[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-level-laser-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-level-laser-therapy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,48,71,105,136,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100640184","comparison-of-rate-of-tooth-movement-between-mops-vs-mops--lllt-combined-100640184",false,"NCT07626580","Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined","Comparison of Rate of Tooth Movement Between Micro-osteoperforations Versus Micro-osteoperforations and Low Level Laser Therapy Combined","Inclusion Criteria:\n\n* • Patients aged 12-30 years requiring fixed orthodontic treatment.\n\n  * Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.\n  * No history of previous orthodontic treatment.\n  * Patients with indications for the extraction of the first premolars on both sides of the maxilla.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).\n\n  * Smokers and individuals with poor oral hygiene.\n  * Pregnant or lactating women.",true,"ALL","18 Years","30 Years",{"count":21,"type":22},33,"ESTIMATED","INTERVENTIONAL",[25],"NA","Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.\n\nTo address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.\n\nStudies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.\n\nThis study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.",[28,29,30],"Orthodontic Tooth Movement","Low Level Laser Therapy","Canine Retraction",[29,32,33,30,34],"LLLT","Micro-Osteoperforations","Maxillary Scan","NOT_YET_RECRUITING","2026-06-01",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":22},"2026-06",{"date":43,"type":22},"2026-12",{"name":45,"class":46},"Riphah International University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":47},"100607622","effects-of-low-level-laser-therapy-on-soft-and-hard-tissue-healing-after-impacted-mandibular-third-molar-extraction-100607622","NCT07190950","Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction","Inclusion Criteria:\n\n* Healthy patients (at least 18 years of age) have both jaws lower impacted third molars indicated to be extracted. Both teeth are the same of\n\nExclusion Criteria:\n\n\\-",{"count":55,"type":22},22,[25],"Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. As a result, after surgery, patients often experience many complications, from swelling, pain, jaw tightness, etc. to alveolar bone loss, periodontal problems distal to the second molar, etc.\n\nTherefore, clinicians are always looking for additional therapies to minimize complications, helping patients have a more comfortable experience after wisdom tooth surgery.\n\nTo date, placing grafting materials such as bone or other biological materials (growth factors, platelet-rich plasma, platelet-rich fibrin) into the tooth socket has been shown to be able to preserve the alveolar crest after extraction. However, these materials require preparation time, are costly, and have the risk of infection related to bone grafts.\n\nMeanwhile, low-level laser therapy (LLLT) is known as a safe, non-invasive therapy that can affect cell metabolism without causing tissue damage. This therapy has been widely applied in many fields of medicine in general and in dentistry in particular. Low-level lasers have been studied to help reduce swelling, pain, and jaw tightness after impacted lower wisdom teeth surgery. In vitro or in vivo studies evaluating the healing effect of low-level lasers have given very positive results. However, there is still a lack of scientific evidence to prove the healing effect of low-level lasers on human tooth extraction sockets.\n\nThe study we conducted is a scientific study, in the field of Dentistry. This study aimed to evaluate the effectiveness of low-level laser on soft tissue and bone healing after surgical extraction of impacted lower third molars in a group of Vietnamese population.",[59,29,60],"Third Molars Extraction","Bone Healing","RECRUITING","2025-11-26",{"date":64,"type":39},"2025-11-28",{"date":66,"type":39},"2024-08-30",{"date":68,"type":22},"2025-12-31",{"name":70,"class":46},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":23,"phases":83,"briefSummary":84,"conditions":85,"keywords":92,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100608752","improving-healing-in-children-after-tooth-extraction-using-laser-therapy-or-hyaluronic-acid-100608752","NCT07205640","Improving Healing in Children After Tooth Extraction Using Laser Therapy or Hyaluronic Acid","Effect of Low-Level Laser Therapy Versus Hyaluronic Acid on Wound Healing After First Permanent Molar Extraction in Children.","LLLT vs HA","Inclusion Criteria:\n\n1. Children aged from six to ten years.\n2. Children of both genders.\n3. Children with badly decayed first permanent molar beyond repair and indicated for extraction.\n4. Parents acceptance to participate in the study.\n\nExclusion Criteria:\n\n1. Medically compromised children.\n2. Uncooperative children.\n3. Children who will not attend the follow up visits","6 Years","10 Years",{"count":82,"type":22},36,[25],"Tooth extraction may be an unpleasant and painful experience for children, Post-extraction wound healing. Low-level laser therapy (LLLT) is a widely used adjuvant treatment for wound healing, resulting in both an increase in cell number and an increase in cell metabolism. HA it is an important component of the extracellular matrix and a constituent of the neural, connective, and epithelial tissues.",[86,87,29,88,89,90,91],"Mesh","Healthy Volunteer","Hyaluronic Acid Gel for Preservation the Extraction Socket","Extraction Socket Healing","Badly Decayed Molars","Tooth Extraction Site Healing",[93,94,95],"hyaluronic acid","low level laser therapy","tooth extraction","2025-09-25",{"date":98,"type":39},"2025-10-03",{"date":100,"type":22},"2025-12-01",{"date":102,"type":22},"2026-12-01",{"name":104,"class":46},"Cairo University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":47},"100599006","low-level-laser-therapy-in-knee-osteoarthritis-effects-on-clinical-outcomes-femoral-cartilage-thickness-and-regional-sarcopenia-100599006","NCT07078877","Low-Level Laser Therapy in Knee Osteoarthritis: Effects on Clinical Outcomes, Femoral Cartilage Thickness and Regional Sarcopenia","Investigation of Sarcopenia in Patients With Knee Osteoarthritis and the Effect of Low-Level Laser Therapy on Sonographically Measured Femoral Cartilage and Quadriceps Thickness, Clinical Outcomes, and Regional Sarcopenia","Inclusion Criteria:\n\nIndividuals with knee osteoarthritis according to ACR criteria, Those at grade 2-3 according to the Kellgren-Lawrence scale, Individuals aged over 50 years\n\nExclusion Criteria:\n\nIndividuals with a history of trauma or surgery to the knee joint, Those who have received intra-articular injection to the knee within the last 3 months, Those who have undergone physical therapy or exercise treatment in the past year, Individuals with a pacemaker, Patients with high cardiac risk, Those with active malignancy, Individuals with genetic bone or joint disease, Those with a BMI \\> 35 kg\u002Fm²","50 Years",{"count":114,"type":22},62,[25],"It was designed as a single-center, prospective, randomized controlled study. The study consists of two groups. Both groups of patients will receive a conventional home based exercise program.\n\nIn addition to the conventional exercise program, patients in the first group will also receive low-level laser therapy (LLLT). If the laser group is found to be superior at the end of the study, the patients who only received the exercise program will be recalled and administered LLLT. Patients who meet the inclusion criteria will be enrolled in the study.\n\nSample size calculations were based on data from a previous study by Alghadir et al. Using a mean of 3.25 and a standard deviation of 2.61 for the WOMAC pain subscale, the number of participants was calculated with 95% power and a 5% significance level. As a result, it was determined that at least 29 patients would be included in each group. Written informed consent will be obtained from each patient before enrollment. Randomization will be performed according to the order of patient admissions. Patients will be evaluated before treatment, and at the 1st and 3rd months post-treatment.\n\nThe dosage of laser application was selected based on the recommendations of the World Association for Photobiomodulation Therapy (WALT). Patients will be treated 5 sessions per week for 2 weeks. The treatment will be applied using the BTL SMART 4000 laser device at a wavelength of 835 nm and a dose of 10 J\u002Fpoint.\n\nThe conventional home based exercise program includes: range of motion (ROM) exercises, stretching, strengthening, relaxation and aerobic exercises. The program will begin with ROM, stretching, relaxation, aerobic, and isometric strengthening exercises. After one week, concentric and eccentric strengthening exercises will be added using elastic bands. The home exercise program will be performed 3 days a week, each exercise in 3 sets of 10 repetitions and 2 minutes of rest between sets. Aerobic walking at a moderate pace for 30 minutes will be recommended. Each patient will be shown and taught the exercises to be performed at home, and will also be provided with illustrated instructions. The home based exercise program will continue for 12 weeks. Patients will be contacted by phone weekly during the first month, and then every two weeks thereafter, to assess their adherence to and continuation of the home based exercise program.\n\nBefore starting treatment, demographic information will be collected, medical history will be taken, and a physical examination will be performed. Pre-treatment evaluations include:\n\n* Measurement of height, weight, and calculation of body mass index (BMI)\n* Femoral cartilage thickness and quadriceps muscle thickness measurement via ultrasound\n* Determination of the Sonographic Thigh Adjustment Ratio (STAR)\n* Application of the SARC-F screening test; those scoring over 4 will undergo whole-body muscle mass measurement\n* Handgrip strength (HGS) measurement using a Jamar hand dynamometer\n* Five-times chair stand test (CST)\n* Timed Up and Go (TUG) test\n* Six-minute walk test\n* Visual Analog Scale (VAS) for pain\n* Western Ontario and McMaster Universities Arthritis Index (WOMAC)\n* Short Form-36 (SF-36) quality of life questionnaire\n\nPost-treatment evaluations (At the end of the 1st month and at the end of the 3rd month) include:\n\n* Calculation of body mass index (BMI)\n* Femoral cartilage thickness and quadriceps muscle thickness (USG)\n* STAR index calculation\n* Handgrip strength using Jamar dynamometer\n* Five-times chair stand test\n* Timed Up and Go test\n* Six-minute walk test\n* Visual Analog Scale (VAS) for pain\n* WOMAC\n* SF-36 Quality of Life Questionnaire",[118,29,119,120],"Knee Osteoarthritis","Regional Sarcopenia","Exercise Theraphy",[122,94,123,124,125],"knee osteoarthritis","regional sarcopenia","Exercise Therapy","sarcopenia","2025-09-14",{"date":128,"type":39},"2025-09-16",{"date":130,"type":39},"2025-07-14",{"date":132,"type":22},"2026-07",{"name":134,"class":135},"Ankara Etlik City Hospital","OTHER_GOV",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100596316","effects-and-feasibility-of-photobiomodulation-at-830nm-nanometers-in-the-treatment-of-diabetic-ulcers-100596316","NCT07043868","Effects and Feasibility of Photobiomodulation at 830nm Nanometers in the Treatment of Diabetic Ulcers","Effects and Feasibility of Photobiomodulation at 830 Nanometers in the Treatment of Diabetic Ulcers: a Randomized, Double-blind Clinical Trial","Inclusion Criteria:\n\n* Volunteers of both sexes\n* Age over 18 years\n* Medical diagnosis of diabetes mellitus (DM)\n* Presence of diabetic ulcer\n\nExclusion Criteria:\n\n* Autoimmune diseases\n* Infected diabetic ulcers\n* Osteomyelitis\n* Ischemia\n* Concomitant psychiatric disorders\n* Contraindications to treatment methods",{"count":144,"type":22},136,[25],"Diabetic foot ulcers (DFU) are among the late complications of DFU, defined as skin lesions that involve the dermis to deeper structures, such as muscles and bones. Although preclinical studies have demonstrated the effects of GaAs 830 nm in diabetic wounds, no clinical studies have been performed, revealing the need for more in-depth analyses to identify the effects and ideal parameterization of PBM with GaAs 830 nm wavelength in the treatment of diabetic ulcers, improving quality of life, as well as to understand the therapeutic feasibility, time required for healing and recurrence rates of these lesions. Experimental, randomized, controlled, double-blind study, with blinding applied to the evaluator and participants. A total of 136 volunteers will be recruited for the research, carried out at the Integrated Center of Medical Specialties (CIEM) - Polyclinic. LLLT GaAs 830nm will be used with three dosages of low, medium and high intensity (4 J\u002Fcm², 8 J\u002Fcm², 12 J\u002Fcm²). The study will have three intervention groups using LLLT with GaAs 830nm and a control group, in which LLLLT will be performed with a GaAs 904nm wavelength and a dose of 10 J\u002Fcm², according to Saura et al (2024). This study was approved by the local Research Ethics Committee (Opinion 7,488,044), conducted in accordance with the Declaration of Helsinki and in accordance with the CONSORT (Consolidated Standards of Reporting Trials) guidelines.",[148,149,150,29],"Diabete Type 2","Diabetic Foot Ulcer","Photobiomodulation",[152,153,94],"diabetic foot ulcer","photobiomodulation","2025-07-05",{"date":156,"type":39},"2025-07-10",{"date":158,"type":22},"2026-01-10",{"date":160,"type":22},"2028-01-10",{"name":162,"class":46},"Federal University of Piaui",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":23,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":47},"100591915","effect-of-photobiostimulation-versus-pulsed-electromagnetic-field-on-quality-of-life-in-adults-with-chronic-rhinosinusitis-100591915","NCT06986629","Effect of Photobiostimulation Versus Pulsed Electromagnetic Field on Quality of Life in Adults With Chronic Rhinosinusitis","Inclusion Criteria:\n\n1. Participants suffering from mild to moderate symptoms (baseline Total nasal symptoms score ≤ 9).\n2. Subjects age range from 20 to 40 years old.\n3. Patients of both sexes.\n4. proven positive allergy test (skin prick test or multiple allergen simultaneous test) to any of the common perennial allergens such as dust mites, molds, insects, and animal dander within the last 12 months\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women.\n* Patients with a definite deviated nasal septum, or history of operation within the last 6 months.\n* Hypertension, diabetes mellitus, malignancy, active pulmonary tuberculosis, active respiratory disease like asthma, or other systemic diseases.\n* Long-term use of corticosteroids or immunosuppressive agents.\n* Participation in another clinical study within 30 days.\n* Hyperthyroidism\n* Patients who had used antihistamines within 1 week, topical corticosteroids within 2 weeks, systemic corticosteroids within 4 weeks, anticholinergic drugs within 3 days, antileukotriene drugs within 1 week, decongestants within 3 days, tricyclic antidepressants or phenothiazines within 2 weeks, nonsteroidal analgesics within 2 weeks, and other drugs that the researchers believed were inappropriate.\n* Patients with Tattoos, moles and dark skin","20 Years","40 Years",{"count":172,"type":22},60,[25],"This study was done to find out the effect of photobiostimulation and pulsed electromagnetic field in patients with chronic rhinosinusitis on:\n\n* Quality of life.\n* Pulmonary function.\n* Mean platelet volume.\n* headache .\n* total nasal symptoms.",[176,177,29,178,179],"Photobiostimulation","Pulsed Electromagnetic Filed","Chronic Rhinosinusitis (Diagnosis)","Quality of Life","2025-05-15",{"date":182,"type":39},"2025-05-23",{"date":184,"type":39},"2025-02-01",{"date":186,"type":22},"2025-08-01",{"name":104,"class":46}]