[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-degenerative-spondylolisthesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-degenerative-spondylolisthesis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100630540","opioid-free-and-opioid-based-anesthesia-in-elective-lumbar-spine-surgery-100630540",false,"NCT07489001","Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","Prospective Comparative Evaluation of Intra-operative and Postoperative Outcomes Associated With Opioid Free Versus Opioid Based Anesthesia Techniques in Patients Undergoing Elective Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Adults aged 18 to 75 years\n* Elective surgery only\n* Scheduled for elective lumbar spinal surgery (lumbar spinal stenosis and\u002For lumbar disc herniation)\n* ASA physical status I-III\n* No previous lumbar spine surgery\n* Able to provide written informed consent\n* BIS monitoring available and recorded\n* Ability to comply with postoperative pain assessment (NRS\u002FVAS)\n* Stable hemodynamic status preoperatively\n\nExclusion Criteria:\n\n* Age younger than 18 or older than 75\n* Inability or unwillingness to provide informed consent\n* Severe psychiatric disease or cognitive impairment\n* Emergency surgery cases\n* BMI \\> 40 kg\u002Fm²\n* Pregnancy\n* Uncontrolled hypertension, arrhythmia, or severe cardiac disease\n* Renal failure\n* Chronic beta-blocker use\n* Coagulation disorders\n* Chronic alcohol dependence or substance use\n* Neurological deficits affecting perception of pain\n* Chronic pain syndrome (fibromyalgia, chronic LBP \\> 3 months)\n* Chronic gabapentinoid use\n* Anemia\n* Known allergy to any anesthetic or analgesic agents used in the study\n* Local infection at the intended ESP block injection site\n* Intraoperative change in anesthetic technique that deviates from initial planned management\n* Pediatric patients (\\\u003C18 years)","ALL","18 Years","75 Years",{"count":20,"type":21},75,"ESTIMATED","OBSERVATIONAL","This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult patients undergoing lumbar spinal surgery. Patients will be managed according to routine clinical practice and assigned to one of three groups based on the analgesic strategy used by the attending anesthesiologist: (1) opioid-free anesthesia using multimodal agents and\u002For erector spinae plane (ESP) block; (2) ESP block plus intraoperative opioids; or (3) opioid-based anesthesia without regional blocks.\n\nThe primary objective is to compare postoperative pain control and opioid requirements within the first 48 hours after surgery. Secondary objectives include evaluating opioid-related side effects such as nausea, vomiting, pruritus, constipation, delayed mobilization, urinary retention, and postoperative complications classified according to the Clavien-Dindo system. Standard postoperative analgesia, including intravenous morphine patient-controlled analgesia (PCA), acetaminophen, and NSAIDs, will be provided for all patients.\n\nThe study aims to determine whether an opioid-free multimodal analgesic approach can reduce opioid consumption and related adverse effects while maintaining adequate analgesia in patients undergoing lumbar spinal surgery.",[25,26,27,28],"Lumbar Spinal Stenosis","Lumbar Disc Herniation With Radiculopathy","Lumbar Degenerative Spondylolisthesis","Lumbar Disc Degeneration",[30,31,32,33,34,35,36,37,38],"Opioid-Free Anesthesia","Multimodal Analgesia","Erector Spinae Plane Block","ESP Block","Postoperative Pain","Opioid-Related Adverse Effects","Opioid Consumption","Lumbar Spine Surgery","Regional Anesthesia","RECRUITING","2026-03-18",{"date":42,"type":43},"2026-03-23","ACTUAL",{"date":45,"type":43},"2025-12-09",{"date":47,"type":21},"2026-12-10",{"name":49,"class":50},"Marmara University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":51},"100615217","clinical-study-on-the-therapeutic-efficacy-of-biportal-endoscopic-decompression-spine-surgery-and-lumbar-decompression-fusion-surgery-in-the-treatment-of-degenerative-lumbar-spondylolisthesis-100615217","NCT07289737","Clinical Study on the Therapeutic Efficacy of Biportal Endoscopic Decompression Spine Surgery and Lumbar Decompression Fusion Surgery in the Treatment of Degenerative Lumbar Spondylolisthesis","Inclusion Criteria:\n\n1. Aged between 50 and 90 years old with a confirmed diagnosis of degenerative lumbar spondylolisthesis;\n2. Clinical symptoms include chronic pain, nerve compression, or motor dysfunction, confirmed by imaging studies (e.g., MRI or CT);\n3. No significant improvement after at least 3 months of conservative treatment (e.g., medication, physical therapy), meeting surgical indications;\n4. Understand and consent to the relevant procedures of this study, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Patients exhibiting acute spinal cord compression symptoms or requiring urgent surgical intervention;\n2. Patients with a history of spinal surgery or conditions such as spinal deformities, severe osteoporosis, or active infections that may compromise surgical outcomes;\n3. Patients with severe comorbidities affecting assessment, such as cardiovascular disease, liver or kidney failure, or uncontrolled diabetes;\n4. Patients with psychiatric disorders or cognitive impairments preventing understanding or cooperation with the study process;\n5. Patients with allergies to anesthetics or surgical equipment that may increase intraoperative risks.","50 Years","90 Years",{"count":61,"type":21},100,"This study aims to systematically evaluate the therapeutic efficacy of dual-channel endoscopic spinal decompression versus lumbar decompression with fusion for degenerative lumbar spondylolisthesis. Patients undergoing either procedure will undergo detailed preoperative and postoperative follow-up to compare outcomes between the two techniques, specifically assessing postoperative pain relief, neurological improvement, and the incidence of surgical complications.",[27],[65,66,27],"lumbar","ube","2025-12-04",{"date":69,"type":43},"2025-12-17",{"date":71,"type":21},"2025-12-10",{"date":73,"type":21},"2030-06-30",{"name":75,"class":50},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine"]