[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-flow-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-flow-anesthesia":84},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,71,103,136],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100596075","low-flow-anesthesia-and-open-heart-surgery-100596075",false,"NCT07040735","Low-Flow Anesthesia and Open-Heart Surgery","The Effect of Low-Flow Anesthesia on Hemodynamics in Open-Heart Surgery","Inclusion Criteria:\n\n-≥18 years and scheduled for open-heart surgery patients\n\n-ASA I-II-III-IV physical class\n\nExclusion Criteria:\n\n* Emergency cases\n* Patients under 18 years of age\n* Patients who have had open heart surgery before\n* Patients for whom the use of inhaled anesthetic agents is contraindicated\n* Patients who do not sign a voluntary consent form","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","OBSERVATIONAL","Low-flow anesthesia (LFA) is a technique in which at least 50% of the exhaled air, after carbon dioxide absorption, is mixed with a certain amount of fresh gas and returned to the patient during the next inspiration. In 1974, R. Virtue defined minimal flow anesthesia (MFA) as 0.5 L\u002Fmin. In 1984, Baker and Simionescu classified LFA as 0.5-1 L\u002Fmin and MFA as 0.25-0.5 L\u002Fmin. The aim of this study is to investigate whether there are hemodynamic differences between open-heart surgery cases performed with LFA at different fresh gas flow rates.",[24,25,26],"Low-flow Anesthesia","Hemodynamics","Open-heart Surgery",[28,25,29],"Low-flow anesthesia","Open-heart surgery","RECRUITING","2026-05-22",{"date":33,"type":34},"2026-05-27","ACTUAL",{"date":36,"type":34},"2025-07-01",{"date":38,"type":20},"2026-09-23",{"name":40,"class":41},"Çağrı Özdemir","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":42},"100590458","perfusion-index-in-pediatric-low-flow-anesthesia-100590458","NCT06967675","Perfusion Index in Pediatric Low-Flow Anesthesia","Changes in Perfusion Index Under Low-Flow Anesthesia and Its Effects on Postoperative Emergence in Pediatric Patients","Inclusion Criteria:\n\n* ASA I-II pediatric patients\n* Age 2 to 12 years\n* Undergoing elective surgery lasting between 1-6 hours\n* Informed consent obtained from parents\u002Fguardians\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, neurological, metabolic, or endocrine disorders\n* Premature birth with corrected age \\\u003C 2 years\n* Obesity or severe malnutrition (BMI \\\u003C5th or \\>95th percentile)\n* Psychiatric or neurodevelopmental disorders (e.g., autism)\n* Malignant hyperthermia or hypersensitivity to anesthetics\n* Emergency surgeries\n* Lack of IV access requiring inhalational induction\n* Contraindications to low-flow anesthesia including:\n* Severe pulmonary disease\n* Congenital heart disease with shunt physiology\n* Anticipated high oxygen demand\n* Airway obstruction risk\n* Surgeries requiring high gas flow or \\>6 hours duration","2 Years","12 Years",{"count":53,"type":20},90,"INTERVENTIONAL",[56],"NA","This study aims to evaluate changes in perfusion index (PI) in pediatric patients undergoing elective surgery under low-flow anesthesia. PI will be monitored at multiple intraoperative and postoperative time points to assess its relationship with hemodynamic stability and depth of anesthesia. The study will also investigate whether low-flow anesthesia affects the incidence of emergence agitation (EA). Patients will be assigned to either low-flow or normal-flow anesthesia groups based on routine clinical practice. No intervention will be applied beyond standard care. The findings are expected to provide insight into the predictive value of PI in postoperative recovery and support safer anesthesia practices in pediatric populations.",[59,60,61],"Perfusion Index","Low-Flow Anesthesia","Postoperative Recovery","2025-07-08",{"date":64,"type":34},"2025-07-10",{"date":66,"type":34},"2025-06-15",{"date":68,"type":20},"2025-08-10",{"name":70,"class":41},"Istinye University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100590941","low--vs-normal-flow-anesthesia-and-delirium-after-hip-fracture-in-the-elderly-100590941","NCT06973967","Low- vs. Normal-Flow Anesthesia and Delirium After Hip Fracture in the Elderly","Evaluation of the Association Between Low-Flow and Normal-Flow Anesthesia and Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery","Inclusion Criteria:\n\nPatients aged 65 years and older who are scheduled to undergo surgical treatment for hip fracture, classified as ASA physical status I-IV, and who have signed the informed consent form will be included in the study.\n\nExclusion Criteria:\n\nPatients with complex fractures (multiple fractures, extremity, abdominal, pelvic or sacral trauma, head trauma, etc.), those with relative contraindications to general anesthesia (e.g., known difficult airway, malignant hyperthermia), patients requiring postoperative intubated intensive care follow-up, those with a history of dementia, sleep disorders, or psychosis, individuals with serious neurological diseases (e.g., Parkinson's disease, stroke sequelae), those with a history of opioid, alcohol, or substance use, patients with cerebrovascular disease, those who underwent surgery within the past 6 months, patients with hearing or vision impairment, bleeding disorders or those taking medications affecting coagulation, patients with hypoalbuminemia (\\\u003C3 g\u002FdL), preoperative anemia with hematocrit \\\u003C30%, known allergy to anesthetic drugs, severe cardiopulmonary failure, immobility, malnutrition, or those who are unable to comply with the study protocol will be excluded from the study.","65 Years",{"count":80,"type":20},128,"The aim of this study is to investigate the relationship between low-flow and normal-flow anesthesia techniques and the development of postoperative delirium in elderly patients undergoing surgery for hip fracture.",[83,84,85,86],"Delirium - Postoperative","Low Flow Anesthesia","Elderly Patients (>65 Years)","Hip Surgery",[88,89,90,91],"delirium","hip surgery","elderly patients","low-flow anesthesia","NOT_YET_RECRUITING","2025-05-14",{"date":95,"type":34},"2025-05-15",{"date":97,"type":20},"2025-05-08",{"date":99,"type":20},"2025-08-07",{"name":101,"class":102},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":54,"phases":115,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100559141","phase-4-low-flow-anesthesia-in-children-undergoing-strabismus-surgery-100559141","NCT06560268","Low Flow Anesthesia in Children Undergoing Strabismus Surgery","Effects of Different Fresh Gas Flows on Emergence Agitation and Anesthetic Agent Consumption in Children Undergoing Strabismus Surgery","LFA in child","Inclusion Criteria:\n\n* 3-10 years old children with strabismus\n\nExclusion Criteria:\n\n* Mental retardation\n* Cardiovascular disease\n* Serebrovasculay disease\n* Renal disease\n* Hepatic disease\n* Pulmonary disease","3 Years","10 Years",{"count":114,"type":20},150,[116],"PHASE4","Emergence agitation (EA) involves restlessness, disorientation, excitation, non-purposeful movement, inconsolability, thrashing, and incoherence during early recovery from general anesthesia. Sevoflurane and desflurane have increased the incidence of EA in children. A proposed explanation for this is that sevoflurane and desflurane cause differential recovery rates in brain function, due to differences in clearance of inhalational anesthetics from the central nervous system; whereas audition and locomotion recover first, cognitive function recovers later, resulting in EA. Low-flow anaesthesia (LFA) occurs when the fresh gas flow (FGF) is significantly lower than the patient's minute volume. In a low-flow system, the recirculated fraction should amount to at least 50% after carbon dioxide (CO2) absorption.In LFA using minimal FGF (250-500 mL\u002Fmin), if the vaporizer is turned off 10-15 minutes before the end of the operation and the FGF is not changed, the inhaled anesthetic agent concentration gradually and slowly decreases to zero and the inhaled agent consumption decreases even more. In a study conducted on infants undergoing cleft lip-palate surgery, it was shown that the incidence of postoperative agitation were statistically lower in infants who administered 0.5 L\u002Fmin FGF.\n\nStrabismus surgery is one of the most frequently performed ophthalmologic operations in children and is associated with moderate postoperative pain and a high incidence of EA (40-86%). The incidence of EA after strabismus surgery is high, especially due to visual disturbances; however, the pathogenesis of this condition remains unclear. In our study, the effects of different FGFs administered in children undergoing strabismus surgery on EA and anesthetic agent consumption will be investigated.",[84,119,120,121],"Sevoflurane","Strabismus","Emergence Delirium",[123,124,125,126],"emergence agitation","strabismus","children","low flow anesthesia","2024-08-23",{"date":129,"type":34},"2024-08-26",{"date":131,"type":20},"2024-11-04",{"date":133,"type":20},"2025-07-04",{"name":135,"class":41},"Cukurova University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":143,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":144,"targetDuration":146,"studyType":21,"phases":4,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":42},"100556119","comparison-of-minimum-flow-and-low-flow-desflurane-anesthesia-in-robotic-assisted-laparoscopic-abdominal-surgery-100556119","NCT06520943","Comparison of Minimum Flow and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery","Comparison of Minimum Flow Desflurane Anesthesia With Respiratory Parameters and Blood Gas Analyses and Low Flow Desflurane Anesthesia in Robotic Assisted Laparoscopic Abdominal Surgery","Inclusion Criteria:\n\n* Patients undergoing robotic-assisted abdominal surgery\n\nExclusion Criteria:\n\n* serious cardiac, respiratory, hepatic, renal, or mental disorders;\n* hearing problems;\n* anxiety, depression, or other psychiatric conditions;\n* patient's request to leave the study",true,{"count":145,"type":20},70,"1 Year","This study aims to compare the use of low fresh gas flow (1 L\u002Fmin) desflurane anesthesia with minimum fresh gas flow (0.5 L\u002Fmin) desflurane anesthesia in patients undergoing robotic-assisted abdominal surgery. The comparison will be based on hemodynamic and respiratory parameters. The secondary aim of our study is to compare the two different fresh gas flow methods in terms of inhalation agent consumption and soda lime consumption.",[149,84,150],"Minimal Flow Anesthesia","Robotic Assisted Laparoscopic Abdominal Surgery","2024-07-23",{"date":153,"type":34},"2024-07-25",{"date":155,"type":20},"2024-07-15",{"date":157,"type":20},"2024-12-31",{"name":159,"class":41},"Ankara City Hospital Bilkent"]