[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-back-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-back-pain":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,191,0,25,[9,49,81,112,135,162,186,211,233,257,283,310,335,361,391,410,438,461,487,505,528,555,577,601,631],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053218","effect-of-dry-needling-plus-vibration-on-myofascial-trigger-points-in-individuals-with-nonspecific-low-back-pain-100053218",false,"NCT06527339","Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain","Acceptability and Effectiveness of Adding a Percutaneous Vibratory Stimulus to Dry Needling for the Treatment of Myofascial Trigger Points in Nonspecific Low Back Pain: A Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Individuals with NSLBP: pain persisting for more than six weeks, located between the twelfth rib and the buttocks, and scoring at least 3 points on the Numeric Pain Rating Scale;\n2. Presence of MTrPs in any of the following muscles that are associated with low back pain (erector spinae muscles, longissimus, iliocostalis, multifidus, gluteus maximus, gluteus medius, and quadratus lumborum);\n3. Aged between 35-65 years: this population exhibits the highest prevalence of low back pain and consequently represents the greatest socio-economic impact on society;\n4. Having signed the informed consent form.\n\nExclusion Criteria:\n\n1. Diagnosis of specific pathologies associated with low back pain (e.g., herniated discs, neurological disorders);\n2. Any form of infiltration within the past 3 months;\n3. Having received any physiotherapy interventions in the lumbopelvic region within the past 4 weeks;\n4. History of surgical intervention in the lumbopelvic region;\n5. Use of anticoagulant or antiplatelet medications within the last week;\n6. Presence of systemic or local lumbar infections;\n7. Pregnancy;\n8. Fear of needles (belonephobia).","ALL","35 Years","65 Years",{"count":21,"type":22},36,"ESTIMATED","INTERVENTIONAL",[25],"NA","Low back pain is one of the most common health issues worldwide, and in most cases, this pain is nonspecific low back pain (NSLBP). NSLBP is characterized by the inability to determine the real source of the pain and commonly presents with myofascial trigger points (MTrPs) in the muscles related to the lumbar region.\n\nOne of the most widely used techniques for treating NSLBP by targeting MTrPs is dry needling (DN), a technique that involves inserting a needle to produce a mechanical effect capable of \"deactivating\" the MTrP and thereby alleviating its symptoms. However, some studies have concluded that other techniques are more effective than DN, such as percutaneous electrolysis (PE).\n\nWhen using the PE technique, it appears that adding a galvanic current enhances the effects of DN. Nonetheless, this poses a greater risk to the patient, as the galvanic current could damage nervous tissue if it comes into contact. For this reason, it is proposed to investigate whether other physical agents that are not electrical could enhance the effect of DN without increasing its risk. This is the case for vibration, a stimulus that has already been used successfully for the treatment of MTrPs, allowing us to investigate whether adding vibration to DN introduces therapeutic capabilities that:\n\n* Maintain or increase the effectiveness of DN in terms of pain and functional capacity.\n* Do not add risks for the patient, unlike PE.\n* Are less painful than DN and cause less post-needling pain than that generated after successive needle insertions with DN. Emphasizing these adverse effects is necessary since most clinical trials do not report these variables, which is fundamental for describing the safety of invasive techniques.\n\nFollowing this idea, the present project will analyze a new invasive therapy for the treatment of MTrPs: dry needling with vibratory stimulus (DN+V), for which the following hypotheses are proposed:\n\n* DN+V, instead of using an electrical stimulus like PE that could cause damage to some tissues, will apply vibration to the DN needles to increase the mechanical stimulus exerted on the MTrP, expecting greater benefits in terms of pain, functional capacity, muscle strength, and other variables of interest in individuals with NSLBP, and possibly requiring less treatment time than DN.\n* In DN, the repeated insertions and withdrawals of the needle in the MTrP provoke a hemorrhagic and inflammatory reaction that translates into hypersensitivity and microscopic tissue injury in the muscle, causing pain during treatment and post-needling pain for the following 24-32 hours. Another study showed that PE caused less post-needling pain than DN, which may be due to the fact that, unlike DN, it is common in PE to only perform a single puncture with each needle and not mobilize them.\n* The methodology for DN+V will be the same as for PE, with a single puncture and no needle manipulation, so it is expected that DN+V, being less invasive than DN, will reduce pain during treatment and post-needling pain compared to that generated by DN. There are studies that support this hypothesis, concluding that needle manipulation in DN produces greater post-needling pain than DN without needle manipulation.",[28,29,30,31],"Low Back Pain","Dry Needling","Trigger Points","Vibration",[33,34,35],"Non-specific low back pain","vibration dry needling","miofascial trigger points","NOT_YET_RECRUITING","2026-07-08",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":22},"2026-09",{"date":44,"type":22},"2027-07",{"name":46,"class":47},"Universidad de Zaragoza","OTHER",2,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100645113","the-relationship-between-lost-extremity-percentage-and-postural-control-neck-and-low-back-pain-daily-living-activities-and-reaction-time-in-individuals-with-unilateral-upper-limb-amputation-100645113","NCT07677969","The Relationship Between Lost Extremity Percentage and Postural Control, Neck and Low Back Pain, Daily Living Activities, and Reaction Time in Individuals With Unilateral Upper Limb Amputation","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Unilateral upper limb amputation\n* Use of a myoelectric or bionic prosthesis for at least 1 year\n* Current prosthesis use for a minimum of 3 months\n\nExclusion Criteria:\n\n* Bilateral upper limb amputation\n* Additional amputation of another limb\n* Use of passive or cosmetic prosthesis\n* Presence of neurological or other significant orthopedic disorders unrelated to amputation","18 Years",{"count":57,"type":22},15,"OBSERVATIONAL","This observational study aims to examine the relationship between the percentage of limb loss and functional outcomes in individuals with unilateral upper limb amputation. Upper limb amputation can affect posture, balance control, pain levels, daily living activities, hand function, and reaction time. However, limited research has investigated how the amount of limb loss influences these outcomes.\n\nParticipants between 18 and 65 years of age who use a myoelectric or bionic prosthesis will undergo a series of assessments. These assessments include measurements of postural control using a force platform, posture analysis, evaluation of neck and low back pain using a visual analog scale, daily living activities using a validated questionnaire, hand dexterity using the Box and Block Test, and reaction time using a visual stimulus device.\n\nThe study does not involve any intervention or treatment. All evaluations will be performed during a single assessment session. The results of this study may help improve rehabilitation planning and provide better understanding of functional changes associated with different levels of limb loss in people with upper limb amputation.",[61,62,63,28,64,65],"Upper Limb Amputation","Postural Control","Neck Pain","Daily Activities","Reaction Time",[61,62,63,67,68,69],"low back pain","Daily Living Activities","reaction time","RECRUITING","2026-06-30",{"date":73,"type":40},"2026-07-01",{"date":75,"type":40},"2026-01-01",{"date":77,"type":22},"2026-12-01",{"name":79,"class":47},"Hacettepe University",1,{"id":82,"slug":83,"hasResults":12,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":48},"100607966","evaluation-of-the-japetw-medical-device-for-low-back-pain-management-100607966","NCT07195422","Evaluation of the Japet.W+ Medical Device for Low Back Pain Management","Evaluation of the Japet.W+ Medical Device for Low Back Pain Management: Performance and Safety Analysis Across Two Patients' Groups","EXODOMICILE","Inclusion Criteria:\n\n* Non-specific chronic low back pain with active discopathy OR Non-specific chronic low back pain without active discopathy,\n* 18 years ≤ Age \\\u003C 80 years,\n* Average pain intensity (VAS) over the last week ≥ 40\u002F100,\n* Patient affiliated to the health social security system,\n* Patient able to understand the information relating to the study and to sign the informed consent form.\n\nExclusion Criteria:\n\n* Specific low back pain (infectious, inflammatory, tumorous, or traumatic in origin).\n* Motor neurological deficits (peripheral or central).\n* Extrapyramidal syndrome.\n* Treatment with implanted neurostimulation.\n* Severe heart or circulatory disease or respiratory problems.\n* Arthrodesis or disc replacement.\n* Surgery for herniated disc (\\\u003C3 months).\n* Spinal fracture or floating ribs (\\\u003C3 months).\n* Skin lesions on the trunk, history of contusions or skin lesions following traction of the trunk.\n* Pregnancy.\n* Patients who cannot tolerate the JAPET.W+ device during an initial trial.\n* Patients under guardianship, curatorship, or legal protection.\n* Participation in another clinical trial.\n* Patients who have worn a device designed to reduce lower back pain regularly during the 2 weeks prior to inclusion (lumbar belt, corset, exoskeleton).","80 Years",{"count":91,"type":22},102,[25],"The JAPET.W+ medical device is a new dynamic distraction support system. It could be considered as a new solution in the therapeutic arsenal for managing common low back pain. This study aims to assess the effectiveness of this device among the two targeted populations during daily use. Each patient will be asked to estimate the intensity of their low back pain several times during the clinical investigation. Our main hypothesis is a reduction in low back pain while wearing the device. The secondary hypothesis is a decrease in activity limitations, an increase in participation, an improvement in quality of life, and a reduction in healthcare product and medication consumption.",[28],[96,97,98,99,100,101],"Low back pain","Active discopathy","Japet.W+","Medical device","Pain assessment","Quality of life","2026-06-24",{"date":104,"type":40},"2026-06-25",{"date":106,"type":40},"2025-09-01",{"date":108,"type":22},"2028-06",{"name":110,"class":111},"Japet Medical Devices","INDUSTRY",{"id":113,"slug":114,"hasResults":12,"nctId":115,"briefTitle":116,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":118,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":80},"100642132","evaluation-of-the-effectiveness-of-physical-therapy-for-low-back-pain-according-to-magnetic-resonance-imaging-findings-100642132","NCT07648927","Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Completion of 15 sessions of physical therapy.\n* Availability of accessible MRI images in the medical records.\n* No history of lumbar spine surgery.\n* Absence of conditions that may cause low back pain, including fibromyalgia, neuropathy, spondyloarthropathy, or scoliosis.\n\nExclusion Criteria:\n\n* Presence of comorbid conditions that may cause low back pain (fibromyalgia, rheumatologic diseases, scoliosis, herpes zoster, polyneuropathy, central pain syndromes).\n* Presence of systemic neuromuscular disorders.\n* Acute disc herniation or vertebral fracture.\n* Receipt of fewer or more than 15 sessions of physical therapy.\n* Missing data in follow-up records.\n* Use of analgesic medications during the treatment period.",{"count":119,"type":22},120,[25],"Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the relationship between MRI findings and treatment outcomes remains unclear. This retrospective study aims to evaluate whether the effectiveness of a standardized physical therapy program differs according to baseline lumbar MRI findings. Medical records of 120 patients with low back pain who underwent lumbar MRI and completed 15 sessions of physical therapy between January 2022 and February 2026 will be reviewed. Patients will be classified into three MRI-based groups: disc herniation, disc degeneration, and non-specific MRI findings. Treatment outcomes will be assessed using changes in Visual Analog Scale (VAS) pain scores and Oswestry Disability Index (ODI) scores before and after treatment. The findings may contribute to identifying patient subgroups that respond differently to conservative treatment and support more individualized rehabilitation strategies.",[28,123,124,125],"Physical Therapy","Lumbar Degenerative Disc Disease","Lumbar Disc Herniation","2026-06-15",{"date":128,"type":40},"2026-06-16",{"date":130,"type":22},"2026-06-10",{"date":132,"type":22},"2026-09-10",{"name":134,"class":47},"Bahçeşehir University",{"id":136,"slug":137,"hasResults":12,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":158,"leadSponsor":160,"locationsCount":4},"100642126","comparison-of-early-mobilization-and-electrical-stimulation-on-functional-recovery-after-lumbar-disc-herniation-surgery-100642126","NCT07575477","Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery","Comparison Of Early Mobilization And Electrical Stimulation-Supported Rehabilitation On Functional Recovery, Pain Level, And Mobility After Lumbar Disc Herniation Surgery: A Prospective Randomized Controlled Trial","EMES-LDH","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Patients who have undergone primary lumbar disc herniation surgery\n* Being in the early postoperative period (within the first 2 weeks after surgery)\n* Clinically stable condition\n* Ability to understand and follow instructions\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* History of previous spinal surgery\n* Presence of severe neurological deficits (e.g., progressive motor loss, cauda equina syndrome)\n* Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)\n* Presence of severe systemic or uncontrolled chronic diseases (e.g., severe cardiovascular, respiratory, or metabolic disorders)\n* Cognitive impairment or inability to cooperate with rehabilitation program Pregnancy",{"count":144,"type":22},60,[25],"This randomized controlled trial aims to compare the effectiveness of early mobilization alone versus early mobilization combined with electrical stimulation on functional recovery following lumbar disc herniation surgery. Lumbar disc herniation is a common cause of low back pain and functional limitation, significantly affecting quality of life.\n\nAlthough surgical intervention is effective in patients who do not respond to conservative treatment, optimal postoperative recovery largely depends on appropriate rehabilitation strategies. Early mobilization is widely recommended to prevent complications, preserve muscle function, and facilitate return to daily activities. In addition, electrical stimulation modalities such as neuromuscular electrical stimulation (NMES) and transcutaneous electrical nerve stimulation (TENS) have been increasingly integrated into rehabilitation programs to enhance pain control, muscle activation, and neuromuscular re-education.\n\nIn this study, a total of 60 participants who have undergone primary lumbar disc herniation surgery will be randomly assigned into two groups. The first group will receive an early mobilization program alone, while the second group will receive early mobilization combined with electrical stimulation (NMES\u002FTENS). The intervention period will last 6 to 8 weeks, with sessions conducted three times per week.\n\nPrimary outcomes include functional disability measured by the Oswestry Disability Index (ODI) and pain intensity measured by the Visual Analog Scale (VAS). Secondary outcomes include functional mobility assessed by the Timed Up and Go (TUG) test, walking speed assessed by the 10-Meter Walk Test (10MWT), and muscle strength evaluated using manual muscle testing (MMT).\n\nThe findings of this study are expected to contribute to the development of evidence-based postoperative rehabilitation protocols and to clarify the clinical effectiveness of electrical stimulation in patients undergoing lumbar disc herniation surgery",[125,28,148],"Postoperative Rehabilitation",[150,151,152,153,154],"Lumbar Surgery","Early Mobilization","Electrical Stimulation","Physiotherapy","Functional Recovery","2026-06-12",{"date":128,"type":40},{"date":71,"type":22},{"date":159,"type":22},"2026-07-30",{"name":161,"class":47},"Istanbul Medipol University Hospital",{"id":163,"slug":164,"hasResults":12,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":89,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":171,"briefSummary":172,"conditions":173,"keywords":175,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":184,"locationsCount":80},"100641861","neurolyser-xr-for-the-treatment-of-sacroiliitis-100641861","NCT07647757","Neurolyser XR for the Treatment of Sacroiliitis","Safety and Efficacy of Using the Neurolyser XR Device for the Treatment of Sacroiliac Joint Related Low Back Pain","Inclusion Criteria:\n\n* Adult males and females, legally able and willing to participate in the study and come for follow-up visits\n* Able and willing to fill the research questionnaires and to communicate with investigator and research team\n* Patient with bilateral or unilateral sacroiliac joint pain of \\> 6 months duration\n* Patients presenting with a) a positive (\\>70% pain relief) to a previous nerve ablation procedure of the sacroiliac joint and \u002F or b) with a positive (\\>70% pain relief) to a previous nerve block procedure of the sacroiliac joint within the last six months)\n* Average pain score of 4 or higher in the last month, (on 0-10 scale).\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding patient\n* Patients presenting with neurological deficits (including lumbosacral radiculopathy but not solitary radicular pain).\n* Patients with history of lumbar and \u002F or sacral spine surgery\n* Patients with the presence of metal hardware at the lumbosacral spine\n* Patients with history of pelvic pathology that may increase procedural risk and \u002F or influence symptoms and \u002F or generate unrelated adverse event (per the discretion of the study principal investigator)\n* Patients unable to understand and complete the research questionnaires in Italian.\n* Patients presenting with any severe medical condition preventing the patient from safely and effectively being treated in the study or reporting study outcome.\n* Patient with extensive scarring in the skin and tissue overlying the treatment area.\n* Patients enrolled in or planned to be enrolled in another clinical trial during the duration of this research project.",{"count":170,"type":22},30,[25],"Our study aims to investigate the safety and efficacy of high intensity focused ultrasound in the management of low back pain due to sacroiliitis. Sacroiliitis is the inflammation of a joint in the lowest part of the spin and it is one of the cause of low back; the diagnosis is essentially based on clinical examination and the confirmation of this diagnosis relies on a significant pain relief following an infiltration of local anesthetic in the joint. One of the potential treatment is to ablate the nerves which carry the painful stimuli from the joint to the central nervous system through; these nerves enter the spinal canal through the sacral foramina which are two series of four pairs of openings located on the sacrum, the triangular bone at the base of the spine. Traditionally, these nerves are ablated by the heat produced by radiofrequency or the cold produced by cryoablation; both techniques require percutaneous needle insertion in close proximity to the targeted nerves, posing potential discomfort and risk of infection for the patient. High intensity focused ultrasound delivered by the device Neurolyser XR uses ultrasounds which are converged to the targeted point thanks to a gel pad positioned on the back of the patient; this mechanism of action does not require sterile conditions as the skin is not pierced and the discomfort of patient is dramatically reduced during the procedure for there is non need to insert and move any needle to properly position it. The correct orientation of the ultrasound beam is guaranteed by the alignment of the targeting system of the device and the X-ray image. The lesion is produced only if there is a bone right under the focus of the ultrasound beam and this is a safety system which assures that no direct injuries of other structures (e.g., vessels, spinal root) can be caused. To date, Neurolyser XR has been extensively used to treat facet joint syndrome through the ablation of the medial branches. However, its application in sacroiliitis has not yet been as deeply investigated.",[174,28],"Sacroiliitis",[176,177,178,67,179],"HIFU","High intensity focused ultrasound","sacroiliitis","nerve ablation",{"date":128,"type":40},{"date":182,"type":22},"2026-07",{"date":44,"type":22},{"name":185,"class":47},"Federico II University",{"id":187,"slug":188,"hasResults":12,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":195,"briefSummary":196,"conditions":197,"keywords":198,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":80},"100618125","assessment-of-the-evolution-of-lumbar-spine-movement-fluidity-using-xsens-inertial-sensors-in-subjects-with-chronic-low-back-pain-before-and-after-rehabilitation-100618125","NCT07327554","Assessment of the Evolution of Lumbar Spine Movement Fluidity Using Xsens Inertial Sensors in Subjects With Chronic Low Back Pain Before and After Rehabilitation","Xmouv - Assessment of the Evolution of Lumbar Spine Movement Fluidity Using Xsens Inertial Sensors in Subjects With Chronic Low Back Pain Before and After Rehabilitation","Xmouv","Inclusion Criteria:\n\n* Age between 18 and 65 years inclusive\n* BMI between 18-30 kg\u002Fm²\n* Chronic low back pain lasting more than three months\n* Rehabilitation care in the Physical Medicine and Rehabilitation Department of Montpellier University Hospital\n\nExclusion Criteria:\n\n* Sciatica episode within the last three months\n* Traumatic, tumoral, or infectious cause of low back pain\n* History of spinal, pelvic, or hip fracture\n* Inflammatory rheumatism\n* Lumbar arthrodesis\n* Severe scoliosis\n* Subject with a legal protection measure (guardianship, curatorship)\n* Subject under legal protection\n* Subject not affiliated to a social security system or not benefiting from such a system\n* Absence of informed written consent\n* Pregnant or breastfeeding women",{"count":7,"type":22},[25],"Low back pain, defined as pain located between the thoracolumbar junction and the lower gluteal fold, becomes chronic in 8% of patients. As the leading cause of disability worldwide, it has major individual and medico-economic consequences.\n\nThree-dimensional biomechanical analysis allows exploration of movement alterations related to low back pain. Although several parameters have already been studied (maximum joint range of motion (ROM), lumbopelvic rhythm, movement variability, gait), no consistent kinematic profile has emerged. Movement fluidity, assessed by the presence of jerks (brief movement disturbances), remains under-described despite its relevance in evaluating movement quality.\n\nInvistigators hypothesize that lumbar spine movement fluidity during flexion improves after a rehabilitation program and correlates with clinical response.\n\nThis project stands out by exploring a rarely studied parameter (movement fluidity) and integrating it as a potential indicator for rehabilitation monitoring.",[28],[96,199,200,201,202],"kinematic","jerk","instability catch","aberrant movement patterns","2026-06-11",{"date":155,"type":40},{"date":206,"type":40},"2026-02-23",{"date":208,"type":22},"2027-04",{"name":210,"class":47},"University Hospital, Montpellier",{"id":212,"slug":213,"hasResults":12,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":23,"phases":221,"briefSummary":223,"conditions":224,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":230,"locationsCount":232},"100643141","phase-2-a-chronic-pain-master-protocol-cpmp-a-study-of-ly4065967-in-participants-with-chronic-low-back-pain-100643141","NCT07641504","A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain","Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY4065967 for the Treatment of Chronic Low Back Pain","BP07","Inclusion Criteria:\n\n* Have a history of low back pain for at least 3 months located between the 12th thoracic vertebra and the lower gluteal folds, with or without radiation\n* Have a body mass index at screening of ≤40 kilograms per meter squared (kg\u002Fm²).\n* Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening\n\nExclusion Criteria:\n\n* Are pregnant or breastfeeding\n* Have used a therapeutic injection to the spine in the 3 months prior to screening\n* Are using a spinal cord stimulator or dorsal root ganglion stimulator\n* Have ongoing complex regional pain syndrome or other concurrent medical conditions that could interfere with the evaluation of CLBP\n* Have a history of major spinal deformity, such as spondylolisthesis, spondylolysis, scoliosis, or spina bifida, that causes instability to the spine\n* Have an abnormal blood pressure (BP) systolic BP is greater than 140 millimeters mercury (\\>140 mm Hg) and diastolic BP\\>90 mm Hg at screening • Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator",{"count":220,"type":22},150,[222],"PHASE2","The main purpose of this study is to test the safety and efficacy of study drug for the treatment of chronic low back pain (CLBP). This trial is part of the chronic pain master protocol H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate the development of new treatments for chronic pain.",[225,28],"Chronic Pain","2026-06-08",{"date":203,"type":40},{"date":182,"type":22},{"date":208,"type":22},{"name":231,"class":111},"Eli Lilly and Company",37,{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":253,"completionDateStruct":254,"leadSponsor":255,"locationsCount":80},"100642339","neuroscience-education-and-spinal-manipulation-on-health-locus-of-control-in-low-back-pain-100642339","NCT07639216","Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain","Pain Neuroscience Education Associated With Spinal Manipulation on Shifting Health Locus of Control in Patients With Low Back Pain: A Randomized Controlled Trial","LHC-LBP","Inclusion Criteria:\n\n* Both sexes.\n* Aged between 18 and 60 years.\n* Diagnosed with non-specific chronic low back pain (lasting 3 months or longer).\n* Functional disability score of 4 points or higher on the Roland-Morris Disability Questionnaire.\n* Has not received manual therapy for their condition within the previous 3 months.\n* Able to understand Portuguese well enough to complete the study questionnaires.\n\nExclusion Criteria:\n\n* Pregnant women.\n* Main area of pain is not located in the lumbar spine.\n* Main pain is located in the leg.\n* Less than 6 months post-surgery in the lumbar spine, lower limbs, or abdominal region.\n* Has undergone any invasive procedure for pain relief within the last 3 months.\n* Scoliosis.\n* Rheumatological diseases.\n* Progressive neurological disease.\n* Disorders related to red flags, such as malignancy\u002Fcancer, acute trauma (e.g., car or motorcycle accidents), fractures, infection, or spinal cord\u002Fcauda equina compression.\n* Chronic low back pain persisting after previous spinal surgery.","60 Years",{"count":243,"type":22},74,[25],"The purpose of this study is to evaluate the effects of combining Pain Neuroscience Education (PNE) with spinal manipulation for individuals suffering from chronic low back pain. Participants will be randomly assigned to one of two groups: one group will receive the combined intervention (neuroscience education plus spinal manipulation), while the control group will receive spinal manipulation alone.\n\nThe primary goal of the researchers is to investigate whether this combined approach can help patients change their health locus of control-shifting from an external belief (that their health depends on external factors or clinicians) to an internal belief (that they have control over their own recovery and pain management). The total study period will last 3 months, consisting of 4 weeks of intervention followed by an 8-week follow-up period to assess long-term changes in pain intensity, disability, and health beliefs.",[28],[248,67,249,250],"internal-external control","spinal manipulation","pain education","2026-06-05",{"date":130,"type":40},{"date":182,"type":22},{"date":44,"type":22},{"name":256,"class":47},"Centro Universitário Augusto Motta",{"id":258,"slug":259,"hasResults":12,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":4,"eligibilityCriteria":263,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":264,"targetDuration":4,"studyType":23,"phases":265,"briefSummary":266,"conditions":267,"keywords":269,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":80},"100643608","foam-roller-versus-self-performed-neurodynamic-sliding-in-people-with-hamstring-tightness-and-low-back-pain-history-100643608","NCT07627581","Foam Roller Versus Self-Performed Neurodynamic Sliding in People With Hamstring Tightness and Low Back Pain History","Effects of Self-Myofascial Release With Foam Roller Versus Self-Performed Neurodynamic Sliding on Hamstring Flexibility in People With Hamstring Tightness and a History of Low Back Pain: A Randomized Pilot Clinical Trial","Inclusion Criteria:\n\n* Men and women aged 16 years or older.\n* History of non-specific low back pain during the previous three months and\u002For recurrent or chronic non-specific low back pain.\n* Limited hamstring flexibility, defined as hamstring tightness with 75 degrees or less of hip flexion with knee extension during the Straight Leg Raise test.\n* No previous surgery involving the spine or lower limb.\n* No hamstring stretching exercises performed in the weeks prior to participation.\n* Ability and willingness to provide informed consent.\n* Availability to perform both self-administered physiotherapy techniques according to the study protocol.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* History of hamstring muscle or tendon injury during the previous year.\n* Lumbar or lower-limb neurological deficits.\n* Lower-limb length discrepancy.\n* Specific spinal pathology, including tumor, infection, fracture, or inflammatory disease.\n* History of lumbar disc herniation.\n* History of whiplash injury.\n* Any contraindication to physical exercise.\n* Menstrual pain at the time of assessment or intervention.\n* Scheduled surgery during the intervention or follow-up period.\n* History of cardiac disease.\n* Incomplete or incorrectly completed questionnaires or missing assessment data.\n* Refusal to complete part or all of the study intervention.\n* Development of a low back pain episode during the study intervention.",{"count":170,"type":22},[25],"This randomized crossover pilot clinical trial evaluated the effects of two self-administered physiotherapy techniques in people with hamstring tightness and a history of non-specific low back pain.\n\nParticipants were randomly assigned to one of two treatment sequences. One sequence performed self-myofascial release using a foam roller first, followed by a one-month washout period, and then performed a self-administered neurodynamic sliding technique. The other sequence performed the neurodynamic sliding technique first, followed by a one-month washout period, and then performed the foam roller intervention.\n\nThe main objective of the study was to compare the effects of both interventions on hamstring flexibility. Secondary outcomes included active knee extension range of motion, dynamic balance, pressure pain threshold, hamstring and gluteus maximus strength, and low back pain intensity.",[28,268],"Hamstring Tightness",[270,271,272,273,96,274],"foam roller","Self-myofascial release","Neurodynamic sliding","Hamstring flexibility","Crossover trial","2026-06-04",{"date":226,"type":40},{"date":278,"type":22},"2026-06",{"date":280,"type":22},"2026-08",{"name":282,"class":47},"Universidad Pontificia de Salamanca",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":291,"targetDuration":4,"studyType":23,"phases":293,"briefSummary":294,"conditions":295,"keywords":300,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":309},"100607611","managing-pain-using-optimized-sequences-by-adjusting-parameters-with-independent-current-control-100607611","NCT07190807","Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control","Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control (MOSAIC Study)","MOSAIC","Key Inclusion Criteria:\n\n* Persistent spinal pain syndrome (PSPS) Type I (or non-surgical refractory back pain), or PSPS Type II (Failed Back Surgery Syndrome, FBSS) diagnosis.\n* Diagnosed with chronic pain of the trunk and\u002For limbs for at least 6 months.\n* 18 years of age or older when written informed consent is obtained\n* Able to independently read and complete all questionnaires and assessments provided in English.\n* Signed a valid, IRB or EC approved informed consent form (ICF) provided in English.\n\nKey Exclusion Criteria:\n\n* Any pain-related diagnosis, medical or psychological condition that, in the Investigator's judgment might confound reporting of study outcomes (e.g., vascular or neurogenic claudication, osteoarthritis, plantar fasciitis, pelvic pain, anginal pain, chronic migraine, acute herniated disc, malignancy, untreated major depression, injury claim).\n* Significant cognitive impairment at Screening and Baseline visit that, in the opinion of the Investigator, would reasonably be expected to impair the study candidate's ability to participate in the study\n* A female who is pregnant, lactating, or is of childbearing potential and planning to get pregnant during the study or not using adequate contraception.\n* Participating (or intends to participate) in another drug or device clinical trial that may influence the data that will be collected for this study.",{"count":292,"type":22},70,[25],"Study to evaluate the effectiveness of time variant pulse (TVP)-SCS in patients with chronic pain using commercially approved Boston Scientific SCS Systems per local Instructions for use (IFU).\n\nIn addition, to compile real-world clinical outcomes in subjects with chronic, intractable low back and\u002For leg pain.",[225,296,28,297,298,299],"Intractable Pain","Chronic Low-back Pain","Chronic Leg Pain","Leg Pain",[301],"Spinal Cord Stimulation",{"date":251,"type":40},{"date":304,"type":40},"2025-11-07",{"date":306,"type":22},"2029-05",{"name":308,"class":111},"Boston Scientific Corporation",7,{"id":311,"slug":312,"hasResults":12,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":317,"enrollmentInfo":318,"targetDuration":4,"studyType":23,"phases":320,"briefSummary":321,"conditions":322,"keywords":323,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":331,"leadSponsor":333,"locationsCount":80},"100637134","low-blood-flow-restriction-training-on-low-back-pain-100637134","NCT07576101","Low Blood Flow Restriction Training on Low Back Pain","Effect of Low Blood Flow Restriction Training on Nonspecific Low Back Pain Patients","Inclusion Criteria:\n\nParticipants falling in this category would be recruited into the study.\n\n1. Both gender\n2. Age is between 18-45 years\n3. Individuals with pain localized posteriorly below the costal margin and above the inferior gluteal folds for more than 12 weeks\n4. A score greater than or equal to 4\u002F10 on Numeric Pain Rating Scale (NPRS)\n5. Hamstring muscle strength graded between (3- to 4) on MMT\n6. Proximal thigh circumference between (27.0 cm to 56.0 cm), measured 10cm below the inguinal crease\n7. Eligible for BFR training as per the Blood Flow Restriction Blood Flow Training Questionnaire\n\nExclusion Criteria:\n\nParticipants falling in this category would be excluded from the study.\n\n1. Patients of spinal stenosis, disc herniation spondylolisthesis, spondylosis or osteoporosis will be excluded\n2. Participants had a history of hip or lower extremity pathology requiring medical or surgical intervention.\n3. History of venous thromboembolism (VTE), clotting or other hematologic disorder\n4. Peripheral arterial disease, hypertension (blood pressure \\>140\u002F90 mm Hg), coronary artery disease\n5. Current Pregnancy\n6. Patients who had difficulties in exercise performance due to mental problems.\n7. Spinal cord infection like Cauda equina syndrome","45 Years",{"count":319,"type":22},44,[25],"The aim of this randomized controlled trial is to find the effectiveness of low load blood restriction training on improving hamstring muscle strength, alleviating pain and reducing functional disability in nonspecific low back pain patients",[28],[324,28,325],"Blood Flow Restriction","hamstring muscle strength","2026-06-01",{"date":328,"type":40},"2026-06-03",{"date":330,"type":40},"2026-05-02",{"date":332,"type":22},"2027-05-12",{"name":334,"class":47},"Riphah International University",{"id":336,"slug":337,"hasResults":12,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":341,"eligibilityCriteria":342,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":343,"targetDuration":4,"studyType":23,"phases":345,"briefSummary":346,"conditions":347,"keywords":348,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":354,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":48},"100631970","contextual-effects-on-inflammatory-biomarkers-and-pain-relief-after-spinal-joint-manipulation-100631970","NCT07507604","Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation","The Influence of Contextual Effects on Biochemical Parameters Associated With Inflammation and the Analgesic Efficacy of Spinal Joint Manipulation Therapy","CONTEXT-PAIN","Inclusion Criteria:\n\n* people with low back pain lasting longer than 3 months, aged 18 to 65 years,\n* highest reported pain intensity during the last 24 hours of at least 4 out of 10 on the 11-point Numeric Pain Rating Scale (NPRS-11), where 0 = no pain and 10 = worst imaginable pain,\n* clinical diagnosis of chronic non-specific low back pain (NSCLBP) based on symptoms located in the lumbar spine region and not on imaging findings,\n* no use of nonsteroidal anti-inflammatory drugs (NSAIDs) for at least 7 days before the study,\n* no use of pain medication for at least 24 hours before the study,\n* no use of corticosteroids,\n* no previous spinal manipulation therapy,\n* no alcohol, nicotine, or coffee consumption for at least 12 hours before the study,\n* written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* physiotherapy students,\n* presence of red flags, such as a history of cancer, constant or non-mechanical pain, progressive or radiating pain, sensory deficits in the trunk or - lower limbs, lower limb muscle weakness, or bladder\u002Fbowel dysfunction,\n* body mass index (BMI) greater than 30,\n* previous lumbar spine surgery,\n* lumbar spine injury within 6 months before the study,\n* diagnosed diabetes,\n* diagnosed rheumatic diseases,\n* affective disorders such as post-traumatic stress disorder (PTSD) or schizophrenia,\n* spondylolisthesis or spondylolysis confirmed by imaging,\n* diagnosed endometriosis,\n* use of hormonal medications,\n* sleep disorders,\n* shift work,\n* musculoskeletal injury within the last 14 days,\n* active infection,\n* pregnancy,\n* endocrine disorders such as hyperthyroidism or hypothyroidism,\n* use of opioid medications, including over-the-counter combination products such as codeine with paracetamol,\n* current or recent use of antidepressants affecting serotonin or dopamine (including SSRIs, SNRIs, tricyclic antidepressants, MAO inhibitors, or ketamine),\n* current diagnosis of major depressive disorder or bipolar disorder, as well as PTSD or schizophrenia,\n* ongoing psychotherapy during the study period,\n* cognitive impairment or significant hearing impairment that may interfere with understanding or processing the observational learning procedure.",{"count":344,"type":22},73,[25],"The goal of this clinical trial is to learn whether contextual effects created by observational learning can change pain relief and inflammation-related biological responses after spinal joint manipulation in adults with chronic non-specific low back pain. The main questions it aims to answer are:\n\nDoes positive, neutral, or negative observational learning change pain after spinal joint manipulation? Does it change disability, lumbar range of motion, stress, fear of movement, empathy, and treatment expectations? Does it change pressure pain threshold, lumbar tissue temperature, and blood markers related to inflammation, including interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and interleukin-10 (IL-10)?\n\nThe researchers will compare 3 groups: a positive expectation group, a neutral group, and a negative expectation group. Before the treatment, each participant will have a short interaction with a trained simulated patient. The simulated patient will present a positive, neutral, or negative experience with spinal manipulation, depending on group assignment. After this, all the participants will receive the same spinal joint manipulation procedure.\n\nThe participants will:\n\n* be randomly assigned to 1 of 3 study groups,\n* complete baseline questionnaires and clinical tests before treatment,\n* take part in a brief observational learning session before manipulation,\n* receive 1 spinal joint manipulation treatment,\n* complete outcome measurements before treatment, about 60 minutes after treatment, and 24 hours after treatment,\n* provide blood samples for analysis of inflammation-related biomarkers.\n\nThis study will include adults aged 18 to 65 years with chronic non-specific low back pain. The main outcome is pain intensity. Secondary outcomes include disability, stress, empathy, fear of movement, lumbar range of motion, tissue temperature, pressure pain threshold, and treatment expectations. Exploratory outcomes include blood biomarkers related to inflammation.",[28],[67,349,350,351,352,353],"spinal joint manipulation","observational learning","contextual effects","placebo","nocebo",{"date":328,"type":40},{"date":356,"type":40},"2026-04-21",{"date":358,"type":22},"2026-09-30",{"name":360,"class":47},"John Paul II University in Biała Podlaska",{"id":362,"slug":363,"hasResults":12,"nctId":364,"briefTitle":365,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":368,"enrollmentInfo":369,"targetDuration":371,"studyType":58,"phases":4,"briefSummary":372,"conditions":373,"keywords":375,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":389,"locationsCount":80},"100640874","the-association-between-amputation-level-and-chronic-low-back-pain-after-combat-related-amputation-100640874","NCT07626294","The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation","LEVEL-BACK","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related lower limb amputation\n* Transtibial, transfemoral, or bilateral lower limb amputation\n* Time since amputation ≥3 months\n* Current or planned prosthesis use\n* Ability to participate in rehabilitation assessment\n* Ability to report low back pain intensity\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Traumatic spinal injury related to the initial combat trauma\n* Previous spinal surgery before amputation\n* Known severe spinal deformity\n* Active spinal infection or malignancy\n* Severe neurological disorder affecting mobility\n* Non-combat-related amputation\n* Inability to complete follow-up assessments\n* Refusal or inability to provide informed consent","50 Years",{"count":370,"type":22},300,"6 Months","Patients with combat-related lower limb amputations frequently experience chronic low back pain during long-term rehabilitation and prosthetic use. Altered biomechanics, asymmetric loading, gait disturbances, and changes in spinal alignment after limb loss may contribute to the development of persistent back pain. The severity and characteristics of low back pain may vary according to the level of amputation.\n\nThe LEVEL-BACK Study is a prospective observational study designed to evaluate the relationship between amputation level and chronic low back pain after combat-related amputation.\n\nParticipants with different levels of lower limb amputation will undergo clinical assessment of low back pain intensity, functional limitations, prosthesis use, and rehabilitation outcomes during follow-up.\n\nThe goal of the study is to improve understanding of how amputation level influences chronic low back pain after combat-related limb loss and to identify patients at increased risk for persistent spinal pain during rehabilitation.",[28,374],"Amputation",[376,377,378,379,380,381,382,383],"Chronic low back pain","Combat-related amputation","Amputation level","Transtibial amputation","Transfemoral amputation","Bilateral amputation","Prosthesis use","Rehabilitation","2026-05-30",{"date":275,"type":40},{"date":387,"type":22},"2026-09-15",{"date":387,"type":22},{"name":390,"class":47},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":397,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":408,"locationsCount":48},"100457028","effect-of-lumbar-surgery-on-complexity-during-a-walking-task-in-chronic-low-back-pain-100457028","NCT05231265","Effect of Lumbar Surgery on Complexity During a Walking Task in Chronic Low Back Pain","Effect of Lumbar Surgery on Complexity During a Walking Task in the Chronic Low Back Pain Patient","LOBAFRACS","Inclusion Criteria:\n\n* Patients with chronic low back pain requiring prosthesis or arthrodesis surgery on one or two levels\n* Subject affiliated or beneficiary of a health insurance plan.\n* The patient must have given their free and informed consent\n\nExclusion Criteria:\n\n* Patients with organic low back pain (infection, tumor, inflammatory rheumatism)\n* Patient with a neurological deficit (cauda equina syndrome or motor testing MRC \\\u003C 3 on a muscle group of the lower limbs)\n* Patient who has already undergone lumbar surgery (except single discectomy)\n* Patient with serious concomitant pathologies\n* Patients participating in a therapeutic study prohibiting participation in another study\n* Patient in an exclusion period from a different study\n* It is impossible to give the subject informed information\n* Patient is unable to express consent\n* The patient is under safeguard of justice or state guardianship\n* Patient is pregnant, parturient or breastfeeding",{"count":400,"type":22},32,"Lumbar surgery is the most common treatment for chronic disabling low back pain with degenerative disc disease. There are few elements to objectively evaluate the improvement of the motor control after surgery and the motor adaptation capacities of the patients.\n\nThe impact of lumbar surgery on complexity in this painful context has never been studied. Theoretically, the restriction of mobility imposed by lumbar surgery should limit the subject's adaptive capacities (of one or more lumbar segments) and thus reduce complexity. Nevertheless, improvement in pain intensity levels could allow the patient to find better motor adaptation capacities, necessary for a positive evolution in the long-term.\n\nThe aim of this study was to investigate the evolution of gait complexity in chronic low back pain patients pre- and post-surgery. If surgery improves the adaptability of walking through an antalgic benefit exceeding the induced stiffness, the complexity of walking should be superior after surgery.\n\nThis is a proof-of-concept study in which the study investigators hypothesize that measuring complexity by fractal analysis during a walking task will show the increase in gait complexity induced by lumbar surgery at 3 and 6 months after surgery.",[28],"2026-05-28",{"date":326,"type":40},{"date":406,"type":40},"2023-10-16",{"date":208,"type":22},{"name":409,"class":47},"Centre Hospitalier Universitaire de Nīmes",{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":23,"phases":419,"briefSummary":420,"conditions":421,"keywords":423,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":80},"100605372","chronic-low-back-pain-and-osteopathic-manipulation-treatment-100605372","NCT07161661","Chronic Low Back Pain and Osteopathic Manipulation Treatment","Feasibility of Implementing Manual Medicine in the Multimodal Management of Veterans and Service Members With Chronic Low Back Pain","Inclusion Criteria:\n\n* 18 years of age and older\n* Seeking care for LBP from a participating VA clinic\n* Able to follow study protocol\n* Willing to be randomized to Usual VA Care or Usual VA Care + OMT\n* Individuals with pain primarily in the LBP region lasting \\> 3 months and present on at least half the days during the past 6 months\n* Pain rating over the past 7 days equal to or greater than 3\u002F10 as indicated on the Numeric Rating Scale for Pain\n\nExclusion Criteria:\n\n* Signs of serious pathology as a cause of LBP\n* Underlying systemic or inflammatory conditions\n* Neurological diseases\n* Pregnancy\n* Previous back surgery or spinal fracture within the past year\n* Active workers' compensation or litigation for back pain\n* Any conditions impeding study protocol implementation or contraindication to OMT\n* No PM\\&R, OMT, chiropractic, or physical treatment where manual techniques are utilized within last 3mo",{"count":418,"type":22},48,[25],"The goal of this clinical trial is to learn if adding Osteopathic Manipulative Therapy (OMT) to the usual medical care provided at the VA (usual VA care) improves treatment outcomes in individuals with chronic low back pain (CLBP). OMT is a set of hands-on techniques a doctor uses to move a patient's muscles and joints which include stretching, gentle pressure, resistance and applying forces to specific areas of the body. This feasibility clinical trial aims to learn about the treatment effects (e.g., effect sizes) of adding OMT to the usual medical care provided at the VA (Usual VA Care) in individuals with LBP.",[422,28],"Chronic Low Back Pain (CLBP)",[424,425,426,427],"Osteopathic manipulative treatment","Physical Medicine and Rehabilitation","Veterans","Osteopathic manipulation","2026-05-21",{"date":430,"type":40},"2026-05-22",{"date":432,"type":40},"2026-03-02",{"date":434,"type":22},"2027-08-31",{"name":436,"class":437},"Edward Hines Jr. VA Hospital","FED",{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":17,"minAge":444,"maxAge":445,"enrollmentInfo":446,"targetDuration":4,"studyType":23,"phases":448,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":457,"leadSponsor":459,"locationsCount":80},"100633386","comparative-effects-of-post-isometric-relaxation-versus-active-isolated-stretch-in-patients-with-piriformis-syndrome-100633386","NCT07526012","Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome","Inclusion Criteria:\n\n* Age between 20-55 years\n* Both genders\n* Buttock pain that may radiates to posterior thigh but not beyond the knee\n* Pain aggravated by sitting, climbing stairs or hip rotation.\n* Tenderness upon palpation over the sciatic foramen.\n* Positive FAIR test.\n\nExclusion Criteria:\n\n* Malignancies\n* History of steroid therapy over 3 months\n* Rheumatoid arthritis or osteoarthritis\n* Avascular necrosis of the femoral head\n* Osteoporosis\n* Fracture of the femur\n* Hip deformity","20 Years","55 Years",{"count":447,"type":22},40,[25],"The purpose of this study is to evaluate the comparative effects of post-isometric relaxation (PIR) and active isolated stretch (AIS) techniques on reducing pain, improving range of motion, and decreasing functional disability in individuals with piriformis syndrome. A total of 40 participants will be recruited, aged 20-55 yrs, with confirmed piriformis syndrome. Participants will be randomized into two equal groups. Group A (post isometric relaxation) and Group B (active isolated stretch). Both groups will receive Conventional Therapy (Thermotherapy, Electrotherapy).\n\nStudy variables include:\n\n* Independent Variable: Post Isometric Relaxation and Active Isolated Stretching.\n* Dependent Variables: Pain (measured by Visual Analog Scale), Functional Disability (assessed via Oswestry Disability Index), Range of Motion (assessed via Goniometer).\n* Control Variables: Age, Gender, BMI, Baseline Pain\u002F Disability Scores\u002FROM\n\nThe intervention will last 2 weeks with 6 sessions (3 sessions per week). Assessments will be conducted at baseline (Week 1, Pre-treatment) and Post every second session. Data will be analyzed to compare immediate and short-term effects of the two interventions.\n\nThis study aims to provide evidence for targeted manual therapy approaches in priformis syndrome, potentially guiding clinicians toward the most effective technique for pain reduction, improve ROM and decrease functional disability.",[451,28,452],"Piriformis Syndrome","Hip Joint","2026-05-18",{"date":455,"type":40},"2026-05-20",{"date":455,"type":22},{"date":458,"type":22},"2026-07-15",{"name":460,"class":47},"Foundation University Islamabad",{"id":462,"slug":463,"hasResults":12,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":468,"targetDuration":470,"studyType":58,"phases":4,"briefSummary":471,"conditions":472,"keywords":474,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":485,"locationsCount":80},"100636562","common-pain-mechanisms-in-migraine-migraine-related-neck-pain-and-lower-back-pain-a-cross-sectional-study-100636562","NCT07567300","Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study","From Mechanisms to Clinical Evidence: A Cross-Sectional Study of Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain","Inclusion Criteria:\n\n* Being between 18 and 65 years of age,\n* Being able to read and understand Turkish,\n* Agreeing to participate voluntarily,\n* Having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria;\n* Having neck pain and\u002For lower back pain without any underlying diagnosis accompanying the migraine diagnosis.\n\nExclusion Criteria:\n\n* A history of neurological disorder (e.g., Multiple Sclerosis),\n* Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis), generalized chronic pain syndromes (e.g., Fibromyalgia),\n* Any other headache disease, any other systemic disease,\n* Acute fracture and infection,\n* Spinal surgery or spinal disease diagnosis within the last 6 months,\n* Serious musculoskeletal trauma within the last 6 months,\n* Pregnancy,\n* A cognitive or psychiatric condition that would prevent completion of the questionnaires,\n* In the control group without a migraine diagnosis,\n* A history of recurrent headaches within the last year.",{"count":469,"type":22},179,"1 Day","Migraine is one of the primary headache disorders with a high prevalence worldwide, leading to significant disability and reduced quality of life. Trigeminal nerve activation and alterations in central pain processing mechanisms play a crucial role in the pathophysiology of migraine. Recent studies suggest that migraine may not only be a headache disorder but also a systemic pain disorder associated with changes in central pain processing mechanisms. Central sensitization is defined as increased sensitivity of nociceptive neurons in the central nervous system to afferent stimuli and is considered a key mechanism in the development and maintenance of chronic pain conditions. This condition is characterized by pain hypersensitivity, allodynia, and generalized pain sensitivity.\n\nIn addition to headaches, other musculoskeletal pains are also frequently reported in migraine patients. Spinal pain, particularly neck and lower back pain, can occur in migraine sufferers, with central sensitization contributing to the condition, considering the spine as a chain. Large population-based studies have shown a significant association between primary headaches and persistent low back pain, and a higher prevalence of concomitant low back pain has been reported in individuals with chronic migraine and chronic tension-type headaches. This association is suggested to be explained by the shared nociceptive pathways of the head and spinal structures and the changes in central pain processing seen in chronic pain conditions.\n\nThis relationship between migraine and musculoskeletal pain is also explained by the presence of shared neuroanatomical structures such as the trigemino-cervical complex. Nociceptive afferents from the upper cervical spine and cranial structures converge at the trigemino-cervical complex level in the brainstem, creating a predisposition to the co-occurrence of head and neck pain. This mechanism suggests that pain or dysfunction in the cervical region in migraine patients may be related to headache symptoms. Studies have shown that neck pain is more common in individuals with migraine than in the general population, and research suggests this rate may be approximately 10-12 times higher compared to healthy individuals. Furthermore, it has been reported that individuals with migraine more frequently experience tenderness in cranio-cervical muscles such as the upper trapezius, sternocleidomastoid, and suboccipital muscles, myofascial trigger points, and increased muscle sensitivity. The literature also emphasizes that these cervical symptoms may be related to migraine frequency, attack severity, and headache-related disability.\n\nThese findings suggest that migraine should be considered not only as a primary headache disorder but also as a complex neurobiological condition associated with widespread pain sensitivity and musculoskeletal symptoms. A better understanding of the relationship between migraine and musculoskeletal pain could be important for developing multidisciplinary treatment approaches. However, clinical studies in the literature that evaluate migraine, accompanying neck pain, and lower back pain together in terms of common pain mechanisms are quite limited. Therefore, the rationale for this study is that examining factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together in migraine patients can lead to a better understanding of the pathophysiology of migraine-related musculoskeletal pain. Based on all these reasons and evidence, the aim of this study is to investigate the possible common pain mechanisms and musculoskeletal pathophysiological processes of migraine-related neck and back pain in migraine patients with accompanying neck and\u002For back pain by evaluating factors such as central sensitization, pain threshold, pain catastrophizing, psychological factors, body awareness, and regional disability together.",[63,473,28],"Migraine",[475,476,67,477,478],"migraine","neck pain","central sensitization","pain threshold","2026-05-16",{"date":481,"type":40},"2026-05-19",{"date":483,"type":22},"2026-04-30",{"date":71,"type":22},{"name":486,"class":47},"Bozok University",{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":445,"enrollmentInfo":494,"targetDuration":4,"studyType":23,"phases":495,"briefSummary":496,"conditions":497,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":498,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":80},"100637408","sensorimotor-training-with-a-mobilized-balance-platform-in-patients-with-chronic-low-back-pain-100637408","NCT07603609","Sensorimotor Training With a Mobilized Balance Platform in Patients With Chronic Low Back Pain","Effects of a Sensorimotor Training Protocol Using a Mobilized Balance Platform on Proprioceptive System, Movement Control, and Quality of Life in Patients With Chronic Low Back Pain","Inclusion Criteria:\n\n* Individuals aged between 18 and 55 years\n* Presence of chronic low back pain lasting at least 3 months\n* Pain intensity score of 3 or higher on the Visual Analog Scale (VAS)\n* Individuals with sufficient cognitive ability to understand and follow study procedures\n* Willingness to participate voluntarily in the study\n\nExclusion Criteria:\n\n* Participation in a similar training program within the last 12 months\n* History of lower extremity or spinal surgery\n* Presence of non-mechanical low back pain, inflammatory disease, or tumor\n* Uncontrolled hypertension or cardiac disease\n* History of malignancy\n* Presence of radicular symptoms associated with low back pain\n* Progressive neurological deficits\n* Neurogenic claudication",{"count":319,"type":22},[25],"This randomized controlled study aims to investigate the effects of a sensorimotor training protocol using a mobilized balance platform device on proprioceptive system function, movement control, balance, physical performance, pain severity, and quality of life in patients with chronic low back pain. A total of 44 patients with chronic low back pain will be recruited from the outpatient clinic of Gaziler Physical Medicine and Rehabilitation Training and Research Hospital.\n\nParticipants will be randomly assigned to either a sensorimotor training group or a control group. The intervention group will receive sensorimotor training using the Huber 360 balance system, while the control group will perform a home exercise program including stretching, spinal mobility, lumbopelvic control, and balance exercises.\n\nPain severity, proprioception, functional status, balance, physical performance, and quality of life will be assessed before and after treatment by an assessor blinded to group allocation.",[28],{"date":430,"type":40},{"date":500,"type":40},"2026-05-04",{"date":502,"type":22},"2026-11-30",{"name":504,"class":47},"Gaziler Physical Medicine and Rehabilitation Education and Research Hospital",{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":12,"sex":17,"minAge":444,"maxAge":445,"enrollmentInfo":512,"targetDuration":4,"studyType":23,"phases":513,"briefSummary":514,"conditions":515,"keywords":517,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":80},"100618932","the-effects-of-eight-week-baduanjin-exercise-on-chronic-low-back-pain-and-disability-among-office-workers-100618932","NCT07338045","The Effects of Eight-Week Baduanjin Exercise on Chronic Low Back Pain and Disability Among Office Workers.","The Effects of Eight-Week Baduanjin Exercise on Chronic Low Back Pain and Disability Among Office Workers","Inclusion Criteria:\n\n\\-\n\nThis study specifically targets office workers diagnosed with mechanical (or non-specific) chronic low back pain, which refers to persistent low back pain without a specific identifiable pathological cause such as disc herniation, spinal stenosis, or inflammatory diseases. Mechanical low back pain is the most common form of chronic low back pain among sedentary populations, particularly office workers, and is primarily attributed to musculoskeletal imbalances, poor posture, and prolonged sitting.Participants were included in the study if they met the following criteria:\n\n1. Age and Occupational Requirements: Office workers between the ages of 20 and 55 years with at least two years of continuous employment.\n2. History of Chronic Low Back Pain: Presence of persistent or recurrent low back pain localized below the costal margin and above the inferior gluteal folds, with a duration of more than three months.\n3. Pain Intensity Assessment: A pain score exceeding 40 mm on a 100 mm Visual Analogue Scale (VAS), indicating a moderate level of pain.\n4. Clinical Diagnosis Confirmation: Participants must be diagnosed with mechanical (non-specific) chronic low back pain by orthopaedic sports medicine specialists from the First Affiliated Hospital of Xi'an Jiaotong University. All participants will be required to submit their annual full-body medical examination report provided by the university between May 30 and July 30 each year. The Principal Investigator will collect these reports in advance and arrange for orthopaedic sports medicine specialists from the affiliated hospital to conduct an on-site screening at Xi'an Jiaotong University City College. During this process, specialists will review participants' medical history, evaluate physical symptoms, and consider available imaging reports (e.g., X-rays or MRI scans if previously conducted) to confirm the absence of specific spinal pathologies such as disc herniation or spinal stenosis. These specialists are experts in diagnosing and managing musculoskeletal conditions related to physical activity and sports, ensuring accurate assessment and classification of participants' chronic low back pain. Their involvement guarantees both clinical validity and safety in participant selection.\n5. Cognitive and Physical Function: Normal cognitive function, adequate communication and interaction skills, and the physical ability to perform the basic movements of Baduanjin exercise. Participants must also have voluntarily provided written informed consent and agreed to comply with all study procedures throughout the research period.\n6. Employment Status: Staff members currently employed at Xi'an Jiaotong University City College. This criterion ensures that the study population consists exclusively of sedentary office workers within the university setting, enhancing homogeneity and relevance to the target demographic.\n\nExclusion Criteria:\n\n\\-\n\nSubjects are excluded from this study if they:\n\n1. Those with other spinal pathologies such as lumbar fractures, lumbar disc herniation, spondylolisthesis, intravertebral occupancy, lumbar spinal stenosis, and severe osteoporosis. These conditions may interfere with the interpretation of outcomes related to chronic low back pain of non-specific origin, and could also affect the safety or effectiveness of the Baduanjin exercise intervention.\n2. Persons with contraindications such as leukaemia, thrombocytopenia and other diseases with bleeding tendency, acute infectious diseases and oncological diseases. These systemic illnesses may affect participant safety or confound the results, and are therefore not included in the target population of office workers with chronic low back pain.\n3. Suffering from diseases of liver and kidney function, serious cardiac disorders, and other diseases affecting the study. The presence of these comorbidities could influence the ability of participants to safely complete the Baduanjin exercise program, and thus they are excluded to ensure homogeneity among the target group of individuals with chronic low back pain.\n4. Women who are pregnant. Pregnancy-related changes in posture and musculoskeletal loading can affect low back pain symptoms and response to exercise, which may confound the study findings.\n5. Subjects who do not agree to sign the informed consent form. All participants will be required to submit their annual full-body medical examination report provided by the university between May 30 and July 30 each year. The Principal Investigator will collect these reports in advance and arrange for orthopaedic sports medicine specialists from the affiliated hospital to conduct an on-site screening at Xi'an Jiaotong University City College. During this process, the specialists will review all relevant medical findings, including imaging results, laboratory tests, and physician notes, to identify any conditions that meet the exclusion criteria. Participants found to have spinal pathologies, systemic illnesses, or other comorbidities that may affect safety, intervention effectiveness, or study outcomes will be excluded from the study. These exclusion criteria are designed to ensure that the final sample consists exclusively of individuals with mechanical (non-specific) low back pain, thereby enhancing the homogeneity of the study population and minimizing confounding factors in evaluating the effects of Baduanjin exercise.",{"count":170,"type":22},[25],"Office workers often suffer from chronic low back pain due to long hours of sitting and poor posture. This study will test whether Baduanjin-a gentle, traditional Chinese exercise-can help reduce pain and improve physical function in office staff with long-standing back pain. Thirty participants will be randomly assigned to either practice Baduanjin for eight weeks or receive no special intervention. Researchers will measure changes in pain levels, movement ability, balance, posture, and daily functioning before and after the program. Baduanjin is a safe, low-cost, and easy-to-learn exercise that could be widely used in community health settings as a non-drug therapy for back pain.",[28,516],"Baduanjin",[518,519],"Office Workers","Non-pharmacological Intervention","2026-05-15",{"date":481,"type":40},{"date":523,"type":40},"2026-03-15",{"date":525,"type":22},"2026-07-31",{"name":527,"class":47},"Universiti Sains Malaysia",{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":536,"sex":17,"minAge":55,"maxAge":537,"enrollmentInfo":538,"targetDuration":4,"studyType":23,"phases":540,"briefSummary":541,"conditions":542,"keywords":544,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":548,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":80},"100551021","phase-2-dronabinol-as-an-adjunct-for-reducing-pain-100551021","NCT06454669","Dronabinol as an Adjunct for Reducing Pain","A Randomized, Double-Blind, Placebo-Controlled, Parallel Groups Study to Explore the Safety and Therapeutic Potential of Dronabinol as an Adjunct for Reducing Pain","DARP","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form.\n2. Stated willingness to comply with all study procedures and availability for the duration of the study.\n3. Ability to take oral medication per protocol.\n4. Male or female, aged 18-64 years.\n5. Has chronic low back pain (i.e., in the space between the lower posterior margin of the rib cage and the horizontal gluteal fold) that has persisted at least 3 months and has resulted in pain on at least half the days in the past 6 months (Items 1 \\& 2 from the Research Standards for Chronic Low-Back Pain (RScLBP) assessment).\n6. For females of reproductive potential: currently practicing an effective form of two types of birth control, which are defined as those, alone or in combination, that result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly, for at least 1 month prior to screening and agrees to use such a method during study participation and for an additional 4 weeks after the end of study medication administration unless she is surgically sterile, partner is surgically sterile, or she is postmenopausal (one year):\n\n   1. oral contraceptives,\n   2. contraceptive sponge,\n   3. patch,\n   4. double barrier (diaphragm\u002Fspermicidal or condom\u002Fspermicidal),\n   5. intrauterine contraceptive system,\n   6. etonogestrel implant,\n   7. medroxyprogesterone acetate contraceptive injection,\n   8. complete abstinence from sexual intercourse, and\u002For hormonal vaginal contraceptive ring.\n7. Agree (if male) to use acceptable methods of contraception if the male participant's partner could become pregnant from the time of the first administration of the study drug until 30 days following the final administration of the study drug. One of the following acceptable methods of contraception must be utilized:\n\n   1. Surgical sterilization (vasectomy)\n   2. The participant's female partner uses oral contraceptives (combination estrogen\u002Fprogesterone pills), injectable progesterone or sub dermal implants (commenced at least 14 days prior to study drug administration to the male participant)\n   3. The participant's female partner uses a medically prescribed topically applied transdermal contraceptive patch (commenced at least 14 days prior to study drug administration to the male participant)\n   4. The participant's female partner has undergone tubal ligation (female sterilization) or is postmenopausal (one year)\n   5. The participant's female partner has undergone placement of an intrauterine device or intrauterine system.\n   6. True abstinence: when this is in line with the preferred and usual lifestyle of the participant.\n8. Agreement to adhere to Lifestyle Considerations throughout study duration.\n9. On a stable opioid treatment regimen, with or without other pharmacologic or nonpharmacologic pain treatments, for ≥3 months at the time of the screening and agree to refrain from adding new analgesic medications or increasing their current dose of analgesic medications for the duration of the study.\n\nExclusion Criteria:\n\n1. Non-English speaking or inability to read and understand English.\n2. Current and unwilling to stop the use of cannabis\u002Fmarijuana and any other cannabinoids, including over the counter CBD products.\n3. Reported allergic reactions to cannabis, CBD, THC, or components of the study interventions.\n4. Have Blood Urea Nitrogen or Creatinine levels outside the normal range, or other clinically significant laboratory abnormalities.\n5. Current use of Antiepileptic drugs.\n6. Current use of barbiturates, benzodiazepines, ethanol, lithium, buspirone, muscle relaxants\n7. Current use of amphetamines, other sympathomimetic agents, atropine, amoxapine, scopolamine, antihistamines, other anticholinergic agents, amitriptyline, desipramine, or other tricyclic antidepressants within 3 months of randomization.\n8. Treatment with another investigational drug or other intervention within 3 months of the screening visit.\n9. Pregnancy, plans to become pregnant, or lactation.\n10. Any interventional pain procedures within 6 weeks prior to screening or at any point during study enrollment.\n11. Surgical intervention or introduction\u002Fincreased dose of an opioid or analgesic regimen at any point during study enrollment.\n12. Implanted spinal cord or dorsal root ganglion stimulator for pain treatment.\n13. Meets the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria for a current major psychiatric illness, such as bipolar disorder, major depression, or psychosis.\n14. Have a history of substance abuse or dependence.\n15. Have a history or current suicidality. Have an increased risk of suicide that necessitates inpatient treatment or warrants therapy excluded by the protocol, and\u002For current suicidal plan, per investigator clinical judgement, based on interview and defined on the Columbia Suicidality Severity Rating Scale (C-SSRS).\n16. Have a history of seizures.\n17. Have uncontrolled renal, hepatic, or other systemic disorders that in the opinion of the investigator may jeopardize the patient.\n18. Have a history of cardiac disorders.\n19. Myocardial infarction or stroke in the previous 6 months.\n20. Resting heart rate of \\> 120.\n21. Systolic blood pressure \\> 140 mm Hg, or diastolic blood pressure \\> 90 mm Hg.\n22. Any uncontrolled communicable disease (e.g., human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS), tuberculosis, coronavirus disease (COVID), etc.).\n23. Have any other illness, condition, or use of medications, which in the opinion of the P.I. and\u002For the admitting clinician would preclude the safe and\u002For successful completion of the study.\n24. Have a history of head trauma, epilepsy, or a cognitive disorder (Alzheimer's Disease, dementia).\n25. Have an electrocardiogram (ECG) abnormalities at screening including but not limited to bradycardia (\\\u003C55 beats per minute); prolonged heart-rate corrected QT interval (QTc) interval (\\>450 msec); Wolff-Parkinson White syndrome; wide complex tachycardia; 2nd degree, Mobitz type II heart block; 3rd degree heart block; left or right bundle branch block; pre-existing severe gastrointestinal narrowing (pathologic or iatrogenic).",true,"64 Years",{"count":539,"type":22},75,[222],"This exploratory, proof-of-concept study is a double-blind (participants and investigators will be blinded), placebo-controlled, randomized, two-arm clinical trial of Marinol \\[dronabinol, synthetic Δ9-tetrahydrocannabinol (THC)\\] for chronic low back pain (cLBP) with a 2:1 allocation ratio. Up to 75 subjects will be enrolled in this pilot study and randomized to receive doses of THC (up to 30 mg\u002Fday), orally, over 8 weeks. This study will be conducted at a single site; it does not include any stratifications, and there is no interim analysis planned. Notably, the goal is to determine whether there is enough evidence of the safety of THC to support the development of later-phase clinical trials. Thus, detailed developmental plans are contingent on the outcomes of this study.",[28,225,543],"Back Injuries",[545,546,547],"dronabinol","Marinol","THC",{"date":453,"type":40},{"date":550,"type":40},"2024-06-15",{"date":552,"type":22},"2029-12-31",{"name":554,"class":47},"Christopher D. Verrico",{"id":556,"slug":557,"hasResults":12,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":4,"eligibilityCriteria":561,"healthyVolunteers":536,"sex":17,"minAge":562,"maxAge":444,"enrollmentInfo":563,"targetDuration":4,"studyType":23,"phases":564,"briefSummary":565,"conditions":566,"keywords":567,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":80},"100602999","blood-flow-restriction-training-as-a-targeted-intervention-for-rowers-with-back-pain-100602999","NCT07130812","Blood Flow Restriction Training as a Targeted Intervention for Rowers With Back Pain.","Breaking the Cycle of Low Back Pain: Blood Flow Restriction Training (BFR) as a Targeted Intervention for Rowers","Inclusion Criteria:\n\n* Aged 13-20 years old\n* Currently active rower (training ≥3 days\u002Fweek or 12 hours\u002Fweek)\n* Mild LBP with a low reactivity (\\\u003C3\u002F10) or recurring LBP within the past 18 months that has affected attendance to team practices\u002Fraces.\n* Able to complete a 2,000-meter rowing erg test\n\nExclusion Criteria:\n\n* Have severe or acute back pain that limits basic movement or requires medical treatment\n* History of spinal surgery or structural spine conditions (scoliosis requiring bracing\u002Fsurgery)\n* Have a contraindication to BFR training, identified via BFR safety screening form:\n* Peripheral vascular disease (PVD)\n* History of vascular surgery in arms or legs\n* Skin grafts on arms or legs\n* Arteriovenous fistula in limbs\n* Cognitive or physical impairment that limits participation\n* Hypertension or high blood pressure (uncontrolled or undiagnosed)\n* Bleeding disorders (e.g., hemophilia)\n* Blood clotting disorders (e.g., lupus, factor-V Leiden)\n* Past history of DVT or pulmonary embolism (PE)\n* Surgery in the past 12 weeks\n* Recent limb immobilization (e.g., cast, boot) in the last 4 weeks\n* History of stroke or transient ischemic attack (TIA)\n* History of cancer\n* Diagnosed heart disease\n* History of rhabdomyolysis\n* Diagnosed diabetes\n* Sickle cell disease\n* History of compartment syndrome\n* History of nerve damage or injury\n* Any prior complications or adverse reactions to BFR training\n* Any other medical conditions that should be cleared by a physician before starting BFR\n* Pregnancy(Self-reported)","13 Years",{"count":119,"type":22},[25],"The purpose of this graduate student research study is to compare the effects of low-load blood flow restriction training (LL-BFR) and heavy-load training (HLT) in high-volume rowers with mild low back pain or recurrent low back pain (LBP), aiming to determine whether LL-BFR offers a safer yet equally effective alternative to HLT for enhancing performance and reducing risk of re-injury.",[28],[568],"blood flow restriction","2026-05-14",{"date":453,"type":40},{"date":572,"type":40},"2025-09-29",{"date":574,"type":22},"2026-12",{"name":576,"class":47},"Loma Linda University",{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":581,"acronym":4,"eligibilityCriteria":582,"healthyVolunteers":536,"sex":17,"minAge":583,"maxAge":241,"enrollmentInfo":584,"targetDuration":586,"studyType":58,"phases":4,"briefSummary":587,"conditions":588,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":80},"100637723","ai-based-phenome-data-analysis-for-predicting-the-onset-of-major-diseases-100637723","NCT07595718","AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases","Inclusion Criteria:\n\n1. Adults aged 30 to 60 years.\n2. Disease group: Participants with a confirmed diagnosis of at least one of the following conditions: type 2 diabetes mellitus, breast cancer, cardiovascular disease, osteoarthritis, or low back pain.\n3. Healthy control group: Participants with no prior diagnosis of type 2 diabetes mellitus, breast cancer, cardiovascular disease, osteoarthritis, or low back pain.\n4. No history or current diagnosis of major medical conditions that may affect study outcomes, including but not limited to chronic kidney disease or liver cirrhosis.\n5. Ability to understand the study procedures and provision of written informed consent prior to participation.\n\nExclusion Criteria:\n\n1. Participants with incomplete or insufficient clinical or health screening data.\n2. Participants considered inappropriate for study participation by the investigator.","30 Years",{"count":585,"type":22},1000,"1 Week","This study aims to develop and validate an artificial intelligence (AI)-based predictive model to estimate the risk of incident onset of five major diseases or conditions: cardiovascular disease, type 2 diabetes mellitus, breast cancer, low back pain, and osteoarthritis, in adults aged 30 to 60 years.\n\nFor each participant, an index date will be defined as the date of a prior health screening or another protocol-defined baseline clinical date. Incident disease status for each target disease or condition will be ascertained by retrospective review of electronic medical records for up to 10 years after the index date.\n\nThe study integrates retrospective clinical, health screening, laboratory, imaging, and electronic medical record data with prospectively collected biospecimen, proteomic, genomic, questionnaire, lifestyle, and digital health data. Prospective study procedures will be completed over approximately 1 week, with up to 2 additional weeks if needed.\n\nBy combining multimodal data, this study seeks to improve disease risk prediction and to identify clinical and biological factors associated with disease onset, ultimately supporting personalized risk stratification and preventive healthcare strategies.",[589,590,28,591,592],"Diabetes Mellitus Type 2","Breast Neoplasms","Osteoarthritis","Cardiovascular Diseases","2026-05-12",{"date":481,"type":40},{"date":596,"type":40},"2026-04-02",{"date":598,"type":22},"2026-12-31",{"name":600,"class":47},"Jae Yong Jeon, MD",{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":4,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":17,"minAge":608,"maxAge":317,"enrollmentInfo":609,"targetDuration":4,"studyType":23,"phases":611,"briefSummary":612,"conditions":613,"keywords":614,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":627,"leadSponsor":629,"locationsCount":4},"100614300","device-based-vs-manual-sensory-training-in-low-back-pain-100614300","NCT07277803","Device-Based vs Manual Sensory Training in Low Back Pain","Effects of Device-Based and Manual Sensory Acuity Training on Chronic Low Back Pain: A Three-Arm Randomized Controlled Trial Protocol","Inclusion Criteria:\n\n* Age between 25-45 years\n* No spinal fracture or acute disc herniation\n* Pain duration ≥ 3 months\n* Pain intensity ≥ 4\u002F10\n* Central Sensitization Scale (CSI) score ≥ 40\n* No current psychiatric illness or cognitive impairment\n* No contraindications to exercise\n\nExclusion Criteria:\n\n* Serious spinal pathologies (lumbar stenosis, spondylolisthesis, tumor, infection, metastasis, osteoporotic fracture, severe structural deformities, inflammatory arthritis)\n* Conditions with radicular involvement or neurological deficits (sciatica, nerve root compression)\n* Systemic or neurological diseases (diabetes mellitus, neuromuscular diseases, serious central or peripheral nervous system diseases, epilepsy)\n* Mental disorders\n* Pregnancy\n* Lower extremity injuries\n* Spinal surgery within the last three years\n* Chronic generalized pain syndromes (fibromyalgia, chronic fatigue syndrome)\n* Individuals receiving other treatment for non-specific chronic low back pain during the study period.","25 Years",{"count":610,"type":22},66,[25],"Chronic low back pain (CLBP) is a leading cause of disability worldwide and affects a large proportion of working-age individuals. Cortical reorganization in CLBP, particularly within the sensorimotor cortex, has been shown to negatively influence sensory acuity and motor control. The neuroplasticity underlying this reorganization may enhance the effectiveness of sensorimotor retraining therapies that involve specific stimulus features targeting somatosensory cortical regions.\n\nThis randomized controlled trial will include three groups: a device-assisted sensory acuity training group, a manual sensory acuity training group, and a control group receiving conventional physiotherapy. In this study, device-assisted sensory acuity training will be delivered using a standardized vibrotactile interface that presents controlled stimuli and records participant responses. The intervention will be structured to target sensory acuity components similar to those addressed in manual training.\n\nAccordingly, the structured training protocol will include:\n\n* localization training to improve detection of stimulus location,\n* orientation discrimination to identify stimulus direction,\n* temporal acuity training to distinguish timing differences between tactile stimuli and\n* graphesthesia training to improve recognition of shapes or letters drawn on the skin through tactile input.\n\nThe primary aim of this study is to evaluate sensory acuity in individuals with CLBP and to determine the effects of a structured manual and technology-based sensory acuity training program, combined with conventional physiotherapy, on pain intensity (VAS), lumbar two-point discrimination, and a composite sensory acuity score.\n\nWe hypothesize that adding manual and technology-based structured sensory acuity training (SAT) program to a conventional physiotherapy regimen including motor control exercises will support central nervous system reorganization, improve sensory profiles, and lead to improvements in pain-related variables, disability, and quality of life.\n\nThrough this structured SAT program, we aim to provide an approach that evaluates and trains multiple dimensions of sensory acuity in CLBP, including localization, orientation, and temporal discrimination.",[28],[615,616,617,67,618,619,620,621,622],"Chronic pain","physiotherapy and rehabilitation","radial\u002Flocal vibration","pain treatment","tactile feedback","mobile applications","wearable technologies","embedded system design",{"date":624,"type":40},"2026-05-13",{"date":626,"type":22},"2026-08-15",{"date":628,"type":22},"2027-12-15",{"name":630,"class":47},"Medipol University",{"id":632,"slug":633,"hasResults":12,"nctId":634,"briefTitle":635,"officialTitle":636,"acronym":4,"eligibilityCriteria":637,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":638,"targetDuration":4,"studyType":23,"phases":639,"briefSummary":640,"conditions":641,"keywords":643,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":651,"completionDateStruct":653,"leadSponsor":655,"locationsCount":80},"100639109","catgut-embedding-for-lumbar-spondylosis-with-blood-stasis-syndrome-100639109","NCT07590050","Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome","Evaluating the Efficacy of Catgut Embedding Therapy in Pain Relief and Quality of Life Improvement for Lumbar Spondylosis With Blood Stasis Syndrome","Inclusion Criteria:\n\n* Age and Gender: Patients aged 18 to 65 years, regardless of gender.\n* Diagnosis of Chronic Low Back Pain: Confirmed diagnosis of low back pain due to lumbar spondylosis with the following criteria:\n\n  * Clinical: Mechanical spinal pain.\n  * Radiographic (X-ray): Joint space narrowing, subchondral sclerosis, and osteophytes on the vertebral bodies.\n  * Absence of systemic symptoms such as fever, unexplained weight loss, or anemia.\n* Duration: Pain duration exceeding 3 months.\n* Pain Intensity: Visual Analog Scale (VAS) score for low back pain \\> 40 mm.\n* Traditional Medicine Diagnosis: Diagnosed with Low back pain under the \"Blood Stasis\" syndrome according to Decision No. 5013\u002FQD-BYT (2020) by the Ministry of Health: Pain occurs after heavy lifting or sudden movement. Severe localized pain, pain increases with movement\u002Fpressure. Limited range of motion. Tongue: Purple or with stasis points. Pulse: Choppy.\n* Communication: Capable of communicating fluently in Vietnamese to complete survey questionnaires.\n* Consent: Volunteers who agree to participate and sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Neurological Deficits: Patients with clinical neurological abnormalities in the lower limbs.\n* Surgical Indications: Patients with indications for spinal surgery due to severe neurological deficits.\n* Co-morbidities: Vertebral fractures, spinal inflammation\u002Finfection, malignant tumors, neuromuscular scoliosis, or degenerative neurological diseases.\n* Hypersensitivity: History of hypersensitivity or adverse reactions to electro-acupuncture or catgut embedding treatments.",{"count":610,"type":22},[25],"The goal of this clinical trial is to learn if catgut embedding works to treat chronic low back pain in adults with lumbar spondylosis and \"Blood Stasis\" syndrome. The main questions it aims to answer are:\n\nDoes catgut embedding lower back pain more effectively than electro-acupuncture?\n\nDoes catgut embedding improve the daily physical activities of participants?\n\nResearchers will compare catgut embedding to electro-acupuncture to see which method works better to reduce pain and improve quality of life. All participants will also receive counseling on lifestyle changes and back exercises.\n\nParticipants will:\n\nBe randomly assigned to receive either catgut embedding (2 sessions over 4 weeks) or electro-acupuncture (20 sessions over 4 weeks).\n\nVisit the clinic for treatments and checkups.\n\nComplete surveys about their pain levels and ability to perform daily tasks at the start, at 2 weeks, and at 4 weeks.",[642,28],"Lumbar Spondylosis",[644,645,646,647,648],"Catgut Embedding","Electro-acupuncture","Polydioxanone (PDO)","Traditional Vietnamese Medicine","Blood Stasis Syndrome","2026-05-10",{"date":520,"type":40},{"date":652,"type":40},"2026-03-11",{"date":654,"type":22},"2026-10-30",{"name":656,"class":47},"University of Medicine and Pharmacy at Ho Chi Minh City"]