[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-limb-amputation-above-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-limb-amputation-above-knee":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,72,94,135,163],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644169","determining-the-effects-of-ischemic-conditioning-and-neuromuscular-electrical-stimulation-on-overall-function-after-lower-limb-amputation-100644169",false,"NCT07664995","Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation","Improving Muscle Strength and Function After Lower Limb Amputation","Inclusion Criteria:\n\n* Older than 18 years old\n* History of unilateral transfemoral or transtibial amputation\n* Able to ambulate independently without the use of aids (i.e., walking cane)\n* Able to walk at least 6 minutes continuously without stopping.\n* Has a safe residuum with no open wounds on either the residual or intact limb\n* Has a prosthetic limb with materials that are sound and safe to withstand the mobility requirements of the study\n\nExclusion Criteria:\n\n* Younger than 18 years old\n* Inability to give informed consent\n* Neurological disorder such as multiple sclerosis that affects gait\n* Currently pregnant (or intend to become pregnant while participating in study)\n* Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. open wounds in the leg)\n* History of uncontrolled hypertension\n* History of heart failure\n* Implanted electrical device such as a pacemaker or defibrillator\n* Head injury within the previous 6 months\n* Seizure disorder\n* History of thrombosis\n* History of sickle cell trait\n* History of genetic disease that impacts gait (e.g. cerebral palsy, muscular dystrophy).","ALL","18 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn if ischemic conditioning and neuromuscular electrical stimulation improves muscle strength and walking behavior in those with limb loss. The main questions this trial aims to answer are:\n\nDoes neuromuscular electrical stimulation improve muscle strength and gait behavior in people who have a leg amputation?\n\nDoes neuromuscular electrical stimulation boost the effects of ischemic conditioning on muscle strength and gait behavior in people who have a leg amputation?\n\nResearchers will compare the effects of neuromuscular electrical stimulation to ischemic conditioning to see if there are any significant differences between the impacts of each intervention. Also, researchers will use both interventions together to see if the interventions can boost each other's positive impacts on walking and function in people with leg amputation.\n\nParticipants will:\n\n* Do ischemic conditioning OR neuromuscular electrical stimulation OR both interventions at home every other day for 2 weeks\n* Visit the laboratory before and after completing interventions for the tests\n* Visit the laboratory one week after the post intervention visit for follow-up tests",[26,27],"Lower Limb Amputation Above Knee","Below Knee Amputation","NOT_YET_RECRUITING","2026-06-17",{"date":31,"type":32},"2026-06-24","ACTUAL",{"date":34,"type":20},"2026-07-01",{"date":36,"type":20},"2027-12",{"name":38,"class":39},"University of Illinois at Chicago","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":40},"100627416","tens-for-restoring-somatotopic-sensory-feedback-in-lower-limb-amputees-and-improving-phantom-limb-perception-100627416","NCT07448350","TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception","Transcutaneous Electrical Nerve Stimulation for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception","SENSE-P","Inclusion Criteria:\n\n* Age between 18 and 80 years;\n* unilateral TTA or TFA at least two months prior the study;\n* stable clinical conditions;\n* skin integrity;\n* absence of cognitive deficits;\n* able to walk using the prosthesis;\n* no previous experience with TENS.\n\nExclusion Criteria:\n\n* Bilateral amputation;\n* open wounds or sores on the residual limb;\n* cognitive deficits;\n* pregnancy;\n* presence of implanted medical device (e.g., cardiac defibrillators, pacemakers or infusion pumps);\n* refusal to sign the informed consent.","80 Years",{"count":51,"type":20},15,[23],"The aim of the study is to evaluate the changes induced by a course of Transcutaneous Electrical Nerve Stimulation (TENS) treatment on the perception of phantom limb pain.\n\nIn particular, we want to evaluate the changes induced by a course of TENS treatment on posture, balance, and gait.\n\nFor each patient, the study will consist of a total of 20 sessions (4 mapping sessions, 3 Stimulus Intensity Discrimination sessions, 10 rehabilitation treatments, and 3 evaluation sessions).\n\nOne session will be carried out each day. Each session will last 60 minutes, except for the evaluation sessions, which are expected to last approximately 90 minutes.\n\nFor the patient, the study ends with the last evaluation, voluntary withdrawal from the study, or the patient's death.",[26,55],"Lower Limb Amputation Below Knee",[57,58,59,60,61],"prosthetics","somatotopic sensations","Transcutaneous Electrical Nerve Stimulation","rehabilitation","sensory feedback restoration","RECRUITING","2026-05-12",{"date":65,"type":32},"2026-05-13",{"date":67,"type":20},"2026-05-05",{"date":69,"type":20},"2027-12-31",{"name":71,"class":39},"Campus Bio-Medico University",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":40},"100622520","microenvironment-in-patients-undergoing-non-traumatic-amputation-100622520","NCT07384689","Microenvironment in Patients Undergoing Non-traumatic Amputation","MiAMII Study - Microdialysis Acquired SaMpling of Ischemia, Inflammation and Antibiotics Locally in Amputation Stump: A Comparative Study in Diabetic and Non-Diabetic Patients Undergoing Non-Traumatic Transfemoral Amputation","MiAMII","Inclusion criteria\n\n* 18 years or older\n* Cognitive ability to provide informed consent\n* Scheduled for transfemoral amputation at Aarhus University Hospital\n\nExclusion criteria\n\n* Non-vascular indication of amputation\n* Already amputated on the contralateral leg\n* Insufficient flap perfusion\n* Allergic or sensitivity to silver or acrylic adhesives",{"count":81,"type":20},20,[23],"The microenvironment of the amputation stump in patients undergoing non-traumatic transfemoral amputation will be investigated with a combination of microdialysis and tissue sampling.",[26],"2026-02-10",{"date":87,"type":32},"2026-02-12",{"date":89,"type":32},"2025-08-01",{"date":91,"type":20},"2028-01",{"name":93,"class":39},"University of Aarhus",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":111,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":40},"100588119","effects-of-microprocessor-controlled-prosthetic-knees-on-fall-related-health-outcomes-in-limited-community-ambulators-100588119","NCT06937242","Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators","Fall-related Health Outcome in Lower Limb Prosthesis Users: A Pragmatic Clinical Trial to Assess Effectiveness of Microprocessor-controlled Prosthetic Knees","Inclusion Criteria:\n\n* Unilateral transfemoral or knee disarticulation limb loss.\n* 6 months or longer since time of limb loss.\n* Current user of a prosthesis with a non-microprocessor-controlled prosthetic knee.\n* Received a replacement prosthesis with a non-microprocessor knee in the past 4-24 months.\n* Clinician has deemed patient limited community ambulator (Medicare functional classification level K2).\n* In addition, Medicare functional classification level K2 as determined by at least one of the following criteria:\n\n  1. Houghton Score: 5-10\n  2. Prosthetic Limb Users Survey of Mobility (PLUS-M) T-Score: if amputation etiology is vascular disease\u002Fdiabetes \\\u003C49.45, otherwise, \\\u003C36.75.\n  3. Amputee Mobility Predictor (AMPPRO) score: 27-42 collected within the last 24 months\n* Ability to read, write, and understand English.\n\nExclusion Criteria:\n\n* Any health condition that would prevent safely completing trial activities.\n* Any individuals that weigh 275 lbs or more.\n* Any individuals who wear their prosthesis less than 3 days a week or less than a total of 24 hours a week\n* Individuals with a history of acute or chronic residual limb breakdown\n* Individuals with declining health status such that he\u002Fshe subsequently reports reduced activity over the past 6 months",{"count":102,"type":20},100,[23],"The goal of this study is to find out if using microprocessor-controlled prosthetic knees (MPKs), prosthetic knees with a built-in computer, improves health outcomes related to falls in adults who use above-knee prostheses. The main questions are:\n\n* Do individuals with MPKs have fewer fall-related health issues compared to those with non-microprocessor-controlled prosthetic knees (nMPKs)?\n* Do individuals with MPKs have increased mobility, faster walking speed, and improved quality of life compared to those with nMPKs?\n\nParticipants who have recently received an nMPK as part of their regular care can join the study. Those randomized to the control group will keep using their nMPK, while those randomized to the intervention group will receive a stance-and-swing MPK or a stance-only MPK.",[106,107,108,109,110,26],"Amputation","Prosthesis User","Amputation; Traumatic, Leg: Thigh, Between Hip and Knee","Limb; Absence, Congenital, Lower","Lower Limb Amputation Above Knee (Injury)",[112,113,114,115,116,117,118,119,120,121,122,123,124],"amputation","lower limb amputation","lower limb prosthesis user","mechanical knee","microprocessor knee","transfemoral amputation","knee disarticulation","prosthetic knee","falls","falling","amputee","transfemoral amputee","MPK","2026-02-03",{"date":127,"type":32},"2026-02-05",{"date":129,"type":32},"2025-07-11",{"date":131,"type":20},"2027-02",{"name":133,"class":134},"Hanger Institute for Clinical Research and Education, LLC","INDUSTRY",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":40},"100617860","clinical-application-observation-on-the-evaluation-of-phantom-limb-pain-with-the-suralis-system-100617860","NCT07324109","Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System","Clinical Application Observation: Evaluation of Phantom Limb Pain After 3 Weeks of Use of a Feedback System Using Vibration (Suralis, Manufacturer: Saphenus)","Inclusion Criteria:\n\n* Unilateral major lower-limb amputation (transtibial or transfemoral)\n* Presence of persistent phantom limb pain, defined as daily pain intensity ≥ 3\u002F10 on the Visual Analog Scale (VAS) during the baseline period\n* Regular daily use of a prosthetic limb (minimum 4 hours\u002Fday)\n* Adequate German language proficiency to understand and complete study questionnaires and follow study procedures\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Unstable wound or skin condition at the residual limb\n* Inconsistent prosthetic use (less than daily or \\\u003C 4 hours\u002Fday)\n* Poorly fitting or non-functional prosthesis (as determined by study team)\n* Incapacity to provide informed consent (e.g., due to cognitive impairment or severe psychiatric illness)\n* Insufficient German language skills to comprehend study materials or complete assessments reliably",{"count":81,"type":20},[23],"This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks. Participants wear the device daily and report pain levels, walking ability, and quality of life - with no known risks, as it's a CE-certified medical device. If pain improves, the study team will help participants apply for insurance coverage to keep using the system long-term. The goal is to offer a simple, non-drug option that may help ease chronic pain and improve daily function for amputees. Participation is voluntary and can be stopped anytime without affecting medical care.",[146,26,55,147],"Phantom Limb Pain After Amputation","Lower Limb Amputation Knee",[149,150,151,152,153],"Phantom limb pain","Vibrotactile feedback","Lower limb amputation","Suralis system","Pain management","2025-12-23",{"date":156,"type":32},"2026-01-07",{"date":158,"type":32},"2025-04-01",{"date":160,"type":20},"2026-07-31",{"name":162,"class":39},"Median",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":21,"phases":173,"briefSummary":174,"conditions":175,"keywords":176,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":189},"100609431","study-on-a-prosthetic-foot-with-adjustable-heel-height-100609431","NCT07214493","Study on a Prosthetic Foot With Adjustable Heel Height","Impact of a Prosthetic Foot With Adjustable Heel Height on Physical Appearance and Participation: a Randomized Crossover Trial.","ADJUST","Inclusion Criteria :\n\n* Adult patient with a major lower limb amputation whose life project includes:\n* movement in buildings other than the home (ICF d4601),\n* movement outside the home and other buildings (ICF d4602),\n* and other specified activities related to movement in other various places (ICF d4608).\n* Patient who has been using an Enregy storage and Return (ESR) foot for at least 3 months\n* Patient who wishes to walk with shoes with different heel heights, and\u002For barefoot\n\nExclusion Criteria:\n\n* Patient with a high impact level (e.g.: sport)\n* Patient with hip disarticulation or equivalent\n* Patient with an unstabilised residual limb and\u002For an unsuitable socket\n* Patient who cannot be fitted with a Taleo Adjust foot due to the technical characteristics of the product (user weight greater than 115kg; required foot size \\\u003C22 or \\>28; mounting height less than 118 mm)\n* Patient whose usual foot has a heel height adjustment system\n* Patient unavailable for the duration of the study and\u002For unable to understand the instructions and\u002For answer questionnaires in French\n* Patient already participating in another study\n* Patient in an emergency situation or pregnant woman",{"count":172,"type":20},30,[23],"Most prosthetic feet have a fixed heel height, which requires users to always wear shoes with the same heel height. A fixed heel height is a significant constraint, whereas the ability to choose one's clothing freely is an important aspect of coping with a physical disability.\n\nThe Taleo Adjust is a prosthetic foot with a hydraulic ankle that allows the user to adjust the heel height from 0 to 7 cm, depending on the type of shoe worn.\n\nThis study aims to evaluate the impact of an adjustable-heel-height foot on physical appearance and participation.",[26,55],[151,177,178,179],"Prosthetic foot","Adjustable heel height","Hydraulic ankle","2025-11-20",{"date":182,"type":32},"2025-11-25",{"date":184,"type":32},"2025-10-08",{"date":186,"type":20},"2026-06-06",{"name":188,"class":134},"Otto Bock France SNC",5]