[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-limb-amputation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-limb-amputation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,40,70,91,112,141,167,196,223,243],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100548051","identification-of-limiting-factors-in-the-locomotor-activity-of-individuals-with-lower-limb-amputation-100548051",false,"NCT06415955","Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation:","Identification of Limiting Factors in the Locomotor Activity of Individuals With Lower Limb Amputation: Biomechanical, Physiological, Psychological.","AMPUTEEFACT","Inclusion Criteria:\n\n* Amputees in PRM hospitalisation at the CHU Nîmes RRL service University Rehabilitation Hospital in Le Grau du Roi.\n* All aetiologies: vascular, traumatic and septic.\n* Appropriate vascular equipment validated by PRM doctor.\n* Able to walk for 5 minutes on a treadmill.\n* Patient affiliated to or benefiting from a health insurance scheme.\n* Adult patient (\\>18 years) and under 80 years of age.\n\nExclusion Criteria:\n\n* Patients with uncorrected or untreated visual disorders.\n* Patients with major cognitive impairment (MOCA\\>23).\n* Patients with vestibular disorders.\n* Patient with uncontrolled epilepsy.\n* Patient with an unhealed amputation stump.\n* Weight \\> 135kg or \\\u003C 20kg\n* Patients with a FAC of 1 (i.e. patients requiring the firm and continuous assistance of another person to carry their weight and maintain their balance) or less.\n* Inability to properly adjust the sling to the corresponding body part due to:\n* Body shape\n* Colostomy bags\n* Skin lesions that cannot be adequately protected.\n* Any other reason that prevents the harness from being adjusted correctly and painlessly.","ALL","18 Years","80 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","The experience of amputation leads to a deterioration in quality of life, with undeniable somatic and functional repercussions. The result is a reduction in general mobility, increased metabolic energy requirements and a feeling of discomfort and pain. The rehabilitation objectives focus on improving, or at least maintaining, the range of movement of the lower limbs, strengthening the overall muscles, ensuring that the equipment is correctly adapted, re-training for physical exertion and working on balance and walking. The rehabilitation objectives focus on social inclusion with the equipment, to optimise the return home and promote social and professional reintegration, and therapeutic education. Factors influencing the postoperative resumption of walking in amputees have been identified as key elements in the success of rehabilitation management. These include maintaining joint range of motion before fitting any equipment, combating postoperative loss of muscle mass, managing cardiorespiratory deconditioning and, finally, resuming walking with the aid of equipment, taking account of fluctuating balance.\n\nThe literature shows that a change in the centre of gravity and postural instability, particularly when changing stance, are responsible for a greater risk of falls in lower-limb amputees. This asymmetry of gait, which is the cause of a greater risk of secondary joint degeneration, is found in both transtibial and transfemoral amputees. This alteration in balance has a direct influence on walking ability, and therefore calls for significant proprioceptive management in the rehabilitation programme. Gait analysis in lower-limb amputees therefore seems essential, both for the purposes of evaluating and monitoring rehabilitation treatment, and for prosthetic selection and adjustment. Three-dimensional assessment of walking in amputees, coupled with force platforms, is the test of choice for providing kinematic, kinetic and spatiotemporal data (motion capture).",[26],"Lower Limb Amputation","RECRUITING","2026-06-23",{"date":30,"type":31},"2026-06-24","ACTUAL",{"date":33,"type":31},"2025-03-15",{"date":35,"type":22},"2026-12",{"name":37,"class":38},"Centre Hospitalier Universitaire de Nīmes","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100633739","evaluation-of-a-new-articulated-prosthetic-foot-comfort-safety-and-biomechanics-in-individuals-with-a-lower-limb-amputation-100633739","NCT07530601","Evaluation of a New Articulated Prosthetic Foot: Comfort, Safety and Biomechanics in Individuals With a Lower-Limb Amputation","Multidimensional Assessment of a New Ankle-Foot Prosthesis in Daily Use: User Comfort, Safety, and Biomechanical Performance","MAP-CSB","Inclusion Criteria:\n\n* Age: 18 - 80 years\n* Gender: Men and Women\n* Level of amputation:\n* Unilateral \u002F bilateral\n* Transtibial \u002F transfemoral \u002F knee disarticulation \u002F hip disarticulation\n* Cause of amputation:\n* Vascular, traumatic, cancer and congenital\n* Medicare Functional Classification Level: K2-K3-K4\n* Completion of post-amputation rehabilitation\n\nExclusion Criteria:\n\n* Any neurological disease\n* Excessive residual limb pain and wounds",{"count":49,"type":22},120,"INTERVENTIONAL",[52],"NA","This clinical investigation aims to evaluate a new articulated prosthetic foot during daily-life activities.",[55],"Lower-Limb Amputation",[57,58],"ankle-foot prosthesis","daily-life activities","NOT_YET_RECRUITING","2026-04-10",{"date":62,"type":31},"2026-04-15",{"date":64,"type":22},"2026-04",{"date":66,"type":22},"2027-06",{"name":68,"class":38},"Vrije Universiteit Brussel",2,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":39},"100364854","study-of-locomotor-expectations-for-ascendingdescending-slope-and-stairs-in-patients-with-limb-amputations-100364854","NCT04030650","Study of Locomotor Expectations for Ascending\u002FDescending Slope and Stairs in Patients With Limb Amputations","JCE","Inclusion Criteria:\n\nHealthy volunteers:\n\n* person who has given oral consent\n* male or female adult\n* person being able to understand simple orders, locomotion instructions\n\nLower limb amputee patients:\n\n* person who has given oral consent\n* male or female adult\n* patient with unilateral major lower limb amputation of any origin (traumatic, vascular, infectious, congenital or neoplastic) with definitive equipment used routinely for at least 3 months.\n* person able to understand simple orders, locomotion instructions\n\nExclusion Criteria:\n\n* person not affiliated or not benefiting from a heath insurance system\n* person subject to a legal protection measure (curatorship, guardianship)\n* person with a legal guardian\n* pregnant or breastfeeding woman\n* adult unable to consent\n* person with a dislocated hip\n* subject with conditions or disabilities other than amputation that affect walking",true,{"count":79,"type":22},70,"Patients with lower limb amputations are equipped with prostheses that can be mechanical and\u002For electronic. These prostheses can be mono-articular (only the ankle) or bi-articular (knee and ankle for example). For amputee patients, situations that may seem trivial, such as climbing and descending stairs, become complex. Thus during the descent of stairs, an unamputated person will slow down the descent by contracting the thigh muscles, which are obviously lacking in the amputee patient. Current prostheses, known as \"intelligent\" (or \"microprocessor\") prostheses, make it possible to adjust the locomotion only once the first step has been taken and to assist the patient during ascent\u002Fdescent situations on slopes and stairs. The next technological challenge in the development of lower limb equipment is to be able to anticipate these complex environmental situations, in order to secure and facilitate movement even before the obstacle is crossed or the terrain changed.\n\nThis project plans to use the locomotor expectations commonly made during walking as a means of regulating the locomotor pattern. We believe that these expectations will depend on the situation, i.e. a particular anticipation when climbing or descending a slope, or when approaching a staircase, etc. To understand and describe these locomotor expectations, we plan to use recent techniques called supervised machine learning. These will make it possible to classify locomotor behaviour when walking on a slope or stairs. In the second phase, we would like to describe precisely the characteristics of the movements of the joints, and of the muscles during these adaptations. The final objective of this work is to create an autonomous sensor system to control the anticipatory behaviour of a lower limb prosthesis.",[26],"2026-03-18",{"date":84,"type":31},"2026-03-20",{"date":86,"type":31},"2019-09-20",{"date":88,"type":22},"2028-05",{"name":90,"class":38},"Centre Hospitalier Universitaire Dijon",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":98,"targetDuration":4,"studyType":50,"phases":100,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":39},"100630314","early-phase-1-motorized-prostheses-for-lower-limb-amputees-100630314","NCT07486063","Motorized Prostheses for Lower-limb Amputees","Lightweight Motorized Prostheses for Lower-limb Amputees","Our inclusion criteria will be\n\n* Above-knee amputation\n* K2\u002FK3\u002FK4 ambulators\n* At least 18 years old\n* At least one year since amputation\n* At least six months since the definitive prosthesis fitting\n* Currently prescribed and using a mechanically passive or microprocessor-controlled prosthesis\n\nOur exclusion criteria will be\n\n* Over 350 lbs. body weight, the weight limit for our safety suspension systems\n* Cognitive deficits or visual impairment that could impair their ability to give informed consent or to follow simple instructions during the experiments\n* Pregnant women due to elevated safety concerns for this population\n* Co-morbidity that limits their ability to participate in the study protocol (e.g., stroke, pacemaker placement that would interfere with the powered prosthesis, severe ischemia, cardiac disease, etc.)\n* Adults who are unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who use a wheelchair for mobility both outdoors and indoors because they may not be able to perform the necessary activities with their passive prosthesis or the powered prosthesis\n* Prisoners, due to concerns with informed consent",{"count":99,"type":22},40,[101],"EARLY_PHASE1","The investigators will assess biomechanical and functional mobility outcomes in individuals with unilateral, above-knee amputations using different knee\u002Fankle configurations of a lightweight powered prosthesis and different volitional controllers in individuals with unilateral, above-knee amputations.",[55],"2026-03-17",{"date":84,"type":31},{"date":107,"type":31},"2025-07-01",{"date":109,"type":22},"2032-06",{"name":111,"class":38},"University of Utah",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":19,"enrollmentInfo":120,"targetDuration":4,"studyType":50,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":139,"locationsCount":39},"100552343","clinical-and-psychological-adjustment-of-patients-with-lla-a-multidisciplinary-rehabilitative-intervention-project-100552343","NCT06471855","Clinical and Psychological Adjustment of Patients With LLA: a Multidisciplinary Rehabilitative Intervention Project","Clinical and Psychological Adjustment of Patients With Lower Limb Amputation: a Multidisciplinary Rehabilitative Intervention Project (AMP_ADinRehab Study)","AMPADinRehab","Inclusion Criteria:\n\n* Risk of amputation or Lower limb amputation or prothesis use for vascular disease and diabetes type 2\n\nExclusion Criteria:\n\n* more than 80 years older\n* severe clinical condition (ie, chronic heart failure \\[New York Heart Association Classification-IV - NYHA-IV\\], ischemic heart disease \\[Canadian Cardiovascular Society Classification-IV - CCS-IV\\], neoplastic disease, acute respiratory disease);\n* non-Italian education\n* severe visual-perceptive deficits\n* severe cognitive impairment (MMSE ≤ 26 Foderaro et al, 2022);\n* severe mental health condition or psychiatric disorder compromising participation in the study;\n* absence or withdrawal of the informed consent to participate.",{"count":79,"type":22},[52],"Most of the limb amputation related to vascular disease is often secondary to a diagnosis of type 2 diabetes mellitus. The amputation involves significant motor, psychological, and social challenges for patients, with a major effect on their psycho-physical health. The psychological processes that characterize this clinical population are still poorly investigated. Adopting a biopsychosocial approach, the present randomized prospective quali-quantitative study protocol aims to evaluate the behavioural and psychological adaptation at various stages of the disease: risk of amputation, lower limb amputation, and prosthesis use. In the last phase, patients with prosthesis will receive traditional rehabilitation treatment and technology-based rehabilitation (experimental) or not (active comparator) with randomized controlled enrolment. The evaluation will be based on a semi-structured interview, specific to the disease stage and constructed using the Three Factor Model, and rating scales. Patient's medical history, functional status (ie, motor functionality, autonomy in BIM and FIM, risk of falls, subjective perceived pain), and psychological aspects (ie, emotional impact, HRQoL, anxiety and depression symptoms, personality traits, acceptance, adherence, body image, the experience of the prosthesis and technology-based rehabilitation, expectations for the future) will be investigated. The audio-recorded and transcribed interviews will be analyzed using the Interpretive Description approach.",[26,124],"Prosthesis User",[126,127,128,129,130,131,132],"Amputee","Multidisciplinary rehabilitation","HRQoL","Psychological adaptation","Usability","HT\u002Frobotic rehabilitation","Psychoeducation","2026-02-20",{"date":135,"type":31},"2026-02-23",{"date":137,"type":31},"2023-06-01",{"date":66,"type":22},{"name":140,"class":38},"Istituti Clinici Scientifici Maugeri SpA",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":148,"targetDuration":150,"studyType":23,"phases":4,"briefSummary":151,"conditions":152,"keywords":153,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100622107","psychometric-evaluation-of-the-multidimensional-scale-of-perceived-social-support-in-lower-extremity-amputation-100622107","NCT07379320","Psychometric Evaluation of the Multidimensional Scale of Perceived Social Support in Lower Extremity Amputation","Validity and Reliability of the Multidimensional Scale of Perceived Social Support in Individuals With Lower Extremity Amputation","Inclusion Criteria:\n\n* Individuals aged 18 years and older.\n* Individuals with unilateral or bilateral lower extremity amputation.\n* Ability to read and understand Turkish.\n* Ability to provide informed consent and complete self-reported questionnaires.\n\nExclusion Criteria:\n\n* Presence of severe cognitive impairment or neurological disorders that may affect comprehension of the questionnaires.\n* Presence of acute psychiatric conditions that may interfere with participation.\n* Presence of additional medical conditions that significantly limit communication or cooperation.",{"count":149,"type":22},55,"7 Days","The purpose of this study is to examine the validity and reliability of the Multidimensional Scale of Perceived Social Support in individuals with lower extremity amputation. Social support plays an important role in psychological well-being, social participation, and adaptation after amputation. However, there is limited evidence regarding whether this scale accurately and consistently measures perceived social support in individuals with lower limb amputation.\n\nParticipants aged 18 years and older with lower extremity amputation will be invited to complete several questionnaires, including the Multidimensional Scale of Perceived Social Support. Some participants will complete the social support questionnaire a second time within a short period to evaluate the consistency of the results. The findings of this study are expected to contribute to the accurate assessment of perceived social support in individuals with lower limb amputation and to support future clinical and research applications.",[26],[154,155,156,157,158],"Lower limb amputation","Perceived social support","Psychometric validation","Reliability","Validity","2026-01-23",{"date":161,"type":31},"2026-01-30",{"date":161,"type":22},{"date":164,"type":22},"2026-12-15",{"name":166,"class":38},"Hacettepe University",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":50,"phases":177,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100613074","muscle-strength-training-in-lower-limb-amputee-patients-100613074","NCT07261852","Muscle Strength Training in Lower Limb Amputee Patients","Effects of Muscle Strength Training in Lower Limb Amputee Patients","Inclusion Criteria:\n\n* Patients with unilateral lower limb amputation\n* Transtibial and\u002For transfemoral amputation\n* Prosthetized\n* Aged 18 to 75 years\n* Who sign the informed consent form\n\nExclusion Criteria:\n\n* That they are unable to complete the initial assessment\n* That they undergo further secondary training","75 Years",{"count":176,"type":22},18,[52],"This study is a clinical trial that evaluates the best treatment option using a strength training protocol and an endurance training protocol in patients with lower limb amputations who use prostheses. The protocol consists of 6 weeks of strength training and 6 weeks of endurance training, with a 1-month washout period between the two.",[26],[181,182,183,184,185,186],"amputees","quality of life","funcionality","muscle strength","movility","endurance training","2025-11-28",{"date":189,"type":31},"2025-12-03",{"date":191,"type":22},"2025-11-30",{"date":193,"type":22},"2027-12",{"name":195,"class":38},"University of Gran Rosario",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":203,"targetDuration":4,"studyType":50,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":39},"100607687","uses-of-phantom-sensations-induced-by-global-and-local-modifications-of-the-prosthetic-socket-as-somatosensory-feedback-during-walking-in-lower-limb-amputees-100607687","NCT07191795","Uses of Phantom Sensations Induced by Global and Local Modifications of the Prosthetic Socket as Somatosensory Feedback During Walking in Lower Limb Amputees","PhantomWalk","Inclusion Criteria:\n\n* Participants with amputations:\n\n  * Major lower limb amputation\n  * Understand and be able to express oneself in the French language (for semi-structured interviews)\n  * Affiliated with a social security scheme\n* Asymptomatic volunteer participants:\n\n  * No major surgery on the lower limbs for at least 3 years\n  * No minor injury to the trunk, lower or upper limbs that could influence walking for at least 1 year\n  * Understand and be able to express oneself in the French language\n  * Affiliated with a social security scheme\n\nExclusion Criteria:\n\n* History of psychiatric disorders\n* Pregnant or breastfeeding woman\n* Minor\n* Adult subject to a legal protection measure\n* Person under guardianship or conservatorship\n* Person under a judicial protection order\n* Pain affecting walking (trunk, residual limb, phantom limb, contralateral limb)\n* Medical treatment incompatible with walking",{"count":204,"type":22},228,[52],"Following lower-limb amputation, the loss of somatosensory information from the missing limb renders walking less automatic, more cognitively demanding, and often asymmetric, which can lead to secondary pathologies.\n\nHypothesis: This study is based on the hypothesis that phantom limb sensations (PLS), when coherent with the prosthetic device's movements and the phases of the gait cycle, can compensate for the loss of somatosensory feedback and thereby improve locomotion for individuals with amputation. It is further hypothesized that it is possible to artificially induce these coherent and useful sensations, notably through \"referred sensations\" elicited by stimulation of the residual limb (e.g., via the prosthetic socket).\n\nObjectives: The project aims to:\n\n* Determine whether the natural presence of phantom limb sensations during walking impacts gait parameters.\n* Confirm in a larger patient population that modifications to the prosthetic socket can induce or enhance phantom sensations that are perceived as useful for walking.\n* Investigate whether these perceptual changes (induced or enhanced) are associated with objective, measurable improvements in gait quality.",[26],[209,210,211,212,213],"Phantom Limb Sensation","Referred Sensation","Somatosensory Feedback","Lower Limb Prosthesis","Prosthetic Gait","2025-09-23",{"date":216,"type":31},"2025-09-25",{"date":218,"type":31},"2024-09-16",{"date":220,"type":22},"2030-09-30",{"name":222,"class":38},"Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":50,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100600175","exploratory-functional-assessment-after-lower-limb-amputation-locomotion-balance-energy-performance-and-strategies-for-adapting-to-orthopaedic-devices-100600175","NCT07094074","Exploratory Functional Assessment After Lower Limb Amputation: Locomotion, Balance, Energy Performance and Strategies for Adapting to Orthopaedic Devices","AMILOCO","Inclusion Criteria:\n\n* Person who has given oral consent\n* Patient able to understand simple commands and packaging instructions\n* Male or female patient over 18 years of age\n* Patient with a lower limb amputation, at tibial or femoral level\n\nExclusion Criteria:\n\n* Person not affiliated to or not benefiting from a social security scheme\n* Person subject to a legal protection measure (curatorship, guardianship)\n* Person subject to a judicial protection measure\n* Pregnant women, women in labour or breastfeeding mothers\n* Adults who are incapable or unable to give their consent\n* Subjects with disarticulated hips\n* Subjects with serious associated pathologies having an impact on walking (other than amputation)",{"count":231,"type":22},100,[52],"The general aim of this exploratory study is therefore to investigate and quantify the functional capacities of patients with lower limb amputations (transtibial and transfemoral), with no change in their management, and to describe any changes in these capacities. The volunteers included in this study will be testing new equipment, all of which will be CE-marked, and will therefore meet all the safety and performance conditions required for use by these patients (equipment that is likely to be prescribed as standard). These devices could benefit from current technological advances that could improve these patients' functional abilities. They will be chosen and adapted according to the volunteer's activity and current equipment.\n\nThis is a local project of the CHU Dijon Bourgogne which will take place on the Technological Investigation Platform located at the Centre de Rééducation et de Réadaptation of the CHU Dijon Bourgogne.\n\nA maximum of 100 patients will take part in the study, divided into two sub-groups of between 5 and 50 patients, depending on the type of brace worn and the level of amputation.\n\nAfter the inclusion visit, each volunteer will undergo 2 assessment visits (the order of assessment of the devices will depend on randomisation) separated by 3 to 6 weeks. Follow-up is for a maximum of 14 weeks.",[26],"2025-07-28",{"date":237,"type":31},"2025-07-30",{"date":239,"type":22},"2025-09",{"date":241,"type":22},"2031-01",{"name":90,"class":38},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":250,"targetDuration":4,"studyType":50,"phases":252,"briefSummary":253,"conditions":254,"keywords":257,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":39},"100503082","perineural-methylene-blue-infusion-in-lower-limb-amputation-surgery-100503082","NCT05830630","Perineural Methylene Blue Infusion in Lower Limb Amputation Surgery","The Preventive Value of Continuous Perineural Methylene Blue Infusion in Patients Undergoing Lower Limb Amputation Surgery","Inclusion Criteria:\n\n* Patients of both genders, suffering from vascular insufficiency of one or both lower limbs and scheduled for above or below knee amputation under general anesthesia.\n\nExclusion Criteria:\n\n* Patients with a history of allergy to local anesthetics.\n* Patients with allergy to methylene blue.\n* Anticoagulant use or coagulopathy.",{"count":251,"type":22},72,[52],"This prospective randomized controlled study will be conducted to evaluate the analgesic effect of continuous perineural infusion of methylene blue with bupivacaine on acute postoperative pain and to evaluate its preventive role against chronic phantom pain in patients undergoing lower limb amputation surgery",[255,256,26],"Perineural","Methylene Blue",[255,258,154],"Methylene blue","2025-07-04",{"date":261,"type":31},"2025-07-09",{"date":263,"type":31},"2023-05-01",{"date":265,"type":22},"2027-05-01",{"name":267,"class":38},"Tanta University"]