[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-radiculopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-radiculopathy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,24,0,[8,43,78,106,137,162,185,208,235,268,296,322,347,368,398,423,441,462,485,511,531,554,580,605],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100642978","effects-of-spinal-mobilization-with-leg-movement-with-and-without-neural-flossing-technique-in-lumbar-radiculopathy-100642978",false,"NCT07646379","Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique in Lumbar Radiculopathy","Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique on Pain, Disability, and Range of Motion in Patients With Lumbar Radiculopathy","Inclusion Criteria:\n\n* • Patients aged between 30-50 years (9)\n\n  * Both male and female genders\n  * Patient should have lower back pain radiating to one side with numbness, tingling, and muscle weakness (12)\n  * Positive Lasegue \\& slump test\n\nExclusion Criteria:\n\n* Any fracture or other injury\n\n  * Any systemic illness\n  * Any inflammatory disease (Rheumatoid arthritis, gout)\n  * Disc herniation\n  * Piriformis syndrome\n  * Lumbar instability\n  * Scoliosis","ALL","30 Years","50 Years",{"count":20,"type":21},36,"ESTIMATED","INTERVENTIONAL",[24],"NA","Lumbar radiculopathy is a spinal condition caused by compression or irritation of the lumbar nerve roots, leading to radiating leg pain, sensory changes, and functional disability. It commonly affects middle-aged and older adults, impairing daily activities and quality of life. Conservative treatments include medication, physiotherapy, and exercise. Spinal Mobilization with Leg Movement (SMWLM), a Mulligan technique, uses passive vertebral mobilization with active leg motion to reduce nerve compression and improve mobility. Neural flossing, or neurodynamic mobilization, enhances nerve mobility by promoting gliding of nerve roots, especially in cases of restricted neural movement. This study aims to evaluate the effects of spinal mobilization with leg movement (SMWLM) with and without neural flossing technique on pain, disability, and range of motion in patients with lumbar radiculopathy.",[27],"Lumbar Radiculopathy",[29],"pain, radiculopathy, range of motion, spinal mobilization","NOT_YET_RECRUITING","2026-06-08",{"date":33,"type":34},"2026-06-12","ACTUAL",{"date":36,"type":21},"2026-05-30",{"date":38,"type":21},"2026-08-30",{"name":40,"class":41},"Riphah International University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":42},"100437952","early-phase-1-brain-mechanisms-supporting-cannabis-induced-pain-relief-100437952","NCT04982965","Brain Mechanisms Supporting Cannabis-induced Pain Relief","Inclusion Criteria:\n\n* Between 21-65 years old\n* Currently 30 days cannabis free\n* Lower back pain for three months or more\n* Are not taking opioids\n* If female and of a child bearing potential age, are not pregnant or nursing mothers\n* Do not have mental or neurological conditions inhibiting sensory\u002Fmotor functions\n* Do not have a lifetime history of dependence on cannabis\n* Do not have a lifetime history of DSM-IV schizophrenia, bipolar disorder, panic disorder, or psychosis\n* Prior THC-containing cannabis experience within the past two years\n* Agrees not to use cannabis outside of the study during participation in the study\n* Agrees not to use opioids or barbiturates during participation in the study\n* Agrees not to drive a motor vehicle within 4 hours following last use of inhaled cannabis during participation in the study\n\nExclusion Criteria:\n\n* Active pulmonary disease\n* Allergy or past adverse effects or negative past experiences from cannabis\n* Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone\n* Any significant illness, including cardiovascular disease, diabetes, renal and liver disease.\n* Any current or history of an immunocompromising disease or condition (such as lupus, psoriasis, multiple sclerosis, etc.)\n* Any current or history of neurologic conditions, including Parkinson disease, dementia, cognitive impairment, history of seizure disorder, and history of traumatic brain injury\u002Fhead injury\n* Any current major psychiatric illness, such as bipolar disorder, major depression, psychosis, substance use disorder, or schizophrenia\n* Any current or history of suicidal ideation or attempt\n* Overt sensitivity to thermal stimulation\n* Resting blood pressure \\> 140\u002F90\n* Resting heart rate \\> 100 beats\u002Fminute\n* Prisoner\n* Institutionalized\n* Claustrophobia\n* MRI contraindications\n* Participation in any new (within 2 weeks prior or any time after enrollment) pain management procedures during the study period\n* Known history of vasovagal fainting, syncope, or severe adverse reactions associated with blood draws or needle procedures",true,"21 Years","65 Years",{"count":53,"type":21},100,[55],"EARLY_PHASE1","Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments. Cannabis may help reduce pain, but researchers do not fully understand how it affects the brain in people with chronic pain. The purpose of this study is to examine how inhaled cannabis changes brain activity and reduces pain in people with chronic low back pain. Results from this study may help researchers better understand how cannabis works for pain and support the development of improved pain treatments.",[58,27,59,60,61,62,63],"Sciatica","Lower Back Pain","Degenerative Disc Disease","Chronic Low-back Pain (cLBP)","Chronic Low Back and Leg Pain","Back Pain",[65,66,67,68],"Cannabis","Vaporized cannabis","THC","chronic low back pain","RECRUITING",{"date":71,"type":34},"2026-06-03",{"date":73,"type":34},"2021-05-07",{"date":75,"type":21},"2027-03-15",{"name":77,"class":41},"University of California, San Diego",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":85,"maxAge":18,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":42},"100637010","efficacy-of-combining-mulligan-spinal-mobilization-with-leg-movement-and-mechanical-lumbar-traction-in-lumbar-radiculopathy-100637010","NCT07573124","Efficacy of Combining Mulligan Spinal Mobilization With Leg Movement and Mechanical Lumbar Traction in Lumbar Radiculopathy","Efficacy of Combining Mulligan's Spinal Mobilization With Leg Movement Technique and Mechanical Lumbar Traction Among Patients With Lumbar Radiculopathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 20-50 years\n* Male and female participants\n* Unilateral radiculopathy due to L4-L5 or L5-S1 disc bulge, confirmed by clinical examination and MRI\n* Symptom duration of 4 weeks to 6 months\n* Positive Straight Leg Raise (SLR) test on the affected leg (\\\u003C70° of hip flexion)\n* Pain intensity \\\u003C7 on the Numeric Pain Rating Scale (NPRS; mild to moderate pain)\n\nExclusion Criteria:\n\n* Cognitive impairment, dementia, central cord signs\n* Inflammatory or degenerative spine conditions\n* Spine surgery within the last 6 months\n* Pregnant women in the later half of 2nd trimester or 3rd trimester\n* Muscular involvement (e.g., Deep Gluteal syndrome, Piriformis syndrome)\n* Currently receiving medications or other contemporaneous treatment","20 Years",{"count":87,"type":21},32,[24],"Lumbar radiculopathy (LR), often caused by disc herniation, results in significant pain, disability, and reduced quality of life. Spinal Mobilization with Leg Movement (SMWLM) is a manual technique that has shown promise, while mechanical lumbar traction is used to reduce nerve compression, though its standalone effectiveness is debated. This randomized controlled trial aims to compare the combined effect of SMWLM plus mechanical lumbar traction against SMWLM alone, both administered with conventional physiotherapy. Outcomes will be assessed over 4 weeks to determine if the combined intervention offers superior pain relief, functional improvement, and range of motion in patients with unilateral L4-L5 or L5-S1 radiculopathy.",[27],[92,93,94,95,96],"Lumbar radiculopathy","Mulligan mobilization","Mechanical lumbar traction","Physical therapy","Randomized controlled trial","2026-05-01",{"date":99,"type":34},"2026-05-07",{"date":101,"type":34},"2026-04-01",{"date":103,"type":21},"2026-11-15",{"name":105,"class":41},"Khyber Medical University Peshawar",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100617049","r-rehab-pathway-versus-usual-care-after-lumbar-radicular-surgery-100617049","NCT07313566","R³ Rehab Pathway Versus Usual Care After Lumbar Radicular Surgery","An Evidence-based Rehabilitation Pathway for Patients Undergoing Surgery for Lumbar Radicular Pain to Promote Return to Work: a Cluster Randomized Trial Comparison With Usual Care.","R³","Inclusion Criteria:\n\n* Radicular pain (for ≥ 6 weeks prior to screening), with a clear indication for lumbar spinal surgery ((micro)discectomy, decompression and\u002For fusion), in accordance with the KCE guidelines (when evidence-based multimodal management has not improved pain or function and radiological findings are consistent with clinical symptoms)\n* Employed (working or on sick leave for less than 1 year due to spinal pathology)\n* Age 18 - 65 years\n* Surgery is scheduled within a timeframe of five days to 2 months after the decision for surgery (4 months for fusion)\n* For lumbar fusion surgery, the fusion should be restricted to one or two levels\n* Able to provide written informed consent, implying that the participant is both physically and cognitively capable of understanding the study information and signing the consent form independently.\n\nExclusion Criteria:\n\nPatients are not eligible for the trial in case of any of the following criteria:\n\n* Lumbar surgery performed for malignant disease, spinal fracture, infectious spinal disease\n* Insufficient knowledge of Dutch or French language to receive education in the recruiting center and to complete the questionnaires (consistent with the language spoken in the recruiting centre)\n* Immediate surgery via emergency admission that precludes prehabilitation\n* Revision fusion surgery\n* Non-residency in Belgium","18 Years",{"count":116,"type":21},480,[24],"The R³ trial is a multicentre cluster randomized controlled trial evaluating an evidence-based, person-centred rehabilitation pathway for patients undergoing lumbar surgery for radicular pain. The pathway includes structured pre-, peri-, and postoperative rehabilitation, early postoperative mobilization, case management, early return-to-work (RTW) guidance, and patient empowerment. Clusters (hospitals) are randomized to implement the R³ pathway (intervention) or continue usual care (control). The primary aim is to determine whether the R³ pathway reduces time to return to work compared with usual care.",[27,120],"Radicular Low Back Pain",[92,122,123,124,125,126],"Return to work","Case manager","Cluster RCT","Rehabilitation","radicular pain","2026-04-28",{"date":129,"type":34},"2026-05-05",{"date":131,"type":34},"2026-03-16",{"date":133,"type":21},"2028-05",{"name":135,"class":41},"Universitaire Ziekenhuizen KU Leuven",16,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":149,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":42},"100629867","tecar-therapy-in-patients-with-lumbar-radiculopathy-100629867","NCT07480252","Tecar Therapy in Patients With Lumbar Radiculopathy","Efficacy of Tecar Therapy Versus Conventional Physical Therapy and Sham Treatment in Patients With Lumbar Radiculopathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Clinical diagnosis of unilateral L5 and\u002For S1 lumbar radiculopathy\n* Symptom duration between 6 weeks and 6 months\n* Average radicular pain intensity ≥3 on the Visual Analog Scale (VAS) during the previous month\n* Availability of lumbar MRI and\u002For EMG performed within the previous 6 months\n* Willingness to participate and ability to provide written informed consent\n\nExclusion Criteria:\n\n* Bilateral lumbar radiculopathy\n* Lumbar spinal canal stenosis confirmed by imaging or suspected clinically (e.g., neurogenic claudication)\n* Lower limb muscle strength \\\u003C4\u002F5 according to the Medical Research Council (MRC) scale\n* Use of analgesic medications other than paracetamol during the study period\n* Physical therapy treatment for low back or radicular pain within the past 3 months\n* Contraindications to physical therapy modalities or Tecar therapy\n* Previous lumbar spine surgery or interventional spinal procedures within the last 6 months\n* Pregnancy, malignancy, or systemic neurological or rheumatologic disease\n* Advanced spinal or lower extremity deformities (e.g., scoliosis \\>20°, grade 3-4 spondylolisthesis, vertebral fracture, advanced coxarthrosis)\n* Inability to complete the intervention protocol or follow-up assessments",{"count":145,"type":21},90,[24],"Lumbar radiculopathy is a common cause of low back and leg pain, most frequently resulting from lumbar disc herniation and nerve root irritation. Conservative management, including physical therapy modalities and exercise therapy, is generally recommended as first-line treatment for patients without progressive neurological deficits. Tecar therapy (Transfer of Energy Capacitive and Resistive) is a non-invasive electrotherapeutic modality that delivers high-frequency electromagnetic energy to deep tissues and has been proposed to reduce pain, enhance microcirculation, and promote tissue recovery. However, evidence regarding its effectiveness in lumbar radiculopathy remains limited.\n\nThe aim of this randomized controlled trial is to evaluate the efficacy of Tecar therapy in patients with lumbar radiculopathy and to compare its clinical effects with conventional physical therapy and sham Tecar treatment.\n\nA total of 90 participants with unilateral L5 and\u002For S1 radiculopathy will be randomized into three groups: (1) conventional physical therapy, (2) Tecar therapy combined with standard physical therapy, and (3) sham Tecar therapy combined with standard physical therapy. All participants will receive standardized postural education and a home exercise program.\n\nThe primary outcome will be pain intensity measured by the Visual Analog Scale (VAS). Secondary outcomes will include functional disability (Oswestry Disability Index), neuropathic pain characteristics (PainDETECT questionnaire), lumbar mobility (Modified-Modified Schober Test), nerve root irritability (Straight Leg Raise test), rescue analgesic consumption, and exercise adherence. Outcomes will be assessed at baseline, post-treatment (week 2), and follow-up visits at weeks 6 and 12.",[27],[150,151],"lumbar radiculopathy","Capacitive and Resistive Energy Transfer","2026-04-13",{"date":154,"type":34},"2026-04-16",{"date":156,"type":21},"2026-04-15",{"date":158,"type":21},"2028-12-15",{"name":160,"class":161},"Izmir City Hospital","OTHER_GOV",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":22,"phases":171,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":42},"100630935","phase-4-dose-dependent-steroid-injections-100630935","NCT07494136","Dose Dependent Steroid Injections","Dose Dependent Response to Interlaminar Steroid Injections for Lumbar Radiculopathy","Inclusion Criteria:\n\n* Adults able to consent\n* Lumbar radiculopathy with MRI-confirmed pathology\n* No history of back surgery\n* Use of interlaminar approach lumbar spine injections\n* No use of oral pain medication other than Tylenol or Acetaminophen during the 6 weeks after injection\n\nExclusion Criteria:\n\n* Adults unable to consent\n* Individuals who are not yet adults (infants, children, teenagers)\n* Pregnant women\n* History of back surgery\n* Use of oral pain meds other than Tylenol or Acetaminophen during the 6 weeks after injection",{"count":170,"type":21},150,[172],"PHASE4","This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and function in lumbar radiculopathy at varying doses, and to evaluate difference in efficacy between triamcinolone and dexamethasone interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, with the overarching hypotheses that there is no difference in reported pain reduction, quality of life, or function among patients receiving low, moderate, or high doses, and no difference in reported pain reduction between triamcinolone and dexamethasone.",[27,58,175],"Back Pain With Radiation","2026-03-20",{"date":178,"type":34},"2026-03-27",{"date":180,"type":21},"2026-05",{"date":182,"type":21},"2027-05",{"name":184,"class":41},"University of Miami",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":42},"100628189","effect-of-sciatic-nerve-neurodynamic-sliding-on-pain-disability-and-balance-in-patients-with-lumbar-radiculopathy-100628189","NCT07458399","Effect of Sciatic Nerve Neurodynamic Sliding on Pain, Disability, and Balance in Patients With Lumbar Radiculopathy","Effect of Sciatic Nerve Neurodynamic Sliding Technique on Pain, Disability, and Balance in Patients With Lumbar Radiculopathy","Inclusion Criteria:\n\n* Chronic unilateral lumbar painful radiculopathy (duration ranged from 3 to 18 months).\n* During the evaluation session, repeated lumbar movements did not improve or worsen lower extremity symptoms.\n* Positive straight leg raise (SLR) response. A positive SLR test was defined as the presence of both of these findings: (1) the test reproduced the patient's symptoms and (2) the symptoms decreased with the ankle plantar flexion component of the test.\n* Unilateral Pain radiating below the knee, with leg pain equal to or more severe than the accompanying back pain.\n* The presence of paresthesia such as pins and needles or numbness in the affected limb, along with neurological deficits-whether motor, sensory, or reflex-that corresponded to the dermatome or myotome of the affected nerve root.\n\nExclusion Criteria:\n\n* Systemic diseases such as autoimmune and metabolic diseases.\n* Previous Lumbar Spine surgery.\n* Lumbar spine stenosis.\n* Spinal deformity.\n* Spinal fracture.\n* Bilateral lower extremity symptoms.\n* Steroid injection or use of anti-inflammatory medications within two to four weeks prior to study commencement.","25 Years","45 Years",{"count":195,"type":21},28,[24],"This study will be conducted to evaluate the effect of sciatic nerve slider mobilization on pain intensity. Also, to evaluate the impact of sciatic nerve mobilization on functional disability, and to determine the influence of sciatic nerve slider neurodynamics on functional balance performance.",[27],"2026-03-04",{"date":201,"type":34},"2026-03-09",{"date":203,"type":21},"2026-03-10",{"date":205,"type":21},"2026-09-30",{"name":207,"class":41},"Cairo University",{"id":209,"slug":210,"hasResults":11,"nctId":211,"briefTitle":212,"officialTitle":213,"acronym":214,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":16,"minAge":216,"maxAge":4,"enrollmentInfo":217,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":4},"100591975","continuous-erector-spinae-block-for-analgesia-following-lumbar-decompression-100591975","NCT06987409","Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression","Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression: A Randomized Controlled Study","Lumbar-ESP","Inclusion Criteria:\n\n* Adult (aged \\>18 years) patients\n* Undergoing lumbar decompression surgery +\u002F- fusion\n* Under the orthopedic surgery team\n\nExclusion Criteria:\n\n* Surgery on an emergency basis (level 1, 2 or 3; \\\u003C8 hours)\n* An ejection fraction \\\u003C30%\n* Severe pre-existing liver disease (Child B or C)\n* Severe kidney disease (Glomerular filtration rate (GFR) \\\u003C30 (mL\u002Fmin\u002F1·73m²))\n* An allergy to ropivacaine\n* Weight \\\u003C50 kg\n* Unable to provide valid consent to study prior to surgery","19 Years",{"count":53,"type":21},[24],"Lumbar spinal surgery is common, and the incidence of spinal fusion has increased dramatically over the past three decades. Patients requiring spinal surgery are typically prescribed several analgesics, (including opioids) while awaiting surgery. Postoperatively, use of high doses of opioids or anti-inflammatory medications have drawbacks. Severe post-operative pain is reported by 45-80% of patients and rates are generally higher in the opioid tolerant patients.\n\nRegional anesthesia (blocking nerves with local anesthetics) works locally, thereby avoiding many side effects associated with other analgesics. One type of nerve block is called erector spinae plane block (ESP). Single injection nerve blocks have been found to decrease pain, nausea, and opioid consumption, while increasing patient satisfaction and quality of recovery. However, these effects only last for 24 hours or less while the worst pain occurs around 36 hours after surgery. Surgeon-placed indwelling catheters could allow infusions of local anesthetics for 54 hours.\n\nThis randomized control trial seeks to assess the effectiveness of surgeon-placed ESP catheters for pain control after lumbar spine surgery.\n\nHypothesis: Patients receiving a cESP will have less pain, improved quality of recovery, and opioid use following lumbar fusion surgery than those receiving current standard of care pain management.\n\nMethodology: Adult patients undergoing lumbar spine surgery under orthopedic surgery in Halifax will be eligible. The study will include 100 participants, randomly assigned to 2 study arms of 50 participants (1:1 basis to Ropivacaine and placebo groups). At the end of surgery, the surgeon will place the ESP catheters in all study patients under sterile conditions before closing the wound. Ropivacaine 0.5% or normal saline (placebo) 15ml will be injected through each catheter (total 30ml). In the postanesthetic care unit (PACU), two elastomeric pumps will be attached to the ESP catheters. These will be filled with either Ropivacaine 0.2% or normal saline (placebo). The elastomeric pumps are small bottle that patients can carry with them after discharge home. The pumps automatically run at an infusion rate of 10 ml\u002Fhr for 54 hours. All patients will also receive the standard of care for pain management for this patient population, which is opioid based with acetaminophen. A quality of recovery (QoR-15) questionnaire will be completed at 72 hours post-operatively. Pain, catheter complication, and opioid use data will be gathered from the patient's charts at 24, 48, and 72 hours post-operatively. At 3- and 6-month follow-ups, patients will complete the Brief Pain Inventory questionnaire. We will analyze differences in pain and opioid consumption at 24, 48, and 72 hours, quality of recovery index scores at 72 hours, postoperative complication rates, and persistent pain at 3 and 6 months.",[221,27,222],"Lumbar Spinal Stenosis","Persistent Postsurgical Pain",[224,225],"Erector spinae block","Regional anesthesia","2026-02-13",{"date":228,"type":34},"2026-02-17",{"date":230,"type":21},"2026-12-01",{"date":232,"type":21},"2028-08-01",{"name":234,"class":41},"Nova Scotia Health Authority",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":22,"phases":245,"briefSummary":246,"conditions":247,"keywords":255,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":42},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation","80 Years",{"count":244,"type":21},125,[172],"Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[221,248,249,250,27,251,252,60,253,254],"Lumbar Disc Herniation","Lumbar Spondylolisthesis","Lumbar Spondylosis","Lumbar Spine Instability","Synovial Cyst","Degenerative Spondylolisthesis","Degenerative Intervertebral Discs",[256,257,258,259],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","2026-02-11",{"date":228,"type":34},{"date":263,"type":34},"2022-02-01",{"date":265,"type":21},"2027-04-30",{"name":267,"class":41},"John O'Toole",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":279,"conditions":280,"keywords":281,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":42},"100623702","pldd-with-or-without-transforaminal-epidural-steroid-injection-in-lumbar-disc-herniation-100623702","NCT07400068","PLDD With or Without Transforaminal Epidural Steroid Injection in Lumbar Disc Herniation","Effect of Adjunct Transforaminal Anterior Epidural Steroid Injection Following Percutaneous Laser Disc Decompression in Patients With Single-Level Lumbar Disc Herniation: A Prospective Observational Study","PLDD-TFESI","Inclusion Criteria:\n\nAge 18 years and older\n\nDiagnosis of single-level lumbar disc herniation confirmed by magnetic resonance imaging (MRI)\n\nPresence of radicular leg pain refractory to conservative treatment\n\nUndergoing routine percutaneous laser disc decompression (PLDD) as part of standard clinical care\n\nAbility to provide informed consent\n\nExclusion Criteria:\n\nMultilevel lumbar disc herniation\n\nExtruded or sequestered disc herniation\n\nSevere spinal canal stenosis or spinal instability\n\nPrevious lumbar spine surgery at the affected level\n\nActive infection or systemic inflammatory disease\n\nCoagulopathy or use of anticoagulant therapy contraindicating intervention\n\nPregnancy\n\nInability to complete follow-up assessments",{"count":277,"type":21},88,"OBSERVATIONAL","This prospective observational study aims to evaluate the clinical outcomes of patients with single-level lumbar disc herniation who undergo routine percutaneous laser disc decompression (PLDD).\n\nIn routine clinical practice, some patients receive an additional transforaminal anterior epidural steroid injection during the same session without an extra puncture. This study will prospectively follow patients who receive PLDD alone and those who receive PLDD combined with epidural steroid injection.\n\nPain intensity, functional status, analgesic use, need for additional interventions, and complications will be assessed over time. The results may help to clarify whether adding epidural steroid injection to PLDD improves clinical outcomes in patients with lumbar disc herniation.",[248,27],[282,283,284,285,286],"Percutaneous Laser Disc Decompression","Transforaminal Epidural Steroid Injection","Minimally Invasive Spine Treatment","Radicular Pain","PLDD","2026-02-03",{"date":289,"type":34},"2026-02-10",{"date":291,"type":21},"2026-03-01",{"date":293,"type":21},"2027-09-01",{"name":295,"class":41},"Mersin University",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":16,"minAge":303,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":22,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":314,"lastUpdatePostDateStruct":315,"startDateStruct":317,"completionDateStruct":319,"leadSponsor":321,"locationsCount":42},"100623216","high-power-laser-versus-pulsed-electromagnetic-therapy-in-lumbar-radiculopathy-100623216","NCT07393750","High-power Laser Versus Pulsed Electromagnetic Therapy in Lumbar Radiculopathy.","High-Power Laser Versus Pulsed Eectromagnetic Therapy on Pain and Hoffman Reflex in Lumbar Radiculopathy.","Inclusion Criteria:\n\n* • Sixty lumbar radiculopathy patients, of both sexes, will represent the sample.\n\n  * The patient's age will range from 55 to 68 years old.\n  * Patients with degenerative lumbar disc lesion at L5-S1 confirmed by MRI and latency in H- reflex.\n  * Patients with unilateral sciatic radiating pain (from 5 to 8 by visual analogue scale).\n  * Patient with normal cognitive function (MME more than 25)\n  * BMI from 20-29.9\n\nExclusion Criteria:\n\n* The patients will be excluded if they have one of the followings:\n\n  1. Patients with pacemakers and presence of electronic implants.\n  2. Pregnant women.\n  3. History of or existing malignant conditions, active tuberculosis of the lungs.\n  4. Any medical condition that may cause sciatic nerve lesion except lumbar radiculopathy, (e.g., diabetes mellitus or collagen disorders).\n  5. Cardiac, renal or hepatic failures recent or previous history of seizures or epilepsy.\n  6. Previous surgery at L5-S1.\n  7. Bleeding disorders.\n  8. Serious infections of a viral, bacterial and fungal origin, conditions after organ transplants, upper motor neuron lesions.\n  9. Patients with cognitive impairment.","55 Years","68 Years",{"count":306,"type":21},60,[24],"To compare between high-power laser versus pulsed electromagnetic therapy on pain and Hoffman reflex in lumbar radiculopathy.",[27,310,311,312,313],"Hoffman's Reflex","Pulsed Electromagnetic Therapy","Laser Therapy","Herniated Lumbar Disc","2026-01-31",{"date":316,"type":34},"2026-02-06",{"date":318,"type":21},"2026-03-29",{"date":320,"type":21},"2027-01",{"name":207,"class":41},{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":328,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":330,"conditions":331,"keywords":332,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":42},"100621174","the-role-of-temporal-changes-in-pain-response-after-transforaminal-epidural-steroid-injection-on-treatment-success-100621174","NCT07367191","The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment Success","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Pre-procedural Numeric Rating Scale (NRS) pain score of 4 or higher\n* Presence of segmental lumbar disc herniation demonstrated on magnetic resonance imaging (MRI) consistent with clinical findings\n* Undergoing fluoroscopy-guided transforaminal epidural steroid injection due to insufficient response to conservative treatments, as determined by the algology clinic\n\nExclusion Criteria:\n\n* Presence of spondylolisthesis, scoliosis, or lumbar spinal stenosis accompanying lumbar disc herniation\n* Presence of malignancy\n* History of lumbar spine surgery for disc herniation\n* Transforaminal epidural steroid injection within the previous 6 months\n* Requirement for repeat epidural steroid injection during the data collection or follow-up period\n* Inability to be contacted for follow-up assessments by telephone",{"count":329,"type":21},120,"Transforaminal epidural steroid injection (TFESI) is a commonly used minimally invasive procedure for the treatment of lumbar radicular pain secondary to disc herniation. Although TFESI has been shown to provide significant pain relief in a substantial proportion of patients, the onset, duration, and temporal pattern of pain relief after the procedure vary considerably among individuals. The relationship between early pain response patterns and long-term treatment success remains poorly understood.\n\nThis prospective observational study aims to evaluate whether temporal changes in pain intensity following TFESI, particularly during the early post-procedural period, are associated with clinical treatment success at mid- and long-term follow-up. Pain intensity will be assessed using the Numeric Rating Scale (NRS) at predefined time points following the procedure, and treatment success will be defined as a ≥50% reduction in NRS score compared with baseline.",[248,27,120,58],[333,334,335,336,283,337],"TFESI","Temporal Pain Response","Numeric Rating Scale","NRS","Treatment Success","2026-01-16",{"date":340,"type":34},"2026-01-26",{"date":342,"type":21},"2026-02-15",{"date":344,"type":21},"2026-10-15",{"name":346,"class":41},"Marmara University",{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":351,"acronym":4,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":353,"targetDuration":4,"studyType":22,"phases":354,"briefSummary":355,"conditions":356,"keywords":357,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":42},"100618181","comparative-effects-between-eldoa-and-spinal-mobilization-with-limb-movement-in-lumbar-radiculopathy-100618181","NCT07328282","Comparative Effects Between ELDOA and Spinal Mobilization With Limb Movement in Lumbar Radiculopathy","Inclusion Criteria:\n\n* Age 30 -50 years\n* both male and female\n* Unilateral lumbar radiculopathy\n* Posteriolateral mild disc herniation on MRI\n* SLR test positive (30 to 70) degree\n* crosed SLR test positive\n* Slump test positive\n* pain and symptoms disturbution in dermatomal pattern of L4 and L5 Exclusion Criteria\n* MRI findings indicating i. Spinal instability ii. Significant neuroforaminal stenosis iii. Structural abnormalities requiring surgical intervention (e.g., large disc herniation )\n* Clinical findings indicating:\n\n  i. Absence of severe neurological and severe motor weakness (Manual Muscle Testing grades 0, 1, or 2) ii. Signs of cauda equina lesion (e.g., saddle anesthesia, bowel\u002Fbladder dysfunction)\n* Diagnosed spinal conditions i. Lumbar spondylolisthesis ii. Lumbar spine fracture iii. Spinal stenosis iv. Spinal tumor v. Ankylosing spondylitis\n* History of previous spinal surgery Pregnancy",{"count":20,"type":21},[24],"This study examines the comparative effects of ELDOA and Spinal Mobilization with Leg Movement (SMWLM) on lumbar radiculopathy",[27],[27,358],"lumbar pain","2025-12-26",{"date":361,"type":34},"2026-01-09",{"date":363,"type":34},"2025-06-01",{"date":365,"type":21},"2026-01-15",{"name":367,"class":41},"Foundation University Islamabad",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":372,"acronym":4,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":374,"enrollmentInfo":375,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":377,"conditions":378,"keywords":383,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":42},"100612652","how-reliable-are-routine-radiological-imaging-methods-in-diagnosing-lumbosacral-transitional-vertebrae-and-identifying-the-pathological-disc-level-100612652","NCT07256366","How Reliable Are Routine Radiological Imaging Methods in Diagnosing Lumbosacral Transitional Vertebrae and Identifying the Pathological Disc Level?","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Presenting to the outpatient clinic with low back and leg pain\n* Diagnosis of lumbar radicular pain based on history, physical examination, and lumbar MRI findings\n* Willingness and ability to provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* History of spinal surgery\n* Patients with incomplete or unavailable medical records within the hospital information system","75 Years",{"count":376,"type":21},250,"The aim of this study is to evaluate how accurately transitional vertebrae can be identified using routinely employed clinical imaging methods, including thoracolumbar direct radiography and lumbar MRI with axial and sagittal sequences. The study also seeks to determine how anatomical markers commonly used in the literature for vertebral level identification correspond to vertebral levels in the Turkish population, and whether a new potential relationship between these anatomical markers can be identified to improve accurate vertebral numbering. Additionally, the study will assess the relationship between thoracolumbar transitional vertebra (TLTV) and lumbosacral transitional vertebra (LSTV) variations, and ultimately aims to provide new data to determine which imaging-based approach offers the highest diagnostic accuracy.",[379,380,381,27,382],"Lumbosacral Transitional Vertebrae","Thoracolumbar Transitional Vertebra","Vertebral Level Misidentification","Spinal Imaging Accuracy",[384,385,386,387,388,389],"LSTV","TLTV","lomber rib","spinal imaging accuracy","transitional vertebrae","vertebral level misidentification","2025-11-20",{"date":392,"type":34},"2025-12-01",{"date":394,"type":21},"2025-12-15",{"date":396,"type":21},"2026-06-15",{"name":346,"class":41},{"id":399,"slug":400,"hasResults":11,"nctId":401,"briefTitle":402,"officialTitle":403,"acronym":4,"eligibilityCriteria":404,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":405,"enrollmentInfo":406,"targetDuration":4,"studyType":22,"phases":408,"briefSummary":409,"conditions":410,"keywords":411,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":42},"100597762","progressive-inhibition-of-neuromuscular-structure-and-neural-tissue-mobilization-100597762","NCT07062705","Progressive Inhibition of Neuromuscular Structure and Neural Tissue Mobilization.","Comparative Effects of Neural Tissue Mobilization and Progressive Inhibition of Neuromuscular Structure (PINS) Technique on Pain, Range and Disability in Patients With Lumbar Radiculopathy.","INCLUSION CRITERIA\n\n* Age group between 18 and 40 years(.\n* Both gender male and female.\n* Participants diagnosed as having a chronic (lasting three months or longer) lumbar radiculopathy.\n* Diagnosed patient of having radiculopathy at level of L4-L5 and L5-S1 lesion (unilateral radiculopathy).\n* Radiating pain evoked by specific clinical tests, including slump and straight leg raise.\n\nExclusion Criteria:\n\n* Individuals having bilateral lumbar radiculopathy.\n* Spondylolysis\u002Fspondylolisthesis\n* Mechanical systemic low back pain or neoplasmic and infectious processes.\n* Participants with severe nerve root compression (non-ambulant\u002Fwheelchair-bound).\n* Any sign or symptom of dementia or other cognitive impairments.\n* Diagnosis of claudication, previous spinal surgery, pregnancy and presence of any of the spinal red flags.","40 Years",{"count":407,"type":21},42,[24],"Lumbar radiculopathy is a neuromusculoskeletal condition that is characterized as radiating pain in the leg described as electric, burning, or sharp, and is associated with dermatomal or myotomal differences and tendon reflex abnormalities. Neural mobilization is a manual therapy technique designed to alleviate nerve pain and dysfunction by gently mobilizing the nerve along its pathway. The Progressive Inhibition of Neuromuscular Structures (PINS) technique is a therapeutic approach that aims to reduce pain and muscle tension by sequentially applying pressure to specific points along a muscle or nerve pathway. This study focuses on pain, range of motion and disability with these techniques in patients with lumbar radiculopathy.",[27],[412,413,414],"Pain","Range","Disability","2025-07-03",{"date":417,"type":34},"2025-07-14",{"date":419,"type":21},"2025-07-24",{"date":421,"type":21},"2025-10-20",{"name":40,"class":41},{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":427,"acronym":4,"eligibilityCriteria":428,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":429,"targetDuration":4,"studyType":22,"phases":431,"briefSummary":432,"conditions":433,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":434,"lastUpdatePostDateStruct":435,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":42},"100596860","comparative-effects-of-maitlands-rotation-mobilization-and-mulligans-spinal-mobilization-with-leg-movement-on-lumbar-radiculopathy-100596860","NCT07050966","Comparative Effects of Maitland's Rotation Mobilization and Mulligan's Spinal Mobilization With Leg Movement on Lumbar Radiculopathy","Inclusion Criteria:\n\n* Age: 18-65 years\n\n  * Both Males and Females\n  * Participants with a diagnosis of chronic (≥3 months) lumbar unilateral radiculopathy referred from Fauji Foundation Hospital, Rawalpindi\n  * NPRS score of \\> 5 and \\\u003C 8\n\nExclusion Criteria:\n\n* Diagnosis of other back conditions (e.g. failed back surgery syndrome, spondylosis, spondylolisthesis, and spinal stenosis, non-specific low back pain, and fracture)\n\n  * Non ambulant\u002Fwheelchair-bound or having cauda equina syndrome\n  * Patient taking anticoagulants\n  * Pregnant Females",{"count":430,"type":21},48,[24],"This study is a randomized control trial and the purpose of this study is to investigate and compare the effects of Maitland's rotation mobilization and Mulligan's spinal mobilization with leg movement (SMWLM) on lumbar radiculopathy patients.",[27],"2025-07-02",{"date":415,"type":34},{"date":437,"type":34},"2024-07-15",{"date":439,"type":21},"2025-06-30",{"name":367,"class":41},{"id":442,"slug":443,"hasResults":11,"nctId":444,"briefTitle":445,"officialTitle":446,"acronym":4,"eligibilityCriteria":447,"healthyVolunteers":11,"sex":16,"minAge":448,"maxAge":18,"enrollmentInfo":449,"targetDuration":4,"studyType":22,"phases":450,"briefSummary":451,"conditions":452,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":42},"100592183","three-dimensional-lumbar-myofascial-release-and-motor-control-in-lumbar-radiculopathy-100592183","NCT06990113","Three-dimensional Lumbar Myofascial Release and Motor Control in Lumbar Radiculopathy","Effect of Three-dimensional Lumbar Myofascial Release With Motor Control Training on Back Perception and Pain in Patients With Lumbar Radiculopathy","Inclusion Criteria:\n\n* Their ages range from 35 to 50 years.\n* Both sex\n* Unilateral lumbar radiculopathy for more than 6 months.\n* Normal body mass index (18.5 - 24.99Kg\u002Fm2).\n\nExclusion Criteria:\n\n* • Any other musculoskeletal disorders of the spine or upper extremity\n\n  * Patients with any other Neurological deficits, psychiatric disease lumbar myelopathy, Cognitive problems, vertebral fractures and previous history of spine or lumbar surgery.\n  * Clinical instability, recent trauma\n  * Structural abnormalities of the spine, osteoporosis, and spasmodic torticollis.\n  * Inflammatory or other specific disorders of spina such as ankylosing spondylitis and rheumatoid arthritis","35 Years",{"count":87,"type":21},[24],"to investigate The Efficacy of three-dimensional lumbar myofascial release with motor control training on back perception and pain in lumbar radiculopathy Patients with lumbar radiculopathy demonstrate impairments in function and range of motion to deficits in patient's quality of life.",[27],"2025-05-18",{"date":455,"type":34},"2025-05-25",{"date":457,"type":34},"2025-04-15",{"date":459,"type":21},"2025-07-15",{"name":461,"class":41},"October 6 University",{"id":463,"slug":464,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":374,"enrollmentInfo":469,"targetDuration":4,"studyType":22,"phases":470,"briefSummary":471,"conditions":472,"keywords":473,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":476,"lastUpdatePostDateStruct":477,"startDateStruct":479,"completionDateStruct":480,"leadSponsor":482,"locationsCount":484},"100581181","effects-of-adding-balneotherapy-to-a-physical-therapy-program-in-patients-with-chronic-lumbar-radiculopathy-100581181","NCT06846970","Effects of Adding Balneotherapy to a Physical Therapy Program in Patients With Chronic Lumbar Radiculopathy","The Effect of Adding Balneotherapy to the Physical Therapy Program on Neuropathic Pain, Disability, Daily Living Activities, and Sleep Quality in Patients With Chronic Lumbar Radiculopathy","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years who have been diagnosed with chronic lumbar radiculopathy based on medical history, physical examination, clinical findings, lumbar MRI, and EMG results, and who present to the outpatient clinic for physical therapy without any contraindications for treatment, will be included in the study after obtaining their informed consent.\n\nExclusion Criteria:\n\n* Patients with thermoregulation disorders or sensory deficits\n* Patients with lesions that impair skin integrity\n* Patients with decompensated heart failure\n* Patients with advanced heart, liver, or kidney failure\n* Patients with advanced, uncontrolled peripheral venous insufficiency\n* Patients with a history of epilepsy or seizures\n* Patients with pregnancy, malignancy, or a recent surgical operation\n* Patients in the acute exacerbation phase of rheumatic diseases\n* Patients with severe anemia\n* Patients with tuberculosis\n* Patients with febrile infectious diseases\n* Patients with diseases associated with bleeding disorders\n* Patients who have undergone regular balneotherapy in the past three months\n* Patients with polyneuropathy or peripheral nerve damage\n* Patients with muscle weakness detected during examination\n* Patients with prostheses\n* Patients with a history of lumbar surgery Exclusion Criteria for Balneotherapy\n* Patients with thermoregulation disorders or sensory deficits\n* Patients with lesions that impair skin integrity\n* Patients with decompensated heart failure\n* Patients with advanced heart, liver, or kidney failure\n* Patients with advanced, uncontrolled peripheral venous insufficiency\n* Patients with a history of epilepsy or seizures\n* Patients with pregnancy, malignancy, or a recent surgical operation\n* Patients in the acute exacerbation phase of rheumatic diseases\n* Patients with severe anemia\n* Patients with tuberculosis\n* Patients with febrile infectious diseases\n* Patients with diseases associated with bleeding disorders\n* Patients who have undergone regular balneotherapy in the past three months\n* Patients with polyneuropathy or peripheral nerve damage",{"count":329,"type":21},[24],"The aim of this study is to investigate the effects of adding balneotherapy to the conventional physical therapy program on neuropathic pain, disability, daily living activities, and sleep quality in patients with chronic lumbar radiculopathy.",[27],[474,475],"Chronic Lumbal Radiculopathy","balneotherapy","2025-03-19",{"date":478,"type":34},"2025-03-21",{"date":476,"type":34},{"date":481,"type":21},"2025-12-31",{"name":483,"class":41},"Afyonkarahisar Health Sciences University",2,{"id":486,"slug":487,"hasResults":11,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":491,"eligibilityCriteria":492,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":493,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":495,"conditions":496,"keywords":497,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":502,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":42},"100403956","prediction-of-tei-success-in-sciatica-100403956","NCT04540068","Prediction of TEI Success in Sciatica","Prediction of Transforaminal Epidural Injection Success in Sciatica","POTEISS","Inclusion Criteria:\n\n* Diagnosis of unilateral lumbar radiculopathy secondary to LDH or one-level spinal stenosis\n* Diagnosis supported by magnetic resonance imaging (MRI) findings\n* Scheduled appointment for TEI\n* Access to e-mail\n* Signed informed consent\n\nExclusion Criteria:\n\n* Diagnosis of unilateral lumbar radiculopathy secondary to LDH or one-level spinal stenosis\n* Age under 18 years\n* Severe multisegmental spinal disease\n* Anatomical abnormalities that may complicate the procedure technically (e.g. severe scoliosis)\n* Active malignancy or infectious disease\n* Use of immunosuppressive drugs\n* Use of systemic corticosteroids in preceding 3 months\n* Previous treatment with TEI for current episode of lumbar radiculopathy\n* History of lower back surgery at the same lumbar level\n* Circumstances that prevent treatment with TEI (e.g. use of anticoagulants that cannot be temporarily discontinued, allergy against steroids or local anaesthetic)\n* Pregnancy\n* Major language barrier",{"count":494,"type":21},388,"Rationale: Treatment with transforaminal epidural injections is part of usual care in patients suffering from lumbar radiculopathy. However, not all patients experience a satisfactory result from this treatment and it is unclear what percentage of patients responds well and if any clinical or radiological factors exist that predict a positive response.\n\nObjectives:\n\nPrimary: to develop a model based on demographic, clinical and radiological parameters for prediction of treatment success after TEI\n\nSecondary: to estimate the short-term efficacy of TEI in patients with LDH and spinal stenosis based on pain, functionality and perceived recovery scores, to determine the correlation between clinical and radiological baseline parameters and physical and psychological patient outcome measures, to determine the rate of additional injections and rate of surgery after treatment with TEI, to determine the short-term (cost)effectiveness of TEI on physical and psychological patient outcome measures, and to determine the rate of complications associated with TEI\n\nStudy design: Prospective cohort study\n\nStudy population: Patients that are scheduled for TEI as part of usual care suffering from a new episode of lumbar radiculopathy\n\nMain study parameters\u002Fendpoints: leg and back pain scores at baseline, 30 minutes, 2 and 6 weeks after treatment. ODI, HADS, Quality of Life and PCI at baseline, 2 and 6 weeks after treatment. Perceived recovery at 2 and 6 weeks after treatment. Usage of healthcare at baseline, 2 and 6 weeks after treatment.",[27,248,221],[498,499,500,501],"Transforaminal Epidural Injection","Lumbar spine","Prospective cohort study","Prediction of success","2025-03-08",{"date":504,"type":34},"2025-03-12",{"date":506,"type":34},"2020-11-15",{"date":508,"type":21},"2026-12",{"name":510,"class":41},"Eduard Verheijen",{"id":512,"slug":513,"hasResults":11,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":242,"enrollmentInfo":518,"targetDuration":4,"studyType":22,"phases":519,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":42},"100527273","effects-of-a-prehabilitation-program-in-patients-undergoing-lumbar-radiculopathy-surgery-100527273","NCT06145620","Effects of a Prehabilitation Program in Patients Undergoing Lumbar Radiculopathy Surgery","Effects of a Prehabilitation Program Based on Therapeutic Exercise, Back Care Education and Neuroscience Pain Education in Patients Undergoing Lumbar Radiculopathy Surgery","Inclusion Criteria:\n\n* Adults aged 18 years or older, diagnosed with lumbar radiculopathy, and scheduled for surgery. The symptoms will be predominantly leg pain with or without neurological deficit, with surgical decompression justified.\n\nExclusion Criteria:\n\n* Patients currently receiving any other non-pharmacological treatment or physical therapy for the management of lumbar radiculopathy.\n* Proposed for surgery with instrumentation (e.g., spinal fusion, arthrodesis).\n* Suffering from a chronic pain-related condition (e.g., fibromyalgia, chronic fatigue syndrome).\n* Symptoms of spinal cord compression.\n* Diagnosed with a malignant tumor.\n* Mental illness.\n* Previously undergone spinal surgery.\n* No access to any internet-enabled device.",{"count":53,"type":21},[24],"The purpose of the following study is to analyze the effects of a prehabilitation program based on therapeutic exercise, back care education and pain neuroscience education through the visualization of videos, compared to standardized written therapeutic exercise in patients undergoing lumbar radiculopathy surgery.",[27],"2025-02-10",{"date":524,"type":34},"2025-02-12",{"date":526,"type":21},"2025-04",{"date":528,"type":21},"2027-04",{"name":530,"class":41},"Cardenal Herrera University",{"id":532,"slug":533,"hasResults":11,"nctId":534,"briefTitle":535,"officialTitle":535,"acronym":536,"eligibilityCriteria":537,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":538,"targetDuration":4,"studyType":22,"phases":540,"briefSummary":541,"conditions":542,"keywords":545,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":553,"locationsCount":42},"100577722","the-effect-of-needle-insertion-angle-on-contrast-distribution-and-treatment-outcomes-in-s1-transforaminal-epidural-steroid-injections-100577722","NCT06801990","The Effect of Needle Insertion Angle on Contrast Distribution and Treatment Outcomes in S1 Transforaminal Epidural Steroid Injections","Transforaminal","Inclusion Criteria:\n\n* Being over 18 years of age\n* Having S1 nerve root compression due to paravertebral disc herniation at the L5-S1 level detected by MRI\n* Having history and physical examination findings consistent with S1 root compression\n* Patients with low back and leg pain who have not responded to conservative treatment methods\n* Being willing to participate in the study and having signed a consent form\n\nExclusion Criteria:\n\n* Having undergone lumbosacral surgery\n* Presence of transitional vertebra\n* Presence of progressive motor deficit\n* Presence of local and\u002For systemic infection\n* History of malignancy\n* Patients with lumbar disc herniation causing root compression outside the L5\u002FS1 level on MRI\n* Patients with bilateral S1 root compression on MRI\n* Presence of spinal stenosis\n* Pregnancy\n* Presence of known coagulopathy\n* Presence of known psychiatric disease diagnosis\n* History of allergy to any of the injection materials\n* Having received an epidural steroid injection within the last 3 months\n* Receiving systemic steroid treatment for any reason",{"count":539,"type":21},66,[24],"Nerve compression due to lumbar disc herniation (lumbosacral radiculopathy) is a condition characterized by pain in the lower back and legs and restricted lumbar joint movement due to the compression of nerves emerging from the lumbar spine caused by the protrusion of the intervertebral disc. Back pain negatively impacts patients' quality of life and emotional well-being. Treatment approaches aim to alleviate pain, improve joint mobility, and restore functionality through the use of pain-relief medications (topical or oral), physical therapy methods, and rehabilitation programs that include exercises for range of motion, stretching, and strengthening. When these approaches prove insufficient, interventional procedures (injection therapy) or surgical interventions come to the forefront.\n\nOne of the proven interventional treatment methods for herniated disc disease is the transforaminal epidural steroid injection (TFESE), which involves the injection of cortisone around the compressed nerve due to the herniation and is frequently performed in our clinic. Transforaminal injections require imaging guidance and the use of contrast media to enhance the safety and effectiveness of the procedure. To visualize the S1 foramen, needle entry is performed using various angles under fluoroscopy guidance. This study will investigate the effect of the needle entry angle on the spread and pattern of contrast media, complications, and treatment outcomes in fluoroscopy-guided S1 transforaminal epidural steroid injections. The research aims to determine whether the needle entry angle influences the pattern of contrast spread and the treatment outcomes in S1 TFESE.\n\nBased on the findings of this study, the goal is to refine the procedure for patients requiring injections at this level in the future, optimizing the technique and clinical outcomes. This will provide essential insights to practitioners, maximize the benefits for the patient group undergoing the procedure, and make a significant contribution to medical science. Detailed information regarding the planned injection therapy by your algology specialist will be provided, and written and verbal consent will be obtained through the \"Epidural Steroid Injection Consent Form.\" Various scales and questionnaires will be administered at specific intervals-prior to the procedure, 1 hour after, 3 weeks after, and 3 months after-to evaluate pain levels, treatment response, and the impact on daily activities. The content of these evaluations will be explained in detail by your physician.\n\nTemporary side effects related to the injection may include increased pain at the injection site, low blood pressure, dizziness, fainting, and allergic reactions, all of which can be managed with appropriate treatment. Although rare, severe side effects such as nerve damage, spinal cord injury, or stroke have been reported in some cases. However, adherence to the guidelines outlined in treatment protocols and the performance of the procedure by adequately trained and experienced physicians significantly reduce the likelihood of these serious side effects. This injection will be performed by an algology specialist with at least 10 years of experience in this field. All necessary precautions will be taken against potential side effects, and the performing team will provide immediate medical intervention in case of complications.\n\nApproximately 66 volunteers will participate in this study, with each follow-up evaluation expected to take about 15 minutes. The identities of participants will remain confidential, and they have the right to withdraw from the study at any time by notifying the researchers. If deemed necessary by the researchers, participants may also be excluded from the study. If a participant declines to participate or is excluded from the study, their treatment will not be interrupted. Participants will not bear any financial responsibility for research-related expenses, and no additional travel costs will be incurred as evaluations will coincide with regular clinic visits.",[543,27,544],"Low Back Pain (LBP)","Intravascular Injection",[546],"lumbar radicular pain , epidural injection , intravascular injection , contrast spread pattern , low back pain","2025-01-25",{"date":549,"type":34},"2025-01-30",{"date":551,"type":34},"2024-09-09",{"date":392,"type":21},{"name":346,"class":41},{"id":555,"slug":556,"hasResults":11,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":242,"enrollmentInfo":561,"targetDuration":4,"studyType":278,"phases":4,"briefSummary":562,"conditions":563,"keywords":567,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":4},"100574254","the-effect-of-sensory-stimulation-threshold-on-the-efficacy-of-pulsed-radiofrequency-applied-to-the-dorsal-root-ganglion-in-patients-with-chronic-lumbar-radicular-pain-100574254","NCT06756893","The Effect of Sensory Stimulation Threshold on the Efficacy of Pulsed Radiofrequency Applied to the Dorsal Root Ganglion in Patients with Chronic Lumbar Radicular Pain","The Effect of Sensory Stimulation Thresholds on the Efficacy of Pulsed Radiofrequency Applied to the Dorsal Root Ganglion in Patients with Chronic Lumbar Radicular Pain","Inclusion Criteria:\n\nPain lasting ≥3 months NRS score ≥4 Unilateral pain Diagnosis of spinal stenosis or lumbar disc herniation causing root compression, confirmed by magnetic resonance imaging (MRI) according to appropriate diagnostic criteria and classification Failure of conservative treatment\n\nExclusion Criteria:\n\nUnwillingness to participate in the study Epidural steroid injection within the past month Uncontrolled psychiatric disorders despite medical treatment Systemic or localized infection signs at the procedure site Severe spinal stenosis Allergy to steroids or contrast agents History of cancer Coagulopathy",{"count":170,"type":21},"Lomber dorsal root ganglion pRF is an interventional treatment options in the treatment of lumbar radicular pain. The goal of this study is to investigate the effect of sensory threshold outcomes on pain severity during dorsal root ganglion pulsed radiofrequency (DRG-pRF). It will also learn effects about disability due to chronic LRP. The main questions it aims to answer are:\n\nDoes lower sensory threshold result in lower pain scores and chronic LRP related disability?\n\nParticipants will:\n\nTake DRG-pRF procedure for 4 minutes. Visit the clinic at 1. and 3. month for questionnaries.",[564,565,566,27,221],"Dorsal Root Ganglion","Pulsed Radiofrequency","Chronic Pain",[568,569,150,570],"dorsal root ganglion","pulsed radiofrequency","pain related disability","2024-12-24",{"date":573,"type":34},"2025-01-03",{"date":575,"type":21},"2025-01-01",{"date":577,"type":21},"2025-10-01",{"name":579,"class":41},"Ankara University",{"id":581,"slug":582,"hasResults":11,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":51,"enrollmentInfo":587,"targetDuration":4,"studyType":22,"phases":589,"briefSummary":590,"conditions":591,"keywords":592,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":42},"100566176","effectiveness-of-high-intensity-laser-therapy-hilt-in-patients-with-chronic-lumbar-radiculopathy-due-to-disc-herniation-100566176","NCT06651775","Effectiveness of High Intensity Laser Therapy (HILT) in Patients With Chronic Lumbar Radiculopathy Due to Disc Herniation.","Effectiveness of High Intensity Laser Therapy (HILT) in Patients With Chronic Lumbar Radiculopathy Due to Disc Herniation","Inclusion Criteria:\n\n* Patients diagnosed with lumbar radiculopathy due to lumbar disc herniation and whose complaints are correlated with lumbar MRI\n* Patients aged 18-65 years\n* Patients who agreed to participate in the study\n* Literate patients\n\nExclusion Criteria:\n\n* Pregnancy\n* Patients with cardiac pacemakers\n* Patients with a diagnosis of inflammatory rheumatic disease,\n* Patients with a diagnosis of polyneuropathy that precludes receiving treatment,\n* Patients with active or history of malignancy within the last 1 year and currently receiving chemotherapy and\u002For radiotherapy,\n* Patients with serious psychiatric illness,\n* Patients with severe coagulation disorders,\n* Spinal Stenosis (patients with spinal canal diameter less than 8 mm)\n* Patients with neurologic deficits that prevent them from receiving treatment,\n* Patients with active infection,\n* Patients with vasculitis,\n* Patients with skin disease in the treated area,\n* Patients who received steroid injections and\u002For physical therapy for the lumbar region within the last 3 months,\n* Patients undergoing lumbar spine surgery,\n* Patients with acute trauma,\n* Patients with a history of lumbar instability,\n* Patients with uncontrolled or severe cardiovascular or metabolic disorders",{"count":588,"type":21},70,[24],"The aim of the researchers in this intervention study was to see the effects of High Intensity Laser Therapy (HILT) on participants' disability, functionality and pain parameters in chronic radicular low back pain due to lumbar disc herniation, and to investigate its superiority over widely used conventional electrotherapy modalities.\n\nThe main question it aims to answer is:\n\nWhat is the short and long term effect of high intensity laser therapy on low back and leg pain in patients with chronic lumbar radiculopathy due to disc herniation?\n\n35 patients in group A will receive the planned Hotpack, TENS, High Intensity Laser Therapy (HILT) and exercise treatments for lumbar radicular low back pain. In group B (comparison group) 35 patients will receive Hotpack, TENS, sham HILT, and exercise treatments.\n\nParticipants will receive 15 sessions of treatment and exercises will be given as a home program. Both groups will complete questionnaires about disability, life functions and pain before and after treatment and at the 3rd month follow-up.",[27],[593,68,594,595],"Activity of Daily Living","high intensity laser therapy","pain","2024-10-23",{"date":598,"type":34},"2024-10-26",{"date":600,"type":34},"2024-05-15",{"date":602,"type":21},"2025-02-15",{"name":604,"class":41},"Ankara City Hospital Bilkent",{"id":606,"slug":607,"hasResults":11,"nctId":608,"briefTitle":609,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":612,"targetDuration":4,"studyType":22,"phases":614,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":618,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":42},"100536397","high-voltage-pulsed-radiofrequency-of-the-lumbar-dorsal-root-ganglion-for-the-treatment-of-chronic-lumbar-radicular-and-neuropathic-pain-a-prospective-doble-blinded-and-randomized-controlled-trial-100536397","NCT06264297","High-Voltage Pulsed Radiofrequency of the Lumbar Dorsal Root Ganglion for the Treatment of Chronic Lumbar Radicular and Neuropathic Pain; A Prospective, Doble-blinded and Randomized Controlled Trial","Radiofrequency","Inclusion Criteria:\n\n* Patients over 18 years of age.\n* Unilateral pain radiating to the lower extremity (with or without lumbar pain), which clinically corresponds to the path of the corresponding dermatomes.\n* Correlation between clinical symptoms and lesion observed by magnetic resonance imaging (MRI).\n* Radicular syndrome of three months or more of evolution.\n* Normal or pathological electromyogram (EMG).\n* Pain with neuropathic characteristics confirmed by the DN4 neuropathic pain questionnaire.\n* Patients with a previous positive block diagnosis.\n* Patients who have signed the informed consent document.\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Patients with non-radicular low back pain.\n* MRI not consistent with the patient\\'s symptoms.\n* Patients with peripheral neuropathy of the lower extremities.\n* Patients with a history or current diagnosis of serious mental disorder.\n* Patients with moderate or severe cognitive impairment, or evidence of acute or subacute confusional syndrome.\n* Infection at the puncture site.\n* Coagulation disorders.\n* Pregnant patients.\n* Patients who refuse to sign the informed consent document.\n* Patients allergic to radiological contrast.",{"count":613,"type":21},98,[24],"The management of chronic lumbar radicular and neuropathic pain is complex and the treatment success rates are low. Pulsed radiofrequency (PRF) has been described in these cases. In order to determine whether high-voltage PRF show better results than PRF a prospective, doble-blinded and randomized study is conducted in patients with chronic lumbar radicular and neuropathic pain.",[565,27],"2024-02-12",{"date":619,"type":34},"2024-02-16",{"date":621,"type":34},"2023-02-20",{"date":623,"type":21},"2027-12",{"name":625,"class":41},"Consorci Sanitari de Terrassa"]