[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-grade-glioma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-grade-glioma":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100577164","stratifying-adult-diffuse-lower-grade-gliomas-based-on-their-varied-metabolic-profiles-stradivari-project-100577164",false,"NCT06794736","STRatifying Adult DIffuse Lower-grade Gliomas Based on Their VARIed Metabolic Profiles (STRADIVARI Project)","STRADIVARI","Prospective Metabolic Cohort:\n\nInclusion Criteria:\n\n* Radiological diagnosis of brain tumor compatible with lower grade glioma\n* Full clinical history\n\nExclusion Criteria:\n\n* Current pregnancy or lactation\n* Patients not able to provide informed consent\n\nRetrospective Cohort of FFPE samples:\n\nInclusion Criteria:\n\n* Confirmed diagnosis of lower grade glioma\n* Full clinical and radiological history","ALL","18 Years",{"count":19,"type":20},110,"ESTIMATED","6 Months","OBSERVATIONAL","The goal of this observational study is to better characterise lower-grade gliomas from a molecular and metabolic point of view, so to identify further subgroups of these tumours with different behaviour and, possibly, different treatment susceptibility.\n\nParticipants of prospective metabolic cohort will be subjected to routine treatment, part of the exceeding tutor material will be subjected to advanced molecular-metabolic analyses to desume their metabolic profile to be then correlated with clinical outcome (progression-free survival, overall survival, response to therapy\u002Fprogression) and diagnosis (astrocytoma\u002Foligodendroglioma and grade).\n\nCritical enzymes identified from metabolic analyses on the first cohort will be tested on a protein level on a retrospective cohort of patients previously operated and for whom fully available clinical history and pathological material is available in Institutional archive (no need for further intervention on these patients) to see if they actually correlate with clinical outcome.",[25],"Lower Grade Glioma",[27,28,29,30],"Lower grade glioma","Metabolomics","Tumor heterogeneity","Patient Stratification","RECRUITING","2025-01-22",{"date":34,"type":35},"2025-01-27","ACTUAL",{"date":37,"type":35},"2024-11-14",{"date":39,"type":20},"2026-08",{"name":41,"class":42},"I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio","OTHER",4]