[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-grade-squamous-intraepithelial-lesions\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-grade-squamous-intraepithelial-lesions":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100520089","comparison-of-5-ala-photodynamic-therapy-and-co2-laser-for-treating-persistent-low-grade-cervical-lesions-with-high-risk-hpv-infection-100520089",false,"NCT06052033","Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection","The Effect of 5-aminolaevulinic Acid Photodynamic Therapy Versus C02 Laser in the Treatment of Persistent Cervical Low-grade Squamous Intraepithelial Lesions With High-risk HPV Infection:A Non-randomized Controlled Trail Study","Inclusion Criteria:\n\n1. Aged 18-65 years old with a history of sexual activity.\n2. Subclinical infected individuals who have been confirmed as HR-HPV positive (if there is the same positive type in the typing test) for more than 1 year using HPV typing test, HPV E6\u002FE7 mRNA test, HPV DNA test, and cervical triple step diagnostic procedure (cytology colposcopy histopathology).\n3. Patients diagnosed with LSIL by pathological examination of cervical biopsy under colposcopy with an interval of more than 1 year.\n4. No fundamental diseases of important organs.\n5. Agree to receive treatment and\u002For follow-up according to regulations and sign an informed consent form.\n6. There has been no history of using other drugs related to HPV infection in the past 3 months.\n\nExclusion Criteria:\n\n1. HR-HPV persistent infection.\n2. A total hysterectomy has been performed.\n3. Concomitant endometrial cancer, ovarian cancer, and other reproductive tract tumors.\n4. Complicated with abnormal heart, liver, and kidney functions, immune dysfunction, or immune system diseases such as systemic lupus erythematosus (SLE).\n5. Using drugs such as immunosuppressants, antiviral agents, and glucocorticoids.\n6. Pregnant and lactating women.\n7. Acute reproductive tract inflammation.\n8. Diabetes patients with uncontrolled blood sugar.\n9. Patients who do not receive full treatment and follow-up.\n10. Those who fail to sign the informed consent form.","FEMALE","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.",[27,28,29,30],"HPV-Related Cervical Carcinoma","Low-Grade Squamous Intraepithelial Lesions","HPV Infection","Photodynamic Therapy",[32,33,34,35],"high-risk hpv infection","hpv persistent","Lsil","cervical lesions","RECRUITING","2025-05-12",{"date":39,"type":40},"2025-05-13","ACTUAL",{"date":42,"type":40},"2023-09-11",{"date":44,"type":21},"2025-06-30",{"name":46,"class":47},"First Affiliated Hospital of Wenzhou Medical University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":48},"100553884","a-multicenter-randomized-controlled-study-of-photoelectric-detection-in-cervical-cancer-screening-100553884","NCT06491888","A Multicenter Randomized Controlled Study of Photoelectric Detection in Cervical Cancer Screening","A Multicenter Randomized Controlled Study of Fluorescence Photoelectric Cervical Lesion Image Detector in Cervical Cancer Screening","Inclusion Criteria:\n\n* 1\\. Age ≥ 18 years old, ≤ 65 years old, with a complete cervix without deformity.\n* 2\\. Have clear cervical cancer screening results, meet HPV16\u002F18 (+) or high-risk HPV (+), and cervical cytology results ≥ ASC-US.\n* 3\\. Fully informed and agreed to participate in the study.\n* 4\\. No history of cervical cancer disease and cancer in other parts.\n\nExclusion Criteria:\n\n* 1\\. Cannot meet all Inclusion Criteria.\n* 2\\. There is clear immunosuppression, such as HIV infection or organ transplantation, etc., and the vagina or cervix is in the acute inflammation stage。\n* 3\\. There are serious bleeding diseases or photosensitive diseases such as abnormal coagulation.",{"count":57,"type":21},4200,[24],"The main purpose of this study is to verify the accuracy of the fluorescence photoelectric cervical lesion image detector relative to the pathological gold standard and the detection rate of CIN 2 +, as well as the significance of it as a shunt tool before colposcopy through a randomized controlled study.\n\nThe secondary objectives were to compare the relative pathological accuracy of the fluorescence photoelectric cervical lesion image detection results with the HPV detection results and cytological results, and to compare the lesion area displayed by the fluorescence photoelectric cervical lesion image detector with the lesion area that appeared after traditional colposcopy chemical staining.\n\nIn this study, 4200 subjects who have been evaluated and can be enrolled (these subjects have the indication of referral to colposcopy) will be included in the study, and they will be divided into two groups according to the principle of randomization. The histological results were obtained after routine colposcopy and biopsy. The experimental group first underwent colposcopy and biopsy after the judgment of the fluorescent photoelectric cervical lesion image detector to obtain histological results. Finally, the accuracy of the relative pathological results, the detection rate of CIN2 +, negative predictive value and positive predictive value of the two groups were compared.",[61,62,63,64],"Uterine Cervical Cancer","Cervical Intraepithelial Neoplasia","High Grade Squamous Intraepithelial Lesions","Low Grade Squamous Intraepithelial Lesions","NOT_YET_RECRUITING","2024-08-13",{"date":68,"type":40},"2024-08-15",{"date":70,"type":21},"2024-08",{"date":72,"type":21},"2025-07",{"name":74,"class":47},"Lei Li",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":48},"100553118","a-multicenter-real-world-study-of-screening-of-cervical-cancer-based-on-photoelectric-detection-100553118","NCT06481930","A Multicenter Real-world Study of Screening of Cervical Cancer Based on Photoelectric Detection",{"count":81,"type":21},20000,"OBSERVATIONAL","The main purpose of this study is to explore the accuracy and clinical value of fluorescent photoelectric cervical lesion image detector as a screening and shunt tool for cervical lesions through a multi-center, large-sample real-world study with histopathology as the gold standard. The secondary purpose of the study was to verify the coincidence of the fluorescent photoelectric cervical lesion image detector with traditional colposcopic chemical staining.\n\nThis study is expected to include 20,000 participants with definite histological results, and compare the specificity and sensitivity, negative predictive value and positive predictive value of three cervical lesion screening methods, such as fluorescent photoelectric cervical lesion image detector, HPV nucleic acid detection and cytology detection. The advantages and disadvantages of fluorescent photoelectric cervical disease image detector, HPV nucleic acid detection and cytology examination were analyzed, and their application scenarios were provided to provide evidence-based medical support for the establishment of comprehensive prevention and treatment system of cervical cancer suitable for China's national conditions.",[61,63,64],"2024-06-30",{"date":87,"type":40},"2024-07-03",{"date":89,"type":21},"2024-07",{"date":91,"type":21},"2026-07",{"name":74,"class":47}]