[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-back-pain-mechanical\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-back-pain-mechanical":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,43,63,90,119,147,173,199,233,260],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100441029","strain-counterstrain-treatment-of-piriformis-pain-100441029",false,"NCT05023005","Strain-Counterstrain Treatment of Piriformis Pain","Inclusion Criteria:\n\n* 18 to 65 years of age\n* Tender point (or trigger point) in piriformis muscle determined by physical exam\n\nExclusion criteria:\n\n* Less than 45 degrees of active hip flexion, less than 5 degrees of active hip internal rotation or less than 30 degrees of active hip external rotation, on side of affected piriformis\n* Unable to lay prone\n* Non-English speaker\n* Inability to attend 2 sessions within the same month\n* Active cancer\n* Pregnant\n* Diagnosis of lumbar radiculopathy\n* Greater than grade 1 lumbar spondylolisthesis\n* Presence of lumbar region Pars Defect\n* Receiving massage, acupuncture, chiropractic treatments, osteopathic treatments during study period.",true,"ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this investigator-initiated study is to provide an efficient and non-invasive treatment option for pain caused by the piriformis muscle.",[27,28,29],"Low Back Pain, Mechanical","Piriformis Syndrome","Somatic Dysfunction of Sacral Region (Finding)","RECRUITING","2026-04-21",{"date":33,"type":34},"2026-04-24","ACTUAL",{"date":36,"type":21},"2026-09",{"date":38,"type":21},"2027-09",{"name":40,"class":41},"Loma Linda University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":42},"100571291","assessing-the-japetw-lumbar-traction-device-in-rehabilitation-for-patients-with-non-specific-mechanical-low-back-pain-100571291","NCT06718348","Assessing the Japet.W+ Lumbar Traction Device in Rehabilitation for Patients With Non-specific Mechanical Low Back Pain","Inclusion Criteria:\n\n* Nonspecific mechanical low back pain for more than 6 weeks,\n* 18 years ≤ Age \\\u003C 80 years,\n* Patient affiliated to the health social security system,\n* Patient able to understand the information relating to the study and to sign the informed consent form\n\nExclusion Criteria:\n\n* Specific low back pain (infectious, inflammatory, tumorous, or traumatic origin),\n* Motor neurological deficits (peripheral or central),\n* Extrapyramidal syndrome,\n* Treatment with implanted neurostimulation,\n* Cardiac or circulatory diseases or serious respiratory problems,\n* Previous recent arthrodesis or recent lumbar prosthesis surgery,\n* Surgery for herniated disc (\\\u003C3 months),\n* Fracture of the dorsolumbar spine or rib (\\\u003C3 months),\n* Skin lesions, contusions and stretching injuries of the trunk,\n* Pregnancy,\n* Individuals not tolerating the JAPET.W+ device during an initial trial,\n* Under guardianship, curatorship or legal protection",{"count":50,"type":21},60,[24],"The study will include patients suffering from nonspecific mechanical low back pain for more than 6 weeks. Two groups will be compared. A Control group and an Experimental group with the exoskeleton JAPET.W",[27],"2026-04-14",{"date":56,"type":34},"2026-04-17",{"date":58,"type":34},"2025-12-20",{"date":60,"type":21},"2026-12-31",{"name":62,"class":41},"Grand Hôpital de Charleroi",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":42},"100633224","effects-of-lumbar-stabilization-exercises-versus-muscular-chain-therapy-in-patients-with-mechanical-chronic-low-back-pain-100633224","NCT07523906","Effects of Lumbar Stabilization Exercises Versus Muscular Chain Therapy in Patients With Mechanical Chronic Low Back Pain","Effects of Lumbar Stabilization Exercises Versus Muscular Chain Therapy on Pain and Functional Disability in Patients With Mechanical Chronic Low Back Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged between 18-30 years will be included in the study.\n* Participants must have a history of mechanical CLBP.\n* The pain must be localized to the lumbar region.\n* Participants must be able to perform physical activities and participate in exercise-based interventions.\n* Participants who have pain range \\> 4 will be included in the study.\n\nExclusion Criteria:\n\n* Patient with structural lesions, such as spondylolisthesis, stenosis, vertebral bone fracture, scoliosis and kyphosis on x-ray, will be excluded.\n* Pregnant females would be excluded.\n* Females with a history of neurological, infections, and systemic disease, including cerebrovascular disease, spondylitis, cancer, spinal cord disease, cauda equine, rheumatologic disorders.\n* Females who have undergone spinal surgery or any surgical intervention related to the lower back or pelvis will be excluded.\n* Lumbar radiculopathy will be excluded in the study.","30 Years",{"count":72,"type":21},42,[24],"The goal of this randomized controlled trial is to compare the effectiveness of lumbar stabilization exercises and muscular chain therapy on reducing pain intensity and functional disability in patients with mechanical CLBP.\n\n* Participants will be randomly assigned to two groups:\n* Group A: Lumbar stabilization exercises\n* Group B: Muscular chain therapy (posterior sagittal muscle chain)\n\nOutcomes will be assessed at baseline and on week 6 to evaluate which exercise program is more effective in reducing pain and improving functional outcomes.",[27],[77,78,79,80],"Low Back Pain","Lumbar Stabilization Exercises","Muscular Chain Therapy","Functional Disability","2026-04-05",{"date":83,"type":34},"2026-04-13",{"date":85,"type":34},"2026-02-04",{"date":87,"type":21},"2026-06-15",{"name":89,"class":41},"Ibadat International University, Islamabad",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":15,"sex":16,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":42},"100581242","the-long-term-effects-of-online-therapeutic-neuroscience-education-in-patients-with-chronic-low-back-pain-100581242","NCT06847763","The Long Term Effects of Online Therapeutic Neuroscience Education in Patients With Chronic Low Back Pain","The Effect of Online Therapeutic Neuroscience Education Added to Conventional Physiotherapy Program on Clinical Outcomes, Treatment Expectations and Satisfaction Levels in Patients With Chronic Low Back Pain","Inclusion Criteria:\n\n* Individuals aged 20-60\n* Literate\n* Having received a score of 24 or above in the Mini-Mental Status Assessment\n* Having internet access\n* Having back pain for more than 3 months\n* Having pain between 3-8 on the Numerical Pain Scale\n* Individuals with chronic back pain whose symptoms are not radicular\n\nExclusion Criteria:\n\n* Having other orthopedic\u002Fneurological disorders that will affect the evaluation and treatment\n* Patients with vertebral compression fractures on MRI and lumbar radiography\n* Patients with unstable neurological findings\n* Patients using analgesic medication during treatment\n* Patients with rheumatological and inflammatory diseases\n* Patients with acute trauma\n* Patients who are pregnant\n* Patients who have undergone lumbar region surgery","20 Years","60 Years",{"count":50,"type":21},[24],"This study aims to evaluate the effects of online Therapeutic Neuroscience Education (TNE) combined with a 6-week conventional physiotherapy program on pain, disability, kinesiophobia, functionality, treatment expectations, and satisfaction in individuals with chronic low back pain (CLBP). The goal is to improve participants' understanding of chronic pain, reduce fear and avoidance behaviors, enhance movement and functionality, and increase treatment satisfaction. The study also seeks to provide a lasting educational resource.\n\nTNE focuses on educating patients about pain neurophysiology, aiming to reduce pain, improve function, and shift perceptions about pain through interactive sessions involving diagrams, metaphors, and examples. Despite evidence supporting TNE's effectiveness for chronic pain conditions, no studies have evaluated its online application or long-term effects.\n\nThe study will include 60 volunteers with CLBP (ages 20-60), randomized into two groups: one receiving conventional physiotherapy and online TNE, and the other receiving conventional treatment alone. The TNE group will participate in six weekly 45-minute online sessions, covering topics like pain neurophysiology, biopsychosocial factors, and pain coping strategies, without addressing anatomical or emotional aspects.\n\nEducational materials, including resources adapted from \"Why You Hurt\" will be presented to the TNE group. Conventional physiotherapy includes hot packs, ultrasound, TENS, and home exercises for both groups.\n\nClinical outcomes will be assessed by a blinded researcher at multiple time points using tools such as pain and disability scales, kinesiophobia measures, functional tests, and questionnaires on treatment expectations and satisfaction. The study is significant for its innovative approach in examining the clinical and long-term effectiveness of online TNE as part of CLBP management.",[27,103],"Chronic Pain",[105,106,107,108,109],"therapeutic neuroscience education","chronic low back pain","kinesiophobia","disability","treatment expectation","2026-03-30",{"date":112,"type":34},"2026-03-31",{"date":114,"type":34},"2026-02-01",{"date":116,"type":21},"2026-10-01",{"name":118,"class":41},"Istanbul Bilgi University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":133,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":42},"100631086","effects-of-post-isometric-relaxation-and-myofascial-release-on-low-back-pain-with-lower-cross-syndrome-100631086","NCT07496099","Effects of Post-Isometric Relaxation and Myofascial Release on Low Back Pain With Lower Cross Syndrome","Combined Effects of Post-Isometric Relaxation and Myofascial Release in Patients With Low Back Pain and Lower Cross Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Participants aged 18-45 years old\n2. having low back pain persisting for at least 4 weeks\n3. with clinical diagnosis of LCS, and hamstring tightness (AKE \\>15°)\n\nExclusion Criteria:\n\n1. Participants with the history of spinal surgery active neurological conditions\n2. systemic disease affecting connective tissue (Rheumatoid arthritis, Systemic lupus erythematosus)\n3. recent lower limb or spinal injury (within 6 months)\n4. pregnancy or inability to lie prone for treatment.","45 Years",{"count":50,"type":21},[24],"This randomized controlled trial aims to evaluate the combined effects of post-isometric relaxation and myofascial release on pain, flexibility, and functional disability in individuals with low back pain associated with lower cross syndrome. Eligible participants aged 18 to 45 years will be randomly allocated into two parallel intervention groups. One group will receive post-isometric relaxation combined with myofascial release, while the comparison group will receive conventional stretching combined with Therapeutic modalities. Outcomes will be assessed at baseline and after completion of the intervention period. The results of this study are expected to contribute to evidence-based physiotherapy management of low back pain associated with postural imbalance.",[27,131,132],"Lower Cross Syndrome","Hamstring Muscle Tightness",[134,135,136],"Hamstring Tightness","Post-Isometric Relaxation with Myofascial Release","low back pain with lower cross syndrome","NOT_YET_RECRUITING","2026-03-22",{"date":140,"type":34},"2026-03-27",{"date":142,"type":21},"2026-03-25",{"date":144,"type":21},"2026-10-20",{"name":146,"class":41},"University of Karachi",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":18,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":158,"conditions":159,"keywords":161,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":172},"100570603","fusion-or-not---a-study-on-low-back-pain-100570603","NCT06709391","Fusion or Not - a Study on Low Back Pain","Fusion or Not- a Randomized Controlled Study on Low Back Pain","Inclusion Criteria:\n\n* Axial, mechanical, stabbing pain localized to the lower lumbar spine, persisting for at least 12 months, in which non-surgical treatments have been unsuccessful\n* A perceived improvement of back muscle strength after structured physical exercise, but severe, quality-of-life-reducing pain persists\n* No symptoms or clinical signs of radiculopathy or neurogenic claudication (spinal stenosis)\n* Numeric rating scale back pain of at least 5 (on a 0-10 (worst) scale)\n* Oswestry Disability index of at least 35 (on a 0-100 (worst) scale)\n* MRI-confirmed degenerative disc disease at L4\u002FL5 and\u002For L5\u002FS1.\n* 25-65 years of age\n* American Society of Anesthesiologists (ASA) classification 1 or 2.\n* No previous spine surgery, except for previous discectomy without fusion on the symptomatic level\n* Written informed consent\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Unable to understand Swedish\n* Unable to attend follow-up visits\n* Severe osteoporosis making the patient unfit for surgery\n* Severe cardiovascular, pulmonary or other chronic disease making the patient unfit for surgery\n* Isthmic or degenerative spondylolisthesis, grade 2 or larger\n* New or old fractures\n* Spondylodiscitis\n* Anchylosing spondylitis or other inflammatory process in the spine\n* Active neoplasm\n* Symptoms and clinical signs of nerve root compression or neurogenic claudication requiring decompressive surgery\n* Prior lumbar spine surgery (previous discectomy without fusion is not an exclusion criteria)","25 Years",{"count":156,"type":21},90,[24],"Problems from the musculoskeletal system are one of the most common reasons for disability and sick leave. These problems include low back pain.\n\nLow back pain affects as many as 8 out of 10 individuals at some point in life. In most people it is quickly transient with little, or only short-term, impact on function and quality of life. In some individuals, the problems can become long-lasting and significantly impair the quality of life.\n\nWhen analgesic and physiotherapeutic treatment have been tried and the problems are still not manageable, and have lasted more than a year, surgical treatment consisting of fusion surgery of the painful part of the spine may come in question. In Sweden, approximately 600 fusion surgeries are performed annually for low back pain.\n\nThere are a few randomized studies comparing fusion surgery for low back pain with non-surgical treatments, but these have showed different results. The effect of fusion surgery on low back pain is therefore uncertain.\n\nSurgical treatments brings with it a clear placebo effect. Other studies on pain in other parts of musculoskeletal system than the back has not been able to show that a surgical treatment is always better than placebo surgery. This has called into question the effect of surgery on many painful conditions of the musculoskeletal system. No placebo-controlled surgical studies have been done on fusion surgery for low back pain. A placebo surgical controlled study is the only way to ascertain whether fusion surgery is the right treatment for low back pain.\n\nIn this study, 90 individuals will undergo surgical treatment for low back pain. After surgical exposure, the surgeon will be informed whether fusion surgery should be performed or not. Half of the patients will undergo a fusion procedure with implants and the other half will not undergo the fusion procedure and will not receive implants.\n\nTreatment randomization will be performed during surgery, and the individuals undergoing treatment and the staff taking care of the individual after surgery will be blinded for treatment allocation during 6 months. That means that the individuals participating in the study and the staff who meet the individuals after surgery won't know if the individual had fusion surgery or no fusion surgery until after the 6 month follow-up.\n\nThe most important outcome of the study is the result of a questionnaire-based measure of back function answered by the participating individuals.",[27,160],"Degenerative Disc Disease Lumbar",[162],"Low back pain, degenerative disc disease, lumbar spine, surgery","2025-09-15",{"date":165,"type":34},"2025-09-16",{"date":167,"type":34},"2025-02-01",{"date":169,"type":21},"2037-12",{"name":171,"class":41},"Uppsala University",4,{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":42},"100604529","effects-of-close-follow-up-on-patients-with-low-back-pain-100604529","NCT07150702","Effects of Close Follow-up on Patients With Low Back Pain","The Effect of Close Follow-up by a Physician in Addition to a Conventional Physical Therapy Program in Patients With Low Back Pain","Inclusion Criteria:\n\n* Patients aged 18-65 with subacute or chronic mechanical back pain and considered appropriate for a physical therapy program.\n\nExclusion Criteria:\n\n* Patients describing inflammatory back pain\n* Spondyloarthropathies and other rheumatological diseases\n* History of spinal surgery\n* Patients with sensory disturbances and psychiatric diagnoses\n* Fibromyalgia\n* Patients with malignancies\n* Patients with active infectious findings\n* Patients with a history of radiotherapy",{"count":181,"type":21},74,[24],"This study will include patients aged 18-65 with subacute or chronic mechanical low back pain who apply to the Physical Medicine and Rehabilitation Clinic. The age, gender, body mass index, duration of low back pain, smoking status, and educational status of the patients included in the study will be recorded. Patients will be randomized into two groups: the study group and the control group. First, the psychosocial risk status of patients in both groups will be determined using the STarT Back Screening Tool. Then, patients in the control group will undergo a conventional physical therapy program that includes hot packs, transcutaneous electrical nerve stimulation, ultrasound, and core stabilization exercises. Patients in the study group will undergo daily close follow-up physician-patient meetings during the sessions, in addition to the conventional physical therapy program applied to the control group. Clinical assessments will be performed using the Visual Analogue Scale (VAS), Tampa Scale of Kinesiophobia, Pain Catastrophizing Scale, Beck's Depression Scale, Roland-Morris Disability Questionnaire, and Leeds Assessment of Neuropathic Symptoms and Signs. Clinical evaluations will be conducted at baseline, on Day 5 post-treatment, and at 1 month post-treatment.",[77,27],[186,187,188,189],"low back pain","physical therapy","mechanical low back pain","pain management","2025-09-13",{"date":165,"type":34},{"date":193,"type":34},"2025-09-01",{"date":195,"type":21},"2025-12-10",{"name":197,"class":198},"Istanbul Training and Research Hospital","OTHER_GOV",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":137,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":42},"100591047","effects-of-a-protocol-of-hip-flexor-stretching-on-chronic-mechanical-non-specific-lbp-100591047","NCT06975345","Effects of a Protocol of Hip Flexor Stretching on Chronic Mechanical, Non-specific LBP.","Short, Medium and Long Term Effects of a Protocol of Hip Flexor Stretching, Exercise and Pain Managment Education, Function and Disability in Patients With Chronic, Mechanical, Non-specific Low Back Pain. Randomized Controlled Clinical Trial.","HipFlexinCLBP","Inclusion Criteria:\n\n* Age 18-75 years\n* Medical diagnosis of chronic, mechanical, non-specific pain in the lumbar spine (M54, M51) - chronic low back pain.\n* Obtaining written consent to conduct research\n* Must be able to swallow tablets\n\nExclusion Criteria:\n\n* Pregnancy\n* Pacemaker\n* Active cancer\n* To consent to conduct research\n* Difficulty communicating\n* The presence of a metal plate in the head and metal screws in the body\n* Condition after operations in the area of the lumbar spine\n* Condition after fractures in the lumbar spine\n* Contraindications to manual therapy or exercise\n* Has participated in a lumbar spine exercise or manual therapy program in the last three months\n* Present clear signs of having suffered a significant lumbar injury\n* Inability to maintain standing or a supine or prone position\n* No possibility to perform the stretching of hip flexors","75 Years",{"count":209,"type":21},100,[24],"The goal of this clinical trial is to compare the effectiveness of a stretching, exercise and education protocol versus usual care in improving pain, function and disability in patients with non-specific mechanical chronic low back pain (CLBP). The research hypothesis is: A combination of hip flexors stretching, exercise and education is more effective than usual care to improve pain, function and disability in patients with CLBP.\n\nParticipants will be randomly allocated in one of the two treatment groups. Pain, function and disability will be assessed before starting treatment, after the end of the treatment and one month , three months and one year after the end of the treatment.",[213,214,27],"Pain","Musculoskeletal Manipulations",[216,217,218,219,220,221,222,223],"manual therapy,","spine,","low back pain,","Chronic Low Back Pain,","Muscle Stretching Exercises,","Range of Motion, Articular,","Body composition,","Numeric Pain Rating Scale (NPRS)","2025-05-07",{"date":226,"type":34},"2025-05-16",{"date":228,"type":21},"2025-07-02",{"date":230,"type":21},"2027-12-31",{"name":232,"class":41},"Wroclaw University of Health and Sport Sciences",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":241,"briefSummary":242,"conditions":243,"keywords":246,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":42},"100569596","effects-of-foundation-and-functional-inspiratory-muscle-training-in-non-specific-chronic-low-back-pain-100569596","NCT06696300","Effects of Foundation and Functional Inspiratory Muscle Training in Non-Specific Chronic Low Back Pain","Comparison of the Effects of Foundation and Functional Inspiratory Muscle Training in Addition to Classical Physiotherapy in Non-Specific Chronic Low Back Pain","Inclusion Criteria:\n\n* Volunteering to participate in the study,\n* Being between the ages of 18-65,\n* Having low back pain that has been ongoing for at least 3 months (12 weeks),\n* Having a Visual Analog Scale (VAS) of pain intensity of ≥3,\n* Being right-hand dominant.\n\nExclusion Criteria:\n\n* Not volunteering to participate in the study,\n* Having a history of cancer,\n* Having a spinal infection,\n* Having a rheumatological condition,\n* Having a spinal fracture,\n* Having red flag signs (sudden and unexpected weight loss, fever, etc.)\n* Having a psychological disorder,\n* Having a previous spinal surgery,\n* Having radiculopathy (neuropathic pain along the lower extremity due to nerve root compression),\n* Not continuing home exercises more than 80%,\n* Having an anatomical and congenital abnormality",{"count":50,"type":21},[24],"This study was planned to examine the effects of basic and functional respiratory muscle training on pain, disability level, and functionality. In this study, participants will be randomly divided into 3 groups. The first group will be treated with physical therapy applications applied in state hospitals for 10 weeks. The second group will receive basic respiratory muscle training treatment in addition to physical therapy in state hospitals. The third group will receive respiratory muscle training with exercise in addition to physical therapy in state hospitals. Evaluations will be made before the first session, after the 30th session, in the 3rd month, in the 6th month, and in the 1st year. There is no interventional method in the evaluations. Pain intensity, disability level, physical activity status, quality of life, fear of movement, pain catastrophizing, anxiety and depression levels will be questioned with scales. In physical measurements, participant's aerobic capacity will be measured with the 2-Minute Walk Test, participants's flexibility with the sit-and-long test, participants's respiratory muscle strength with the MIP\u002FMEP device, participants's core endurance with the trunk flexor muscle endurance test, participants's lower and upper extremity muscle strength with a handheld dynamometer, participants's postural control with the Biodex balance device, and participants's muscle thickness with an ultrasound.",[27,244,245],"Low Back Pain, Chronic","Non Specific Chronic Low Back Pain",[77,247,248,249,250],"Respiratory Muscle Strength","Muscle Training","Classical Physiotherapy","Ultrasound","2024-12-29",{"date":253,"type":34},"2024-12-31",{"date":255,"type":34},"2024-12-15",{"date":257,"type":21},"2026-12-01",{"name":259,"class":41},"Kirsehir Ahi Evran Universitesi",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":269,"phases":4,"briefSummary":270,"conditions":271,"keywords":272,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":42},"100488579","radiofrequency-denervation-and-brain-imaging-100488579","NCT05641948","Radiofrequency Denervation and Brain Imaging","Radiofrequency Denervation and Brain Structure, Function And Connectivity In Chronic Low Back Pain Patients","Inclusion Criteria:\n\n* Age 18 years or older\n* Chronic moderate to severe cLBP (defined by average pain intensity of ≥ 4 in the 11 point Numerical Pain rating scale and a minimum duration of 1 year)\n* Identified by clinical team as suitable for RFD pathway\n* Predominantly nociceptive pain (as defined by PainDetect score ≤12)\n* Stable on current analgesic regime\n* Able to communicate in English\n* Has the capacity to and agrees to give informed consent for participation in the study\n* Positive response to a single diagnostic MBB with 1 ml or less of local anaesthetic (bupivacaine 0.5%) at each level. (a positive response is defined as ≥80% pain relief at 3 hours, based on patient reported assessment)\n\nExclusion Criteria:\n\n* Any patient whose physical condition will preclude them from lying still for the duration of the brain scan.\n* Contraindication to magnetic resonance scanning such as an implantable cardiac device.\n* Women who are, or may be, pregnant. (Pregnant patients do not undergo pain procedures under radiological guidance as per routine clinical care)\n* Significant anxiety and depression (as defined by HADS score ≥ 9)\n* Clinical suspicion that alternative diagnosis is the reason for LBP\n* Presence of chronic primary pain conditions (Fibromyalgia, chronic widespread pain, Complex Regional Pain Syndrome, Chronic Primary Headache, Orofacial pain, Chronic primary visceral pian and Chronic Primary musculoskeletal pain as defined by ICD-11 classification)\n* Presence of thoracic or neck pain\n* History of previous RF denervation\n* Regular use of two or more dependence forming drugs (opioids, gabapentinoids, Benzodiazepines, tricyclics antidepressants and z-drugs)",{"count":268,"type":21},40,"OBSERVATIONAL","The goal of this observational study is to learn about changes in brain and its activity of following radiofrequency denervation treatment for chronic low back pain. The main question it aims to answer are:\n\n* report the magnitude of the brain changes following radiofrequency treatment for low back pain.\n* identify changes unique to radiofrequency treatment\n\nPatients with nociceptive type low back pain of moderate to severe intensity will be identified to undergo radiofrequency treatment. They will have 3 MRI scans - Baseline, after the diagnostic injections and 3 months after radiofrequency treatment. They will also fill questions relating to their pain, disability and health related quality of life.",[27],[273,274],"Neuroimaging","Radiofrequency denervation","2024-12-18",{"date":277,"type":34},"2024-12-24",{"date":279,"type":34},"2023-04-03",{"date":281,"type":21},"2026-09-30",{"name":283,"class":41},"University of Aberdeen"]