[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-disc-herniation-with-radiculopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-disc-herniation-with-radiculopathy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100625154","findisc-pain-finnish-discectomy-trial-on-the-benefits-and-harms-of-surgery-in-patients-with-lumbar-disc-herniation-100625154",false,"NCT07418944","FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation","FINDISC-Pain, Finnish Discectomy Trial - a Randomised, Placebo-surgery Controlled Trial. An Efficacy Trial Designed to Prove That Discectomy Can Work.","FINDISC-Pain","Inclusion Criteria:\n\n* Age 18-60 years\n* Diagnosed unilateral lower extremity radiculopathy (sciatica) secondary to lumbar disc herniation (LDH)\n* Single LDH at the level of L3\u002F4, L4\u002F5 or L5\u002FS1 on magnetic resonance imaging\n* Symptom duration minimum 6 weeks\n* NRS worst leg pain 5 or higher\n* Patient has not responded to at least one form of non-operative care\n* Patient willing to undergo surgery\n* Patient willing and able to give consent and comply with study procedures\n* Sufficient proficiency in the language of the study site to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* Doubtful nerve root compression\n* Spinal stenosis or any other confounding spinal condition\n* Far lateral disc herniation\n* Serious neurological deficit\n* Previous spinal surgery\n* Any contraindication to MRI\n* BMI \\> 35 or lumbar subcutaneous fat \\> 50 mm as determined from the MRI\n* ASA classification \\> 2\n* Being pregnant","ALL","18 Years","60 Years",{"count":21,"type":22},122,"ESTIMATED","INTERVENTIONAL",[25],"NA","The FINDISC trial studies whether common back operation, microdiscectomy, is effective and safe for treating sciatica caused by a lumbar disc herniation. The study includes people whose leg pain has not improved after at least six weeks of non-surgical treatment.\n\nThe FINDISC trial aims to recruit and randomly allocate 122 participants to receive either the actual operation (discectomy) or a placebo (sham) surgery. The placebo (sham) procedure involves anesthesia and an approach similar to the real operation, but no removal of disc material or bone. Participants and healthcare staff, excluding the surgical team, will not know which treatment was given. The study compares pain relief, recovery, daily functioning, quality of life, and harms between the two groups.\n\nThe goal of the study is to provide reliable evidence to help patients and clinicians decide whether microdiscectomy offers meaningful benefits compared with placebo surgery.",[28,29],"Lumbar Disc Herniation With Radiculopathy","Sciatica",[31,32,33,34,35,36],"randomized controlled trial","Placebos","Surgery","placebo-controlled trial","discectomy","patient acceptable symptoms state","RECRUITING","2026-05-20",{"date":40,"type":41},"2026-05-22","ACTUAL",{"date":43,"type":41},"2026-02-19",{"date":45,"type":22},"2030-12",{"name":47,"class":48},"Helsinki University Central Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":49},"100630540","opioid-free-and-opioid-based-anesthesia-in-elective-lumbar-spine-surgery-100630540","NCT07489001","Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","Prospective Comparative Evaluation of Intra-operative and Postoperative Outcomes Associated With Opioid Free Versus Opioid Based Anesthesia Techniques in Patients Undergoing Elective Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Adults aged 18 to 75 years\n* Elective surgery only\n* Scheduled for elective lumbar spinal surgery (lumbar spinal stenosis and\u002For lumbar disc herniation)\n* ASA physical status I-III\n* No previous lumbar spine surgery\n* Able to provide written informed consent\n* BIS monitoring available and recorded\n* Ability to comply with postoperative pain assessment (NRS\u002FVAS)\n* Stable hemodynamic status preoperatively\n\nExclusion Criteria:\n\n* Age younger than 18 or older than 75\n* Inability or unwillingness to provide informed consent\n* Severe psychiatric disease or cognitive impairment\n* Emergency surgery cases\n* BMI \\> 40 kg\u002Fm²\n* Pregnancy\n* Uncontrolled hypertension, arrhythmia, or severe cardiac disease\n* Renal failure\n* Chronic beta-blocker use\n* Coagulation disorders\n* Chronic alcohol dependence or substance use\n* Neurological deficits affecting perception of pain\n* Chronic pain syndrome (fibromyalgia, chronic LBP \\> 3 months)\n* Chronic gabapentinoid use\n* Anemia\n* Known allergy to any anesthetic or analgesic agents used in the study\n* Local infection at the intended ESP block injection site\n* Intraoperative change in anesthetic technique that deviates from initial planned management\n* Pediatric patients (\\\u003C18 years)","75 Years",{"count":59,"type":22},75,"OBSERVATIONAL","This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult patients undergoing lumbar spinal surgery. Patients will be managed according to routine clinical practice and assigned to one of three groups based on the analgesic strategy used by the attending anesthesiologist: (1) opioid-free anesthesia using multimodal agents and\u002For erector spinae plane (ESP) block; (2) ESP block plus intraoperative opioids; or (3) opioid-based anesthesia without regional blocks.\n\nThe primary objective is to compare postoperative pain control and opioid requirements within the first 48 hours after surgery. Secondary objectives include evaluating opioid-related side effects such as nausea, vomiting, pruritus, constipation, delayed mobilization, urinary retention, and postoperative complications classified according to the Clavien-Dindo system. Standard postoperative analgesia, including intravenous morphine patient-controlled analgesia (PCA), acetaminophen, and NSAIDs, will be provided for all patients.\n\nThe study aims to determine whether an opioid-free multimodal analgesic approach can reduce opioid consumption and related adverse effects while maintaining adequate analgesia in patients undergoing lumbar spinal surgery.",[63,28,64,65],"Lumbar Spinal Stenosis","Lumbar Degenerative Spondylolisthesis","Lumbar Disc Degeneration",[67,68,69,70,71,72,73,74,75],"Opioid-Free Anesthesia","Multimodal Analgesia","Erector Spinae Plane Block","ESP Block","Postoperative Pain","Opioid-Related Adverse Effects","Opioid Consumption","Lumbar Spine Surgery","Regional Anesthesia","2026-03-18",{"date":78,"type":41},"2026-03-23",{"date":80,"type":41},"2025-12-09",{"date":82,"type":22},"2026-12-10",{"name":84,"class":48},"Marmara University"]