[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-back-pain-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-back-pain-chronic":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,91,116,142,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100609458","a-prospective-study-to-evaluate-the-efficacy-of-iovera-lumbar-medial-branch-cryoneurolysis-versus-radiofrequency-ablation-for-the-treatment-of-chronic-low-back-pain-100609458",false,"NCT07214844","A Prospective Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Chronic Low Back Pain","A Prospective, Randomized, Assessor Blind, Active-controlled, Single-center Study to Evaluate the Efficacy of Iovera Lumbar Medial Branch Cryoneurolysis Versus Radiofrequency Ablation for the Treatment of Facet-mediated Chronic Low Back Pain","Inclusion Criteria:\n\nSubjects must meet all of the following inclusion criteria to be eligible for participation:\n\n* Subjects at least 18 years of age at Screening\n* Primary complaint of axial low-back pain suggestive of bilateral facet joint involvement (i.e., facet mediated CLBP) by evidence of provocative testing (e.g., axial loading, paraspinal tenderness)\n* Low back pain is chronic (i.e., ≥ 3 months' duration)\n* Low back pain is moderate to severe (score of ≥ 5 to ≤ 9) on the 0 to 10 NRS at Screening\n* Low back pain causes functional impairment (≥ 30% on ODI) at Screening\n* Successful trial of two diagnostic medial branch blocks consisting of two positive blocks with local anesthetic only (i.e., no steroids) that results in at least 80% relief of primary (index) pain for the duration of the local anesthetic used\n* Failure of at least three months of conservative non-operative therapy (e.g., physical therapy, chiropractic care, sleep hygiene, weight loss, spinal injections, NSAIDs, physician-directed exercise program or other appropriate analgesics)\n* Able to provide informed consent, adhere to the study visit schedule, and complete all study assessment\n\nExclusion Criteria:\n\nSubjects who meet any of the following exclusion criteria will not be eligible for participation in this study:\n\n* Active workers' compensation, personal injury, Social Security disability insurance (SSDI), or other litigation\u002Fcompensation related to the spine\n* Serious spinal disorders (verified on magnetic resonance imaging (MRI)) that may impact outcomes, including any of the following:\n\n  1. Suspected cauda equina syndrome (e.g., bowel\u002Fbladder dysfunction)\n  2. Infection\n  3. Tumor\n  4. Traumatic fracture\n  5. Systemic inflammatory spondyloarthropathy\n  6. Lumbar radiculopathy\u002Fradiculitis (i.e., root irritation and deficit)\n  7. Neurogenic claudication Prior lumbar spinal fusion surgery at the intended treatment levels\n* Comorbidity that, in the judgment of the Investigator, may affect the subject's ability to participate in the study including lumbar radiculopathy and neuropathic pain disorder\n* Currently pregnant, nursing, or planning to become pregnant during the study\n* Known contraindication to study device, including any of the following:\n\n  1. Cryoglobulinemia\n  2. Paroxysmal cold hemoglobinuria\n  3. Cold urticaria\n  4. Raynaud's disease\n  5. Open and\u002For infected wounds at or near the treatment site\n  6. Coagulopathy\n* Severe chronic pain disorder that in the opinion of the investigator may impact study outcomes\n* Presence of any of the following:\n\n  1. Spinal neurostimulator\n  2. Intrathecal analgesic drug pump\n  3. Cardiac implantable device\n* Current manifestation of poorly controlled mental illness or catastrophizing that in the opinion of the investigator may meaningfully impact treatment outcomes, including any of the following:\n\n  1. Mood disorder (e.g., depression, bipolar)\n\n     Patient Health Questionnaire (PHQ-9) ≥ 12 at Screening\n  2. Psychotic disorder (e.g., schizophrenia)\n  3. Catastrophizing\n\nPatient Catastrophizing Scale (PCS) score \\> 30 at Screening\n\n* Subject received other spine intervention\u002Ftherapies in the 30 days prior to block administration (e.g., spinal injections, minimally invasive therapies, surgical therapies) at the intended lumbar treatment levels\n* Subject received radiofrequency ablation in the low back region ≤ 6 months before study enrollment at the intended lumbar treatment levels\n* Pain relief following diagnostic medial branch blocks lasted longer than the duration of the local anesthetic used (i.e., \\> 24 hours)\n\n  1. History, suspicion, or clinical manifestation of:\n  2. Alcohol abuse or dependence\n  3. Illicit drug use\n* Opioid abuse or dependence (≥40 mg medication PO\u002Fday in past 30 days)\n* Given the COVID-19 pandemic, the subject must be medically fit\u002Fcleared for surgery by the investigator. If there is a concern about a subject's recent or potential exposure to COVID-19, or if the subject is not medically fit\u002Fcleared for surgery due to suspected COVID-19 illness\u002Fsymptoms (or other serious illness), the subject must be excluded.","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","INTERVENTIONAL",[23],"NA","A research study is being conducted to compare two treatments for long-term low back pain:\n\n* One uses the iovera° system, which applies cold to certain nerves in the lower back.\n* The other is the standard treatment called radiofrequency ablation, which uses heat.\n\nThe primary objective is to find out which treatment works better to reduce back pain. Participants in this study will be randomly placed in one of the two treatment groups. The clinical research team will check on participant pain levels and overall health before and after the procedure for about 12 months. The entire study will last about 14 months for each participant.",[26],"Low Back Pain, Chronic",[28,29,30,31,32],"Iovera","Radiofrequency ablation","cryoneurolysis","low back pain","lumbar medial branch","RECRUITING","2026-06-16",{"date":36,"type":37},"2026-06-17","ACTUAL",{"date":39,"type":37},"2026-04-16",{"date":41,"type":20},"2028-05",{"name":43,"class":44},"Montefiore Medical Center","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100631700","active-coping-interdisciplinary-program-for-chronic-pain-physiotherapy-unit-spain-100631700","NCT07504094","Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)","Interdisciplinary Active Coping Program for Chronic Pain in the Physiotherapy Unit in Primary Care - Teruel Health Sector (Aragón, Spain)","Inclusion Criteria:\n\n* Adult (18 years or older)\n* Diagnosis of non-oncological chronic back pain\n* Referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche . (UFAP) from one of the following basic health zones: Teruel Centro, Teruel Ensanche, Albarracín, Alfambra, Cella, or Villel\n* Able to provide voluntary written informed consent\n\nExclusion Criteria:\n\n* Oncological pain\n* Cognitive impairment that prevents following the program\n* Spinal surgery in the last year\n* Internal electrostimulator device (e.g. pacemaker, spinal cord stimulator)",{"count":54,"type":20},20,[23],"The goal of this observational intervention study is to evaluate the impact of a multidisciplinary active coping program for chronic back pain in adults referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche. The main questions it aims to answer are:\n\n* Does the program improve physical function, measured through gait speed, balance, and chair stand tests?\n* Does it reduce pain-related psychological factors such as kinesiophobia, catastrophizing, anxiety, and depression?\n* Does it improve quality of life and sleep quality, and reduce analgesic medication use?\n\nParticipants will attend group sessions on pain neuroscience education, followed by sessions on healthy habits, nutrition and sleep hygiene and group psychological intervention focused on emotional wellbeing tools, and will complete therapeutic exercise sessions over the course of the program. They will also complete validated questionnaires and physical assessments at three timepoints: at baseline, at the end of the program, and at a 6-month follow-up.",[58,59,60,26,61,62],"Chronic Back Pain","Chronic Pain","Back Pain","Musculoskeletal Pain","Kinesiophobia",[64,65,66,67,68,58,69,70,71,72,73,74,75,76,77,78,79],"Pain Neuroscience Education","Therapeutic Exercise","Multidisciplinary Intervention","Active Coping","Psychological Intervention","Chronic Musculoskeletal Pain","Central Sensitization","Pain Catastrophizing","Primary Care","Physiotherapy","Primary Care Physiotherapy Unit","Quality of Life","Physical Function","Sleep Quality","Anxiety","Depression","NOT_YET_RECRUITING","2026-03-26",{"date":83,"type":37},"2026-03-31",{"date":85,"type":20},"2026-04-01",{"date":87,"type":20},"2028-02",{"name":89,"class":44},"Universidad de Zaragoza",2,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":90},"100630197","effects-of-retro-walking-along-with-core-stabilization-in-non-specific-chronic-low-back-pain-patients-100630197","NCT07484542","Effects of Retro-Walking Along With Core Stabilization in Non-specific Chronic Low Back Pain Patients","Inclusion Criteria:\n\n* Subjects of either gender.\n* Age range of 25-50 years.\n* Subjects with non-specific chronic low back pain (more than 3 months).\n* Subjects with VAS score equal or more than 5.\n\nExclusion Criteria:\n\n* Subjects with acute injury of spine.\n* Subjects with ankylosing spondylitis.\n* Patients with referred pain.\n* Subjects with operative history of spine or hip.\n* Pregnant females or child birth for less than 6 months.\n* Subjects with any systemic disease or TB of spine.","25 Years","50 Years",{"count":100,"type":20},42,[23],"The aim of this study is to find the effects of retro walking along with core stabilization on pain, disability and balance in non-specific chronic low back pain patients. Randomized controlled trials will be done at Railway general hospital, Rawalpindi and Care plus medical center, Islamabad. The sample size was 42. The subjects were divided in two groups, 21 subjects in group A will undergo retro-walking along with core stabilization and 21 in group B will undergo only core stabilization exercises. Conventional physical therapy protocol will apply to both groups. Sampling technique applied was purposive nonprobability sampling technique. Only 25-40 years individual with chronic low back pain were included. Tools used in the study are visual analogue scale, Oswestry Disability Index and G\\&B app. Data will be analyzed through Statistical Package for the Social Sciences version 21.",[26],[31,105,106],"Retro walking","core stabilization","2026-03-16",{"date":109,"type":37},"2026-03-20",{"date":111,"type":20},"2026-02-28",{"date":113,"type":20},"2026-06-01",{"name":115,"class":44},"Riphah International University",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":123,"sex":16,"minAge":17,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100586923","a-combined-exercise-programme-involving-strengthening-flexibility-and-aerobic-exercise-for-lower-back-pain-100586923","NCT06921694","A Combined Exercise Programme Involving Strengthening, Flexibility and Aerobic Exercise for Lower Back Pain","A Combined Exercise Programme Involving Strengthening, Flexibility and Aerobic Exercise for Lower Back Pain: a Randomised-controlled Study","Inclusion Criteria:\n\n* Aged 18-45 years\n* Participant is willing and able to give informed consent for participation in the study\n* Suffering from chronic NSLBP (more than 3 months, localised below the costal margin and above the gluteal folds)\n* Suffers from pain or functional limitations as a result of their LBP (minimum VAS (back) score of 3\u002F10 or ODI score of at least 5\u002F50 or RMD score of at least 5\u002F24 (note, unlike ODI, RMD does not describe specific cuts offs for different levels of disability)\n* Able to exercise\n\nExclusion Criteria:\n\n* Radiating pain to leg \u002F sciatica \u002F acute radiculopathy\n* Specific diagnosis\u002Fcondition for LBP (e.g. herniated disk, degenerative disk disease, spondylolysis, spinal stenosis, spinal tumour, facet joint damage)\n* History of osteoporosis , arthritis, scoliosis, or kyphosis.\n* Current spinal infection, cancer or a current fracture (any bone).\n* History of spinal\u002Fback surgery\n* Unable to participate in physical activity and exercise\n* Pregnant or breast feeding\n* History of substance abuse\n* History of psychiatric illness (eg. depression, dementia, schizophrenia) for which currently taking medication\n* History or current neurological condition (e.g. epilepsy)\n* Not in possession or have access to adapted equipment (phone, computer, functioning WIFI)\n* Unable to understand and communicate in English\n* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance",true,"45 Years",{"count":126,"type":20},88,[23],"This randomised controlled trial will evaluate the effectiveness of different exercise modalities for individuals with low back pain. Participants will be allocated to one of three groups: a control arm (usual exercise), a running-based intervention, or a swimming\u002Fcycling-based intervention. Outcomes related to pain and function will be measured at baseline, 8 weeks, and 12 months.",[26],[131,132],"chronic non specific low back pain","exercise intervention","2025-12-04",{"date":135,"type":37},"2025-12-12",{"date":137,"type":37},"2025-04-01",{"date":139,"type":20},"2026-09-30",{"name":141,"class":44},"University of Nottingham",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":21,"phases":152,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":45},"100569596","effects-of-foundation-and-functional-inspiratory-muscle-training-in-non-specific-chronic-low-back-pain-100569596","NCT06696300","Effects of Foundation and Functional Inspiratory Muscle Training in Non-Specific Chronic Low Back Pain","Comparison of the Effects of Foundation and Functional Inspiratory Muscle Training in Addition to Classical Physiotherapy in Non-Specific Chronic Low Back Pain","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being between the ages of 18-65,\n* Having low back pain that has been ongoing for at least 3 months (12 weeks),\n* Having a Visual Analog Scale (VAS) of pain intensity of ≥3,\n* Being right-hand dominant.\n\nExclusion Criteria:\n\n* Not volunteering to participate in the study,\n* Having a history of cancer,\n* Having a spinal infection,\n* Having a rheumatological condition,\n* Having a spinal fracture,\n* Having red flag signs (sudden and unexpected weight loss, fever, etc.)\n* Having a psychological disorder,\n* Having a previous spinal surgery,\n* Having radiculopathy (neuropathic pain along the lower extremity due to nerve root compression),\n* Not continuing home exercises more than 80%,\n* Having an anatomical and congenital abnormality","65 Years",{"count":151,"type":20},60,[23],"This study was planned to examine the effects of basic and functional respiratory muscle training on pain, disability level, and functionality. In this study, participants will be randomly divided into 3 groups. The first group will be treated with physical therapy applications applied in state hospitals for 10 weeks. The second group will receive basic respiratory muscle training treatment in addition to physical therapy in state hospitals. The third group will receive respiratory muscle training with exercise in addition to physical therapy in state hospitals. Evaluations will be made before the first session, after the 30th session, in the 3rd month, in the 6th month, and in the 1st year. There is no interventional method in the evaluations. Pain intensity, disability level, physical activity status, quality of life, fear of movement, pain catastrophizing, anxiety and depression levels will be questioned with scales. In physical measurements, participant's aerobic capacity will be measured with the 2-Minute Walk Test, participants's flexibility with the sit-and-long test, participants's respiratory muscle strength with the MIP\u002FMEP device, participants's core endurance with the trunk flexor muscle endurance test, participants's lower and upper extremity muscle strength with a handheld dynamometer, participants's postural control with the Biodex balance device, and participants's muscle thickness with an ultrasound.",[155,26,156],"Low Back Pain, Mechanical","Non Specific Chronic Low Back Pain",[158,159,160,161,162],"Low Back Pain","Respiratory Muscle Strength","Muscle Training","Classical Physiotherapy","Ultrasound","2024-12-29",{"date":165,"type":37},"2024-12-31",{"date":167,"type":37},"2024-12-15",{"date":169,"type":20},"2026-12-01",{"name":171,"class":44},"Kirsehir Ahi Evran Universitesi",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":178,"maxAge":149,"enrollmentInfo":179,"targetDuration":4,"studyType":21,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100574468","comparative-effects-of-group-based-exercises-with-and-without-cognitive-functional-therapy-on-clinical-outcomes-in-patients-with-chronic-low-back-pain-100574468","NCT06759675","Comparative Effects of Group Based Exercises with and Without Cognitive Functional Therapy on Clinical Outcomes in Patients with Chronic Low Back Pain","Inclusion Criteria:\n\n* Pain level equal or more than 3 on NPRS A score of fourteen percent 14% or more on the Oswestry Disability Index (ODI) Low back pain for at least 6months duration\n\nExclusion Criteria:\n\n* Red flags (neoplastic diseases or cancer in the spine, inflammatory diseases, infections, and fractures) Neurological symptoms and psychiatric, rheumatologic, and cardiac diseases Radiculopathy with symptoms Lumbar stenosis Spondylolisthesis History of spinal surgeries Pregnancy","35 Years",{"count":180,"type":20},40,[23],"1.1Research objective The objective of the study is to find the comparative effects of group based exercises with and without cognitive functional therapy on clinical outcomes in patients with chronic low back? 1.2 Hypothesis Null Hypothesis H0= There is no significant difference of clinical outcomes between the cognitive functional therapy with group exercises and group based exercises only in patients with chronic low back pain.\n\nAlternative Hypothesis H1= There is a significant difference of clinical outcomes between the cognitive functional therapy with group exercises and group based exercises only in patients with chronic low back pain.",[26],[185,186,187],"Cognitive Functional therapy","group based exercise","chronic low back","2024-12-28",{"date":190,"type":37},"2025-01-06",{"date":192,"type":20},"2025-01",{"date":194,"type":20},"2025-05",{"name":196,"class":44},"University of Faisalabad"]