[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-back-pain-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-back-pain-chronic":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,47,75,111,133,161],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100642244","trial-to-test-the-efficacy-of-using-magnetic-fields-to-stimulate-the-back-to-treat-chronic-lower-back-pain-100642244",false,"NCT07652944","Trial to Test the Efficacy of Using Magnetic Fields to Stimulate the Back to Treat Chronic Lower Back Pain.","A Single-Blind Randomized Clinical Trial to Evaluate the Efficacy of High Vector Electrokinetics (HiVE), A Form of Peripheral Magnetic Stimulation, In Treatment of Chronic Back Pain","Inclusion Criteria:\n\n* Diagnosed with chronic low back pain (greater than or equal to 12 weeks) with or without concurrent neck pain.\n* Low back pain in the paraspinal region (L1-S2) by asking the patient to point to their area of pain.\n* 18 - 64 years old (on the day of informed consent)\n* Willing and able to attend all study visits.\n* No medication changes for at least 30 days before study enrollment (self-report)\n* Eligible for care at participating military treatment facilities\n* Able to read and understand English.\n* Negative pregnancy test for women capable of pregnancy.\n\nExclusion Criteria:\n\n* Diagnosed with low back pain of less than 12 weeks duration\n* History of back fractures or surgical repair of the back\n* History of depression with vagus nerve stimulation\n* Any type of transcranial magnetic stimulation (TMS), or rPMS treatment prior to study enrollment.\n* Currently using any other adjunctive treatments for chronic back pain such as low-level laser treatment, ultrasound, dry needling, chiropractor manipulations, cervical collars, TENS units, or other stimulation, eastern medicine regimens including Qi Gong or Tai Chi. (Exception: strength building physical therapy, non-neuropathic pain modifiers, and non-anticonvulsant routine pain medicine regimens such as NSAIDS and Acetaminophen are allowed).Scheduled for nerve ablation, dry needling, trigger point injections, nerve block, therapeutic ultrasound, other stimulation, or similar adjunct treatments during the study period.\n* Diagnosed with a specific low back pain: osteoarthritis, rheumatoid arthritis, phantom limb pain, central pain syndrome, spinal cord damage, myofascial pain syndrome, or other more specific diagnosis (at investigators discretion).\n* Unstable or poorly controlled mental health diagnosis (e.g., current changes in medication or medical management).\n* Dermal or subdermal implants (e.g., aneurysm clips, shunts, stimulators, ferro magnetic implants, stents, or electrodes, or pacemakers) or any other metal object within or near the site of stimulation which cannot be safely removed.\n* Clinically significant abnormality or clinically significant unstable medical condition that, in the investigator's judgment, might pose a potential safety risk to the subject or limit interpretation of the trial results.\n* Any condition which, in the judgment of the investigator, would prevent the patient from completing study procedures.\n* Pregnancy\n* Younger than 18 years old (on the day of informed consent)\n* Older than 64 years old (on the day of informed consent)\n* NOT willing or able to attend all study visits.\n* Medication changes for back pain less than 30 days prior to study enrollment (self-report)\n* NOT eligible for care at participating military treatment facilities\n* NOT able to read and understand English.","ALL","18 Years","64 Years",{"count":20,"type":21},88,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this study is to see if a new way to treat back pain without the use of medications is effective. We plan use Transcranial Magnetic Stimulation (TMS), a wand-like device, to excite the nerves of people with lower back pain to see if we can decrease pain and improve quality of life.\n\nThis study will have two groups and randomly assign participants to a group. One group will have their back nerves stimulated with the TMS device and the other group will not.\n\nParticipants will also need to do back exercises at home once a day, and complete questionnaires at each visit before and after each treatment. The total time commitment will be 5 to10 visits with one visit occurring each weekday and each visit lasting up to 30 minutes.",[27],"Lower Back Pain Chronic",[29,30,31,32,33],"magnetic stimulation","lower back pain","rPMS","HiVE","repetitive peripheral magnetic stimulation","RECRUITING","2026-06-11",{"date":37,"type":38},"2026-06-17","ACTUAL",{"date":40,"type":21},"2026-07",{"date":42,"type":21},"2027-02",{"name":44,"class":45},"Joe X. Zhang","FED",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100640567","the-potential-of-transcutaneous-electrical-nerve-stimulation-to-improve-pain-experienced-during-posterior-branch-blocks-in-patients-with-lumbar-posterior-joint-syndrome-100640567","NCT07627490","The Potential of Transcutaneous Electrical Nerve Stimulation to Improve Pain Experienced During Posterior Branch Blocks in Patients With Lumbar Posterior Joint Syndrome","The Value of Transcutaneous Electrical Nerve Stimulation (TENS) for Improving Pain Experienced During Posterior Branch Blocks in Patients With Lumbar Posterior Joint Syndrome: a Single-center, Randomized, Double-blind, Parallel-group, Controlled, Superiority Trial","TENS-INFIDOL","Inclusion Criteria:\n\n* Chronic low back pain (lasting more than 3 months)\n* Patient followed in a Chronic Pain Unit (CETD, Toulouse University Hospital)\n* Clinical and radiological diagnosis (CT scan or MRI) of posterior joint syndrome\n* Patient with an indication for infiltration therapy, feasible under standard conditions\n\nExclusion Criteria:\n\n* Spinal surgery\n* Contraindications for TENS:\n\n  * Wearing an electronic medical device (pacemakers, defibrillators, etc.)\n  * Pregnancy\n  * Area of cutaneous anesthesia\n  * Patient with an active malignant tumor\n  * Patient with deep vein thrombosis\n  * Patient with damaged or fragile skin\n* Insulin-dependent or uncontrolled diabetes\n* Uncontrolled hypertension\n* Allergy to the local anesthetics used\n* Severe psychiatric disorder\n* Lumbar injection within the previous 6 months",{"count":56,"type":21},52,[24],"Procedural pain is inadequately managed in two-thirds of patients undergoing invasive medical procedures. Several techniques exist for managing procedural pain, but they all present implementation challenges and are not without side effects. Therefore, a new, non-pharmacological, inexpensive, and easy-to-use approach would be of significant benefit. Transcutaneous electrical nerve stimulation (TENS) for pain relief could represent this alternative. Few studies have been conducted on the benefits of TENS in managing procedural pain, for example, in shoulder arthrodistension. This project proposes to study it in the context of posterior ramus infiltration in patients eligible for this indication, in the context of chronic low back pain associated with posterior joint syndrome.",[27],[61,62,63],"chronic lower back pain","pain","transcutaneous electrical neurostimulation","NOT_YET_RECRUITING","2026-05-29",{"date":67,"type":38},"2026-06-04",{"date":69,"type":21},"2026-09-01",{"date":71,"type":21},"2028-09-01",{"name":73,"class":74},"University Hospital, Toulouse","OTHER",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":46},"100602735","comparison-of-clinical-outcomes-complications-rate-and-treatment-costs-of-mini-tlif-and-midlif-in-the-treatment-of-discogenic-low-back-pain-100602735","NCT07127380","Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain","MID-MIS Trail Protocol - Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain","MID-MIS","Inclusion Criteria:\n\n* Discogenic lower lumbar-sacral pain lasting longer than one year\n* Failure of conservative treatment, including rehabilitation and pain management\n* Lumbar discopathy qualified for interbody fusion and pedicle screw stabilization\n* Informed consent of the patient for the study and proposed treatment\n\nExclusion Criteria:\n\n* Contraindications to surgery under general anesthesia\n* Age \\\u003C 18 years\n* Pregnancy, breastfeeding\n* Lack of informed consent to participate in the study\n* Lumbar-sac discopathy requiring surgical treatment at more than two levels\n* Spinal deformities: adult idiopathic scoliosis, degenerative scoliosis, deformity due to spinal malignancy, inflammatory spinal disease, post-traumatic, or associated with congenital anomalies\n* Lower lumbar-sacral pain syndrome, which, in the investigator's opinion, has an etiology other than degenerative spine disease (e.g., cancer-related pain, ankylosing spondylitis)\n* Spinal oncology disease\n* True and degenerative spondylolisthesis\n* Contraindications to performing MRI of the lumbar-sacral spine",{"count":84,"type":21},100,[24],"Background\n\nDegenerative disc disease (DDD) is the leading cause of lower back pain and disability, which prevalence increasing with age. When conservative treatment fails, surgical methods of spinal fusion are employed. Minimally invasive techniques, including minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and midline lumbar interbody fusion (MIDLIF), have well-documented advantages over traditional open transforaminal interbody fusion (open-TLIF). However, data comparing these two minimally invasive methods in treating DDD are minimal and sometimes contradictory. I am running a few minutes late; my previous meeting is running over.\n\nMethods This is a prospective, randomized, partially blinded, two-arm trial aiming to compare the outcomes, complications, and treatment costs of MIS-TLIF and MIDLIF in patients with discogenic low back pain. A total of 100 adult patients with lumbosacral spine pain and radicular symptoms, unresponsive to conservative treatment for over one year, will be enrolled. Patients will be randomized (1:1) into two arms: MIS-TLIF (control, n=50) and MIDLIF (intervention, n=50), with a 12-month follow-up. Inclusion criteria include age ≥18 years and discopathy at one or two levels requiring interbody stabilization. Exclusion criteria include multilevel pathology, spinal deformities, and pain causes other than degenerative disease. Primary endpoints assess pain (VAS, NRS scales), disability (COMI, ODI questionnaires), and quality of life (EQ-5D-5L questionnaire) at 1, 3, 6, and 12 months post-surgery. Secondary endpoints include complication rates (nerve root damage, infections), costs (hospitalization, implants), length of hospital stay, procedure duration, blood loss, morphometric parameters (intervertebral space height), and adjacent segment disease based on imaging studies (MRI, CT, X-ray). Data analysis uses parametric\u002Fnon-parametric tests (e.g., t-test, Mann-Whitney) in the R software. The trial adheres to the Helsinki Declaration, with ethics approval (no. 112\u002F2024).\n\nDiscussion Data on the comparison of MIDLIF and MIS-TLIF in treating DDD are minimal and inconsistent. Some reports have advantaged MIDLIF in shorter operative time, decreased intraoperative blood loss, and reduced hospital stays, while others favor MIS-TLIF. This trial addresses these gaps by providing high-quality evidence on clinical superiority, cost-effectiveness, and long-term outcomes compering MIDLIF and MIS-TLIF. There is a high need for a high-quality, prospective study to examine this problem.",[27,88,89,90],"Lumbar Degenerative Disease","Lumbar Disc Degeneration","Degenerative Disc Disease(DDD)",[92,93,89,94,95,96,97,98,99,100,101],"Degenerative Disc Disease","Lower Back Pain","Discogenic Pain","MIS-TLIF","MIDLIF","mini-TLIF","Minimally Invasive Transforaminal Lumbar Interbody Fusion","Midline Lumbar Interbody Fusion","Spinal stabilization","Spinal fusion","2026-04-14",{"date":104,"type":38},"2026-04-15",{"date":106,"type":38},"2025-01-19",{"date":108,"type":21},"2028-01-31",{"name":110,"class":74},"Copernicus Memorial Hospital",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":46},"100489810","randomized-trial-for-clbp-gokhale-project-100489810","NCT05657964","Randomized Trial for cLBP (Gokhale Project)","A Randomized Comparative Effectiveness Trial of Two Postural Therapies for People With Chronic Lower Back Pain (cLBP)-Gokhale Project","Gokhale","Inclusion Criteria:\n\n* 18-65 years old (working age population).\n* NPRS score 4 or more for lower back.\n* RMDQ score 7 and above.\n* English speaking population\n* Need insurance\n\nExclusion Criteria:\n\n* Pregnancy (as stated by patient)\n* With cognitive or communication impairment .\n* Patients recommended for surgery\n* Participating in other form of intervention.\n* Prior history of chronic neurological disorder that impacts mobility (e.g. stroke, Parkinson's disease, multiple sclerosis)\n* Fibromyalgia\n* Underwent PT treatment for low back pain in the last 6 months\n* Underlying mental disorder\u002Funtreated depression or presence of neurologic disorders such as MS, Alzheimers, Parkinsons","65 Years",{"count":84,"type":21},"OBSERVATIONAL","The study aims to compare the effectiveness of the Gokhale Method posture therapy for low back pain (LBP) management to standard physical therapy (PT) with posture training. The second aim of this study is to evaluate usability and user adherence of the online\u002Fdigital intervention through the Gokhale Method Foundation Class (online delivery with smartphone App).\n\nThe investigator hopes to learn:\n\nThe effectiveness of the Gokhale Method posture therapy for low back pain management, in comparison to the effectiveness of standard physical therapy with posture training.\n\nthe usability and user adherence of the online\u002Fdigital intervention through the Gokhale Method Foundation Class (online delivery with smartphone App).",[27],"2026-01-07",{"date":126,"type":38},"2026-01-09",{"date":128,"type":38},"2024-07-01",{"date":130,"type":21},"2030-12-31",{"name":132,"class":74},"Stanford University",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":119,"enrollmentInfo":141,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":159,"locationsCount":4},"100614104","interoceptive-awareness-physical-activity-body-awareness-and-emotional-status-in-individuals-with-non-specific-chronic-low-back-pain-100614104","NCT07275255","Interoceptive Awareness, Physical Activity, Body Awareness and Emotional Status in Individuals With Non-Specific Chronic Low Back Pain","Non-Specific Chronic Low Back Pain: Investigation of Interoceptive Awareness, Physical Activity Level, Body Awareness and Emotional Status in Individuals With Non-Specific Chronic Low Back Pain","NSCLBP-AWARE","Inclusion Criteria:\n\n* Adults aged 18-65 years.\n* Diagnosed with non-specific chronic low back pain.\n* Duration of pain ≥ 3 months.\n* Self-reported average pain score ≥ 4\u002F10 on the Visual Analog Scale.\n* Ability to understand and complete self-report questionnaires.\n\nExclusion Criteria:\n\n* Low back pain due to specific pathologies (e.g., tumor, infection, fracture, inflammatory disease).\n* Serious systemic, neurological, or psychiatric comorbidities.\n* History of spinal surgery within the past year.\n* Pregnancy.\n* Language or cognitive impairments preventing questionnaire completion.",{"count":142,"type":21},130,"This observational cross-sectional study aims to examine the relationships between interoceptive awareness, physical activity level, body awareness, emotional status, and pain intensity in individuals with non-specific chronic low back pain. Non-specific chronic low back pain refers to pain in the lumbar region lasting for at least three months without an identifiable structural or pathological cause.\n\nParticipants aged 18-65 years who meet the diagnostic criteria for non-specific chronic low back pain will be evaluated using validated self-report questionnaires. These include measures of interoceptive awareness, body awareness, alexithymia, physical activity level, and pain intensity. Sociodemographic and clinical characteristics such as age, gender, education level, duration of pain, medication use, height, weight, and BMI will also be collected.\n\nThe purpose of the study is to better understand how internal body perception, physical activity, emotional processing, and body awareness interact with pain experience in this population. Findings may contribute to the development of individualized rehabilitation programs and inform clinicians about the multidimensional factors influencing chronic low back pain.",[27,145],"Non Specific Chronic Low Back Pain",[147,148,149,150,151,152],"Interoceptive Awareness","Body Awareness","Non-specific Chronic Low Back Pain","Chronic Low Back Pain","Alexithymia","Physical Activity","2025-12-15",{"date":155,"type":38},"2025-12-16",{"date":157,"type":21},"2026-01-01",{"date":69,"type":21},{"name":160,"class":74},"Istinye University",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":168,"targetDuration":170,"studyType":121,"phases":4,"briefSummary":171,"conditions":172,"keywords":173,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":46},"100598847","the-relation-of-the-anatomic-morphology-of-lumbar-transverse-processes-and-the-success-rate-of-facet-joint-radiofrequency-denervation-100598847","NCT07076810","The Relation of the Anatomic Morphology of Lumbar Transverse Processes and the Success Rate of Facet Joint Radiofrequency Denervation","Morphology of Lumbar Transverse Processes and Relationship With the Success of Lumbar Medial Branch Radiofrequency Ablation in Facet Syndrome","Inclusion Criteria:\n\n* Lumbar facet joint-originated lower back pain longer then 6 months.\n\nExclusion Criteria:\n\n* Younger then 18\n* Reluctance to participate in the study\n* Severe anatomic deformation in lumbar vertebral region\n* Presence or suspicion of pregnancy\n* Inability to answer the questions of the study",{"count":169,"type":21},40,"1 Month","Adult patients who were planned for lumbar facet joint medial branch nerve Radiofrequency ablation under fluoroscopic guidance because of facet joint-originated chronic lower back pain will be included in this study. Pain scores (Numerical Rating Scale and Oswestry Disability Index) will be recorded before and one month after the intervention. The morphology of the transverse processes and the facet joints (sizes and angles) will be evaluated using the computer tomography images that patients have in routine examination process. The possible relationship between the success rate of the procedure and the morphology of the transverse processes will be assessed by statistical analysis.",[27],[30,174,175,176],"radiofrequency","facet joint","transverse process","2025-08-17",{"date":179,"type":38},"2025-08-19",{"date":181,"type":21},"2025-09-01",{"date":183,"type":21},"2026-06-30",{"name":185,"class":74},"Ondokuz Mayıs University"]