[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-anterior-resection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-anterior-resection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100619075","prolars-trial-prospective-longitudinal-follow-up-of-low-anterior-resection-syndrome-lars-and-corefo-score-after-rectum-surgery-in-patients-undergoing-upfront-surgery-or-different-neo-adjuvant-treatment-regimens-100619075",false,"NCT07339904","ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens","ProLARS","Inclusion Criteria:\n\n* 18 years or older.\n* Diagnosis of rectal cancer, discussed at the multidisciplinary consultation, with the intention to perform a sphincter preserving total mesorectal excision (TME) or partial mesorectal excision (PME), regardless of the need of neoadjuvant treatment.\n\nExclusion Criteria:\n\n* History of inflammatory bowel disease (Crohn's disease, ulcerative colitis) due to often persistent bowel complaints and therefore distorted baseline and follow-up data.\n* Dementia or intellectual disability.\n* Patients who are obstructive and in need a decompressive stoma or rectal stenting due to the lack of baseline data as they are often admitted to the hospital in an urgent setting","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection. Symptoms can range from faecal incontinence and frequent loose stools to urgency and incomplete emptying with great impact on quality of life. Little is known about the longitudinal evolution of LARS and the impact of different schedules of neoadjuvant chemoradiotherapy combined with surgery.\n\nThe investigators aim to investigate the incidence and evolution of functional bowel complaints in function of different neoadjuvant treatment regimens, type of surgery and adjuvant therapy in patients who undergo surgery for rectal cancer. The investigators focus on following objectives: evolution of LARS- and COREFO-scores per treatment regimen and their impact on work incapacity; identification of possible risk factors potentially related to functional outcome; monitoring and treatment of LARS.\n\nMETHODS This will be a multicentre prospective interventional study. The study population will consist of adult patients with rectal cancer, regardless of any neo-adjuvant therapy. Patients will be included for 5 years with a 2 year postoperative follow-up. Interim analysis will be made after 2 years of inclusion. Patients with intellectual disability or clinical colon obstruction are excluded. Automated online questionnaires including LARS and COREFO scores, incapacity for work and defecation quality will be sent at different time points (figure 1) using REDCap.\n\nRESULTS and CONCLUSIONS Longitudinal change of LARS- and COREFO-scores will be visually summarized. Patient, disease or procedure specific risk factors will be assessed as well.\n\nLARS is proven to be the principal postoperative problem after rectal surgery. If the investigators can predict the severity of LARS (minor or major LARS), this can be extremely helpful in deciding whether to perform a sphincter-sparing resection or a rectal amputation instead. Furthermore, the investigators want to offer perspective to patients who are susceptible to a disturbed postoperative bowel function.",[26,27,28,29,30],"Rectal Adenocarcinoma","LARS - Low Anterior Resection Syndrome","Rectal Resection","Low Anterior Resection","Total Mesorectal Excision",[32,33,34,35,36],"LARS","Rectal resection","Total mesorectal excision","Low anterior resection","Rectal carcinoma","RECRUITING","2026-01-05",{"date":40,"type":41},"2026-01-14","ACTUAL",{"date":43,"type":41},"2024-08-26",{"date":45,"type":20},"2029-08",{"name":47,"class":48},"University Hospital, Antwerp","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100555970","effectiveness-of-pelvic-floor-exercise-to-prevent-lars-low-anterior-resection-syndrome-100555970","NCT06519006","Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome)","Effectiveness of Pelvic Floor Exercise to Prevent LARS (Low Anterior Resection Syndrome) After Mini-invasive Low Anterior Resection in Patients With Rectal Cancer","CH1","Inclusion Criteria:\n\n* Cognitive functions make it possible to understand and sign the patient\\'s informed consent and consent to participate in the study\n* Surgical procedure - mini-invasive low anterior rectal resection\n\nExclusion Criteria:\n\n* not agreeing to participate in the study\n* request to practice pelvic floor exercises despite being in the control group\n* non-compliance\n* serious psychiatric diagnoses",true,"19 Years",{"count":61,"type":20},50,[23],"The main aim of this randomized study will be to determine the effectiveness of pelvic floor exercises on the incidence or severity of LAR syndrome in patients after mini-invasive rectal resection.\n\nThe main questions it aims to answer are:\n\n* Does pelvic floor exercise after low anterior resection prevent LARS (low anterior resection syndrome)?\n* What is the adherence of patients to prescribed home exercise after surgery?\n* Quality of life after LAR\n\nResearchers will compare the group of patients with pelvic floor exercises to those without and determine the occurrence and severity of LARS.\n\nParticipants will:\n\n* under the professional guidance of a physiotherapist, the day before surgery and in the first 4 postoperative days be educated to exercise the pelvic floor\n* continue exercise at home for a month (according to the instructions together with the infographic)",[65,27,66,67,29],"Prevention","Pelvic Floor Disorders","Rectal Cancer",[69],"prevention, LARS, pelvic floor exercise, LAR","2024-07-19",{"date":72,"type":41},"2024-07-25",{"date":74,"type":41},"2024-04-01",{"date":76,"type":20},"2026-05",{"name":78,"class":48},"F. D. Roosevelt University Hospital",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":32,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100467546","impact-of-early-postoperative-treatment-with-posterior-tibial-nerve-stimulation-on-the-incidence-and-duration-of-low-anterior-rectal-resection-syndrome-100467546","NCT05368168","Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome","Inclusion Criteria:\n\n* Patients undergoing elective surgery (scheduled, non-urgent) who underwent anterior rectal resection or transit reconstruction with low anastomosis (below 10 cm from the anal margin) at the Hospital Álvaro Cunqueiro in Vigo after the start date of the study.\n* Anastomotic tightness (absence of dehiscence).\n* Patients older than 18 years old.\n* Acceptance to participate in the study.\n\nExclusion Criteria:\n\n* Inability to understand the study instructions and recommendations.\n* Dementia or any type of mental disability.\n* Palliative surgery.\n* Patients with pacemakers.\n* Anti-coagulated patients.\n* Patients with trophic lesions on the skin of the ankles.",{"count":86,"type":20},114,[23],"The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.\n\nSurgical resections with sphincter preservation are frequently (60% of cases) associated with problems related to intestinal and defecatory function, which together are called Anterior Resection Syndrome (ARS) with varying degrees of severity.\n\nAmong the different treatments the investigators find posterior tibial nerve stimulation, a simple and non-invasive technique, which is currently used.\n\nThe study aims to analyze whether postoperative posterior tibial nerve stimulation in patients undergoing low anterior resection of the rectum has an impact on the incidence and duration of low anterior resection syndrome (LARS) and therefore on the quality of life of patients undergoing this type of intervention.\n\nTherefore, treatment with PNTS is currently established for the management of LARS symptoms. Given that a large percentage of patients operated on for rectal neoplasms will develop this syndrome, the investigators intend to apply this treatment before the onset of symptoms in patients at risk for LARS. It is also an intervention with a low rate of side effects, the benefit that the investigators can obtain from its preventive application is clearly superior to the risk of undergoing such treatment.\n\nThe investigators´ hypothesis is: Posterior tibial stimulation for 6 weeks post-operative of low anterior resection with anastomosis has a favorable impact by reducing the incidence and duration of ARS and improving the quality of life of patients undergoing anterior rectal resections for cancer.",[90,91,29],"Rectal Disorders","Low Anterior Resection Syndrome",[93,94,95],"Posterior tibial nerve stimulation (PTNS)","Urgent PC","Transcutaneous neurostimulator","2023-07-05",{"date":98,"type":41},"2023-07-06",{"date":100,"type":41},"2022-06-03",{"date":102,"type":20},"2027-01",{"name":104,"class":48},"Innovacion en Cirugía Vigo"]