[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-back-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-back-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,71,98,130,157,180,204,240,262,283,308,333],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100641865","phase-1-adia-med-of-winter-park-llc-lower-back-pain-research-study-100641865",false,"NCT07587047","Adia Med of Winter Park LLC Lower Back Pain Research Study","A Randomized, Placebo-Controlled, Single-Blind, Crossover Study to Evaluate the Safety and Preliminary Efficacy of a Single Intravenous AdiaVita (Umbilical Cord Blood - Stem Cells and Exosomes) Infusion in Adults With Chronic Mechanical Lower Back Pain","Inclusion Criteria:\n\n* Age 18-85 years\n* Chronic lower back pain ≥3 months\n* MRI within 12 months demonstrating one or more qualifying diagnoses:\n\nDegenerative disc disease Disc bulge or herniation Modic changes Facet joint osteoarthritis Mixed disc and facet pathology\n\n* Baseline VAS-Average ≥4\u002F10\n* Able to comply with study visits and procedures\n* Able to provide written informed consent\n* Able to meet study cost requirements ($5,000 study fee plus MRI costs, if applicable) as described in the informed consent\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Prisoners or decisionally impaired adults\n* Active malignancy (except non-melanoma skin cancer)\n* Immunodeficiency or active systemic infection\n* Prior lumbar surgery within 12 months\n* Epidural steroid or facet joint injection within 3 months\n* Participation in another interventional trial within 30 days\n* Known allergy to product components\n* Any medical condition posing unacceptable risk per investigator judgment.\n* Prior stem cell therapy: History of stem cell therapy (including umbilical cord blood-derived stem cells or exosomes) at any time prior to screening","ALL","18 Years","85 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","The goal of this clinical study is to evaluate the safety and preliminary efficacy of an investigational umbilical cord blood-derived stem cell and exosome infusion in adults with chronic lower back pain associated with degenerative spine disease. The primary questions this study aims to answer are whether the investigational infusion is safe and well tolerated and whether treatment may reduce pain and improve physical function and quality of life. Researchers will compare the investigational infusion to a placebo (saline solution) to evaluate potential treatment effects in participants with chronic mechanical lower back pain. Participants will receive either the investigational infusion or placebo intravenously during a study visit, complete pain, disability, and quality-of-life assessments, undergo magnetic resonance imaging (MRI) and laboratory testing, and attend follow-up evaluations over a 6-month period. Participants initially assigned to placebo may later receive the investigational treatment during an open-label crossover phase of the study.",[27,28,29],"Chronic Mechanical Lower Back Pain","Lower Back Pain","Chronic Lower Back Pain",[31,32,33],"stem cell","stem cell therapy","chronic lower back pain","RECRUITING","2026-06-16",{"date":37,"type":38},"2026-06-17","ACTUAL",{"date":35,"type":21},{"date":41,"type":21},"2028-01",{"name":43,"class":44},"Adia Med of Winter Park LLC","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100643490","association-between-trendelenburg-sign-and-lumbar-mri-abnormalities-100643490","NCT07629466","Association Between Trendelenburg Sign and Lumbar MRI Abnormalities","Association of the Trendelenburg Sign With Spinopelvic Biomechanics and Lumbar MRI Abnormalities\"","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Patients who have previously presented to the clinic with a complaint of low back pain.\n* Willingness and ability to provide written informed consent for participation in the study.\n* Availability of lumbar MRI images obtained within the previous 12 months and accessible for evaluation.\n\nExclusion Criteria:\n\n* Presence of red flag conditions associated with low back pain, including malignancy, infection, acute trauma, or significant neurological deficits.\n* History of lumbar spine surgery.\n* Structural spinal anomalies such as sacralization or lumbarization.\n* Spinal deformities, including scoliosis.\n* Rheumatologic diseases affecting the spine (e.g., axial spondyloarthritis).\n* Significant radiculopathy or advanced neurological deficits, and the presence of extruded or sequestrated lumbar disc herniation.\n* Clinically significant lumbar spinal stenosis.\n* Spondylolysis and\u002For spondylolisthesis.\n* Acute vertebral fracture, compression fracture, or recent fracture associated with severe osteoporosis.\n* Hip or pelvic conditions that may directly influence the Trendelenburg sign, including: History of hip arthroplasty or hip surgery, advanced hip osteoarthritis, residual deformity following lower-extremity fracture, significant leg length discrepancy (\\>2 cm).\n* Systemic or neuromuscular disorders, including multiple sclerosis, myopathies, amyotrophic lateral sclerosis (ALS), stroke, or peripheral neuropathies.\n* Pregnancy.\n* Severe knee or ankle pathology or other conditions causing substantial gait impairment.","65 Years",{"count":55,"type":21},120,"1 Day","OBSERVATIONAL","The Trendelenburg sign is a common clinical finding indicating hip abductor dysfunction and altered pelvic stability. The relationship between the Trendelenburg sign, spinopelvic biomechanics, hip muscle strength, and lumbar magnetic resonance imaging (MRI) abnormalities remains insufficiently understood. This study aims to investigate the association between Trendelenburg sign positivity and lumbar MRI findings, including facet arthropathy, ligamentum flavum hypertrophy, multifidus muscle morphology, and psoas muscle characteristics, as well as spinopelvic biomechanical parameters and hip abductor muscle strength.",[60,28],"Facet Joint Arthropathy","NOT_YET_RECRUITING","2026-06-09",{"date":64,"type":38},"2026-06-10",{"date":66,"type":21},"2026-06-04",{"date":68,"type":21},"2026-10-10",{"name":70,"class":44},"Bahçeşehir University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":45},"100637637","investigating-medical-massage-therapy-for-patients-with-sub-acute-lower-back-pain-100637637","NCT07615816","Investigating Medical Massage Therapy for Patients With Sub-Acute Lower Back Pain","Zeel LBP","Inclusion Criteria:\n\n* Active-duty service member\n* 18-64 (inclusive) years of age\n* Medical evidence of subacute low back pain (as indicated by complications lasting 1-3 months)\n* Willingness to comply with treatment and follow-up schedule\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Current dx of any of the following:\n* Presence of significant comorbid pain (e.g., polytrauma)\n* Cancer - active\u002Fongoing treatment for\n* Active Infections, including skin lesions and rashes\n* Flu or other severe cold virus or COVID\n* Severe depression or anxiety\n* Symptomatic Inflammatory\u002FAutoimmune diseases such as Rheumatoid\n* Arthritis and Ankylosing Spondylitis. Acute exacerbation and not in remission\n* High Grade Spondylolisthesis (Grade III and Grade IV)\n* Fibromyalgia\n* Severe Osteoporosis (BMD with T-score of -2.5 or lower, along with the presence of one or more fragility fractures)\n* Neurogenic conditions\n* Spinal Stenosis with active neurogenic claudication\n* Cauda Equina Syndrome - acute\n* Radiating pain below the knee or in the presence of true Neurological signs (numbness\u002Fweakness)\n* Historical dx of any of the following:\n* Spinal Cord injuries with persisting neurogenic sensory or motor loss\n* Lumbar spine back surgery within the past year\n* Received spinal interventions (e.g., surgery, nerve ablations, steroid injections, etc.) within the past 6 months\n* Current use of blood thinners\u002Fanticoagulants\n* Is enrolled or plans to enroll in another clinical trial during this study that would affect the patient's safety or results of this trial\n* \\[Females only\\] Currently pregnant (self-reported) or plans to become pregnant during the study intervention period","64 Years",{"count":80,"type":21},220,[82],"NA","The goal of this clinical trial is to determine if a weekly regimen of Medical Massage Therapy (MMT) with provider-directed care shortens the duration of Medically Restricted Duty Days (MRDD) periods in Active-Duty Service Members with Subacute Lower Back Pain (LBP) compared to provider-directed care alone.\n\nThe main question the study aims to answer is, when used as an adjunct to provider-directed care, a consistent program of MMT provided by a qualified practitioner, will shorten the duration of MRDD periods, reduce pain, and decrease unnecessary healthcare utilization in patients with Subacute LBP compared to provider-directed care alone. Researchers will study this hypothesis through the comparison of Group #1 (provider-directed care alone) and Group #2 (provider-directed care and MMT).\n\nParticipants randomized into the two study groups will be following a 12-week study design (+\u002F- 2 weeks) comprised of their compliance to their provider-directed care, the study intervention (if randomized to Group #2) and study case report forms (CRFs); with a final follow up visit (up to 4 weeks following their final treatment visit).",[28,85,86],"Subacute Lower Back Pain","Medical Massage Therapy",[86,88,85,28],"Active Duty Service Members","2026-06-03",{"date":91,"type":38},"2026-06-05",{"date":93,"type":38},"2026-06-01",{"date":95,"type":21},"2027-01-31",{"name":97,"class":44},"The Geneva Foundation",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":16,"minAge":105,"maxAge":53,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":109,"conditions":110,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":45},"100437952","early-phase-1-brain-mechanisms-supporting-cannabis-induced-pain-relief-100437952","NCT04982965","Brain Mechanisms Supporting Cannabis-induced Pain Relief","Inclusion Criteria:\n\n* Between 21-65 years old\n* Currently 30 days cannabis free\n* Lower back pain for three months or more\n* Are not taking opioids\n* If female and of a child bearing potential age, are not pregnant or nursing mothers\n* Do not have mental or neurological conditions inhibiting sensory\u002Fmotor functions\n* Do not have a lifetime history of dependence on cannabis\n* Do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, panic disorder, or psychosis\n* Prior THC-containing cannabis experience within the past two years\n* Agrees not to use cannabis outside of the study during participation in the study\n* Agrees not to use opioids or barbiturates during participation in the study\n* Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study\n\nExclusion Criteria:\n\n* Active pulmonary disease\n* Allergy or past adverse effects or negative past experiences from cannabis\n* Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone\n* Any significant illness, including cardiovascular disease, diabetes, renal and liver disease.\n* Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.)\n* Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury\u002Fhead injury\n* Any current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia\n* Any current or history of suicidal ideation or attempt\n* Overt sensitivity to thermal stimulation\n* Resting blood pressure \\> 140\u002F90\n* Resting heart rate \\> 100 beats\u002Fminute\n* Prisoner\n* Institutionalized\n* Claustrophobia\n* MRI contraindications\n* Participation in any new (within 2 weeks prior or any time after enrollment) pain management procedures during the study period\n* Known history of vasovagal fainting, syncope, or severe adverse reactions associated with blood draws or needle procedures",true,"21 Years",{"count":20,"type":21},[108],"EARLY_PHASE1","Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.",[111,112,28,113,114,115,116],"Sciatica","Lumbar Radiculopathy","Degenerative Disc Disease","Chronic Low-back Pain (cLBP)","Chronic Low Back and Leg Pain","Back Pain",[118,119,120,121],"Cannabis","Vaporized cannabis","THC","chronic low back pain","2026-05-30",{"date":89,"type":38},{"date":125,"type":38},"2021-05-07",{"date":127,"type":21},"2027-03-15",{"name":129,"class":44},"University of California, San Diego",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":142,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":45},"100596049","electronic-approach-to-the-human-massage-therapist-100596049","NCT07040397","Electronic Approach to the Human Massage Therapist","Comparing an Electronic Approach to the Human Massage Therapist.","Inclusion Criteria:\n\n* be 18 years of age or older.\n* report a primary pain point in the lower back.\n* Pain intensity reported at baseline\n* Women of childbearing potential who self-report not being pregnant and agree to employ an effective method of birth control (surgical sterilization or oral contraceptives, barrier method with spermicides, intrauterine device, etc.) during the study period\n* be able to participate fully in all aspects of the study.\n* have understood and signed study informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Patients with the inability to stay in a prone position\n* Patients with bleeding disorders\n* Patients with allergies and\u002For local skin affectations\n* have used pain medications or participated in a pain treatment within three days of study enrollment.\n* have an implanted device (including a lap band) in the targeted area of massage therapy.\n* have used an investigational drug within 30 days of study enrollment.\n* have a history of any major cardiovascular events including heart valve disease, ongoing angina, cardiac arrhythmias, congestive heart failure, acute coronary syndrome, stroke, transient ischemic attack, or peripheral vascular disease.\n* have clinically significant acute or chronic progressive or unstable neurologic, hepatic, renal, cardiovascular, lymphatic, respiratory, metabolic disease (such as uncontrolled diabetes type 2) active cancer, actively receiving treatment for cancer or within 1 year of cancer remission.\n* surgical intervention for pain within 1 month prior to enrollment.\n* active infection, wound or other external trauma to the areas to be treated with massage therapy.\n* have a known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder adherence.",{"count":138,"type":21},40,[82],"The purpose of this study is to gather information about patient experience receiving a massage through a robotic EMMA (Expert Manipulative Massage Automation) compared to receiving a massage from a massage therapist.",[28],[143,144,145,146,147],"massage","Low Back Pain","automated massage","EMMA (expert manipulative massage automation)","electric massager","2026-05-01",{"date":150,"type":38},"2026-05-04",{"date":152,"type":38},"2026-01-30",{"date":154,"type":21},"2026-10-01",{"name":156,"class":44},"Mayo Clinic",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":45},"100602357","phase-1-safety-and-pk-of-intrathecal-cntx-3001-for-intractable-chronic-low-back-pain-100602357","NCT07122453","Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain","A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Single Ascending Doses of Intrathecal CNTX-3001 in Subjects With Intractable Chronic Moderate to Severe Low Back Pain","Inclusion:\n\n* Have stable intractable, chronic moderate to severe low back pain\n* Must have failed all 3 of the following categories of therapies:\n\n  1. Physical medicine modalities for at least 6 weeks (e.g., physical therapy, occupational therapy, or chiropractic treatment directed at chronic low back pain)\n  2. Three or more classes of pharmacologic treatments\n  3. One or more non-surgical and\u002For surgical interventions addressing the primary cause of chronic low back pain\n* If the intractable low back pain is accompanied by radicular pain, back pain must be dominant over leg pain and may not radiate below the knee\n* Has normal leg strength in both legs (able to stand\u002Fwalk)\n* Willing and able to undergo the lumbar puncture\n* On a stable analgesic regimen, or a stable dose of an opioid medication for \\>3 months\n* Non- or ex-smoker and has not used any nicotine-containing products within 3 months\n* Men or women able to abide by reproductive and contraceptive requirements\n* Has a body mass index (BMI) between 18 and 35 kg\u002Fm2, with weight ≥60 kg\n\nExclusion\n\n* Substantial increase or decrease in pain over the prior 3 months.\n* Low back pain that only occurs with specific activities or body positions.\n* Has asthma or other severe respiratory disease requiring daily prescription medication\n* History of, or current cancer (except basal cell carcinoma), cardiac disease, immunological disorders, meningitis, or bleeding disorders\n* Confirmed diagnosis of fibromyalgia or myalgic encephalomyelitis\n\nExclusion\n\n* Substantial increase or decrease in pain over the prior 3 months\n* Low back pain that only occurs with specific activities or body positions\n* Has asthma or other severe respiratory disease requiring daily prescription medication\n* History of, or current cancer (except basal cell carcinoma), cardiac disease, immunological disorders, meningitis, or bleeding disorders\n* Confirmed diagnosis of fibromyalgia or myalgic encephalomyelitis","75 Years",{"count":166,"type":21},16,[24],"This clinical study is being conducted to evaluate the safety, tolerability, plasma pharmacokinetics and efficacy of an investigational drug called CNTX-3001. This Phase 1 study is the first time that CNTX-3001 will be given to people (first-in-human study). The study is being done to evaluate whether CNTX-3001, given into the intrathecal space by lumbar puncture, can be administered safely to participants who have been diagnosed with intractable chronic moderate to severe low back pain and who have not responded well to other treatments in the past.\n\nCNTX-3001 is a novel, non-opioid small molecule",[28],"2026-03-19",{"date":172,"type":38},"2026-03-23",{"date":174,"type":21},"2026-03",{"date":176,"type":21},"2027-01",{"name":178,"class":179},"Centrexion Therapeutics","INDUSTRY",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":45},"100601585","pain-intervention-with-needling-pilot-of-integrated-neuromodulation-techniques-100601585","NCT07112404","Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques","PINPOINT Study: Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques","PINPOINT","Inclusion Criteria:\n\n* Both males and females between the ages of 18 and 65 will be included in this study.\n\nPhase 1 Inclusion criteria\n\n\\- Healthy adults who report no pain for more than 1 day in the past 3 months in their lumbar region. Lumbar region will include posterior lumber musculature, lumbar spine, sacroiliac pain, or superior gluteal area pain.\n\nPhase 2 Inclusion criteria\n\n* Adults experiencing chronic low back pain. Chronic low back pain will be identified as having pain the lumbar region for at least 3 months. The pain may be constant or episodic in nature.\n* Participants will be included if they experience pain at least 75% of the days in the past 3 months. All pain levels will be included. Lumbar region will include posterior lumber musculature, lumbar spine, sacroiliac pain, or superior gluteal area pain.\n\nExclusion Criteria:\n\n* Individuals who are currently seeking any form of medical treatment for lumbar conditions beyond routine physician follow-up appointments in order to avoid confounding variables, regardless of pain-free status. These may include, but are not limited to, seeking treatment from a chiropractor, acupuncturist, or massage therapist or medical procedures such as injections into the lumbar region for pain.\n* Additionally, those with previous lumbar surgeries or those with previous major injuries to the lumbar spine that may have resulted in structural abnormalities that may compromise needle placement will be excluded. If surgical procedures did not alter structural alignment, then it will be allowed. For example, an approved procedure may include discectomy or nerve ablation, while a not approved procedure would include a lumbar fusion or scoliosis rod placement.\n* Additionally, if a person is experiencing radicular symptoms from a back injury, despite not feeling the symptoms in the lumbar region, will not be considered. Radicular symptoms will be defined as those present past the knee and\u002For electrical in nature. Individuals with neurological conditions or those who need the services of another due to cognitive deficits will not be considered for this study.\n* Furthermore, as this study relies on an intact sensory system, participants with conditions that may affect sensory processing (e.g., peripheral neuropathy, skin conditions, or circulatory disorders) will be excluded through careful screening.\n\nAdditional exclusion criteria\n\n* Will include the following conditions identified as contraindications for dry needling: those with impaired sensitivity, taking anticoagulants, a compromised immune system, a local or systemic infection, an active tumor, history of lymph node removal, history of autoimmune disease, allergy to metals such as nickel or chromium, history of cosmetic procedures in the area, pregnant individuals, or osteoporosis.\n* Non-English-speaking subjects will be excluded from the study due to the need to understand any communication while dry-needling procedures are taking place.",{"count":189,"type":21},42,[82],"The study's purpose is to determine the effects of three different dry needling sessions on pain and quality of life for those with chronic low back pain. Dry needling is a therapeutic procedure in which a very thin, monofilament needle is inserted through the skin to reach a target tissue like a muscle to help reduce pain, improve muscle activation, and increase blood flow. Dry needling has also been shown to improve nervous system function.",[193,116,28,194],"Pain","Quality of Life","2026-03-11",{"date":197,"type":38},"2026-03-16",{"date":199,"type":38},"2025-10-23",{"date":201,"type":21},"2027-09",{"name":203,"class":44},"The University of Texas Medical Branch, Galveston",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":104,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":211,"targetDuration":4,"studyType":22,"phases":213,"briefSummary":214,"conditions":215,"keywords":222,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":45},"100605850","low-back-and-neck-pain-in-nursing-students-at-the-university-of-the-west-indies-100605850","NCT07167888","Low Back and Neck Pain in Nursing Students at The University of The West Indies","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Nursing Students at The University of the West Indies, Mona: A Two-Phase Study","Inclusion Criteria:\n\n1. All students enrolled in the student nursing program at the University of the West Indies, Mona Campus, Jamaica during the period October 4, 2025 to October 3, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":212,"type":21},400,[82],"The purpose of this study is to identify the prevalence of neck and low back pain in nursing students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and to determine the outcome of a standardised spine exercise program on nursing students experiencing neck and low back pain, using a prospective randomised control design.",[116,144,216,217,218,219,28,220,221],"Musculoskeletal Pain","Neck Pain","Spine Health","Musculoskeletal Pain Disorder","Nursing Students","Preclinical Education",[223,224,225,226,227,228,229,230],"lower back pain","low back pain","musculoskeletal pain","neck pain","rehabilitation","university student","nursing students","spine health","2026-02-20",{"date":233,"type":38},"2026-02-24",{"date":235,"type":21},"2026-04-01",{"date":237,"type":21},"2027-03-31",{"name":239,"class":44},"The University of The West Indies",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":22,"phases":249,"briefSummary":250,"conditions":251,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":261},"100605779","peripheral-nerve-stimulation-with-the-sprint-system-in-chronic-psijc-pain-100605779","NCT07166952","Peripheral Nerve Stimulation With the SPRINT® System in Chronic PSIJC Pain","Peripheral Nerve Stimulation With the SPRINT® System in Chronic Posterior Sacroiliac Joint Complex Pain","Inclusion Criteria:\n\n* Sacroiliac pain as diagnosed above\n* Subject greater than 18 years old\n* Subject is severely debilitated by SIJ pain, with initial ODI score \\> 40%\n* Subject received conservative treatment for at least three months including physiotherapy and pain medication\n* Subject is able to understand and consent to the study and device management and participating in follow-up surveys\n* Subject is scheduled for a commercial SPRINT case that has been authorized through their healthcare insurance\n\nExclusion Criteria:\n\n* Pregnancy\n* Subject is under the age of 18 years\n* Acute traumatic injury of the sacral iliac joint\n* Active inflammation or neoplastic infiltration of the SIJ\n* Neoplastic diseases of the spine\n* Spinal surgery within the last three months\n* Sacroiliac joint steroid injection within the past 1 month or sacral lateral branch radiofrequency ablation within the past 6 months\n* Contraindication for Neuromodulation Device (severe psychiatric disease, severe coagulation disorder, acute infection, active autoimmune disease with immunosuppression)",{"count":248,"type":21},10,[82],"Chronic lower back pain is a significant cause of disability, affecting 21-68% of people 60 years of age and older (source). Of these cases, 15-30% are attributed to posterior sacroiliac joint complex (PSIJC) pain (source), making it a target for treatment. Peripheral Nerve Stimulation (PNS) is a procedure that involves the placement of a lead under the skin with local anesthetic and electrically stimulating designated spinal nerves that deliver pain signals to the brain. It has emerged as a promising alternative to drug, injection, and radioablative therapies. Its use has been supported by previous studies of subjects who received permanent neurostimulation and experienced benefits such as decreased sensation of pain and perceived level of disability. SPRINT is a minimally invasive PNS system of interest due to its ability to provide long-term pain relief after temporary administration of PNS. The aim of this study is to understand whether the FDA-cleared SPRINT PNS system is safe and effective for the treatment of chronic PSIJC pain. This prospective clinical study will assess 10 subjects that meet the inclusion and exclusion criteria across 5 separate time points- 1.) Screening; 2.) Procedure within 3 months of screening; 3.) 12-day post-procedure follow-up; 4.) 3-month post-procedure follow-up; 5.) 3-Month post lead removal follow-up. The subjects will be required to complete physical examinations, and VAS and ODI questionnaires at timepoints 3, 4, and 5.",[28],"2025-11-12",{"date":254,"type":38},"2025-11-14",{"date":256,"type":38},"2025-10-26",{"date":258,"type":21},"2027-10-31",{"name":260,"class":44},"Medical University of South Carolina",2,{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":270,"targetDuration":4,"studyType":22,"phases":272,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":281,"locationsCount":45},"100608155","effect-of-dynamic-sitting-on-pain-development---part-2-100608155","NCT07197879","Effect of Dynamic Sitting on Pain Development - Part 2","Effect of Dynamic Sitting on Pain Development - Part 2 - a Randomized Controlled Cross-over Study","DynSit-Pain 2","Inclusion Criteria:\n\n* Signed Informed consent\n* People aged between 18 and 65 years\n* People classified as pain developers (e.g.: a 10 mm increase in pain on a 100 mm paper-based VAS)\n* Office workers\n* Employment status: \\> 25 h \u002F week\n* Sufficient knowledge of German (min. B2 level)\n* Body height of at least 160cm required\n* Electrically or manually height-adjustable table at main workstation\n\nExclusion Criteria:\n\n* Physical or mental limitations that make dynamic sitting or use of the procedure chair difficult (e.g. wheelchair users, vestibular dysfunction)\n* Pregnancy\n* Sitting for less than 20 hours per week at the main workplace\n* Body weight over 110 kg and a body height over 195 cm\n* Regular therapy or medication for pain or medication that affects the perception of pain (e.g. certain psychotropic drugs according to the package leaflet)\n* office chair to which it is not possible to attach the swivel mechanism prototype\n* Presence of any chronic disease that may influence pain perception (e.g., chronic kidney disease, fibromyalgia, neuropathy, chronic fatigue syndrome)",{"count":271,"type":21},20,[82],"As a follow-up project to the Dyn-Sit-Pain study, this research aims to investigate the overall health as well as the physical and mental well-being through dynamic office chairs. The development of an innovative dynamic office chair concept will be professionally and scientifically supported, and the developed prototypes will be examined within the framework of usability studies.",[28],"2025-09-26",{"date":277,"type":38},"2025-09-29",{"date":279,"type":38},"2025-05-12",{"date":237,"type":21},{"name":282,"class":44},"University of Applied Sciences for Health Professions Upper Austria",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":104,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":296,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":261},"100340036","neck-and-low-back-pain-in-medical-students-at-the-university-of-the-west-indies-mona-jamaica-100340036","NCT03707288","Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica","The Prevalence of Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica","Inclusion Criteria:\n\n1. All students enrolled in the medical program at the University of the West Indies, Mona Campus, Jamaica during the period October 1, 2018 to January 2, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":291,"type":21},1000,[82],"The purpose of this study is to identify the prevalence of neck and low back pain in medical students enrolled at the University of the West Indies, Mona; to assess their knowledge, attitude and practice of good spine health and to determine the outcome of a standardised spine exercise program on medical students experiencing neck and low back pain, using a prospective randomised control design.",[116,144,217,295,28,218,216,219],"Neck Pain Musculoskeletal",[223,224,226,297,230,298,299,225],"neck and back pain","medical students","university students","2025-09-03",{"date":302,"type":38},"2025-09-10",{"date":304,"type":38},"2018-10-01",{"date":306,"type":21},"2026-12-02",{"name":239,"class":44},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":312,"acronym":4,"eligibilityCriteria":313,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":314,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":315,"conditions":316,"keywords":319,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":324,"lastUpdatePostDateStruct":325,"startDateStruct":327,"completionDateStruct":329,"leadSponsor":331,"locationsCount":4},"100595761","bone-enhanced-ultrasound-beus-data-library-development-project-100595761","NCT07036653","Bone Enhanced Ultrasound (BEUS) Data Library Development Project","Inclusion Criteria:\n\n* Individuals who have had previous CT or MRI scans of their spine in the past 5 years\n\nExclusion Criteria:\n\n* \\\u003C 18 years old",{"count":20,"type":21},"A common treatment for low back pain involves fluoroscopy-guided spinal facet joint injections and\u002For medial branch nerve blocks. Unfortunately, fluoroscopy requires expensive equipment and personnel and exposes patients and healthcare providers to ionizing radiation. Ultrasound offers a safer, lower-cost alternative, but the traditional 2-dimensional (2D) ultrasound systems are limited due to poor image quality, particularly in patients with higher body mass index (BMI).\n\nAs an alternative, a novel Bone Enhanced Ultrasound (BEUS) technology uses artificial intelligence (AI) to create real-time 3-dimensional (3D) images of the spine to guide needle placement for these injections. The AI software is trained by overlaying computed tomography (CT) and ultrasound images from a patient dataset to recognize anatomical landmarks. BEUS aims to ultimately replace fluoroscopy for spinal injections, reducing radiation exposure, lowering healthcare costs, and improving accessibility, especially in rural settings where CT and fluoroscopy are unavailable.\n\nA key limitation, however, is that the current AI system is trained based primarily on patients (mostly pediatric) undergoing perioperative assessment of scoliosis. To address this, the current study aims to develop a new, more clinically relevant training AI dataset by collecting spinal ultrasounds from up to 100 adult participants (most\u002Fall of whom are followed at the local chronic pain clinic for low back pain) with existing spinal CT or magnetic resonance imaging (MRI) scans. This dataset will be used to retrain the current AI model to enhance the accuracy of 3D spinal reconstructions, thereby improving the clinical relevance of the BEUS system.",[28,317,318],"Facet Joint Pain; Low Back Pain","Osteoarthritis (OA)",[320,321,322,323],"Facet joint injection","Spine ultrasound","3D ultrasound","Low back pain","2025-07-28",{"date":326,"type":38},"2025-07-29",{"date":328,"type":21},"2025-09-01",{"date":330,"type":21},"2025-12-31",{"name":332,"class":44},"Queen's University",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":104,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":340,"targetDuration":4,"studyType":22,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":4},"100574392","the-effect-of-kinesio-taping-applied-to-operating-room-nurses-on-low-back-pain-fatigue-and-sleep-quality-100574392","NCT06758687","The Effect of Kinesio Taping Applied to Operating Room Nurses on Low Back Pain, Fatigue, and Sleep Quality","The Effect of Kinesio Taping Applied to Operating Room Nurses on Low Back Pain, Fatigue, and Sleep Quality: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Working in the operating room for at least one year\n\nExclusion Criteria:\n\n* Presence of conditions that will prevent the application of kinesio tape (excessive hair in the area where it is applied, skin rash, urticaria, etc.)\n* Necessity for continuous use of analgesics\n\nExclusion Criteria for the Study\n\n* Desire to leave the study while the study is ongoing\n* Allergic reaction or skin irritation to kinesio tape during the study\n* Use of analgesics during the period when kinesio tape is applied",{"count":20,"type":21},[82],"This study aims to determine the effects of kinesiology taping applied to operating room nurses on lower back pain, fatigue, and sleep quality. The research will be conducted using a randomized controlled experimental design with pre-test and post-test control groups. The universe of the study will consist of 100 operating room nurses working in a university hospital. The sample size has been calculated as a total of 84 nurses (Intervention group: 42; Control group: 42) based on power analysis calculations. The study will commence after obtaining the necessary permissions. Data collection will involve the use of the Descriptive Information Form, Visual Analog Scale, Quebec Back Pain Disability Scale, Visual Analogue Scale for Fatigue, and the Richards-Campbell Sleep Questionnaire. Participants who consent to the study will be administered the Descriptive Information Form, Visual Analog Scale, Quebec Back Pain Disability Scale, Visual Analogue Scale for Fatigue, and Richards-Campbell Sleep Questionnaire before the application of kinesiology tape. Subsequently, a physiotherapist from the research team will apply kinesiology tape to the paravertebral muscles using the muscle technique. As the literature suggests that the most suitable number of days for kinesiology tape application is four, participants will be instructed not to remove the tapes for four days. Additionally, participants will be informed that they can continue their daily activities and shower with the kinesiology tape on. The Visual Analog Scale will be applied to the participants at the end of the workday on the day of the kinesiology tape application and at the end of the workday for four days. At the end of the fourth day, all data collection tools will be applied. Seven days after the application, the scales will be filled out again by the nurses to determine if the effects of the kinesiology tape persist. Participants in the control group who agree to participate in the study will have data collected at the same time intervals as the intervention group participants using the same data collection tools. The Visual Analogue Scale will be administered to participants at the end of the day the data collection tools are filled out and at the end of the workday for four consecutive days. At the end of the fourth day, all data collection tools will be applied again. Seven days after the application, all scales will be refilled by the nurses..",[28,344],"Kinesio Taping",[346,223,347,348,349],"Operating room nurse","sleep quality","fatigue","kinesio taping","2025-01-03",{"date":352,"type":38},"2025-01-06",{"date":354,"type":21},"2025-01",{"date":356,"type":21},"2025-12",{"name":358,"class":44},"Nigde Omer Halisdemir University"]