,287],"elderly people","children of parents with mental illness","psychosocial health","intergenerational tandems","2026-05-06",{"date":290,"type":39},"2026-05-12",{"date":166,"type":20},{"date":293,"type":20},"2026-12-01",{"name":295,"class":46},"Universitätsklinikum Hamburg-Eppendorf",{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":305,"briefSummary":306,"conditions":307,"keywords":310,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":47},"100629196","activating-social-resources-in-psychotherapy-seeking-individuals-effectiveness-and-timing-of-a-social-support-just-in-time-adaptive-intervention-100629196","NCT07471529","Activating Social Resources in Psychotherapy-Seeking Individuals: Effectiveness and Timing of a Social Support Just-in-Time Adaptive Intervention","Inclusion Criteria:\n\n* indicating to seek outpatient psychotherapy\n* elevated levels of self-reported depressive symptoms (Beck Depression Inventory-II (BDI) score \\> 13 (out of 63); Kühner et al., 2007)\n* owning a smartphone\n* signing the informed consent form\n\nExclusion Criteria:\n\n* first session for outpatient psychotherapy is scheduled within four weeks\n* suicidal ideation (values \\> 2 in BDI item 9)\n* presence of manic symptoms (Mood Disorder Questionnaire (MDQ) score \\> 7), - shift work\n* age below 18 or above 70","70 Years",{"count":304,"type":20},120,[23],"This study evaluates a Just-In-Time Adaptive Intervention (JITAI) aiming to foster social support processes for adults with elevated depressive symptoms awaiting outpatient psychotherapy. Utilizing a daily-level micro-randomized trial (MRT) design conducted over 21 days, participants are assessed six times daily. Participants are randomized across four conditions: (1) vulnerability-triggered, (2) vulnerability and receptivity-triggered, (3) support-need-triggered, and (4) a no-intervention control. The primary objective of this study is to evaluate the effectiveness of the JITAI in reducing daily depressive symptoms and increasing received social support (primary outcomes), as well as reducing daily loneliness and enhancing perceived social support (secondary outcomes). Furthermore, the study aims to compare the relative efficacy of three distinct triggering strategies to identify the most effective timing for intervention delivery.",[27,308,309],"Social Support","Depressive Symptoms",[308,27,311,312,313,309],"Just-in-Time Adaptive Intervention","JITAI","Ecological Momentary Intervention","2026-04-29",{"date":316,"type":39},"2026-04-30",{"date":318,"type":39},"2026-04-22",{"date":320,"type":20},"2026-12",{"name":322,"class":46},"University of Zurich",{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":21,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":346,"locationsCount":107},"100600291","enhancing-internet-delivered-cognitive-behaviour-therapy-with-additional-content-100600291","NCT07095582","Enhancing Internet-Delivered Cognitive Behaviour Therapy With Additional Content","Enhancing Therapist-Guided Internet-Delivered Cognitive Behaviour Therapy for Depression and Anxiety With Additional Content","Inclusion Criteria:\n\n* Saskatchewan resident,\n* Aged 18 years or older,\n* Self-reported difficulty with depression and\u002For anxiety,\n* Access to a computer (or other appropriate device) and the Internet,\n* Willingness to learn information and skills to self-manage mental health difficulties, and\n* Total score on UCLA-3 is greater than 5 at screening\n\nExclusion Criteria:\n\n* Current severe medical or psychiatric condition that requires immediate treatment (e.g. current mania or psychosis, actively suicidal or unable to keep themselves safe, medical condition requiring immediate surgery or other invasive treatment);\n* Unable to read and understand English (All content is provided in English and staff is English speaking)",{"count":331,"type":20},494,[23],"This study evaluates the effectiveness of additional content on loneliness offered alongside the Wellbeing Course - an internet-delivered cognitive behavioral therapy (ICBT) intervention for symptoms of depression and anxiety- in improving treatment outcomes for individuals with elevated scores on loneliness seeking treatment for depression and anxiety at a routine care online therapy clinic (the Online Therapy Unit). In this partially randomized control trial, the investigators aim to contribute to the literature by examining whether providing additional content on loneliness alongside the Wellbeing Course enhances engagement, satisfaction, and treatment outcomes among clients experiencing frequent loneliness compared to those completing only the Wellbeing Course. Over 8 weeks, participants will review course materials (with the addition of the loneliness content for those assigned to the loneliness content condition) online and complete questionnaires assessing changes in various outcomes over time.",[27,68,209],[27,68,209,336,337,338,339,340],"Internet-delivered cognitive behavioral therapy","Randomized controlled trial","Personalized therapy","Therapist assistance","Mental health system","2026-04-28",{"date":314,"type":39},{"date":344,"type":39},"2025-06-18",{"date":320,"type":20},{"name":347,"class":46},"University of Regina",{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":352,"acronym":353,"eligibilityCriteria":354,"healthyVolunteers":56,"sex":16,"minAge":355,"maxAge":356,"enrollmentInfo":357,"targetDuration":4,"studyType":21,"phases":359,"briefSummary":360,"conditions":361,"keywords":362,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":47},"100610093","sauna-for-offline-connections-and-interactive-authentic-living-100610093","NCT07223099","Sauna for Offline Connections and Interactive, Authentic Living","SOCIAL","Inclusion Criteria:\n\n* Aged 19-22\n* English-speaking\n* Able to provide written informed consent\n* Graduated from high school or high school equivalent\n* Elevated level of loneliness\n* Able and willing to receive study text messages\n* Able to attend weekly in-person sauna visits in San Francisco, CA\n\nExclusion Criteria:\n\n* Self-reported heat intolerance\n* Pregnancy, active lactation, or intention to become pregnant during the study period\n* Regular use of any nicotine products, including cigarettes, vapes, chewing tobacco, or other forms of nicotine (if use is not regular, must be willing to refrain for 24 hours before and 24 hours after sauna visits)\n* Current social heat practices 2 or more times per month (e.g., visiting sauna or hot tub facilities with others present)\n* Unwilling to refrain from using marijuana products and alcohol for the 24 hours before and 24 hours after sauna visits\n* Unwilling to refrain from heavy exercise on the day of sauna visits\n* Any medical condition that, in the opinion of investigators, may increase the risk of sauna use or introduce excessive variance into physiological or behavioral responses to sauna visits\n* Use of any medication that might impact thermoregulatory capacity or that, in the opinion of investigators, would increase risk of study participation or introduce excessive variance into physiological or behavioral responses to sauna visits","19 Years","22 Years",{"count":358,"type":20},15,[23],"This pilot trial will test an intervention (sauna visits) targeting reductions in loneliness in adults aged 19-22 years.\n\nParticipants will:\n\n* Visit a sauna in San Francisco once per week for 2 hours by themselves or with a friend, for 8 weeks total\n* Complete online surveys throughout their participation\n\nThe main question this pilot trial aims to answer are:\n\n* To what extent do participants find the study design acceptable?\n* To what extent do participants complete the weekly sauna visits?\n* To what extent do participants complete the weekly online surveys?",[27],[27,363,364,365,366],"Sauna","Gen Z","Young adult","Emerging adult","2026-04-21",{"date":369,"type":39},"2026-04-24",{"date":371,"type":39},"2026-04-20",{"date":373,"type":20},"2027-03-30",{"name":375,"class":46},"University of California, San Francisco",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":384,"targetDuration":4,"studyType":21,"phases":386,"briefSummary":387,"conditions":388,"keywords":402,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":408,"lastUpdatePostDateStruct":409,"startDateStruct":411,"completionDateStruct":412,"leadSponsor":414,"locationsCount":4},"100619558","communityrx-dementia--peer-navigation-crxdpeer-100619558","NCT07346183","CommunityRx-Dementia + Peer Navigation (CRxDpeer)","CommunityRx-Dementia + Peer Navigation (CRxDpeer): A Real-World Implementation and Effectiveness Study of an IT-Based Social Care Intervention","CRxDpeer","Inclusion Criteria:\n\n* Self-identifies as a caregiver of a home-dwelling person with Alzheimer's disease or related dementias (ADRD)\n* Resides in the target geographic region of the study\n* Has access to a cell phone and agrees to receive text messages from the study\n* Has an email address that they can receive emails from\n* Individuals under the age of 18 who are emancipated minors in the state of Illinois and a caregiver of a person with dementia\n\nExclusion Criteria:\n\n* Minors who are not emancipated in the state of Illinois.\n* Previously participated in the intervention arm of the CommunityRx-Dementia clinical trial",{"count":385,"type":20},330,[23],"The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a \"peer mentor\", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of personalized community resource information for social and caregiving needs through delivery of a resource list (HealtheRx) at the baseline encounter and coaching on how to communicate with service providers, coordinate services and manage social support (e.g., connect with their peer navigator, reach out to friends or relatives for support, identify support groups, etc.) and (c) ongoing navigation-focused support meant to boost the baseline intervention, including a series of proactive text messages over 12 months. During this time, the subject can respond to and communicate with the peer navigator for ongoing support.",[389,390,391,27,392,393,394,395,396,209,397,68,398,399,400,401],"Alzheimer s Disease","Dementia","Caregiver","Health-Related Social Needs","Social Care","Healthcare Utilization","End of Life Care","Caregiver Burden","Stress","Self-Efficacy","Peer Support","Implementation Science","Advance Care Planning",[403,404,405,406,407],"resource navigation","peer navigator","peer mentor","social care","dementia caregiver","2026-04-06",{"date":410,"type":39},"2026-04-07",{"date":166,"type":20},{"date":413,"type":20},"2029-02-28",{"name":415,"class":46},"University of Chicago",{"id":417,"slug":418,"hasResults":12,"nctId":419,"briefTitle":420,"officialTitle":421,"acronym":4,"eligibilityCriteria":422,"healthyVolunteers":12,"sex":16,"minAge":149,"maxAge":4,"enrollmentInfo":423,"targetDuration":4,"studyType":21,"phases":424,"briefSummary":425,"conditions":426,"keywords":430,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":441,"locationsCount":4},"100630506","engage-coaching-r33-phase-100630506","NCT07488559","Engage Coaching (R33 Phase)","Engage Coaching to Reduce Social Isolation and Loneliness to Prevent Suicide in Later Life","Inclusion criteria:\n\n* Age 60 or older\n* Access to social activities outside the home, including through living in senior living communities\n* Clinically-significant loneliness over the prior month.\n\nExclusion criteria:\n\n* Current problem drinking\n* Psychosis\n* Significant cognitive impairment\n* Hearing problems that preclude engagement with S-ENG and research assessors.",{"count":304,"type":20},[23],"The purpose of this study is to test whether an individual coaching program helps adults age 60 and older feel more connected to other people in ways that matter to them.",[427,27,428,429],"Social Connection","Suicide Ideation","Social-emotional Quality of Life",[27,431,432,433,434],"Older adults","Ecological momentary assessment","Engage Psychotherapy","Late-life suicide","2026-03-23",{"date":437,"type":39},"2026-03-27",{"date":439,"type":20},"2026-05-15",{"date":43,"type":20},{"name":442,"class":46},"University of Rochester",{"id":444,"slug":445,"hasResults":12,"nctId":446,"briefTitle":447,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":12,"sex":16,"minAge":302,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":450,"briefSummary":451,"conditions":452,"keywords":454,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":462,"completionDateStruct":464,"leadSponsor":466,"locationsCount":47},"100630971","the-role-of-solo-music-listening-in-reducing-loneliness-and-increasing-social-connectedness-in-older-adults-100630971","NCT07494604","The Role of Solo Music Listening in Reducing Loneliness and Increasing Social Connectedness in Older Adults","Inclusion Criteria:\n\n* Over the age of 70\n* Access to internet\n\nExclusion Criteria:\n\n* Cognitive Impairment\n* Self-reported hearing loss",{"count":304,"type":20},[23],"Loneliness has become an increasingly prevalent concern among older adults. A number of adverse physical and mental health outcomes may result from loneliness in this age group including cognitive decline and depression. These outcomes may lead to a higher strain on healthcare systems. Finding accessible and cost-effective strategies for reducing loneliness and increasing feelings of social connectedness is important for the well-being of older adults. Solo music listening is commonly used to regulate emotions and to promote well-being. While some preliminary evidence suggests that these benefits may extend to loneliness, research has not been clear on the functions or qualities of music that are most effective for older adults. This research project will consist of two parts. In Part 1, an interview will be conducted with older adults to determine what functions of music are most often used and most beneficial when their goal is to reduce loneliness. Part 2 will consist of a between-subjects experiment with four conditions. The top three characteristics obtained from Part 1 will represent the three music conditions, and the fourth condition will be a pink-noise control. Prior to the experiment, participants will self-select three pieces from each of the three music conditions. After selecting their music, they will be randomly assigned to either a music or pink-noise condition. Participants in the three music conditions will listen to the three self-selected pieces that adhere to their assigned condition. Loneliness and social connection outcomes will be assessed before and after listening using a Visual Analogue Scale (VAS). Potential moderators will be assessed after listening, which include nostalgia, absorption in music, and music reward. The results of this project will clarify whether psychological benefits of decreased loneliness and increased social connectedness can be found through music listening to enhance well-being, and whether singing along provides additional benefits. These findings may also be useful in developing future music-based interventions for reducing loneliness.",[27,259,453],"Music Listening Intervention",[455,94,456,457,458,459],"music","social conectedness","older adults","aging","music listening","2026-03-20",{"date":437,"type":39},{"date":463,"type":20},"2026-03-15",{"date":465,"type":20},"2027-12-20",{"name":467,"class":46},"Toronto Metropolitan University",{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":56,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":475,"targetDuration":4,"studyType":21,"phases":477,"briefSummary":478,"conditions":479,"keywords":480,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":482,"lastUpdatePostDateStruct":483,"startDateStruct":485,"completionDateStruct":487,"leadSponsor":489,"locationsCount":47},"100616669","developing-and-testing-a-machine-learning-enabled-mindfulness-intervention-for-reducing-loneliness-among-hong-kong-chinese-older-adults-100616669","NCT07308613","Developing and Testing a Machine Learning Enabled Mindfulness Intervention for Reducing Loneliness Among Hong Kong Chinese Older Adults","Developing and Testing a Machine Learning Enabled Mindfulness Intervention for Reducing Loneliness Among Hong Kong Chinese Older Adults: A Hybrid Experimental Design Study","Inclusion Criteria:\n\n* Aged 65 or older\n* Possess a smartphone with an Android or iOS operating system\n* Communicable in Cantonese\n* Lonely (cut-off \\>\u002F=6 on the three-item UCLA Loneliness Scale)\n\nExclusion Criteria:\n\n* Cognitive impairment, psychiatric disorder, learning disability\n* Active suicide ideation\n* Engaged in psychotherapy and psychosocial interventions in the past year",{"count":476,"type":20},250,[23],"Develop and test an effective machine learning enabled application-based (app-based) mindfulness intervention for reducing loneliness of Hong Kong Chinese older adults.",[27],[27,31,30,481],"hybrid SMART-MRT","2026-03-18",{"date":484,"type":39},"2026-03-19",{"date":486,"type":20},"2026-05-01",{"date":488,"type":20},"2027-12-31",{"name":244,"class":46},{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":496,"eligibilityCriteria":497,"healthyVolunteers":56,"sex":16,"minAge":498,"maxAge":499,"enrollmentInfo":500,"targetDuration":4,"studyType":21,"phases":502,"briefSummary":503,"conditions":504,"keywords":507,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":513,"lastUpdatePostDateStruct":514,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":518,"locationsCount":47},"100629370","social-media-diet-and-psychological-outcomes-in-university-students-100629370","NCT07473791","Social Media Diet and Psychological Outcomes in University Students","The Effect of a Social Media Diet on Loneliness, Fear of Missing Out, and Sleep Quality Among University Students: A Randomized Controlled Trial","The Effect of","Inclusion Criteria:\n\n* Being between the ages of 18-25.\n* Being a student at Gumushane University Kelkit Sema Dogan Vocational School of Health Services.\n* Having a daily social media usage time of at least 2 hours (verified by smartphone screen time settings).\n* Owning a smartphone (Android or iOS).\n* Volunteering to participate in the study and providing written informed consent.\n\nExclusion Criteria:\n\n* Having a diagnosed clinical sleep disorder (e.g., sleep apnea, chronic insomnia) or using prescribed sleep medication.\n* Having a diagnosed psychiatric disorder that may interfere with social media use or perception of loneliness.\n* Use of other digital detox or time-management applications during the study period.\n* Being unable to provide weekly screen time screenshots.\n* Planning to change smartphone device during the 4-week intervention period.","17 Years","25 Years",{"count":501,"type":20},70,[23],"This study aims to examine the effect of a social media diet intervention on loneliness, fear of missing out (FoMO), and sleep quality among university students. Excessive social media use has been associated with several negative psychological outcomes, including increased loneliness, heightened FoMO, and poor sleep quality.\n\nIn this randomized controlled trial, university students will be randomly assigned to either an experimental group or a control group. Participants in the experimental group will follow a social media diet intervention that involves limiting daily social media use for a specified period, while participants in the control group will continue their usual social media use without restrictions.\n\nLoneliness, FoMO, and sleep quality will be measured at baseline and after the intervention using validated scales. The findings of this study are expected to provide evidence on whether reducing social media use can improve psychological well-being and sleep quality among university students.",[27,505,506],"Fear of Missing Out","Sleep Quality",[508,509,510,511,512],"Social Media Diet","Digital Detox","University Students","Behavioral Intervention","Randomized Controlled Trial","2026-03-16",{"date":482,"type":39},{"date":516,"type":39},"2026-03-10",{"date":242,"type":20},{"name":519,"class":46},"Gümüşhane Universıty",{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":21,"phases":528,"briefSummary":529,"conditions":530,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":534,"completionDateStruct":536,"leadSponsor":538,"locationsCount":47},"100556131","a-novel-conditioning-approach-to-counter-loneliness-in-adults-100556131","NCT06521099","A Novel Conditioning Approach to Counter Loneliness in Adults","Inclusion Criteria:\n\n* No histories of learning impairment, major psychiatric disorders or neurological disorders other than depression\n* Normal intelligence\n* At least primary school education\n\nExclusion Criteria:\n\n* On medication or treatments within 2 weeks prior to the beginning of the study that would affect the individual's brain, cognitive and affective functions",{"count":527,"type":20},136,[23],"This study aims to test the efficacy of a 6-session conditioning paradigm by investigating the conditioning-induced change in the socio-affective processing, loneliness, depressive symptoms, and neural correlates of lonely adults.",[27],"2026-02-27",{"date":533,"type":39},"2026-03-02",{"date":535,"type":39},"2025-08-19",{"date":537,"type":20},"2026-06",{"name":244,"class":46},{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":16,"minAge":546,"maxAge":547,"enrollmentInfo":548,"targetDuration":4,"studyType":21,"phases":549,"briefSummary":550,"conditions":551,"keywords":552,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":107},"100577964","establishing-social-connections-in-urban-areas-evaluating-a-community-based-programme-100577964","NCT06805136","Establishing Social Connections in Urban Areas: Evaluating a Community-based Programme","Tackling Youth Loneliness in Urban Areas: Measuring Feasibility, Acceptability, and Benefits of a Community-based Intervention.","Inclusion Criteria:\n\n* Age 20-40\n* Reside in London\n* Reports that they are some of the time or often lonely in response to a single questionnaire item (\"How often do you feel lonely?)\n* No prior interaction with the community-based intervention we are investigating\n* Able to communicate in English sufficiently well to engage in qualitative interviews and complete the outcome measures and questionnaires.\n* Available and willing to participate in the study for 18 weeks\n\nExclusion Criteria:\n\n* Age \\\u003C 20 or age \\>40.\n* Resides outside of London.\n* Does not report frequent levels of loneliness (\"hardly ever or never\" in response to single questionnaire item).\n* Previously attended any event or is an existing member of the community-based programme that is forming the intervention arm.\n* Unable to communicate even with communication support.\n* Planned unavailability for \\>3 weeks during intervention and follow up periods.\n* Participating in another research project related to loneliness.\n* Reports current severe unstable health problems (mental or physical) or is deemed overburdened with respect to participating in research.","20 Years","40 Years",{"count":501,"type":20},[23],"The aim of this study is to evaluate the feasibility and acceptability of a new community-based programme designed to tackle loneliness for young and working-age adults. The programme focuses on encouraging social interactions and connections through offering community initiatives and activities, online spaces for interaction, and free or low-cost social events for young adults. Further aims of this study are to determine the cost-effectiveness of the programme.",[27],[27,553,554,555,556,557,558],"Young adults","Social interaction","Community intervention","Urban","Feasibility","Acceptability","2026-02-26",{"date":531,"type":39},{"date":562,"type":39},"2025-02-12",{"date":564,"type":20},"2028-06-01",{"name":566,"class":46},"Queen Mary University of London",{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":571,"acronym":4,"eligibilityCriteria":572,"healthyVolunteers":56,"sex":16,"minAge":179,"maxAge":4,"enrollmentInfo":573,"targetDuration":4,"studyType":21,"phases":575,"briefSummary":576,"conditions":577,"keywords":579,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":47},"100602404","alleviating-loneliness-in-older-adults-living-in-poverty-a-multi-level-intervention-100602404","NCT07123064","Alleviating Loneliness in Older Adults Living in Poverty: A Multi-level Intervention","Inclusion Criteria:\n\n* aged 65 years or older\n* living in poverty (defined: inability to afford at least 5 items on the material deprivation index)\n* proficiency in spoken Cantonese\n* experiencing loneliness (defined: score of ≥ 6 on the 3-item UCLA Loneliness Scale)\n\nExclusion Criteria:\n\n* cognitive impairments, psychiatric disorders, learning disabilities, or active suicidal ideation\n* actively participating in other psychotherapy or psychosocial interventions in the past 1 year\n\nExclusion Criteria:\n\n\\-",{"count":574,"type":20},1344,[23],"The study aims to reduce loneliness among Hong Kong Chinese older adults living in poverty with a multi-level intervention involving components at the individual, interpersonal, and community levels.",[27,578],"Poverty",[27,578,580,31,30,581,582,583,584],"Cluster Randomized Controlled Trials","SOLUS-D Programme","Group 4 Health","Neighbour Every Day","Hong Kong","2026-02-24",{"date":531,"type":39},{"date":588,"type":20},"2026-04-01",{"date":590,"type":20},"2029-05-31",{"name":244,"class":46},{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":598,"eligibilityCriteria":599,"healthyVolunteers":12,"sex":16,"minAge":57,"maxAge":600,"enrollmentInfo":601,"targetDuration":4,"studyType":21,"phases":602,"briefSummary":603,"conditions":604,"keywords":605,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":611,"lastUpdatePostDateStruct":612,"startDateStruct":614,"completionDateStruct":616,"leadSponsor":618,"locationsCount":47},"100555311","need-to-be-needed-n2bn-intervention-100555311","NCT06510439","Need to be Needed (N2BN) Intervention","Randomized, Controlled Trial of Need to be Needed (N2BN) Intervention to Improve Social Connection, Reduce Social Isolation and Loneliness","N2BN RCT","Inclusion Criteria:\n\n1. A research diagnosis of Major Depression, Bipolar I, II, or Schizophrenia Spectrum disorder.\n\n   Participants will be screened by research staff using sections of the Mini-International Neuropsychiatric Interview (MINI; Sheehan et al., 1998) that will identify research diagnoses of: Major Depression, Bipolar I, II, or Schizophrenia Spectrum disorder.\n2. Ages 18 years old and older\n3. Living in the community\n4. Able to communicate in written and oral English\n5. UCLA-Loneliness Scale score of 6 or higher\n\nExclusion Criteria:\n\n1. Having a legal guardian\n2. Unable to give informed consent.\n3. Living situation which restricts their ability to move freely\n\nPotential participants failing to meet screening criteria will be informed at the time that we are not able to enroll them in the study at this time. Any interview notes, or information recorded on the MINI will be destroyed or securely deleted.\n\nThe study will not enroll any vulnerable populations.","99 Years",{"count":304,"type":20},[23],"The proposed study is a randomized, controlled trial (RCT) that will examine the effectiveness of an intervention designed to reduce social isolation and loneliness of adults with serious mental illness (SMI). The intervention will focus on improving their sense of mattering by using acts of kindness and experiencing gratitude through volunteering. 120 participants will be randomly assigned to the intervention group or the attention control group. Over the course of the 6-month intervention, participants in the intervention arm, will receive weekly support from the interventionist. The interventionist and the participant will collaboratively set goals and develop an initial intervention plan, which is informed by the participants interests, values and goals. The attention control group will receive non-directive listening support through research assistants.\n\nData collection for all participants will occur at baseline, at the mid-point of the intervention at 3 months, and at the end of the 6-month intervention. Participants will be asked questions about quality of experience, social context and satisfaction, mattering components, kindness, gratitude, and loneliness. We will gather data on demographic background, life transitions, social network characteristics, internalized stigma, neighborhood climate, depression, and trait measures of mattering and loneliness during intake and exit interviews. Additionally, participants of the intervention arm will be asked to provide feedback about the intervention.",[27,28],[606,94,607,608,609,610],"mattering","social isolation","need to be needed","neededness","volunteering","2026-01-16",{"date":613,"type":39},"2026-01-21",{"date":615,"type":39},"2024-10-07",{"date":617,"type":20},"2035-05-31",{"name":619,"class":46},"Temple University",{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":626,"eligibilityCriteria":627,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":628,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":630,"conditions":631,"keywords":635,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":638,"lastUpdatePostDateStruct":639,"startDateStruct":641,"completionDateStruct":643,"leadSponsor":645,"locationsCount":47},"100616445","cohort-study-on-medical-students-mental-health-100616445","NCT07305701","Cohort Study on Medical Students' Mental Health","Mental Health of Medical Students in Orleans: a Cohort Study of a New Faculty","OSMOSE","Inclusion Criteria:\n\n* Students who have been enrolled in first year of health studies at the University of Orléans\n* Aged 18 or over\n\nExclusion Criteria:\n\n* Does not speak French\n* Person under legal guardianship\n* Person deprived of liberty\n* Person under guardianship or trusteeship",{"count":629,"type":20},10000,"The main objective of this study is to identify risk factors for depression among medical students by comparing them to students who completed their first year but did not enter the medical program (students not accepted into the second year of medical school).\n\nMajor Depressive Disorder (MDD) will be assessed using a validated tool: the Composite International Diagnostic Interview Short-Form (CIDI-SF).\n\nThis a prospective, longitudinal, cohort study. The plan is to inform each new cohort of students at the Orléans University Hospital medical school for 10 years. It is estimated that 5,000 to 10,000 students will be able to participate in the study.\n\nA link to access the study questionnaire will be sent to students by email via the registrar's office, with one email per week for four weeks. The email will contain a link to a web page where the questionnaire can be completed. The questionnaire will be available online on computers or smartphones for six weeks: from mid-October to the end of November. The questionnaire will be completed each year for the duration of the study or until the student completes their studies.\n\nDuration of the inclusion period: 10 years Duration of participation for each participant: maximum 12 years Total duration of the study: 22 years As the cohort progresses, longitudinal analyses may be conducted to study the evolution of various disorders over time, adjusting for known confounding factors. Following the initial analyses of this study, a new interventional study will be set up to identify students at risk and offer them appropriate care.",[632,64,65,633,634,27],"Major Depressive Disorder","Alcoholism","Marijuana Abuse",[67,636,95,637],"Medical students","epidemiology","2025-12-26",{"date":640,"type":39},"2025-12-31",{"date":642,"type":39},"2025-10-22",{"date":644,"type":20},"2047-10-31",{"name":646,"class":46},"Centre Hospitalier Régional d'Orléans",{"id":648,"slug":649,"hasResults":12,"nctId":650,"briefTitle":651,"officialTitle":652,"acronym":4,"eligibilityCriteria":653,"healthyVolunteers":12,"sex":16,"minAge":149,"maxAge":4,"enrollmentInfo":654,"targetDuration":4,"studyType":21,"phases":656,"briefSummary":657,"conditions":658,"keywords":659,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":667,"locationsCount":4},"100615135","nostalgia-intervention-on-alleviating-loneliness-amongst-older-adults-100615135","NCT07288671","Nostalgia Intervention on Alleviating Loneliness Amongst Older Adults","Effects of a Nostalgia Intervention on Alleviating Loneliness Amongst Community-dwelling Older Adults: A Cluster-randomised Waitlist-controlled Trial","Inclusion Criteria:\n\n* older adults aged 60 years or above\n* residing in the community\n* capable of speaking and understanding Chinese\n* experiencing loneliness (scoring ≥3 on a three-item loneliness screening scale)\n\nExclusion Criteria:\n\n* currently undergoing psychological intervention\n* having a clinical diagnosis of mental illness\n* being cognitively impaired (Abbreviated Mental Test score \\\u003C6)\n* having visual\u002Flanguage\u002Fcommunication difficulties",{"count":655,"type":20},294,[23],"The proposed study will utilise a two-arm, cluster-randomised, waitlist-controlled trial to (1) examine the effects of the nostalgia intervention on loneliness, negative emotions, social connectedness, meaning in life and nostalgia amongst community-dwelling older adults in Hong Kong; (2) investigate whether the effect of the nostalgia intervention on loneliness is mediated by improvements in negative emotions, social connectedness and meaning in life; and (3) explore the experiences and perceptions of older adults participating in the nostalgia interventions, focusing on their views regarding the impact of the intervention on their loneliness.",[27],[94,457,660],"nostalgia intervention","2025-12-17",{"date":663,"type":39},"2025-12-23",{"date":665,"type":20},"2026-09-01",{"date":43,"type":20},{"name":223,"class":46},{"id":669,"slug":670,"hasResults":12,"nctId":671,"briefTitle":672,"officialTitle":673,"acronym":674,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":16,"minAge":149,"maxAge":4,"enrollmentInfo":676,"targetDuration":4,"studyType":21,"phases":677,"briefSummary":678,"conditions":679,"keywords":682,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":683,"startDateStruct":685,"completionDateStruct":687,"leadSponsor":688,"locationsCount":47},"100586724","a-virtual-life-story-club-intervention-to-improve-loneliness-and-apathy-in-community-dwelling-older-adults-100586724","NCT06919094","A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults","A Virtual Life Story Club Intervention to Improve Loneliness and Apathy in Community-Dwelling Older Adults: A Mixed-Methods Feasibility Study","LSC Feasible","Inclusion Criteria:\n\n* Age 60 and over\n* English or Spanish fluency\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Dementia based on Aging and Dementia (AD8) score of ≥4 or previous dementia diagnosis\n* Severe auditory or visual loss\n* Lack of access to internet connection or phone",{"count":19,"type":20},[23],"Reminiscence therapy is a non-invasive, non-pharmacological intervention that has been shown to improve cognition, mood, functional status, quality of life, and apathy in older adults. Group reminiscence therapy combines structured social engagement and recounting of personal stories that address both social connection (a risk factor for cognitive decline) and cognition. Life story club© (LSC) is an established, non-profit organization that provides virtual, group reminiscence therapy for older adults to reduce loneliness and promote a sense of belonging and has not been formally studied.",[680,27,681],"Apathy","Reminiscence Therapy",[680,28,27,681],{"date":684,"type":39},"2025-12-19",{"date":686,"type":39},"2025-08-15",{"date":221,"type":20},{"name":689,"class":46},"Montefiore Medical Center"]