[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-disc-herniation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-disc-herniation":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,44,71,99,123,146,176,212,241,271,296,322,357,386,413,438,461,480,506,528,550,572,595,615,643],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100603694","magnesium-sulfate-for-prevention-of-emergence-agitation-in-lumbar-disc-surgery-100603694",false,"NCT07139847","Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery","Effect of Intraoperative Magnesium Infusion on Postoperative Emergence Agitation in Patients Undergoing Lumbar Microdiscectomy","Inclusion Criteria:\n\nAge between 18 and 70 years\n\nASA physical status classification I or II\n\nScheduled for elective single-level lumbar microdiscectomy under general anesthesia\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nSevere cardiovascular disease\n\nHistory of psychiatric disorder\n\nNeuromuscular disease\n\nPregnancy or breastfeeding\n\nHepatic or renal dysfunction\n\nCurrent use of calcium channel blockers, hypnotics, anxiolytics, or antipsychotic medications\n\nKnown allergy to magnesium sulfate or study-related medications\n\nRefusal to participate in the study","ALL","18 Years","70 Years",{"count":21,"type":22},70,"ESTIMATED","1 Month","OBSERVATIONAL","In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under general anesthesia. The medical records of patients aged 18-70 years with an ASA physical status of I-II were retrospectively reviewed. Patients were evaluated according to whether they received intraoperative magnesium sulfate infusion as part of anesthetic management. The primary outcome measure was the incidence of emergence agitation in the post-anesthesia care unit; this assessment was based on Ramsay Sedation Scale scores recorded in the post-anesthesia care unit at admission and at 5, 10, 15, and 30 minutes. Secondary outcome measures included postoperative pain scores assessed using the Numeric Rating Scale, intraoperative remifentanil consumption, recovery and extubation times, tramadol requirement in the post-anesthesia care unit, and possible adverse events related to magnesium infusion.",[27,28,29],"Lumbar Disc Herniation","Emergence Agitation","Magnesium Sulfate",[29,27,31],"Postoperative Complications","NOT_YET_RECRUITING","2026-06-20",{"date":35,"type":36},"2026-06-25","ACTUAL",{"date":38,"type":22},"2026-07-05",{"date":40,"type":22},"2026-09-30",{"name":42,"class":43},"Ondokuz Mayıs University","OTHER",{"id":45,"slug":46,"hasResults":12,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100642132","evaluation-of-the-effectiveness-of-physical-therapy-for-low-back-pain-according-to-magnetic-resonance-imaging-findings-100642132","NCT07648927","Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Completion of 15 sessions of physical therapy.\n* Availability of accessible MRI images in the medical records.\n* No history of lumbar spine surgery.\n* Absence of conditions that may cause low back pain, including fibromyalgia, neuropathy, spondyloarthropathy, or scoliosis.\n\nExclusion Criteria:\n\n* Presence of comorbid conditions that may cause low back pain (fibromyalgia, rheumatologic diseases, scoliosis, herpes zoster, polyneuropathy, central pain syndromes).\n* Presence of systemic neuromuscular disorders.\n* Acute disc herniation or vertebral fracture.\n* Receipt of fewer or more than 15 sessions of physical therapy.\n* Missing data in follow-up records.\n* Use of analgesic medications during the treatment period.","65 Years",{"count":52,"type":22},120,"INTERVENTIONAL",[55],"NA","Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the relationship between MRI findings and treatment outcomes remains unclear. This retrospective study aims to evaluate whether the effectiveness of a standardized physical therapy program differs according to baseline lumbar MRI findings. Medical records of 120 patients with low back pain who underwent lumbar MRI and completed 15 sessions of physical therapy between January 2022 and February 2026 will be reviewed. Patients will be classified into three MRI-based groups: disc herniation, disc degeneration, and non-specific MRI findings. Treatment outcomes will be assessed using changes in Visual Analog Scale (VAS) pain scores and Oswestry Disability Index (ODI) scores before and after treatment. The findings may contribute to identifying patient subgroups that respond differently to conservative treatment and support more individualized rehabilitation strategies.",[58,59,60,27],"Low Back Pain","Physical Therapy","Lumbar Degenerative Disc Disease","2026-06-15",{"date":63,"type":36},"2026-06-16",{"date":65,"type":22},"2026-06-10",{"date":67,"type":22},"2026-09-10",{"name":69,"class":43},"Bahçeşehir University",1,{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100642126","comparison-of-early-mobilization-and-electrical-stimulation-on-functional-recovery-after-lumbar-disc-herniation-surgery-100642126","NCT07575477","Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery","Comparison Of Early Mobilization And Electrical Stimulation-Supported Rehabilitation On Functional Recovery, Pain Level, And Mobility After Lumbar Disc Herniation Surgery: A Prospective Randomized Controlled Trial","EMES-LDH","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Patients who have undergone primary lumbar disc herniation surgery\n* Being in the early postoperative period (within the first 2 weeks after surgery)\n* Clinically stable condition\n* Ability to understand and follow instructions\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* History of previous spinal surgery\n* Presence of severe neurological deficits (e.g., progressive motor loss, cauda equina syndrome)\n* Contraindications to electrical stimulation (e.g., pacemaker, implanted electronic devices)\n* Presence of severe systemic or uncontrolled chronic diseases (e.g., severe cardiovascular, respiratory, or metabolic disorders)\n* Cognitive impairment or inability to cooperate with rehabilitation program Pregnancy",{"count":80,"type":22},60,[55],"This randomized controlled trial aims to compare the effectiveness of early mobilization alone versus early mobilization combined with electrical stimulation on functional recovery following lumbar disc herniation surgery. Lumbar disc herniation is a common cause of low back pain and functional limitation, significantly affecting quality of life.\n\nAlthough surgical intervention is effective in patients who do not respond to conservative treatment, optimal postoperative recovery largely depends on appropriate rehabilitation strategies. Early mobilization is widely recommended to prevent complications, preserve muscle function, and facilitate return to daily activities. In addition, electrical stimulation modalities such as neuromuscular electrical stimulation (NMES) and transcutaneous electrical nerve stimulation (TENS) have been increasingly integrated into rehabilitation programs to enhance pain control, muscle activation, and neuromuscular re-education.\n\nIn this study, a total of 60 participants who have undergone primary lumbar disc herniation surgery will be randomly assigned into two groups. The first group will receive an early mobilization program alone, while the second group will receive early mobilization combined with electrical stimulation (NMES\u002FTENS). The intervention period will last 6 to 8 weeks, with sessions conducted three times per week.\n\nPrimary outcomes include functional disability measured by the Oswestry Disability Index (ODI) and pain intensity measured by the Visual Analog Scale (VAS). Secondary outcomes include functional mobility assessed by the Timed Up and Go (TUG) test, walking speed assessed by the 10-Meter Walk Test (10MWT), and muscle strength evaluated using manual muscle testing (MMT).\n\nThe findings of this study are expected to contribute to the development of evidence-based postoperative rehabilitation protocols and to clarify the clinical effectiveness of electrical stimulation in patients undergoing lumbar disc herniation surgery",[27,58,84],"Postoperative Rehabilitation",[86,87,88,89,90],"Lumbar Surgery","Early Mobilization","Electrical Stimulation","Physiotherapy","Functional Recovery","2026-06-12",{"date":63,"type":36},{"date":94,"type":22},"2026-06-30",{"date":96,"type":22},"2026-07-30",{"name":98,"class":43},"Istanbul Medipol University Hospital",{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":53,"phases":109,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":70},"100376551","phase-4-subjective-intraoperative-use-of-epidural-steroid-administration-following-discectomy-100376551","NCT04182997","Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy","Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy for Herniated Lumbar Discs Is There a Role? - A Randomized Control Trial","Intra-Op","Inclusion Criteria:\n\n* Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation\n* Failed conservative treatment - rest, anti-inflammatory medications, physical therapy\n* Radiculopathy present - positive tension signs or sensory\u002Fmotor neurologic deficits present\n* Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation\n\nExclusion Criteria:\n\n* Concomitant spinal stenosis, segmental instability, or spondylolisthesis\n* Previous surgery at the affected level or recurrent herniation\n* Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression\n* Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment\n* Diagnosis of or symptoms concerning for cauda equina syndrome",{"count":108,"type":22},200,[110],"PHASE4","The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.",[27],"RECRUITING","2026-05-31",{"date":116,"type":36},"2026-06-03",{"date":118,"type":36},"2019-11-21",{"date":120,"type":22},"2026-12",{"name":122,"class":43},"University of Missouri-Columbia",{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":53,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100638982","electroacupuncture-for-insomnia-in-patients-with-chronic-sciatica-due-to-lumbar-disc-herniation-a-randomized-controlled-trial-100638982","NCT07576348","Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial","Inclusion Criteria:\n\nParticipants will be eligible if they meet all of the following criteria:\n\n1. Aged 18-75 years, of either sex;\n2. Diagnosis with lumbar disc herniation accompanied by unilateral chronic sciatica (disease duration ≥ 3 months);\n3. Experiencing moderate to severe radiating leg pain (below the knee), defined as a Numerical Rating Scale (NRS) score ≥ 4 at screening within the past 24 h;\n4. Diagnosis of chronic insomnia, with a Pittsburgh Sleep Quality Index (PSQI) total score \\> 7;\n5. Onset or exacerbation of insomnia temporally associated with the onset or worsening of sciatica symptoms;\n6. Willing to participate and able to provide written informed consent.\n\nExclusion Criteria:\n\nParticipants will be excluded if any of the following criteria are met:\n\n1. Spinal or structural conditions: lumbar spinal stenosis, spondylolisthesis, vertebral fracture, spinal infection (e.g., tuberculosis), or tumor;\n2. Surgical indications: cauda equina syndrome, conus medullaris syndrome, or other conditions requiring urgent surgical intervention;\n3. Severe systemic diseases: unstable cardiovascular, hepatic, renal, respiratory, or hematological disorders, or metabolic conditions that may significantly affect study outcomes (e.g., uncontrolled diabetes or thyroid disease);\n4. Neurological or psychiatric disorders: major neurological diseases (e.g., epilepsy, Parkinson's disease, dementia, multiple sclerosis) or severe psychiatric disorders (e.g., schizophrenia);\n5. Clinically significant depression or anxiety, defined as Patient Health Questionnaire-9 (PHQ-9) ≥ 10 and\u002For Generalized Anxiety Disorder-7 (GAD-7) ≥ 10;\n6. Other primary sleep disorders, including obstructive sleep apnea, narcolepsy, or restless legs syndrome;\n7. Use of centrally acting medications: regular use (≥ 3 days\u002Fweek within 4 weeks prior to enrolment) of medications affecting the central nervous system (e.g., opioids, sedative-hypnotics, antidepressants) without an adequate washout period (≥ 2 weeks or longer depending on drug half-life);\n8. Irregular sleep patterns, including night shift work (≥ 2 times\u002Fweek between 22:00-06:00) or highly irregular sleep-wake cycles;\n9. Pregnancy or lactation;\n10. History of substance abuse or dependence;\n11. Lumbar spine surgery or interventional procedures within the past 3 months;\n12. History of acupuncture treatment;\n13. Implanted electronic devices (e.g., pacemakers) or metal implants at acupuncture sites;\n14. Participation in another clinical trial within the past 3 months;\n15. Severe sensory or cognitive impairment affecting assessment compliance;\n16. Any other condition deemed by investigators to compromise safety or data integrity.","75 Years",{"count":131,"type":22},114,[55],"The goal of this clinical trial is to learn if electroacupuncture can improve sleep in people with chronic sciatica caused by lumbar disc herniation. It will also assess the safety of this treatment. The main questions it aims to answer are whether electroacupuncture improves sleep quality and whether it reduces pain and improves daily function. Researchers will compare electroacupuncture to a sham treatment, which looks like real acupuncture but has little or no therapeutic effect, to determine its effectiveness. Participants will be randomly assigned to receive electroacupuncture or sham treatment, will receive treatment three times per week for four weeks, and will complete questionnaires about their sleep, pain, and daily activities.",[135,27,136],"Sciatica","Insomnia","2026-05-04",{"date":139,"type":36},"2026-05-08",{"date":141,"type":22},"2026-05",{"date":143,"type":22},"2027-03",{"name":145,"class":43},"Shanghai Yueyang Integrated Medicine Hospital",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":154,"targetDuration":4,"studyType":53,"phases":155,"briefSummary":156,"conditions":157,"keywords":161,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":4},"100634903","comparison-of-5-vs-8-cmho-peep-on-respiratory-mechanics-in-prone-lumbar-surgery-100634903","NCT07545733","Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery","The Effect of Different PEEP Levels Accompanied by PCV-VG Mode on Respiratory Mechanics and Gas Exchange in Lumbar Surgeries Performed in the Prone Position Under TIVA","PROPEEP","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective lumbar spine surgery in the prone position\n* Planned general anesthesia with total intravenous anesthesia (TIVA)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* History of significant pulmonary disease (e.g., COPD, asthma)\n* Severe cardiovascular disease\n* Pregnancy\n* Known difficult airway\n* Requirement for intraoperative vasopressor infusion due to hemodynamic instability\n* Conversion to different surgical position or change in surgical plan\n* Incomplete data or protocol deviation",{"count":80,"type":22},[55],"This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.",[27,158,159,160],"Spinal Surgery","Prone Position","General Anesthesia",[162,163,164,165,159,166],"PEEP","Driving Pressure","Mechanical Power","PCV-VG Ventilation","Lung Protective Ventilation","2026-04-28",{"date":169,"type":36},"2026-04-29",{"date":171,"type":22},"2026-05-01",{"date":173,"type":22},"2026-09-03",{"name":175,"class":43},"Harran University",{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":53,"phases":186,"briefSummary":187,"conditions":188,"keywords":198,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":208,"leadSponsor":210,"locationsCount":70},"100622663","biologic-injection-for-adults-with-lumbar-disc-herniation-100622663","NCT07386548","Biologic Injection For Adults With Lumbar Disc Herniation","Bone Marrow Aspirate Concentrate Injection With MRI's - A Prospective Randomized Control Trial","BMAC","Inclusion Criteria:\n\n* Male or female patients ≥ 18 years of age\n* Clinically and\u002For radiographically (MRI) confirmed diagnosis of degenerative disc disease of the lumbar spine, lumbar disc herniation, and indication for lumbar microdiscectomy surgery\n* Unresponsive to conservative\u002Fnon-operative treatment for \\>3 months\n* Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups and observe the treatment plan\n\nExclusion Criteria:\n\n* Prisoners\n* Individuals who are not yet adults (infants, children, teenagers)\n* Individuals who are not able to clearly understand English\n* Adults with diminished capacity to consent\n* Major cognitive impairment causing to inability to understand and provide informed consent\n* Active malignancy\n* Active chronic or acute infection\n* Autoimmune disorder that impacts the lumbar spine (ankylosing spondylitis, lupus e.g.)\n* Bone marrow-derived or non-bone marrow-derived cancer\n* Low platelet count or clotting disorders\n* Prior surgery at the level to be treated or the adjacent level",{"count":185,"type":22},90,[55],"The goal of this clinical trial is to find out whether adding a bone-marrow aspirate concentrate (BMAC) injection during surgery can improve recovery in adults undergoing lumbar microdiscectomy for a lumbar disc herniation.\n\nThe main questions it aims to answer are:\n\n* Does the BMAC injection lead to better disc tissue health after surgery (as seen on MRI scans)?\n* Does the BMAC injection lead to greater improvement in pain and disability compared to surgery alone?\n\nParticipants will be adults aged 18 and older who are scheduled for lumbar microdiscectomy surgery.\n\nResearchers will compare one group of participants receiving the standard-of-care surgery plus the BMAC injection with another group receiving the same surgery without the injection to see if the injection offers added benefit.\n\nParticipants will:\n\n* Have surgery (microdiscectomy) with or without the injection.\n* Complete pain and disability questionnaires at several times over 2 years.\n* Undergo MRI scans at baseline and follow-up to assess disc structure and tissue health.\n* Provide samples of leftover disc or bone-marrow tissue (as applicable) from surgery for analysis.",[189,190,191,192,27,193,194,195,58,196,197],"Degenerative Disc Disease","DDD","Degenerative Disc Disease Lumbar","Degenerative Disc Disease, Lumbar","Disc Herniation, Lumbar","Bone Marrow Aspirate Concentrate","Intervertebral Disc Displacement","Chronic Low Back Pain (CLBP)","CLBP - Chronic Low Back Pain",[199,200,201,202,203],"degenerative disc disease","lumbar disc herniation","bone marrow aspirate concentrate","intervertebral disc displacement","low back pain","2026-04-14",{"date":206,"type":36},"2026-04-16",{"date":171,"type":22},{"date":209,"type":22},"2030-12",{"name":211,"class":43},"Weill Medical College of Cornell University",{"id":213,"slug":214,"hasResults":12,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":220,"targetDuration":4,"studyType":53,"phases":221,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":4},"100633079","daytime-vs-evening-rehabilitation-in-lumbar-disc-herniation-patients-at-high-risk-for-obstructive-sleep-apnea-100633079","NCT07522021","Daytime vs Evening Rehabilitation in Lumbar Disc Herniation Patients at High Risk for Obstructive Sleep Apnea","Effects of Daytime and Evening Rehabilitation Programs on Sleep Quality and Daytime Sleepiness in Patients With Lumbar Disc Herniation at High Risk for Obstructive Sleep Apnea: A Randomized Controlled Trial","REHAB-TIME","Inclusion Criteria:\n\n* Individuals aged 18-65 years\n* High risk for obstructive sleep apnea, defined as a score \\>4 on the STOP-Bang questionnaire (Snoring, Tiredness, Observed apnea, high blood pressure, Body mass index, Age, Neck circumference, and Gender)\n* Presence of lumbar disc herniation (bulging, protrusion, or extrusion) at L1-S1 levels confirmed by magnetic resonance imaging (MRI)\n* Chronic low back pain lasting at least 3 months with clinical symptoms consistent with imaging findings\n* Mild to moderate radicular symptoms For participants over 55 years of age: single-level or dominant-level protrusion or extrusion-type disc herniation to minimize confounding effects of multilevel degeneration\n* Pain intensity ≥4 on the Visual Analog Scale (VAS) within the last week\n* Ability to participate regularly in the physiotherapy and rehabilitation program\n* Willingness to provide written informed consent Exclusion Criteria:\n* Presence of sequestrated disc herniation or cauda equina compression confirmed by magnetic resonance imaging (MRI)\n* Progressive motor deficit or significant muscle weakness\n* Indication for urgent surgical intervention\n* History of previous lumbar spine surgery\n* Low back pain due to specific causes (e.g., spinal tumor, infection such as spondylodiscitis, inflammatory rheumatic diseases, or traumatic fracture)\n* Previous use of continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BiPAP) therapy\n* Shift work or irregular sleep patterns\n* Major changes in sleep medication within the last 4 weeks\n* Contraindications to electrotherapy (e.g., pacemaker or implanted electronic devices, suspected malignancy, sensory loss in the treatment area, open wounds, or infection)\n* Cardiopulmonary conditions that contraindicate exercise\n* Uncontrolled hypertension or advanced heart failure\n* Pregnancy\n* Severe psychiatric disorders or cognitive impairment\n* Neurological disorders (e.g., multiple sclerosis, stroke sequelae)\n* Epidural or facet joint injection within the last 3 months\n* Diagnosed severe obesity hypoventilation syndrome or severe chronic obstructive pulmonary disease (COPD)\n* Refusal to provide informed consent",{"count":80,"type":22},[55],"Lumbar disc herniation is a common musculoskeletal condition that negatively affects quality of life, physical function, and daily activities. Previous studies have shown that individuals with lumbar disc herniation often experience poor sleep quality, which is closely related to pain severity and functional limitations. In addition, a bidirectional relationship exists between chronic pain and sleep disturbances, where poor sleep can increase pain perception, and pain can further impair sleep.\n\nObstructive sleep apnea (OSA) is a common sleep-related breathing disorder associated with reduced sleep quality, daytime dysfunction, and adverse health outcomes. The STOP-Bang questionnaire (Snoring, Tiredness, Observed apnea, high blood Pressure, Body mass index, Age, Neck circumference, and Gender) is a widely used and practical screening tool to identify individuals at high risk for OSA in clinical settings.\n\nPhysiotherapy and rehabilitation programs are commonly used in the conservative management of lumbar disc herniation and have been shown to improve pain and functional outcomes. However, the effect of the timing of rehabilitation (daytime versus evening) on sleep-related outcomes has not been sufficiently investigated. Considering that circadian rhythms influence pain perception, physiological processes, and sleep regulation, the timing of rehabilitation interventions may play an important role in clinical outcomes.\n\nTherefore, this randomized controlled trial aims to investigate the effects of daytime versus evening rehabilitation programs on sleep quality and daytime sleepiness in patients with lumbar disc herniation who are at high risk for obstructive sleep apnea.",[27,224],"Obstructive Sleep Apnea Risk Management",[27,226,227,228,229,89,230,231],"Obstructive Sleep Apnea risk management","Sleep Quality","Daytime Sleepiness","Rehabilitation","Exercise Therapy","Randomized Controlled Trial","2026-04-03",{"date":234,"type":36},"2026-04-13",{"date":236,"type":22},"2026-04-10",{"date":238,"type":22},"2026-11-12",{"name":240,"class":43},"Mardin Artuklu University",{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":248,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":250,"conditions":251,"keywords":254,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100632663","clinical-and-mri-findings-in-lumbar-disc-disease-100632663","NCT07516613","Clinical and MRI Findings in Lumbar Disc Disease","Correlation Between Clinical Parameters and MRI Imaging Findings in Lumbar Disc Disease","Inclusion Criteria:\n\n* Adult patients aged 18-70 years presenting with clinical symptoms suggestive of lumbar disc disease (low back pain with or without radiculopathy).\n* Patients with MRI-confirmed lumbar disc pathology (disc bulge, protrusion, extrusion, or sequestration) at one or more levels.\n* Patients who have had lumbar MRI performed within 3 months prior to enrollment.\n* Patients able to communicate clearly and complete assessment questionnaires.\n* Patients providing written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with previous lumbar spine surgery.\n* Patients with spinal fractures, tumors, infections, or inflammatory spondyloarthropathies (e.g., ankylosing spondylitis).\n* Patients with severe psychiatric disorders that interfere with assessment.\n* Patients with contraindications to MRI (e.g., pacemakers, metallic implants).\n* Patients with cauda equina syndrome requiring emergency surgical intervention.\n* Patients with peripheral neuropathy from systemic causes (e.g., diabetes mellitus with confirmed neuropathy, renal failure).\n* Pregnant women.\n* Patients who refuse to participate or provide informed consent.",{"count":249,"type":22},96,"Low back pain related to lumbar disc disease is a very common condition. Doctors frequently use Magnetic Resonance Imaging (MRI) to look at the spine and diagnose these problems. However, it is not always clear how well the severity of the damage seen on an MRI matches the actual symptoms a patient is experiencing. Sometimes, patients with severe MRI findings have mild symptoms, and vice versa.\n\nThe purpose of this observational study is to understand the relationship between a patient's clinical symptoms and their MRI results. Researchers want to see if the severity of the spinal damage shown on an MRI can accurately predict how much pain or disability a patient has.\n\nParticipants in this study are adults (ages 18-70) who are already experiencing symptoms of lumbar disc disease and have recently had an MRI. During the study, participants will:\n\n* Complete a questionnaire about the intensity of their back and leg pain.\n* Fill out a survey about how their back pain affects their daily activities.\n* Undergo a standard physical and neurological examination by a doctor to check their reflexes, muscle strength, and sensation.\n\nResearchers will then compare these physical examination and questionnaire results with the detailed findings from the patient's MRI scans. The goal of this research is to improve diagnostic accuracy and help doctors make better, more personalized treatment decisions for future patients with lower back pain.",[252,58,27,253],"Lumbar Disc Disease","Lumbosacral Radiculopathy",[255,256,257,258,259,260,261],"Magnetic Resonance Imaging (MRI)","Visual Analog Scale (VAS)","Oswestry Disability Index (ODI)","Pfirrmann Grading System","Nerve Root Compression","Spinal Canal Stenosis","Disc Degeneration","2026-04-01",{"date":264,"type":36},"2026-04-08",{"date":266,"type":22},"2026-04",{"date":268,"type":22},"2027-05",{"name":270,"class":43},"Assiut University",{"id":272,"slug":273,"hasResults":12,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":278,"sex":17,"minAge":279,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":53,"phases":283,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":70},"100615520","iastm-and-vibration-effects-on-pain-functionality-and-kinesiophobia-in-lumbar-disc-herniation-100615520","NCT07293676","IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation","The Effects of Instrument-Assisted Soft Tissue Mobilization and Vibration Therapy on Pain, Functionality, and Kinesiophobia in Individuals With Lumbar Disc Herniation","Inclusion Criteria:\n\n* Individuals between 30 and 60 years of age\n* Individuals diagnosed with lumbar disc herniation at the protrusion level\n* Individuals with no cognitive, intellectual, or mental impairments and who are able to express themselves\n* Individuals with a VAS score greater than 5\n* Individuals experiencing pain for at least 3 months\n\nExclusion Criteria:\n\n* Individuals with a history of lumbar surgery\n* Individuals who are pregnant\n* Individuals who have had a spinal tumor or any other malignancy within the past six months\n* Individuals who have received physiotherapy for low back pain within the last six months\n* Individuals with orthopedic conditions such as fractures\n* Individuals diagnosed with neurological, rheumatological, or psychological disorders\n* Individuals with diagnoses such as infection, spondylosis, spondylolysis, osteoporosis, or ankylosing spondylitis will be excluded from the study.",true,"30 Years","60 Years",{"count":282,"type":22},45,[55],"The aim of this study is to investigate the effects of Instrument-Assisted Soft Tissue Mobilization and vibration massage therapy on pain, functionality, and kinesiophobia in individuals with lumbar disc herniation.",[286,27,287],"Vibration","Soft Tissue Mobilization","2026-03-24",{"date":290,"type":36},"2026-03-27",{"date":292,"type":36},"2026-01-05",{"date":294,"type":22},"2026-05-15",{"name":98,"class":43},{"id":297,"slug":298,"hasResults":12,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":303,"targetDuration":4,"studyType":53,"phases":305,"briefSummary":306,"conditions":307,"keywords":309,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":4},"100627013","comparison-of-virtual-reality-based-and-routine-preoperative-education-on-surgical-anxiety-and-salivary-cortisol-100627013","NCT07443111","Comparison of Virtual Reality-Based and Routine Preoperative Education on Surgical Anxiety and Salivary Cortisol","Comparative Evaluation of the Effect of Virtual Reality-Based Preoperative Education on Surgical Anxiety Using Psychometric Measures and Salivary Cortisol: A Randomized Controlled Pilot Trial","Inclusion Criteria:\n\nAge between 18 and 65 years\n\nHospitalized patients scheduled for elective lumbar disc herniation surgery in the preoperative period\n\nAmerican Society of Anesthesiologists (ASA) physical status I-III\n\nAble to read and understand Turkish and be literate\n\nSufficient cognitive capacity to understand the informed consent form (no advanced dementia, severe aphasia, impaired consciousness, or neurological\u002Fpsychiatric condition interfering with communication)\n\nWilling to complete the State Anxiety Inventory - State form (STAI-S) for surgical anxiety assessment and to provide a saliva sample using a non-invasive method\n\nNo severe visual impairment that would prevent the use of a virtual reality headset (visual impairments correctable with glasses or contact lenses are acceptable)\n\nProvision of written and verbal informed consent\n\nExclusion Criteria:\n\nPresence of an emergency or urgent neurosurgical indication (e.g., traumatic acute subdural hematoma, acute intracranial hemorrhage with herniation signs)\n\nHistory of diagnosed epilepsy, particularly photosensitive epilepsy\n\nSevere cognitive impairment, severe aphasia, lack of cooperation, or altered level of consciousness\n\nHistory of psychiatric hospitalization within the last 6 months due to severe psychiatric disorders such as psychotic disorder, bipolar disorder, or severe major depressive disorder\n\nChronic systemic steroid use or endocrine disorders significantly affecting adrenal cortex function (e.g., Cushing syndrome, Addison's disease)\n\nUntreated severe thyroid disease that may affect cortisol metabolism\n\nHistory of severe vertigo or vestibular disorders with prior intolerance to VR-like visual stimuli\n\nSevere visual impairment not correctable with glasses or contact lenses that would prevent adequate perception of VR content\n\nInability to complete the VR session due to nausea, dizziness, or similar symptoms during headset use (in such cases, the intervention will be discontinued and the participant will be withdrawn from the study)\n\nSevere oral lesions, active serious oral infection, or significant salivary gland pathology interfering with saliva sampling\n\nKnown pregnancy or suspected pregnancy\n\nParticipation in another randomized controlled trial or VR-based intervention within the last 3 months\n\nWithdrawal of consent during the study or cancellation\u002Fpostponement of the scheduled surgical procedure",{"count":304,"type":22},56,[55],"This randomized controlled pilot study aims to compare the effects of virtual reality-based preoperative education and routine preoperative education on surgical anxiety in patients undergoing lumbar disc surgery. In addition to evaluating psychological outcomes, the study will also compare psychometric anxiety assessments with a biological stress marker, salivary cortisol, to examine the relationship between subjective and physiological stress responses.\n\nPreoperative anxiety is common among surgical patients and may negatively influence both emotional well-being and physiological stress regulation. Virtual reality-based education may provide a more immersive and engaging learning experience compared to routine education, potentially reducing anxiety levels.\n\nParticipants will be randomly assigned to either a virtual reality-based education group or a routine preoperative education group. Surgical anxiety will be assessed using validated psychometric measurement tools, and physiological stress response will be evaluated through salivary cortisol analysis. The study will further explore the concordance between psychometric findings and biological stress indicators.\n\nThe results may contribute to the development of innovative, evidence-based nursing interventions and provide insight into the relationship between psychological and biological indicators of preoperative anxiety.",[27,308],"Preoperative Anxiety",[310,27,308,311,231,312],"Virtual Reality","Salivary Cortisol","Nursing Intervention","2026-02-25",{"date":315,"type":36},"2026-03-02",{"date":317,"type":22},"2026-02-27",{"date":319,"type":22},"2026-05-27",{"name":321,"class":43},"Bezmialem Vakif University",{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":53,"phases":332,"briefSummary":333,"conditions":334,"keywords":343,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":348,"lastUpdatePostDateStruct":349,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":70},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation","80 Years",{"count":331,"type":22},125,[110],"Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[335,27,336,337,338,339,340,189,341,342],"Lumbar Spinal Stenosis","Lumbar Spondylolisthesis","Lumbar Spondylosis","Lumbar Radiculopathy","Lumbar Spine Instability","Synovial Cyst","Degenerative Spondylolisthesis","Degenerative Intervertebral Discs",[344,345,346,347],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","2026-02-11",{"date":350,"type":36},"2026-02-17",{"date":352,"type":36},"2022-02-01",{"date":354,"type":22},"2027-04-30",{"name":356,"class":43},"John O'Toole",{"id":358,"slug":359,"hasResults":12,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":363,"targetDuration":365,"studyType":24,"phases":4,"briefSummary":366,"conditions":367,"keywords":372,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":382,"leadSponsor":383,"locationsCount":385},"100624720","investigation-of-preoperative-factors-influencing-the-outcome-of-motor-deficits-in-patients-undergoing-lumbar-microdiskectomy-100624720","NCT07413302","Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy","Inclusion Criteria:\n\n* Patients suffering from lower limb paresis (motor deficit) caused by lumbar disk herniation undergoing a single-level microdiskectomy\n* Age (years) \\> 17\n\nExclusion Criteria:\n\n* Age (years) \\\u003C 18\n* Medical history of lumbar spine surgery\n* Absence of limb paresis\n* Motor deficit caused by other than disk herniation aetiologies\n* Reoperation within 6 months after microdiskectomy\n* Microdiskectomy at more than one level\n* Cauda equina syndrome\n* Peripheral neuropathy",{"count":364,"type":22},40,"6 Months","Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy. This clinical study aims to investigate preoperative factors that may influence the postoperative outcomes of patients undergoing this procedure.",[368,369,370,371,27],"Motor Deficits","Lumbar Discectomy","Muscle Weakness","Paresis",[373,200,374,375,376,377],"microdiscectomy","motor deficit","lower limb paresis","prognostic factors microdiscectomy","disc herniation outcome","2026-02-09",{"date":350,"type":36},{"date":381,"type":36},"2024-07-03",{"date":120,"type":22},{"name":384,"class":43},"Aristotle University Of Thessaloniki",3,{"id":387,"slug":388,"hasResults":12,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":392,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":394,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":396,"conditions":397,"keywords":398,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":70},"100623702","pldd-with-or-without-transforaminal-epidural-steroid-injection-in-lumbar-disc-herniation-100623702","NCT07400068","PLDD With or Without Transforaminal Epidural Steroid Injection in Lumbar Disc Herniation","Effect of Adjunct Transforaminal Anterior Epidural Steroid Injection Following Percutaneous Laser Disc Decompression in Patients With Single-Level Lumbar Disc Herniation: A Prospective Observational Study","PLDD-TFESI","Inclusion Criteria:\n\nAge 18 years and older\n\nDiagnosis of single-level lumbar disc herniation confirmed by magnetic resonance imaging (MRI)\n\nPresence of radicular leg pain refractory to conservative treatment\n\nUndergoing routine percutaneous laser disc decompression (PLDD) as part of standard clinical care\n\nAbility to provide informed consent\n\nExclusion Criteria:\n\nMultilevel lumbar disc herniation\n\nExtruded or sequestered disc herniation\n\nSevere spinal canal stenosis or spinal instability\n\nPrevious lumbar spine surgery at the affected level\n\nActive infection or systemic inflammatory disease\n\nCoagulopathy or use of anticoagulant therapy contraindicating intervention\n\nPregnancy\n\nInability to complete follow-up assessments",{"count":395,"type":22},88,"This prospective observational study aims to evaluate the clinical outcomes of patients with single-level lumbar disc herniation who undergo routine percutaneous laser disc decompression (PLDD).\n\nIn routine clinical practice, some patients receive an additional transforaminal anterior epidural steroid injection during the same session without an extra puncture. This study will prospectively follow patients who receive PLDD alone and those who receive PLDD combined with epidural steroid injection.\n\nPain intensity, functional status, analgesic use, need for additional interventions, and complications will be assessed over time. The results may help to clarify whether adding epidural steroid injection to PLDD improves clinical outcomes in patients with lumbar disc herniation.",[27,338],[399,400,401,402,403],"Percutaneous Laser Disc Decompression","Transforaminal Epidural Steroid Injection","Minimally Invasive Spine Treatment","Radicular Pain","PLDD","2026-02-03",{"date":406,"type":36},"2026-02-10",{"date":408,"type":22},"2026-03-01",{"date":410,"type":22},"2027-09-01",{"name":412,"class":43},"Mersin University",{"id":414,"slug":415,"hasResults":12,"nctId":416,"briefTitle":417,"officialTitle":417,"acronym":4,"eligibilityCriteria":418,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":419,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":420,"conditions":421,"keywords":423,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":70},"100621174","the-role-of-temporal-changes-in-pain-response-after-transforaminal-epidural-steroid-injection-on-treatment-success-100621174","NCT07367191","The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment Success","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Pre-procedural Numeric Rating Scale (NRS) pain score of 4 or higher\n* Presence of segmental lumbar disc herniation demonstrated on magnetic resonance imaging (MRI) consistent with clinical findings\n* Undergoing fluoroscopy-guided transforaminal epidural steroid injection due to insufficient response to conservative treatments, as determined by the algology clinic\n\nExclusion Criteria:\n\n* Presence of spondylolisthesis, scoliosis, or lumbar spinal stenosis accompanying lumbar disc herniation\n* Presence of malignancy\n* History of lumbar spine surgery for disc herniation\n* Transforaminal epidural steroid injection within the previous 6 months\n* Requirement for repeat epidural steroid injection during the data collection or follow-up period\n* Inability to be contacted for follow-up assessments by telephone",{"count":52,"type":22},"Transforaminal epidural steroid injection (TFESI) is a commonly used minimally invasive procedure for the treatment of lumbar radicular pain secondary to disc herniation. Although TFESI has been shown to provide significant pain relief in a substantial proportion of patients, the onset, duration, and temporal pattern of pain relief after the procedure vary considerably among individuals. The relationship between early pain response patterns and long-term treatment success remains poorly understood.\n\nThis prospective observational study aims to evaluate whether temporal changes in pain intensity following TFESI, particularly during the early post-procedural period, are associated with clinical treatment success at mid- and long-term follow-up. Pain intensity will be assessed using the Numeric Rating Scale (NRS) at predefined time points following the procedure, and treatment success will be defined as a ≥50% reduction in NRS score compared with baseline.",[27,338,422,135],"Radicular Low Back Pain",[424,425,426,427,400,428],"TFESI","Temporal Pain Response","Numeric Rating Scale","NRS","Treatment Success","2026-01-16",{"date":431,"type":36},"2026-01-26",{"date":433,"type":22},"2026-02-15",{"date":435,"type":22},"2026-10-15",{"name":437,"class":43},"Marmara University",{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":442,"acronym":443,"eligibilityCriteria":444,"healthyVolunteers":12,"sex":17,"minAge":445,"maxAge":280,"enrollmentInfo":446,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":448,"conditions":449,"keywords":450,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":459,"locationsCount":70},"100618753","evaluation-of-the-effectiveness-of-focused-radiofrequency-tecar-therapy-on-pain-disability-function-and-quality-of-life-in-patients-with-lumbar-disc-herniation-100618753","NCT07335718","Evaluation of the Effectiveness of Focused Radiofrequency (TECAR) Therapy on Pain, Disability, Function, and Quality of Life in Patients With Lumbar Disc Herniation","TECAR THERAPY","Inclusion Criteria:\n\n* Having low back pain lasting longer than 12 weeks\n\nHaving a diagnosis of lumbar disc herniation (bulging, protruded, or extruded)\n\nBeing able to comply with the exercise program\n\nWillingness to participate in the study Being between 20 and 60 years of age\n\nExclusion Criteria:\n\nBeing younger than 20 years or older than 60 years\n\nHaving a known and\u002For newly diagnosed malignancy\n\nPresence of cardiac implants such as a pacemaker\n\nHaving inflammatory low back pain\n\nHaving absolute spinal stenosis (anteroposterior diameter of the spinal canal \\\u003C 10 mm and anteroposterior diameter of the lateral recess \\\u003C 3 mm)\n\nHistory of surgery due to lumbar disc herniation, lumbar spinal stenosis, vertebral fracture, or similar conditions\n\nPresence of lumbar spondylolisthesis\n\nPatients with sequestered disc herniation\n\nPatients with polyneuropathy\n\nPatients with central pain following stroke\n\nPatients with neurological deficits\n\nHaving a diagnosed neurodegenerative disease\n\nHaving a systemic musculoskeletal disease\n\nPatients with acute deep vein thrombosis\n\nPregnancy\n\nPresence of infection at the skin surface where treatment will be applied\n\nUnexplained weight loss\n\nBladder and\u002For bowel incontinence\n\nHaving received physical therapy modalities or injections for low back pain within the last 1 month\n\nHaving cognitive impairment\n\nRefusal to participate in the study\n\n\\-","20 Years",{"count":447,"type":22},54,"Low back pain is a very common health problem in societies, regardless of the underlying cause. Its lifetime prevalence has been reported to be as high as 75-80%. Low back pain negatively affects the quality of life of affected individuals. In addition to diagnostic and treatment costs, it can lead to serious physical disability, resulting in loss of workforce and placing a substantial economic burden on countries. Many different factors play a role in the etiology of low back pain. According to etiology, it can be classified as idiopathic, mechanical, rheumatologic, metabolic, endocrine, infectious, neoplastic, neurologic\u002Fpsychiatric disorders, and pain of visceral origin. The treatment of low back pain can be classified into medical treatment, physical therapy, percutaneous invasive interventions, and surgical intervention. TECAR therapy is also one of the treatment modalities routinely used in clinical practice. Our aim is to develop more effective physical therapy programs.",[27],[27,451,452],"TECAR Therapy","Pain","2026-01-02",{"date":455,"type":36},"2026-01-13",{"date":457,"type":36},"2025-01-01",{"date":433,"type":22},{"name":460,"class":43},"Ankara City Hospital Bilkent",{"id":462,"slug":463,"hasResults":12,"nctId":464,"briefTitle":465,"officialTitle":465,"acronym":4,"eligibilityCriteria":466,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":467,"targetDuration":4,"studyType":53,"phases":469,"briefSummary":470,"conditions":471,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":477,"leadSponsor":479,"locationsCount":4},"100616986","comparison-between-insertion-of-bilateral-straight-cages-versus-unilateral-banana-cage-in-lumbar-fusion-surgery-100616986","NCT07312747","Comparison Between Insertion of Bilateral Straight Cages Versus Unilateral Banana Cage in Lumbar Fusion Surgery","Inclusion Criteria:\n\n* • Symptomatic discogenic low back pain with Radiological evidence of disc degeneration, instability, or spondylolisthesis\n\n  * Failed medical treatment \\> 6 months\n\nExclusion Criteria:\n\n* • Patients unfit for surgery .\n\n  * Active spinal infection ,Osteoporosis",{"count":468,"type":22},30,[55],"\\- To compare the clinical outcomes of bilateral straight cages and unilateral banana cage insertion in lumbar interbody fusion surgery, assess radiological outcomes, including intervertebral disc height, lumbar lordosis angle, and radiographic evidence of fusion, evaluate the rate of complications, such as cage migration, subsidence, pseudoarthrosis, and adjacent segment degeneration and analyze differences in operative time, blood loss, and length of hospital stay between the two techniques",[27],"2025-12-17",{"date":474,"type":36},"2025-12-31",{"date":476,"type":22},"2026-01-01",{"date":478,"type":22},"2028-02-01",{"name":270,"class":43},{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":486,"eligibilityCriteria":487,"healthyVolunteers":278,"sex":17,"minAge":280,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":489,"conditions":490,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":497,"lastUpdatePostDateStruct":498,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":70},"100616770","gait-and-paraspinal-semg-in-degenerative-spinal-diseases-100616770","NCT07309926","Gait and Paraspinal sEMG in Degenerative Spinal Diseases","Comparative Analysis of Spatiotemporal Gait Parameters and Paraspinal Surface Electromyography Parameters in Degenerative Spinal Diseases: A Cross-Sectional Study Using Motion Capture and Electromyographic Ensemble Averaging","TDGKSEPDSD","Inclusion Criteria:\n\n1. Patients with the following single disease: degenerative scoliosis, coronal imbalance, lumbar spinal stenosis, lumbar disc herniation, spinal cord-type cervical spondylosis;\n2. Age ≥ 60 years, regardless of gender;\n3. Planned to undergo elective open spinal fusion surgery;\n4. Voluntarily participate in the study, understand and agree to the study content, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous spinal surgery;\n2. Combined with other neuromuscular diseases (such as Parkinson's disease), inflammatory diseases (such as ankylosing spondylitis), infectious diseases (such as spinal tuberculosis), sepsis, tumors, or lower limb joint diseases that may cause low back and lower limb pain, affecting physical activity;\n3. Suffering from severe cardiovascular, cerebral, liver, or kidney disease;\n4. Suffering from mental illness, dementia, or unable to cooperate to complete clinical research.\n\n   * Skin rupture in the waist;",{"count":52,"type":22},"This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondylotic myelopathy (CSM)-alongside a healthy control group. The analysis focuses on spatiotemporal gait characteristics (step length, stride length, cadence), lower limb kinematics and kinetics (hip\u002Fknee\u002Fankle joint angles, moments, and powers during stance and swing phases), and surface EMG amplitudes (thoracic erector spinae, multifidus, gluteus maximus, and rectus abdominis muscles) during standardized walking tasks. Additionally, radiological parameters (e.g., pelvic incidence-lumbar lordosis mismatch, C2-C7 sagittal vertical axis, coronal Cobb angle) will be correlated with gait and muscle activation deviations. The study employs motion capture systems, force plates, and high-density EMG to objectively differentiate disease-specific movement impairments. Findings from this study may establish biomechanical and neuromuscular signatures for each degenerative condition, providing a framework for personalized rehabilitation strategies, gait retraining, and surgical outcome assessment in spinal disorders. Comparative analysis with healthy controls will further elucidate pathological alterations in gait and muscle recruitment patterns caused by degenerative spinal diseases.",[491,492,493,494,495,335,27,496],"Adult Spinal Deformity","Degenerative Scoliosis","Sagittal Deformity","Sagittal Imbalance","Coronal Vertical Axis","Cervical Spondylosis With Myelopathy","2025-12-15",{"date":499,"type":36},"2025-12-30",{"date":501,"type":22},"2025-12-10",{"date":503,"type":22},"2029-12-01",{"name":505,"class":43},"Xuanwu Hospital, Beijing",{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":4,"eligibilityCriteria":512,"healthyVolunteers":278,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":513,"targetDuration":4,"studyType":53,"phases":514,"briefSummary":515,"conditions":516,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":70},"100606089","the-effect-of-ney-music-on-patients-undergoing-lumbar-disc-surgery-100606089","NCT07171008","The Effect of Ney Music on Patients Undergoing Lumbar Disc Surgery","The Effect of Ney Music on Pain, Anxiety, Sleep, and Quality of Life in Patients Undergoing Lumbar Disc Surgery","Inclusion Criteria:\n\n* Having undergone lumbar disc surgery under general anesthesia\n\n  * 18 years old and over,\n  * At least 3 hours have passed from the analgesic administration,\n  * Patients willing to participate in the study will be included in the study.\n\nExclusion Criteria:\n\n* Patient-controlled analgesia (PCA) is applied,\n\n  * Over 70 years old,\n  * Using anxiolytic and sedative drugs,\n  * Having a psychiatric illness,\n  * Patients with communication barriers will not be included in the study.",{"count":80,"type":22},[55],"This randomized controlled study aims to investigate the effects of ney music listening, a traditional Turkish wind instrument, on pain, anxiety, sleep quality, and vital signs in patients undergoing lumbar disc herniation surgery. Participants will be randomly assigned to intervention and control groups. The intervention group will receive a 15-minute ney music session at three different time points: preoperative (on the day of surgery), postoperative 3rd hour, and postoperative day 1. The control group will receive standard postoperative nursing care without music intervention. Data will be collected at the same time points in both groups using the Visual Analog Scale (VAS), State-Trait Anxiety Inventory (STAI-I), Richard-Campbell Sleep Questionnaire, and vital signs. The study seeks to evaluate the non-pharmacological benefits of therapeutic music in postoperative recovery.",[27,517,518],"Surgery","Nurse's Role","2025-11-23",{"date":521,"type":36},"2025-11-25",{"date":523,"type":36},"2025-04-01",{"date":525,"type":22},"2025-12-01",{"name":527,"class":43},"Niran Çoban",{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":17,"minAge":535,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":53,"phases":538,"briefSummary":539,"conditions":540,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":548,"locationsCount":70},"100581655","baduanjin-with-resistance-training-program-100581655","NCT06853132","Baduanjin With Resistance Training Program","Baduanjin With Resistance Training Program for Elderly Patients With Osteoporosis and Lumbar Disc Herniation","Inclusion Criteria:\n\n* Patients diagnosed with LDH and OP based on the chart and clinical diagnostic criteria.\n* Age of female patients ≥ 45 years，age of male patients ≥ 50 years.\n* Visual analogue scale (VAS) ≥ 3 points.\n* Surgical operation will be performed during the 7-day admission period.\n* Mandarin speakers.\n\nExclusion Criteria:\n\n* Severe primary diseases: ulcerative colitis, gastrointestinal bleeding, pancreatitis, lung cancer, pneumonia, acute respiratory distress syndrome or psychosis, depression, anxiety or substance abuse, identified by diagnosis and interview.\n* Current engagement in regular physical activity routines over the past 3 months: aerobic exercises for at least 30 minutes, at least 3 times per week.\n* Taken drugs within 3 months before enrollment: bisphosphonates, glucocorticoids, calcitonin, anticonvulsant drugs, heparin, etc.","45 Years",{"count":537,"type":22},110,[55],"The purpose of this study is to improve symptoms of Lumbar Disc Herniation (LDH) and Osteoporosis (OP) by implementing an evidence-based Baduanjin exercise to reduce pain and increase muscle strength and quality of life in Chinese patients. This study will provide new sights of exercise of elderly patients with LDH and OP for elderly patients.",[541,27],"Osteoporosis","2025-11-17",{"date":544,"type":36},"2025-11-21",{"date":546,"type":36},"2025-08-30",{"date":94,"type":22},{"name":549,"class":43},"Yale University",{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":129,"enrollmentInfo":557,"targetDuration":4,"studyType":53,"phases":559,"briefSummary":560,"conditions":561,"keywords":562,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":570,"locationsCount":70},"100607130","lumbar-disc-hernia-erector-spinae-plane-block-ilesi-100607130","NCT07184554","Lumbar Disc Hernia, Erector Spinae Plane Block, Ilesi","Comparison of the Effectiveness of Lumbar Erector Spinae Plane Block and Lumbar Interlaminar Epidural Steroid Injection in Patients With Lumbar Disc Herniation.","Inclusion Criteria:\n\n* Patients with chronic low back pain caused by L4-L5 and L5-S1 lumbar disc herniation accompanied by radicular pain, including those diagnosed by MRI, will be included.\n* Patients with low back pain above VAS 5 for more than 6 weeks will be included.\n* Failure of pain treatment with conservative methods such as analgesics and physical therapy\n\nExclusion Criteria:\n\n* Patients who have previously undergone lumbar surgery,\n* Patients with spinal deformity and stenosis,\n* Patients with uncontrolled diabetes\n* Patients allergic to the drugs to be used will not be included in the study.\n* Presence of psychiatric comorbidity\n* Local or systemic infection\n* Coagulopathy\n* Presence of rheumatological disease",{"count":558,"type":22},80,[55],"The study is designed as an observational study. Patients who have been treated and completed treatment for lumbar discopathy in our clinic will be followed. Patients will not be divided into groups beforehand, and this will not cause changes to the treatment plan. Patients who have undergone fluoroscopy-guided lumbar interlaminar epidural steroid injection (LESI) and ultrasound-guided lumbar erector spinae plane block (LESP), routinely performed in our clinic for the treatment of back and leg pain due to lumbar disc herniation, will be compared to the effectiveness of these methods on pain at baseline before the procedure and at 2, 6, and 12 weeks afterward using the Visual Analogue Scale for Pain Relief (VAS) and Oswestry Disability Index (ODI). The baseline values will be recorded from the patient files and by request before the start of follow-up.",[27],[563],"espb, lesi, lumbar disc herniation","2025-09-24",{"date":566,"type":36},"2025-09-25",{"date":568,"type":22},"2025-09-20",{"date":499,"type":22},{"name":571,"class":43},"Diskapi Teaching and Research Hospital",{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":17,"minAge":579,"maxAge":580,"enrollmentInfo":581,"targetDuration":4,"studyType":53,"phases":582,"briefSummary":583,"conditions":584,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":594},"100517970","non-pharmacological-treatment-vs-pharmacological-treatment-for-non-acute-lumbar-disc-herniation-100517970","NCT06024460","Non-pharmacological Treatment vs Pharmacological Treatment for Non-acute Lumbar Disc Herniation","Comparative Effectiveness of Non-pharmacological Treatment and Pharmacological Treatment for Non-acute Lumbar Disc Herniation: a Multi-centered, Pragmatic Randomized Controlled, Parallel-grouped Study","Inclusion Criteria:\n\n* aged 19 to 69 years.\n* lower back pain that has persisted for at least 1 month.\n* a Numeric Rating Scale (NRS) score of 5 or higher for either lower back pain or radiating leg pain over the past three consecutive days.\n* confirmed lumbar disc herniation on MRI that can explain the lower back pain.\n* who have provided written informed consent and agreed to participate in the clinical study.\n\nExclusion Criteria:\n\n* diagnosed with specific severe diseases that could be the cause of lower back pain or leg pain (e.g., spinal metastasis, acute fractures, and spinal dislocation).\n* showing progressive neurological deficits or severe neurological symptoms.\n* with pain originating from soft tissue disorders other than the spine (e.g., tumors, fibromyalgia, rheumatoid arthritis, gout).\n* with other chronic conditions (e.g., stroke and myocardial infarction, renal disease, diabetic neuropathy, dementia, epilepsy) that may interfere with the treatment effect or result interpretation.\n* taking steroids, immunosuppressive drugs, psychiatric medications, or other medications that may impact the study results.\n* acupuncture or nerve block treatment is inappropriate or unsafe, such as those with a history of bleeding disorders, receiving anticoagulant therapy, or diagnosed with uncontrolled diabetes.\n* taken non-steroidal anti-inflammatory drugs (NSAIDs) or other pain-affecting drugs or received acupuncture treatment within the past 5 days.\n* Pregnant women, those planning pregnancy, or breastfeeding women.\n* within 3 months after lumbar surgery.\n* who have not completed participation in another clinical study within the past month or have plans to participate in another clinical study within 6 months from the selection date or during the study participation and follow-up period.\n\nInability to provide written informed consent.\n\n\\- Other cases where the researchers determine that participation in the clinical study would be difficult.","19 Years","69 Years",{"count":108,"type":22},[55],"This is a randomized controlled study comparing non-pharmacological treatment to proactive pharmacological treatment for patient with non-acute lumbar disc herniation with moderate or higher levels of pain. The study involves 200 adult patients aged 19-69, with 50 patients from each participating hospital. Patients will be randomly assigned to either the non-pharmacological treatment group or the pharmacological treatment group 1:1 ratio. Specific interventions will be determined by doctors and Korean medicine doctors without predefined treatment strategies. The non-pharmacological treatment include acupuncture, electroacupuncture, spinal manual therapy and motion style acupuncture. The pharmacological treatment include medication prescription, injection, and nerve block. Treatment period is 8 weeks, and f\u002Fu for 3 years.",[27],"2025-09-09",{"date":587,"type":36},"2025-09-11",{"date":589,"type":36},"2023-08-09",{"date":591,"type":22},"2030-12-31",{"name":593,"class":43},"Jaseng Medical Foundation",4,{"id":596,"slug":597,"hasResults":12,"nctId":598,"briefTitle":599,"officialTitle":600,"acronym":4,"eligibilityCriteria":601,"healthyVolunteers":12,"sex":17,"minAge":579,"maxAge":50,"enrollmentInfo":602,"targetDuration":4,"studyType":53,"phases":604,"briefSummary":605,"conditions":606,"keywords":4,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":613,"locationsCount":70},"100605339","the-influence-of-the-timing-of-postoperative-rehabilitation-intervention-on-the-clinical-efficacy-of-unilateral-biportal-endoscopic-spine-system-in-the-treatment-of-lumbar-disc-herniation-100605339","NCT07161232","The Influence of the Timing of Postoperative Rehabilitation Intervention on the Clinical Efficacy of Unilateral Biportal Endoscopic Spine System in the Treatment of Lumbar Disc Herniation","The Influence of the Timing of Postoperative Rehabilitation Intervention on the Clinical","Inclusion Criteria:\n\n* Aged between 19 and 65 years.\n\nDiagnosed with lumbar disc herniation by imaging and scheduled for unilateral biportal endoscopic (UBE) surgery.\n\nPresenting with radicular pain in the lower extremity, with a history of less than 1 year.\n\nAble to understand Chinese and complete questionnaires independently.\n\nPhysically capable of participating in exercise rehabilitation.\n\nWilling to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Aged under 18 or over 65 years.\n\nCombined with other spinal pathologies (e.g., ankylosing spondylitis, rheumatoid arthritis, spinal tumor, spinal fracture, cauda equina syndrome).\n\nDiagnosis of neurological disorders (e.g., multiple sclerosis, Parkinson's disease).\n\nPresence of uncontrolled cardiovascular, respiratory, or peripheral vascular diseases.\n\nHistory of severe psychiatric disorders (e.g., schizophrenia).\n\nPrevious history of spinal surgery.\n\nPregnancy or lactation.\n\nInability to understand or comply with the study procedures.",{"count":603,"type":22},72,[55],"This study focuses on the impact of the timing of postoperative rehabilitation intervention on the clinical efficacy of unilateral biportal endoscopic spine surgery in the treatment of lumbar disc herniation. The main objective is to explore this impact and provide high-quality evidence-based medical evidence for making reasonable clinical decisions.",[27,84],{"date":608,"type":36},"2025-09-08",{"date":610,"type":36},"2025-03-28",{"date":612,"type":22},"2027-03-28",{"name":614,"class":43},"Li Xiang",{"id":616,"slug":617,"hasResults":12,"nctId":618,"briefTitle":619,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":622,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":624,"conditions":625,"keywords":628,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":70},"100599496","the-role-of-cutibacterium-acnes-in-the-development-of-degenerative-lumbar-intervertebral-disc-disease-100599496","NCT07085247","The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease","The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease and the Clinical Effect of Microdiscectomy","Inclusion Criteria:\n\n* minimum age of 18 years\n* MRI of the lumbosacral spine performed one month ± 2weeks before surgery showing a disc protrusion, herniation, or free nucleus pulposus sequestration\n* matching physical examination findings including positive straight leg raise test, dermatomal sensory deficits, myotome motor deficits, and diminished deep tendon reflexes.\n\nExclusion Criteria:\n\n* antibiotics or corticosteroid use the month before surgery\n* ongoing bacterial or viral infection\n* immunocompromised patient\n* trauma\n* undefined radiological mass\n* inflammatory arthritis\n* other rheumatologic diseases.",{"count":623,"type":22},400,"The goal of this study is to clarify the role of the bacterium Cutibacterium acnes in the development of degenerative disc disease in patients with lumbar disc herniation who underwent microdiscectomy as part of their regular medical care.",[27,626,627,58],"Lumbar Disc Degeneration","Cutibacterium Acnes",[629,630,631,632,633],"Cutibacterium acnes","Degenerative disc disease","Low back pain","Microdiscectomy","Clinical outcome","2025-08-26",{"date":636,"type":36},"2025-08-27",{"date":638,"type":36},"2025-06-01",{"date":640,"type":22},"2028-12-31",{"name":642,"class":43},"Masaryk University",{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":650,"targetDuration":4,"studyType":53,"phases":651,"briefSummary":652,"conditions":653,"keywords":654,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":662,"completionDateStruct":664,"leadSponsor":665,"locationsCount":70},"100604602","a-comparison-between-biportal-and-uniportal-endoscopic-lumbar-discectomy-100604602","NCT07151651","A Comparison Between Biportal and Uniportal Endoscopic Lumbar Discectomy","Endoscopic Lumbar Discectomy: A Comparative Study Between Uniportal and Biportal Endocopic Techniques on Clinical and Surgical Outcomes","Inclusion Criteria:\n\n* All patients should fulfill the following criteria\n\n  1. Patients aged 18-70 years.\n  2. single-level lumbar disc herniation (L3-L4, L4-L5, or L5-S1) confirmed by MRI.\n  3. Persistent symptoms not responding to conservative management (≥6 weeks).\n\nExclusion Criteria:\n\n* All patients should not have any of the following criteria\n\n  1. Multilevel disc herniation.\n  2. Previous lumbar spine surgery, trauma or injection.\n  3. Severe spinal stenosis.\n  4. Severe osteoporosis, infection, or malignancy or autoimmune disease affecting the spine.\n  5. Uncontrolled medical comorbidities contraindicating surgery.\n  6. Instability: spondylolisthesis\\>grade 1\n  7. Marked obesity.(BMI \\>35-40 kg\u002Fm2 )",{"count":80,"type":22},[55],"This study aims to provide a detailed comparison between different methods of lumbar discectomy by the use of different types of spine endoscopy to evaluate the benefits and drawbacks of each type",[27],[655,656,657,658],"Lumar discectomy","Endoscopy","Uniportal","Biportal","2025-08-25",{"date":661,"type":36},"2025-09-03",{"date":663,"type":22},"2025-09-01",{"date":410,"type":22},{"name":666,"class":43},"Sohag University"]