[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"low-vision\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:low-vision":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,65,87,131,154,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100637773","vision-rehabilitation-training-with-multimodal-feedback-in-central-vision-loss-100637773",false,"NCT07577219","Vision Rehabilitation Training With Multimodal Feedback in Central Vision Loss","Inclusion Criteria:\n\nBilateral central scotomas confirmed via computerized tangent screen Visual acuity between 20\u002F60 and 20\u002F200 (0.5 - 1.00 logMAR) in either eye Stable central vision loss (no change in visual acuity \\>0.2 logMAR in past 6 months) Age 14 years or older, with diagnosis of macular disease Normal cognitive function (Mini-Mental State Examination score ≥24) Ability to provide informed consent and complete study visits No major hearing loss Fluent in English\n\nExclusion Criteria:\n\nUnstable ocular disease (e.g., ongoing treatments and\u002For injections) Peripheral vision loss of less than 40 degrees Conditions affecting oculomotor control independent of CVL","ALL","14 Years",{"count":18,"type":19},12,"ESTIMATED","INTERVENTIONAL",[22],"NA","Central vision loss from macular degeneration creates blind spots that impair reading, face recognition, and navigation. Individuals must learn to use peripheral vision, requiring retraining of eye movements. Our preliminary research using high-speed eye tracking demonstrated that people with larger scotomas have impaired eye movement control, and that single-session visual feedback training showed limited immediate benefit, though combining feedback types showed promise.\n\nThis study will evaluate whether extended binocular training (5 weekly sessions) with multimodal feedback improves eye movement control in 8-15 participants with bilateral central vision loss. Unlike conventional monocular rehabilitation systems, our approach trains both eyes simultaneously using real-time visual and auditory feedback during saccadic and smooth pursuit tasks. Participants will receive gaze-contingent scotoma awareness feedback, preferred retinal locus feedback, and auditory cues while performing eye tracking exercises.\n\nPrimary outcomes include saccadic accuracy (latency, landing error, amplitude) and smooth pursuit parameters (gain, tracking accuracy). Secondary outcomes include contrast sensitivity and self-reported visual function. Success could establish an evidence base for accessible home-based training using virtual reality technology, potentially benefiting millions with macular degeneration.",[25,26,27],"Low Vision","Central Visual Impairment","Macular Degeneration","RECRUITING","2026-05-05",{"date":31,"type":32},"2026-05-11","ACTUAL",{"date":34,"type":32},"2026-01-31",{"date":36,"type":19},"2026-12-01",{"name":38,"class":39},"New England College of Optometry","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":64},"100600025","validation-of-a-virtual-reality-test-for-the-assessment-of-visually-impaired-patients-undergoing-low-vision-rehabilitation-100600025","NCT07092124","Validation of a Virtual Reality Test for the Assessment of Visually Impaired Patients Undergoing Low Vision Rehabilitation","VisionumVR","Inclusion Criteria:\n\n* Patient (regardless of visual pathology) who is about to begin or has begun orthoptic low vision rehabilitation;\n* Patient requiring at least five orthoptic rehabilitation sessions that can be completed before the end of the study;\n* Binocular visual acuity ≥ 1\u002F20 (≤ 1.3 logMAR), regardless of type of vision loss (central, mixed, or peripheral);\n* Sufficient knowledge of the French language.\n\nExclusion Criteria:\n\n* Neurodegenerative diseases or any other condition that could interfere with the planned assessments in this study (known epilepsy and\u002For history of seizures, dysfunction of the dominant upper limb, etc.);\n* Medications that may cause motor, visual, or cognitive impairments (neuroleptics, etc.) or interfere with the study assessments;\n* Pregnant women (pregnancy can cause vision fluctuations, and wearing a virtual reality headset is not recommended);\n* Participation in another clinical trial that may interfere with the current study;\n* Inability to follow instructions or read.","18 Years",{"count":50,"type":19},60,[22],"Low vision rehabilitation is a vital part of care for visually impaired patients, who are usually referred to orthoptists to develop visual strategies and optimize residual vision. This rehabilitation significantly improves quality of life by enhancing autonomy and reducing depression. It employs various tools, from traditional exercises to specialized software. Advances in virtual reality (VR) offer new promising opportunities by creating immersive environments tailored to patients' residual vision, increasing motivation and exercise effectiveness. In this context, VisionumVR was developed-a VR test using the Meta Quest 3 headset to assess functional vision during rehabilitation. It evaluates hand-eye coordination, visual discrimination, and visual exploration through a daily-life-inspired task. This standardized 20-minute test aims to measure patients' progress throughout their orthoptic rehabilitation.",[25],"2025-11-26",{"date":56,"type":32},"2025-11-28",{"date":58,"type":32},"2025-10-30",{"date":60,"type":19},"2027-02",{"name":62,"class":63},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",2,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":20,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":40},"100507519","obstacle-negotiation-in-older-people-with-and-without-vision-impairment-100507519","NCT05888441","Obstacle Negotiation in Older People With and Without Vision Impairment","Impact of Stepping Over Obstacles of Different Contrast and Height on Gait and Eye Movements in Older Adults With and Without Vision Impairment","Inclusion Criteria:\n\n* Age 18 or over\n* Able to walk independently\n* Either have normal vision, or impaired vision.\n\n  * Impaired vision is defined as binocular visual acuity of 20\u002F25 or worse with or without a central scotoma; and\u002For binocular visual field that is restricted to an average of 100 degrees in diameter or less\n  * Control subjects will have visual acuity of 20\u002F40 or better.\n\nExclusion Criteria:\n\n* Not cleared by a medical provider for moderate physical activity\n* Self-report or have a history of: vestibular disorder or deafness\n* Medical history of any condition that affects the ability to walk for up to 2 hours with breaks, such as feeling dizzy or faint, chest pain, palpitations, pain or numbness in the legs, shortness of breath,\n* Cognitive limitations either by self-report or a score on the Mini Mental State Exam below 24 (out of 30)\n* Walking or gait abnormalities, such as those caused from an injury, surgery, severe arthritis, or neurological condition such as Parkinson's disease\n* Unable to walk without any walking aids such as a walker, cane, guide dog, or oxygen tank.\n* Does not speak English",true,{"count":74,"type":19},200,[22],"Falls are common among people with vision impairment and can lead to devastating health consequences. Understanding the functions of vision and how the visual characteristics of obstacles in the walking path impact the gait of people with vision impairment is necessary to create strategies to prevent falls in this population. The purpose of this study is to determine how adults with vision impairment change their gait behavior when stepping over obstacles that vary in height and contrast to the ground. We will then determine the mechanisms of gaze behavior that correlate to the gait behavior.",[25],"2025-11-12",{"date":80,"type":32},"2025-11-13",{"date":82,"type":32},"2023-04-14",{"date":84,"type":19},"2028-12-31",{"name":86,"class":39},"Indiana University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":72,"sex":15,"minAge":48,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":20,"phases":96,"briefSummary":97,"conditions":98,"keywords":99,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":40},"100609777","wearable-echolocation-aids-using-parametric-sound-100609777","NCT07218991","Wearable Echolocation Aids Using Parametric Sound","Inclusion Criteria:\n\n* Subject has provided informed consent in a manner approved by the Institutional Review Board (IRB) and is willing and able to comply with the trial procedures.\n* Adults at least 18 years of age and no older than 100 years of age at the time of consent.\n* Individuals in good health who can perform daily activities without assistance and can walk independently.\n* Normal vision (with or without corrective lenses) if there is no uncorrectable visual impairment.\n\nExclusion Criteria:\n\n* History of gait problems.\n* Foot or leg impairments.\n* Hearing impairment.\n* Vertigo or other balance problems.\n* Pregnant individuals.\n* Any medical condition that, in the opinion of the investigator, would place the subject at increased risk for participation.\n* Medications that may cause dizziness or weakness.\n* Concurrent participation on another research study.\n* Use of an investigational agent in the 30 days prior to signing informed consent.\n* History of prior non-compliance.\n* Presence or history of psychiatric condition (including anxiety, psychosis, drug, or alcohol addiction) that would, in the opinion of the investigator, make it difficult for the subject to comply with the study procedures or follow the investigators instructions.\n* Non-English-speaking individuals.\n* Individuals from special or vulnerable populations (i.e., adults unable to consent, minors, incarcerated individuals).\n* Body weight greater than 700 pounds.","100 Years",{"count":95,"type":19},50,[22],"The objective of this study is to study a novel device designed to aid patients with impaired vision to safely navigate their environment. Subjects for this study will be individuals with normal vision, either with or without correction. The subjects will wear a device to simulate impaired vision and will be asked to walk a path with randomly placed obstacles during two trials. One of the trials will consist of the subject wearing the simulator alone. The other trial will consist of the subject wearing the simulator and the study device. The study device is designed to be worn by the study subject and will emit tones to indicate obstacles in the environment as the subject walks on the path with random obstacles. The tones will indicate that there is an obstacle in the individual's path and will increase in intensity as the subject moves closer to the object.Invest",[25],[100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121],"low vision","visual impairment","blindness","blind","visual aid","visual rehabilitation","sensory compensation","echolocation","parametric sound","parametric sound technology","wearable echolocation device","echolocation technology","directional sound waves","echolocation headphones","assistive device","echolocation skills","ultrasound waves","sound waves","adaptive low vision navigation aid","low vision simulation goggles","navigation aid","low vision simulator","2025-10-24",{"date":124,"type":32},"2025-10-28",{"date":126,"type":32},"2025-02-21",{"date":128,"type":19},"2028-01-31",{"name":130,"class":39},"The University of Texas Medical Branch, Galveston",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":20,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":153},"100524373","beacon-sensors-and-telerehabilitation-to-assess-and-improve-use-of-devices-best-aid-for-low-vision-100524373","NCT06107881","Beacon Sensors and Telerehabilitation to Assess and Improve Use of Devices (BeST-AID) for Low Vision","BeST-AID","Inclusion Criteria:\n\n* adults with any level of vision loss due to any ocular disease who are age 18 and older, and who have received new magnification device(s) for the first time (i.e., hand-held optical magnifiers, portable electronic video magnifiers, high near add powers of +4.00 or greater, visual assistive mobile apps for their smartphone\u002Ftablet, some stand magnifiers and CCTVs) from one of our participating low vision rehabilitation sites at the four academic centers and one private practice.\n\nExclusion Criteria:\n\n* schedules not permitting participation in planned study visits (including planning to move far from their clinical provider's office within the first 4-months of the study (i.e., cannot attend in-office visits) or take extended vacation that would not allow them to complete study procedures during the first four months of the study period),\n* inability to understand study procedures or communicate responses to visual stimuli in a consistent manner (greater than mild cognitive impairment as per TICS),\n* substance abuse,\n* significant hearing loss (unable to hear communication by phone or via videoconferencing),\n* significant medical condition likely to limit participation or lifespan,\n* individuals who require other types of LVR training or intervention (e.g., psychosocial).\n* For Bluetooth low energy beacon sensors, exclusion would occur if their magnifier device has features that would not work in conjunction with the beacon sensors: (1) hands-free and do not have a place where the patient's hand is holding the device during use (therefore, they would not register a significant change in temperature), (2) no surface area of at least 1\"x1\" to which the beacon sensor could be attached without interfering with the device, or (3) use of visual assistive mobile apps only.",{"count":139,"type":19},350,[22],"One goal of this research is to conduct a non-inferiority trial of telerehabilitation versus in-office care to provide follow-up training to individuals with low vision to enhance their quality of life by using magnification devices and\u002For visual assistive mobile apps for important daily activities, such as reading and\u002For other valued tasks. This is a high priority given the increasing prevalence of low vision, paucity of low vision rehabilitation providers, and barriers related to access to care, such as transportation and geography, which can be essentially eliminated with telerehabilitation. Another goal of this project is to determine whether significant changes in environmental data collected by Bluetooth low energy beacon sensors can be used as a solution to monitor and indicate when low vision patients' have abandoned the use of their magnification devices, which has the potential to substantially enhance patient management by providing timely low vision rehabilitation services.",[25,143],"Low Vision Aids","2025-09-18",{"date":146,"type":32},"2025-09-23",{"date":148,"type":32},"2023-12-15",{"date":150,"type":19},"2028-06-30",{"name":152,"class":39},"University of California, Los Angeles",9,{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":15,"minAge":162,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":20,"phases":165,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":176,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":64},"100493300","effectiveness-of-av-stimulation-in-immersive-vr-to-improve-visual-perception-and-driving-performance-100493300","NCT05703360","Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance","Effectiveness of Audiovisual Stimulation in Immersive Virtual Reality to Improve Visual Perception and Driving Performance: a Pilot Study","Re:DriVR","Inclusion Criteria:\n\n* Male and female \\> 25 years old.\n* Visual field defects due to TBI or stroke\n* BCVA ≥ 20\u002F50.\n* Previously held a valid driving license and were active drivers.\n* Ability to follow the visual and auditory stimuli and training instructions.\n* Online auditory test positive (-5dBHL to 60dBHL range) at 125 Hz (for research purposes only)\n* Home Wi-Fi access.\n\nExclusion Criteria:\n\n* Both eyes with media opacity that impairs visual field testing.\n* Inability to perform during testing and training.\n* Cognitive\u002Fmotor condition incompatible with driving simulator and\u002For VR.\n* Recreational or medicinal consumption of psychoactive drugs.\n* 3 consecutive VRISE scores \\\u003C 25 at inclusion.\n* History of vertigo or dizziness.\n* Visual neglect.\n* Prior\u002Fcurrent vision rehabilitation interventions.\n* Photosensitive epilepsy.","25 Years",{"count":164,"type":19},30,[22],"The goal of this clinical trial is to evaluate the effectiveness of an immersive virtual-reality (IVR) based stimulation program, in improving visual perception for people who have lost their driver's license due to perceptual or cognitive impairments.\n\nThe main questions it aims to answer are:\n\n1. Can the 6-week IVR stimulation program help improve driving performance?\n2. Will participants experience improvement in visual detection and perception after training?\n\nStudy Design Summary:\n\n* Participants will be randomized into a waitlist group or intervention-first group\n* The VR-based intervention will consist of training every 2 days for six weeks\n* Waitlist group will wait 6 weeks before starting intervention at study midpoint (week 7)\n* Intervention-first group will begin with intervention (week 1-6) and then stop intervention at study midpoint\n* Participants will complete tests related to driving performance, visual attention, and visual fields at the start of study, midpoint, and end of study\n\nResearchers will analyze data for changes from baseline in outcome measures.",[168,169,25,170,171,172,173,174,175],"Stroke","Visual Impairment","Virtual Reality","Visual Spatial Processing","Visual Field Defect","Visual Processing Speed","Cognitive Impairment","Driving Impaired","NOT_YET_RECRUITING","2024-12-16",{"date":179,"type":32},"2024-12-19",{"date":181,"type":19},"2025-02-01",{"date":183,"type":19},"2025-12-01",{"name":185,"class":39},"University Health Network, Toronto",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":15,"minAge":48,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":20,"phases":195,"briefSummary":197,"conditions":198,"keywords":199,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":40},"100377100","phase-1-socially-assistive-robots-to-enhance-magnification-device-use-for-reading-100377100","NCT04190134","Socially Assistive Robots to Enhance Magnification Device Use for Reading","Development of a Behavioral Intervention With Socially Assistive Robots to Enhance Magnification Device Use for Reading","Inclusion Criteria:\n\n* Individuals with any level of vision loss due to any ocular disease,\n* age 18 and older,\n* received a magnification device(s) (i.e., hand-held optical magnifiers, portable electronic video magnifiers, some stand magnifiers and CCTVs) from the UCLA Vision Rehabilitation Center.\n\nExclusion Criteria:\n\n* schedules not permitting participation in planned study sessions or visits (including planning to move or take extended vacation during study period),\n* inability to understand study procedures or communicate responses to visual stimuli in a consistent manner (cognitive impairment as per TICS),\n* substance abuse,\n* significant hearing loss (unable to hear communication by phone or from robot),\n* significant medical condition likely to limit participation or lifespan,\n* their magnifier device has features that would not work in conjunction with the beacon sensors: (1) hands-free and do not have a place where the patient's hand is holding the device during use (therefore, they would not register a significant change in temperature), and\u002For (2) no surface area of at least 1\"x1\" to which the beacon sensor could be attached without interfering with the device.",{"count":194,"type":19},20,[196],"PHASE1","The aims of this exploratory research project are to customize, deploy and evaluate the preliminary efficacy of a socially assistive robot as a novel approach to motivate and encourage optimal, long-term use of new magnification devices for reading in individuals with vision loss. The goals are to promote patient acceptance, adherence and skills reinforcement to achieve proficiency in the use of the magnifier, in order to attempt to reduce visual disability while performing important daily activities, such as reading tasks. This is a high priority given the increasing prevalence of low vision, paucity of low vision rehabilitation providers, and barriers related to access to care, such as transportation and geography, all of which motivate the development of this complementary approach for the provision of additional support at home by the socially assistive robot.",[25],[200],"robot","2024-07-17",{"date":203,"type":32},"2024-07-19",{"date":205,"type":32},"2022-04-22",{"date":207,"type":19},"2025-02",{"name":152,"class":39}]