[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lower-limb-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lower-limb-injury":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,68,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100568735","translation-and-validation-of-the-limbs-pain-autonomy-depression-anxiety-and-quality-of-life-scales-in-albanian-100568735",false,"NCT06685094","Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian","Cross-cultural Adaptation, Translation and Validation of the Assessment Scales of the Upper and Lower Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life for Use in the Albanian-speaking Population","Inclusion Criteria:\n\n* articular and muscular pain\n* back pain\n* presence of rheumatologic symptoms\n* functional misbalance\n* scoliosis\n* musculoskeletal disorders\n\nExclusion Criteria:\n\n* no native albanian language\n* severe trauma to the lumbar spine or hip(s)\n* tumor\n* metabolic disease",true,"ALL","18 Years","80 Years",{"count":21,"type":22},300,"ESTIMATED","OBSERVATIONAL","The cross-cultural adaptation will be performed according to the internationally recommended methodology, using the following guidelines: translation, back-translation; revision by a committee, questionnaire diffusion and data collection and analyzing.\n\nThe psychometric properties will be evaluated by administering the questionnaire to approximately 300 participants. Reliability will be estimated through stability and homogeneity assessment",[26,27,28,29,30],"Musculoskeletal Pain","Autonomy","Healthy","Upper Limb Injury","Lower Limb Injury","RECRUITING","2026-06-02",{"date":34,"type":35},"2026-06-04","ACTUAL",{"date":37,"type":35},"2025-06-30",{"date":39,"type":22},"2027-09-01",{"name":41,"class":42},"Universidad Católica San Antonio de Murcia","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":43},"100374016","blood-flow-restriction-therapy-in-lower-limb-extensor-injuries-100374016","NCT04149977","Blood Flow Restriction Therapy in Lower Limb Extensor Injuries","Blood Flow Restriction Therapy in Lower Limb Extensor Injuries: A Randomized Controlled Double-Blind Study","Inclusion Criteria:\n\n* Must be at least 18 years of age and younger than 65 years of age\n* ASA class I-II\n* Diagnosed with a lower limb extensor injury (quadriceps tendon rupture, patella tendon rupture, patella fracture)\n* Intention to receive physical therapy as standard of care\n\nExclusion Criteria:\n\n* Legally incompetent or mentally impaired (e.g. minors, Alzheimer's subjects, dementia, etc.)\n* Younger than 18 years of age or older than 65\n* Any patient considered a vulnerable subject\n* Patients with impaired circulation, peripheral vascular compromise, previous revascularization of the extremity, or severe hypertension\n* Concomitant lower extremity traumatic injuries, delaying or precluding the subject's ability to participate in the therapy\n* Immobile or use of mobile assistive device prior to injury\n* No prior extensor injuries\n* Patients with Sickle cell anemia or venous thromboembolism\n* Patients with cancer or Lymphectomies\n* Patients with increased intracranial pressure\n* Patients with intention to receive standard therapy and not the study therapy","65 Years",{"count":53,"type":22},128,"INTERVENTIONAL",[56],"NA","The primary objective of the study is to determine the efficacy of blood flow restriction therapy on patients with lower limb extensor injuries by measuring pre and post blood flow restriction therapy strength and muscle mass.",[30],"2025-09-24",{"date":61,"type":35},"2025-09-26",{"date":63,"type":35},"2021-09-01",{"date":65,"type":22},"2026-06-01",{"name":67,"class":42},"NYU Langone Health",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":75,"targetDuration":4,"studyType":54,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":43},"100587046","improving-walking-after-a-lower-limb-injury-using-a-custom-motorized-orthosis-100587046","NCT06923293","Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis","Individualizing Powered Orthotic Intervention for Improved Gait Outcomes Using ML-enabled Methods","Inclusion Criteria:\n\n* Have a lower limb injury greater than a year ago.\n* Be 18-80 years old.\n* Be able to stand for 30 minutes.\n* Have enough range of motion in my ankle to comfortably wear the AFO.\n* Be able to follow directions and commands.\n* Be willing and able to give informed consent.\n* Be able and willing to comply with study procedures, verbal instructions, and follow-up requirements.\n\nExclusion Criteria:\n\n* Have any joint or muscle tightness that would limit my movement while walking with the AFO.\n* Have any medical issue that prevents me from supporting my weight and walking (e.g. orthopedic injuries, pain, severe spasticity).\n* Have any medical issues that affect my unaffected side.\n* Have skin issues that would prevent wearing the device.\n* Have a pre-existing condition that caused exercise intolerance. (Documented uncontrolled hypertension, coronary artery disease, abnormal heart rate or rhythm, or congestive heart failure).\n* Have been hospitalized for heart attack, heart surgery or acute heart failure within 3 months of enrollment in study.\n* Have nervous system issues that affect my movement (for example Parkinson's disease, multiple sclerosis).\n* Have additional orthopedic issues that interfere with my walking or limit my range of motion in my legs.\n* Have any other medical conditions that my doctor or physical therapist feels would affect my ability to use the device.",{"count":76,"type":22},19,[56],"The purpose of this research study is to assess the ease, convenience, and efficacy of walking when using a motor powered ankle foot orthosis (AFO) brace, in adults who have had a lower limb injury.",[30],"2025-08-25",{"date":82,"type":35},"2025-08-26",{"date":84,"type":35},"2025-06-01",{"date":86,"type":22},"2027-06-01",{"name":88,"class":42},"Kessler Foundation",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":54,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":102,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":43},"100576029","multimodal-analgesia-versus-peripheral-nerve-block-for-postoperative-pain-management-after-lower-limb-injury-surgery-100576029","NCT06779968","Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery","Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status classification I-III\n* Patients (or their guardians) voluntarily participate in this study and sign a written informed consent form\n* Patients (or their guardians) are able to understand the study content and cooperate with the study protocol\n\nExclusion Criteria:\n\n* Known allergy to local anesthetics or opioid analgesics.\n* Presence of contraindications to local or epidural anesthesia.\n* Presence of undiagnosed or poorly characterized neuropathic pain.\n* Presence of severe mental illness that would impede the participant's ability to cooperate with study assessment and treatment procedures.\n* Clinically significant coagulopathy or current use of anticoagulant medications.\n* Presence of infection at the planned puncture site or systemic infection.\n* Pregnancy or lactation.","2 Years",{"count":98,"type":22},150,[56],"The purpose of this clinical trial is to understand the effectiveness of femoral nerve block, combined sciatic and femoral nerve block, lumbar plexus block, epidural block, and intravenous analgesia pump in the application of lower limb injury (total knee replacement, knee arthroscopy, patella fracture, femoral shaft fracture) surgery. It will also understand the safety of the drugs liposomal bupivacaine and ropivacaine. The main question it aims to answer is: Does nerve block reduce the number of times participants need to use analgesics postoperatively? The researchers will compare femoral nerve block, combined sciatic and femoral nerve block, lumbar plexus block, epidural block, and intravenous analgesia pump to see which analgesic method has the best postoperative analgesic effect. Participants will: undergo nerve block first, then endotracheal intubation general anesthesia after entering the operating room; record vital signs during surgery, record postoperative analgesic doses, NRS pain scores, patient satisfaction, and postoperative nausea and vomiting.",[30],"NOT_YET_RECRUITING","2025-01-14",{"date":105,"type":35},"2025-01-17",{"date":107,"type":22},"2025-01-20",{"date":109,"type":22},"2025-05-10",{"name":111,"class":42},"Xiaguang Duan"]