[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-spinal-stenosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-spinal-stenosis":24},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,43,72,96,123,151,166,195,224,248,274,305,326,351,376,403,434,462,491,514,539,561,585,611,638],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100291373","mild-percutaneous-image-guided-lumbar-decompression-a-medicare-claims-study-100291373",false,"NCT03072927","MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study","Inclusion Criteria:\n\n* Medicare beneficiaries receiving MILD or interspinous process decompression\n* Diagnosis of LSS with NC\n\nExclusion Criteria:\n\n* Patients that have received a laminectomy, laminotomy, fusion, interspinous process decompression, or MILD in the lumbar region during the 12 months prior to the index date","ALL","18 Years",{"count":19,"type":20},8000,"ESTIMATED","OBSERVATIONAL","This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by the sponsor.",[24],"Lumbar Spinal Stenosis",[24,26,27,28,29],"Interspinous process decompression","MILD","Medicare","Medicare Advantage","RECRUITING","2026-06-23",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":34},"2017-03-10",{"date":38,"type":20},"2026-12",{"name":40,"class":41},"Stryker Instruments","INDUSTRY",2326,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100642599","surgical-treatment-of-adjacent-segment-stenosis-100642599","NCT07661199","Surgical Treatment of Adjacent Segment Stenosis","STASS","Inclusion Criteria:\n\n* Age ≥18 years.\n* Oswestry Disability Index (ODI) between 30% and 80% at screening.\n* Symptomatic adjacent segment stenosis following degenerative lumbar fusion surgery.\n* Persistent symptoms despite at least 6 weeks of appropriate conservative treatment.\n* Radiological evidence of adjacent segment spinal stenosis on magnetic resonance imaging (MRI).\n* Ability to understand the study procedures and complete patient-reported outcome questionnaires.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Adjacent segment kyphosis or scoliosis greater than 10 degrees.\n* Screw loosening or pseudarthrosis of the previous fusion construct.\n* Known current pregnancy or breastfeeding.\n* Acute traumatic spinal injury or fracture.\n* Active inflammatory disease of the spine.\n* Active neoplastic disease of the spine.\n* Contraindication to spinal surgery.\n* Inability to provide informed consent or complete study questionnaires.\n* Symptoms attributable to spinal stenosis are not the predominant clinical complaint\n* Foraminal stenosis grade ≥2 according to the Lee classification.\n* Dynamic spondylolisthesis ≥3 mm on flexion-extension radiographs.\n* Persons involuntarily detained by judicial or administrative order.",{"count":51,"type":20},338,"INTERVENTIONAL",[54],"NA","The goal of this clinical trial is to learn whether microdecompression alone is as effective as decompression with extension of fusion surgery in patients with symptomatic adjacent segment stenosis after previous lumbar fusion surgery.\n\nThe main questions it aims to answer are:\n\nIs microdecompression alone non-inferior to decompression with extension of fusion in improving disability 24 months after surgery, as measured by the Oswestry Disability Index (ODI)? Does microdecompression alone result in similar or lower rates of complications, reoperations, pain, and radiological progression compared with decompression and fusion?\n\nResearchers will compare microdecompression alone to decompression with extension of lumbar fusion to determine whether the less invasive procedure can achieve similar clinical outcomes while reducing surgical burden and preserving spinal structures.\n\nParticipants will:\n\nBe randomly assigned to one of two treatment groups: microdecompression alone or decompression with extension of lumbar fusion.\n\nUndergo the assigned surgical treatment. Attend clinical and radiological follow-up visits at 6, 12, and 24 months after surgery.\n\nComplete questionnaires assessing disability, pain, quality of life, sleep quality, and mental health.\n\nUndergo routine imaging and clinical examinations to evaluate treatment outcomes and possible complications.",[57,24],"Adjacent Segment Disease",[57,59,24],"Adjacent Segment Stenosis","NOT_YET_RECRUITING","2026-06-18",{"date":63,"type":34},"2026-06-22",{"date":65,"type":20},"2026-10-01",{"date":67,"type":20},"2031-03-01",{"name":69,"class":70},"Charite University, Berlin, Germany","OTHER",1,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":71},"100643078","role-of-intraoperative-computed-tomography-in-assessment-of-spine-instability-in-lumbar-degenerative-disease-100643078","NCT07644507","Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease","Analysis of Intraoperative Computed Tomography Images in the Assessment of Radiological Features of Lumbar Spine Instability in Patients Undergoing Surgery for Degenerative Disease: Validation of Diagnostic Parameters","INSIGHT-CT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Degenerative lumbar spine pathology requiring surgical treatment (e.g., degenerative spondylolisthesis, lumbar spinal stenosis, isthmic spondylolisthesis)\n* Planned or performed lumbar decompression with instrumented fusion\n* Available intraoperative computed tomography (CT) with comparative preoperative imaging (retrospective cohort), or intraoperative CT performed during the index surgery (prospective cohort)\n* No prior surgery at the spinal level under evaluation; previous surgery at other levels permitted\n* Stable general medical condition allowing planned clinical evaluation\n* Written informed consent prior to participation (prospective cohort only)\n\nExclusion Criteria:\n\n* Non-degenerative spinal pathology, including acute traumatic spinal injury, primary or metastatic spinal tumor, spinal infection (e.g., osteomyelitis, discitis), or inflammatory spinal disease (e.g., ankylosing spondylitis)\n* Inadequate or incomplete imaging data, including poor-quality intraoperative CT or absence of comparative preoperative imaging\n* Emergency or non-elective surgery\n* Revision surgery involving the same spinal level(s)\n* Inability to provide informed consent (prospective cohort only)\n* Neuromuscular or congenital spinal deformity significantly altering spinal biomechanics (e.g., scoliosis \\>20°, congenital segmentation anomalies)",{"count":81,"type":20},100,"This study examines how well computed tomography (CT) imaging performed during spine surgery - known as intraoperative CT - can detect instability in the lower (lumbar) part of the spine. Spinal instability means that the bones of the spine move more than they normally should, which can contribute to pain and may affect the outcome of surgery.\n\nBefore surgery, doctors usually check for this instability using X-rays taken while the patient bends forward and backward. These X-rays do not always show instability clearly. During surgery, the patient lies face down and the muscles are fully relaxed, which can change how the spine appears on imaging.\n\nThe purpose of this study is to learn whether CT images taken during surgery can identify signs of lumbar spinal instability as reliably as standard imaging performed before surgery, and whether they can reveal signs of instability that were not visible beforehand. To do this, the researchers will review imaging and clinical information from adults who are undergoing surgery for degenerative (wear-related) conditions of the lower spine.\n\nThis study does not change a patient's surgery or treatment. It only analyzes imaging and clinical information that are already part of standard care. The findings may help guide imaging and surgical decisions in lumbar spine surgery in the future.",[84,85,86,24],"Degenerative Lumbar Spine Diseases","Lumbar Spinal Instability","Degenerative Spondylolisthesis","2026-06-10",{"date":89,"type":34},"2026-06-12",{"date":91,"type":20},"2026-08-01",{"date":93,"type":20},"2027-12-01",{"name":95,"class":70},"4th Military Clinical Hospital with Polyclinic, Poland",{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":16,"minAge":103,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100518735","analysis-of-lumbar-spine-stenosis-specimens-for-identification-of-transthyretin-cardiac-amyloidosis-100518735","NCT06034405","Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis","Inclusion Criteria:\n\n1. Clinically indicated spinal decompressive surgery within 20 years prior to enrollment.\n2. Age ≥50 years at the time of the surgery.\n3. Able to understand and sign the informed consent document after the nature of the study has been fully explained.\n\nExclusion Criteria:\n\nThe presence of any of the following excludes eligibility for enrollment in this study:\n\n1. Confirmed primary amyloidosis (AL) or secondary amyloidosis (AA).\n2. Known TTR amyloidosis.\n3. Other reason that would make the subject inappropriate for entry into this study.",true,"50 Years",{"count":105,"type":20},1663,"Primary objective:\n\nTo identify older adults with transthyretin cardiac amyloidosis (ATTR-CA) early in the course of the illness, at a time when disease modifying therapies are most effective.\n\nThe specific aims of this epidemiologic investigation include:\n\n1. To identify subjects with previous lumbar spinal stenosis (LSS) Surgery who have evidence of transthyretin (TTR) amyloid deposits in spinal specimens and could be at risk for ATTR cardiac amyloidosis.\n2. To evaluate for ATTR-CA among those with localized TTR in the spinal tissue.\n\nThe study will also explore the following:\n\n1. The prevalence of amyloid in lumbar spinal stenosis specimens by Congo Red staining.\n2. The prevalence of TTR deposits among subjects with amyloid as determined by mass spectrometry.\n3. Evaluation of a novel artificial intelligence technique for that can identify amyloid histologically with standard H\\&E staining.\n4. Difference in ATTR-CA prevalence between subjects with TTR and indeterminate amyloid deposits in subject's spine by myocardial uptake of technetium pyrophosphate scan (Tc99-PYP).",[24,108,109,110,111,112],"Cardiac Amyloidosis","ATTR Amyloidosis Wild Type","ATTR Gene Mutation","ATTRV122I Amyloidosis","Cardiomyopathy, Hypertrophic","2026-06-02",{"date":115,"type":34},"2026-06-04",{"date":117,"type":34},"2023-09-19",{"date":119,"type":20},"2028-05",{"name":121,"class":70},"Columbia University",6,{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":16,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":150},"100520504","activity-levels-amongst-patients-with-lumbar-spinal-stenosis-100520504","NCT06057428","Activity Levels Amongst Patients With Lumbar Spinal Stenosis","Activity Levels Amongst Elderly Patients With Symptomatic Lumbar Spinal Stenosis Before and After Decompressive Surgery","B-ATLAS","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Referred to decompressive spinal surgery due to symptomatic lumbar spinal stenosis at ≥ 1 level\n* Central canal LSS grade B or C (Schizas classification) at ≥ 1 level by Magnetic Resonance Imaging\n* Minimum of 3 months of unsuccessful non-operative treatment\n\nExclusion Criteria:\n\n* Signs of malignancy or infection in the spinal column\n* Severe comorbidities incl. neurodegenerative conditions which may contribute to balance problems\n* Revision surgery (previous decompression surgery at the same vertebral level)\n* Spinal surgery up to 1 year prior to the date of inclusion\n* Mini Mental State Exam (MMSE) score of ≤ 27 points\n* Degenerative spondylolisthesis more than 3mm on pre-operative imaging diagnostics","65 Years",{"count":133,"type":20},80,"Lumbar spinal stenosis (LSS) is one of the most common degenerative diseases of the spinal column, with symptoms including low back pain which worsens with ambulation, poor balance, decreased activity due to pain, and a marked decrease in quality of life (QoL). Prevalence rises with age, and current treatment options range from varied conservative management strategies, to surgical intervention with decompression of neural structures.\n\nWhile the effects of surgical decompression on back pain and QoL has been widely researched, the effects of surgery on activity levels is less well understood. Though patients generally have subjective improvements in this parameter after surgery, objective measurements in this patient group have been lacking.\n\nThis study aims to investigate the effects of decompressive surgery on activity levels in elderly patients with LSS. Measurements of activity will be taken before and after decompressive surgery, as well as with regular intervals during a two-year follow-up period.\n\nA better understanding of the effect that LSS has on activity may lead to more patients being able to receive surgical treatment, which is hypothesized to lead to an increase in QoL and less perceived disability amongst this patient group.",[24],[137,138,139,140],"Spinal stenosis","Elderly","Activity","Surgery","2026-06-01",{"date":143,"type":34},"2026-06-03",{"date":145,"type":34},"2023-09-21",{"date":147,"type":20},"2028-12",{"name":149,"class":70},"Region Zealand",2,{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":16,"minAge":131,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":158,"conditions":159,"keywords":160,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":164,"leadSponsor":165,"locationsCount":150},"100521920","balance-amongst-patients-with-lumbar-spinal-stenosis-100521920","NCT06075862","Balance Amongst Patients With Lumbar Spinal Stenosis","Postural Imbalance Amongst Elderly Patients With Symptomatic Lumbar Spinal Stenosis Before and After Decompressive Surgery",{"count":133,"type":20},"Lumbar spinal stenosis (LSS) is one of the most common degenerative diseases of the spinal column, with symptoms including low back pain which worsens with ambulation, poor balance, decreased activity due to pain, and a marked decrease in quality of life (QoL). Prevalence rises with age, and current treatment options range from varied conservative management strategies, to surgical intervention with decompression of neural structures.\n\nWhile the effects of surgical decompression on back pain and QoL has been widely researched, the effects of surgery on patient balance is less well understood. Though patients generally have subjective improvements in this parameter after surgery, objective measurements in this patient group have been lacking.\n\nThis study aims to investigate the effects of decompressive surgery on postural balance in elderly patients with LSS. Measurements of postural balance will be taken before and after decompressive surgery, as well as with regular intervals during a two-year follow-up period.\n\nA better understanding of the effect that LSS has on balance may lead to more patients being able to receive surgical treatment, which is hypothesized to lead to an increase in QoL and less perceived disability amongst this patient group.",[24],[137,138,161,140],"Balance",{"date":143,"type":34},{"date":145,"type":34},{"date":147,"type":20},{"name":149,"class":70},{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":12,"sex":16,"minAge":173,"maxAge":174,"enrollmentInfo":175,"targetDuration":4,"studyType":52,"phases":177,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":71},"100640258","hybrid-vs-fluoroscopy-guided-interlaminar-epidural-injection-in-lumbar-spinal-stenosis-100640258","NCT07612982","Hybrid vs Fluoroscopy-Guided Interlaminar Epidural Injection in Lumbar Spinal Stenosis","Comparison of Hybrid and Fluoroscopy-Guided Interlaminar Epidural Steroid Injections on Patient Satisfaction, Radiation Dose and Procedure Time in Lumbar Spinal Stenosis","Inclusion Criteria:\n\n* Age between 40 and 75 years\n* Diagnosis of lumbar spinal stenosis confirmed by clinical evaluation and magnetic resonance imaging (MRI)\n* Presence of neurogenic claudication symptoms for at least 3 months\n* Inadequate response to conservative treatment, including medication, physical therapy, or exercise\n* Numeric Rating Scale (NRS) pain score ≥ 4 at baseline\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Previous lumbar spine surgery\n* Vertebral fracture, spinal malignancy, or history of significant lumbar trauma\n* Peripheral vascular claudication or clinically significant peripheral polyneuropathy\n* Epidural steroid injection within the past 6 months\n* Medical conditions severely limiting ambulation unrelated to lumbar spinal stenosis (e.g., severe cardiopulmonary disease or advanced hip\u002Fknee osteoarthritis)\n* Pregnancy or breastfeeding\n* Coagulation disorders or inability to safely discontinue anticoagulant or antiplatelet therapy according to guideline recommendations\n* Known allergy to local anesthetics, corticosteroids, or contrast agents\n* Active local or systemic infection\n* Body mass index (BMI) \\> 30 kg\u002Fm²","40 Years","75 Years",{"count":176,"type":20},44,[54],"Lumbar spinal stenosis is a common degenerative condition that can cause chronic low back and leg pain, especially during walking or standing. Interlaminar epidural steroid injections are widely used to relieve pain and improve function in patients who do not respond adequately to conservative treatments.\n\nThese injections are usually performed under fluoroscopic guidance, which allows accurate needle placement but exposes patients and healthcare providers to ionizing radiation. Ultrasound guidance has emerged as an alternative technique that avoids radiation exposure; however, ultrasound alone may not always confirm correct epidural spread of the injected medication.\n\nThis prospective, randomized clinical trial aims to compare two commonly used imaging approaches for interlaminar epidural steroid injections in patients with lumbar spinal stenosis: fluoroscopy-guided injection and ultrasound-guided injection with fluoroscopic confirmation (hybrid technique). The study will evaluate patient satisfaction, radiation exposure, procedure time, technical success, pain relief, and functional outcomes.\n\nThe results of this study are expected to help identify the most effective and safe imaging guidance method for interlaminar epidural steroid injections in patients with lumbar spinal stenosis.",[24],[181,182,183,184,185],"Fluoroscopy","Radiation exposure","Patient satisfaction","Interventional Ultrasonography","Epidural Injections","2026-05-28",{"date":188,"type":34},"2026-05-29",{"date":190,"type":20},"2026-07",{"date":192,"type":20},"2027-01",{"name":194,"class":70},"Marmara University",{"id":196,"slug":197,"hasResults":12,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":12,"sex":16,"minAge":173,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":52,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":71},"100639241","comparative-analysis-of-two-transforaminal-lumbar-interbody-fusion-tlif-procedures-in-the-treatment-of-single-level-lumbar-spinal-stenosis-lss-a-single-center-prospective-randomized-controlled-trial-100639241","NCT07588555","Comparative Analysis of Two Transforaminal Lumbar Interbody Fusion (TLIF) Procedures in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled Trial","Comparative Analysis of L-Unitary Soft Endoscope Transforaminal Lumbar Interbody Fusion (LUSE-TLIF) Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF) in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ranging from 40 to 70 years, irrespective of sex.\n* Presence of bilateral lower-limb pain and neurogenic claudication, with or without low back pain.\n* Preoperative computed tomography or magnetic resonance imaging confirming single-level lumbar spinal stenosis accompanied by grade II or higher lumbar spondylolisthesis and\u002For lumbar instability.\n* Persistent pain within 7 days prior to enrollment, with inadequate response to nonsurgical treatment for more than 3 months.\n* Willingness to provide written informed consent and ability to comply with the study protocol and visit schedule.\n\nExclusion Criteria:\n\n* Patients with evidence of vascular claudication identified by lower-limb color Doppler ultrasound.\n* Patients with a history of previous lumbar spine surgery.\n* Coexistence of severe lumbar disc herniation, spinal deformity, spinal tumor, infection, or inflammatory diseases.\n* Pregnancy or lactation.\n* Presence of severe underlying medical conditions or psychiatric disorders that preclude tolerance of the procedure.\n* Known concurrent diseases considered by the investigator to preclude study entry.\n* Inability to comply with study assessments or complete questionnaires for any reason.\n* Patients deemed unsuitable for participation in this trial as judged by the investigator.","70 Years",{"count":204,"type":20},276,[54],"Lumbar spinal stenosis (LSS), a common degenerative lumbar condition characterized by low back pain, leg pain, and neurogenic claudication, significantly impairs patients' quality of life. Its prevalence continues to rise with the aging population. For patients who do not respond to conservative treatment, surgical intervention remains a key therapeutic approach, with lumbar interbody fusion (LIF) being a commonly employed procedure. The technique has evolved from posterior lumbar interbody fusion (PLIF) to transforaminal lumbar interbody fusion (TLIF) and, more recently, to minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). Although MIS-TLIF can effectively reduce tissue trauma and complications, it still faces clinical challenges such as intraoperative visual blind spots and the potential for postoperative chronic back pain associated with reliance on conventional pedicle screws. To address these limitations, our research team independently developed a highly integrated, miniaturized (with an outer diameter of only 1.8 mm), and maneuverable L-Unitary Soft Endoscope (LUSE) minimally invasive system. Its unique design helps avoid obstruction of the surgical field and allows flexible adjustment during the procedure. Currently, there is a lack of clinical efficacy evaluations in China on the use of this LUSE system for TLIF surgery (referred to as LUSE-TLIF) in treating LSS. Therefore, this study aims to systematically compare LUSE-TLIF with the currently mainstream MIS-TLIF, evaluating its safety, efficacy, and clinical outcomes in the treatment of LSS, in order to provide spine surgeons with a novel and potentially superior minimally invasive surgical option.",[24],[209,210,211,212,213],"Lumbar spinal stenosis","LUSE-TLIF","MISTLIF","Lumbar Spondylolisthesis","Lumbar Instability","2026-05-08",{"date":216,"type":34},"2026-05-14",{"date":218,"type":34},"2026-03-18",{"date":220,"type":20},"2031-12-31",{"name":222,"class":223},"The Third Affiliated Hospital of Southern Medical University","OTHER_GOV",{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":102,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":52,"phases":234,"briefSummary":236,"conditions":237,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":247},"100528162","phase-4-efficacy-of-m640-in-acute-lumbosacral-musculoskeletal-conditions-100528162","NCT06157177","Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.","Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica","Inclusion Criteria:\n\n* No clinically significant conditions impacting quality or quantity of pain\n* Baseline Numeric Pain Scale ≥ 6\n* Capable of answering text or email survey reminders\n* Low back pain with or without sciatica\n\nExclusion Criteria:\n\n* Current use of other skeletal relaxants\n* Current use of other pain relievers\n* Current use of cimetidine or monoamine oxidase inhibitors","80 Years",{"count":233,"type":20},50,[235],"PHASE4","The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about:\n\n* Amount and quality of pain\n* Interference with physical activity\n* Interference with sleep",[238,24],"Sciatica Acute",{"date":240,"type":34},"2026-05-12",{"date":242,"type":34},"2023-11-15",{"date":244,"type":20},"2026-11-15",{"name":246,"class":41},"Primus Pharmaceuticals",24,{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":52,"phases":258,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":71},"100443736","phase-3-lumbar-steroid-use-in-patients-undergoing-posterior-lumbar-decompression-100443736","NCT05058287","Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression","Topical Epidural Steroid Usage in Patients Undergoing Posterior Lumbar Decompression: A Randomized Control Trial","Inclusion Criteria:\n\n* Patients scheduled to undergo 1 to 2 level laminectomy\n* Between the ages of 18-85\n\nExclusion Criteria:\n\n* Minimally invasive surgery\n* Prior daily opioid usage within 6 months.\n* Use of concomitant procedures such as spinal fusion, revision procedure at the same level.\n* History of a chronic pain syndrome, uncontrolled diabetes defined as A1C \\> 6.5, immunocompromised condition such as active cancer treatment, history of transplant, benign prostatic hyperplasia or history of urinary retention, and other conditions which require chronic steroid therapy or immunosuppressants.\n* Non-English speakers\n* Patients allergic to Depo-Medrol and\u002For glucocorticoids, or other steroids","85 Years",{"count":257,"type":20},150,[259],"PHASE3","This study seeks to evaluate the impact of intra-operative topical epidural steroid usage in patients undergoing 1-2 level lumbar laminectomy. The study will examine post-operative opioid usage, length of stay, return to work, and patient reported outcomes following these procedures.",[262,24,263,264],"Opioid Use","Pain, Postoperative","Pain, Back","2026-04-23",{"date":267,"type":34},"2026-04-28",{"date":269,"type":34},"2021-11-05",{"date":271,"type":20},"2026-12-31",{"name":273,"class":70},"Hospital for Special Surgery, New York",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":174,"enrollmentInfo":281,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":283,"conditions":284,"keywords":288,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":71},"100630540","opioid-free-and-opioid-based-anesthesia-in-elective-lumbar-spine-surgery-100630540","NCT07489001","Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery","Prospective Comparative Evaluation of Intra-operative and Postoperative Outcomes Associated With Opioid Free Versus Opioid Based Anesthesia Techniques in Patients Undergoing Elective Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Adults aged 18 to 75 years\n* Elective surgery only\n* Scheduled for elective lumbar spinal surgery (lumbar spinal stenosis and\u002For lumbar disc herniation)\n* ASA physical status I-III\n* No previous lumbar spine surgery\n* Able to provide written informed consent\n* BIS monitoring available and recorded\n* Ability to comply with postoperative pain assessment (NRS\u002FVAS)\n* Stable hemodynamic status preoperatively\n\nExclusion Criteria:\n\n* Age younger than 18 or older than 75\n* Inability or unwillingness to provide informed consent\n* Severe psychiatric disease or cognitive impairment\n* Emergency surgery cases\n* BMI \\> 40 kg\u002Fm²\n* Pregnancy\n* Uncontrolled hypertension, arrhythmia, or severe cardiac disease\n* Renal failure\n* Chronic beta-blocker use\n* Coagulation disorders\n* Chronic alcohol dependence or substance use\n* Neurological deficits affecting perception of pain\n* Chronic pain syndrome (fibromyalgia, chronic LBP \\> 3 months)\n* Chronic gabapentinoid use\n* Anemia\n* Known allergy to any anesthetic or analgesic agents used in the study\n* Local infection at the intended ESP block injection site\n* Intraoperative change in anesthetic technique that deviates from initial planned management\n* Pediatric patients (\\\u003C18 years)",{"count":282,"type":20},75,"This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult patients undergoing lumbar spinal surgery. Patients will be managed according to routine clinical practice and assigned to one of three groups based on the analgesic strategy used by the attending anesthesiologist: (1) opioid-free anesthesia using multimodal agents and\u002For erector spinae plane (ESP) block; (2) ESP block plus intraoperative opioids; or (3) opioid-based anesthesia without regional blocks.\n\nThe primary objective is to compare postoperative pain control and opioid requirements within the first 48 hours after surgery. Secondary objectives include evaluating opioid-related side effects such as nausea, vomiting, pruritus, constipation, delayed mobilization, urinary retention, and postoperative complications classified according to the Clavien-Dindo system. Standard postoperative analgesia, including intravenous morphine patient-controlled analgesia (PCA), acetaminophen, and NSAIDs, will be provided for all patients.\n\nThe study aims to determine whether an opioid-free multimodal analgesic approach can reduce opioid consumption and related adverse effects while maintaining adequate analgesia in patients undergoing lumbar spinal surgery.",[24,285,286,287],"Lumbar Disc Herniation With Radiculopathy","Lumbar Degenerative Spondylolisthesis","Lumbar Disc Degeneration",[289,290,291,292,293,294,295,296,297],"Opioid-Free Anesthesia","Multimodal Analgesia","Erector Spinae Plane Block","ESP Block","Postoperative Pain","Opioid-Related Adverse Effects","Opioid Consumption","Lumbar Spine Surgery","Regional Anesthesia",{"date":299,"type":34},"2026-03-23",{"date":301,"type":34},"2025-12-09",{"date":303,"type":20},"2026-12-10",{"name":194,"class":70},{"id":306,"slug":307,"hasResults":12,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":12,"sex":16,"minAge":173,"maxAge":312,"enrollmentInfo":313,"targetDuration":4,"studyType":52,"phases":314,"briefSummary":316,"conditions":317,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":150},"100438691","early-phase-1-study-comparing-local-mac-anesthesia-in-lumbar-decompression-100438691","NCT04992572","Study Comparing Local\u002F MAC Anesthesia in Lumbar Decompression","Randomized Study Comparing Local\u002F MAC Anesthesia to General for 1-3 Level Lumbar Decompressions","Inclusion Criteria:\n\nPatients with lumbar stenosis to be decompressed over 1-3 segments\n\n* Ages 40-95\n* Appropriate for general anesthesia\n\nExclusion Criteria:\n\n* Planned significant nerve root retraction\n* Previous fusion operation\n* Unable to comply with follow up\n* Patients with daily morphine equivalents or more 100mg\n* Patients with a known hypersensitivity to propofol or any of DIPRIVAN Injectable Emulsion components.\n* Patients with allergies to eggs, egg products, soybeans or soy products.","95 Years",{"count":81,"type":20},[315],"EARLY_PHASE1","Explore efficacy, complications, and other factors associated with anaesthetic choice- To evaluate the efficacy of local + MAC as an alternative anesthetic to general anesthesia and to analyze patients' outcomes and experiences.",[24],{"date":319,"type":34},"2026-03-20",{"date":321,"type":34},"2021-12-01",{"date":323,"type":20},"2028-12-31",{"name":325,"class":70},"Stanford University",{"id":327,"slug":328,"hasResults":12,"nctId":329,"briefTitle":330,"officialTitle":331,"acronym":332,"eligibilityCriteria":333,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":334,"targetDuration":4,"studyType":52,"phases":336,"briefSummary":337,"conditions":338,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":348,"locationsCount":350},"100629005","cle-pad--prevalence-of-pad-in-patients-with-surgically-lumbar-spinal-stenosis-100629005","NCT07469020","CLE-PAD : Prevalence of PAD in Patients With Surgically Lumbar Spinal Stenosis","CLE-PAD : Prevalence of Lower Extremity Peripheral Artery Disease in Patients With Surgically Lumbar Spinal Stenosis","CLE-PAD","Inclusion Criteria:\n\n* Presenting with a lumbar spinal stenosis with surgical indication, either unoperated or operated on less than 3 months ago\n* Affiliated with a social security scheme\n* Having received oral and written information about the protocol and having signed a written consent form to participate in this research.\n\nExclusion Criteria:\n\n* emergency surgical care\n* Contraindication to contrast enhanced CT scan\n\n  * Stroke or myocardial infarction (MI) within the last 3 months\n  * Known severe or poorly tolerated arrhythmia\n  * Known severe or symptomatic left ventricular outflow obstruction\n  * Decompensated heart failure\n  * History within the last 3 months of venous thromboembolic disease, myopericarditis, endocarditis, aortic dissection or intracardiac thrombus\n  * Severe uncontrolled hypertension (BP \\> 200\u002F110 mmHg)\n  * Inability to walk on the treadmill\n  * Major lower limb amputation\n  * Adult subject to legal protection",{"count":335,"type":20},49,[54],"The goal of this interventional study is to evaluate the rate of existing lower limb peripheral artery disease (PAD) in patients with surgically lumbar spinal stenosis (LSS). PAD and LSS can present similar symptoms and it can be difficult to diagnose PAD using conventional methods, depending on the location of the arterial disease. The main questions it aims to answer are :\n\n* What's the prevalence of PAD in LSS patients?\n* Which exam among routine tools is the most accurate to diagnose PAD in this population? Around their surgery for LSS (a few weeks before or after), participants will be included in a vascular medicine service. After checking of eligibility criteria, they will undergo a contrast-enhanced CT scan for the diagnosis of PAD and various routine diagnostic tests: Doppler ultrasound, treadmill tests, pressure index, pulse palpation.",[339,24,340],"PAD - Peripheral Arterial Disease","Lower Limb Arterial Disease","2026-03-09",{"date":343,"type":34},"2026-03-13",{"date":345,"type":20},"2026-05",{"date":347,"type":20},"2026-08",{"name":349,"class":70},"Rennes University Hospital",3,{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":255,"enrollmentInfo":358,"targetDuration":359,"studyType":21,"phases":4,"briefSummary":360,"conditions":361,"keywords":366,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":369,"startDateStruct":371,"completionDateStruct":373,"leadSponsor":375,"locationsCount":71},"100610916","presence-of-dural-pulsation-in-patients-diagnosed-with-lumbar-spinal-stenosis-100610916","NCT07233798","Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis","Correlation of the Presence of Dural Pulsation With Clinical and Radiological Parameters in Patients Diagnosed With Lumbar Spinal Stenosis","Inclusion criteria\n\n* Aged between 18 and 85 years\n* Patients experiencing low back and\u002For leg pain attributable to lumbar spinal stenosis\n* Presence of lumbar spinal stenosis at least at one level consistent with clinical symptoms on lumbar MRI\n* Willingness to participate in the study Exclusion criteria\n* Body Mass Index (BMI) ≥ 35 kg\u002Fm²\n* Patients with radiculopathy due to lumbar disc herniation\n* Patients with axial low back pain caused by facet syndrome, sacroiliac dysfunction, or discogenic pain\n* History of lumbar spine surgery\n* Individuals with mental retardation\n* Patients with major psychiatric comorbidities\n* Patients with congenital spinal anomalies\n* Inflammatory rheumatic diseases characterized by osteophyte formation and ligament calcification, such as ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH)\n* Pregnancy\n* Patients with heart failure",{"count":81,"type":20},"1 Year","Lumbar spinal stenosis is defined as the narrowing of the spinal canal resulting from degenerative changes in the spinal joints, intervertebral discs, and the ligamentum flavum.\n\nPressure fluctuations within the cerebral and spinal vascular systems lead to the formation of pulsations. The periodic occurrence of these pulsations in the dura mater is referred to as spinal dural pulsation.The vibratory movements of the dura mater have been interpreted as an indicator that the spinal cord is freely mobile within the subarachnoid space and not subjected to any external compression.This study aims to investigate whether the presence of dural pulsation is associated with clinical and radiological parameters in patients diagnosed with lumbar spinal stenosis",[24,362,363,364,365],"Numerical Rating Scale","Disability Physical","Magnetic Resonance","Claudication",[367,368],"Dural Pulsation","oswestry disability index",{"date":370,"type":34},"2026-03-11",{"date":372,"type":34},"2025-12-07",{"date":374,"type":20},"2026-12-30",{"name":194,"class":70},{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":16,"minAge":384,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":52,"phases":386,"briefSummary":387,"conditions":388,"keywords":391,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":4},"100591975","continuous-erector-spinae-block-for-analgesia-following-lumbar-decompression-100591975","NCT06987409","Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression","Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression: A Randomized Controlled Study","Lumbar-ESP","Inclusion Criteria:\n\n* Adult (aged \\>18 years) patients\n* Undergoing lumbar decompression surgery +\u002F- fusion\n* Under the orthopedic surgery team\n\nExclusion Criteria:\n\n* Surgery on an emergency basis (level 1, 2 or 3; \\\u003C8 hours)\n* An ejection fraction \\\u003C30%\n* Severe pre-existing liver disease (Child B or C)\n* Severe kidney disease (Glomerular filtration rate (GFR) \\\u003C30 (mL\u002Fmin\u002F1·73m²))\n* An allergy to ropivacaine\n* Weight \\\u003C50 kg\n* Unable to provide valid consent to study prior to surgery","19 Years",{"count":81,"type":20},[54],"Lumbar spinal surgery is common, and the incidence of spinal fusion has increased dramatically over the past three decades. Patients requiring spinal surgery are typically prescribed several analgesics, (including opioids) while awaiting surgery. Postoperatively, use of high doses of opioids or anti-inflammatory medications have drawbacks. Severe post-operative pain is reported by 45-80% of patients and rates are generally higher in the opioid tolerant patients.\n\nRegional anesthesia (blocking nerves with local anesthetics) works locally, thereby avoiding many side effects associated with other analgesics. One type of nerve block is called erector spinae plane block (ESP). Single injection nerve blocks have been found to decrease pain, nausea, and opioid consumption, while increasing patient satisfaction and quality of recovery. However, these effects only last for 24 hours or less while the worst pain occurs around 36 hours after surgery. Surgeon-placed indwelling catheters could allow infusions of local anesthetics for 54 hours.\n\nThis randomized control trial seeks to assess the effectiveness of surgeon-placed ESP catheters for pain control after lumbar spine surgery.\n\nHypothesis: Patients receiving a cESP will have less pain, improved quality of recovery, and opioid use following lumbar fusion surgery than those receiving current standard of care pain management.\n\nMethodology: Adult patients undergoing lumbar spine surgery under orthopedic surgery in Halifax will be eligible. The study will include 100 participants, randomly assigned to 2 study arms of 50 participants (1:1 basis to Ropivacaine and placebo groups). At the end of surgery, the surgeon will place the ESP catheters in all study patients under sterile conditions before closing the wound. Ropivacaine 0.5% or normal saline (placebo) 15ml will be injected through each catheter (total 30ml). In the postanesthetic care unit (PACU), two elastomeric pumps will be attached to the ESP catheters. These will be filled with either Ropivacaine 0.2% or normal saline (placebo). The elastomeric pumps are small bottle that patients can carry with them after discharge home. The pumps automatically run at an infusion rate of 10 ml\u002Fhr for 54 hours. All patients will also receive the standard of care for pain management for this patient population, which is opioid based with acetaminophen. A quality of recovery (QoR-15) questionnaire will be completed at 72 hours post-operatively. Pain, catheter complication, and opioid use data will be gathered from the patient's charts at 24, 48, and 72 hours post-operatively. At 3- and 6-month follow-ups, patients will complete the Brief Pain Inventory questionnaire. We will analyze differences in pain and opioid consumption at 24, 48, and 72 hours, quality of recovery index scores at 72 hours, postoperative complication rates, and persistent pain at 3 and 6 months.",[24,389,390],"Lumbar Radiculopathy","Persistent Postsurgical Pain",[392,393],"Erector spinae block","Regional anesthesia","2026-02-13",{"date":396,"type":34},"2026-02-17",{"date":398,"type":20},"2026-12-01",{"date":400,"type":20},"2028-08-01",{"name":402,"class":70},"Nova Scotia Health Authority",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":410,"targetDuration":4,"studyType":52,"phases":412,"briefSummary":413,"conditions":414,"keywords":421,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":71},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation",{"count":411,"type":20},125,[235],"Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[24,415,212,416,389,417,418,419,86,420],"Lumbar Disc Herniation","Lumbar Spondylosis","Lumbar Spine Instability","Synovial Cyst","Degenerative Disc Disease","Degenerative Intervertebral Discs",[422,423,424,425],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","2026-02-11",{"date":396,"type":34},{"date":429,"type":34},"2022-02-01",{"date":431,"type":20},"2027-04-30",{"name":433,"class":70},"John O'Toole",{"id":435,"slug":436,"hasResults":12,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":440,"eligibilityCriteria":441,"healthyVolunteers":102,"sex":16,"minAge":442,"maxAge":4,"enrollmentInfo":443,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":445,"conditions":446,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":71},"100616770","gait-and-paraspinal-semg-in-degenerative-spinal-diseases-100616770","NCT07309926","Gait and Paraspinal sEMG in Degenerative Spinal Diseases","Comparative Analysis of Spatiotemporal Gait Parameters and Paraspinal Surface Electromyography Parameters in Degenerative Spinal Diseases: A Cross-Sectional Study Using Motion Capture and Electromyographic Ensemble Averaging","TDGKSEPDSD","Inclusion Criteria:\n\n1. Patients with the following single disease: degenerative scoliosis, coronal imbalance, lumbar spinal stenosis, lumbar disc herniation, spinal cord-type cervical spondylosis;\n2. Age ≥ 60 years, regardless of gender;\n3. Planned to undergo elective open spinal fusion surgery;\n4. Voluntarily participate in the study, understand and agree to the study content, and sign the informed consent form.\n\nExclusion Criteria:\n\n1. History of previous spinal surgery;\n2. Combined with other neuromuscular diseases (such as Parkinson's disease), inflammatory diseases (such as ankylosing spondylitis), infectious diseases (such as spinal tuberculosis), sepsis, tumors, or lower limb joint diseases that may cause low back and lower limb pain, affecting physical activity;\n3. Suffering from severe cardiovascular, cerebral, liver, or kidney disease;\n4. Suffering from mental illness, dementia, or unable to cooperate to complete clinical research.\n\n   * Skin rupture in the waist;","60 Years",{"count":444,"type":20},120,"This cross-sectional observational study aims to quantitatively compare three-dimensional gait parameters, surface electromyography (EMG) patterns, and radiological parameters among patients with different degenerative spinal conditions-including lumbar disc herniation (LDH), lumbar spinal stenosis (LSS), lumbar sagittal imbalance (LSI), degenerative lumbar scoliosis (DLS), and cervical spondylotic myelopathy (CSM)-alongside a healthy control group. The analysis focuses on spatiotemporal gait characteristics (step length, stride length, cadence), lower limb kinematics and kinetics (hip\u002Fknee\u002Fankle joint angles, moments, and powers during stance and swing phases), and surface EMG amplitudes (thoracic erector spinae, multifidus, gluteus maximus, and rectus abdominis muscles) during standardized walking tasks. Additionally, radiological parameters (e.g., pelvic incidence-lumbar lordosis mismatch, C2-C7 sagittal vertical axis, coronal Cobb angle) will be correlated with gait and muscle activation deviations. The study employs motion capture systems, force plates, and high-density EMG to objectively differentiate disease-specific movement impairments. Findings from this study may establish biomechanical and neuromuscular signatures for each degenerative condition, providing a framework for personalized rehabilitation strategies, gait retraining, and surgical outcome assessment in spinal disorders. Comparative analysis with healthy controls will further elucidate pathological alterations in gait and muscle recruitment patterns caused by degenerative spinal diseases.",[447,448,449,450,451,24,415,452],"Adult Spinal Deformity","Degenerative Scoliosis","Sagittal Deformity","Sagittal Imbalance","Coronal Vertical Axis","Cervical Spondylosis With Myelopathy","2025-12-15",{"date":455,"type":34},"2025-12-30",{"date":457,"type":20},"2025-12-10",{"date":459,"type":20},"2029-12-01",{"name":461,"class":70},"Xuanwu Hospital, Beijing",{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":16,"minAge":469,"maxAge":174,"enrollmentInfo":470,"targetDuration":4,"studyType":52,"phases":472,"briefSummary":473,"conditions":474,"keywords":477,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":489,"locationsCount":150},"100460304","necessity-of-fusion-following-decompression-surgery-in-patients-with-single-level-lumbar-stenosis-100460304","NCT05273879","Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis","Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis: Study Protocol for an Open-label Multicenter Non-inferiority Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* age of patients from 45 to 75 years;\n* stenosis C or D according to Shizas et al. according to MRI at the level of L2-L3, L3-L4, L4-L5 or L5-S1;\n* clinical manifestations of lumbar stenosis (neurogenic claudication syndrome and\u002For radiculopathy);\n* lack of effect from conservative therapy within 3 months;\n* Informed consent to take part in the study.\n\nExclusion Criteria:\n\n* spondylolisthesis more than 3 mm;\n* spinal instability according to functional radiography;\n* sagittal imbalance (type 4 according to C. Barrey);\n* bone density of the vertebrae at the level of the operation is less than 100 HU;\n* clinically significant spinal stenosis at 2 or more levels;\n* previously performed surgeries on the spine;\n* risk of anesthesia 4 or 5 according to ASA;\n* inability to take part in control examinations within 2 years after the operation;\n* participation in other clinical trials related to surgical or conservative treatment of diseases of the spine.","45 Years",{"count":471,"type":20},86,[54],"Long-term clinical results of two methods of surgical treatment (spinal decompression with or without fusion) in patients with single-level lumbar stenosis will be compared. A clear framework for surgical treatment methods and standardized postoperative rehabilitation treatment will be set to obtain the maximum homogeneity of the patient groups.\n\nThis trial should provide the first level of evidence for the need for spinal fusion in patients with single-level lumbar stenosis, subject to the high homogeneous comparison groups. Additional results will allow comparing the economic aspects of different surgical treatments for 2 years after surgery.",[24,475,476],"Spinal Stenosis","Spinal Fusion",[478,479,480,481,482],"lumbar spine","lumbar fusion","laminotomy","decompression without fusion","lumbar stenosis","2025-12-11",{"date":485,"type":34},"2025-12-18",{"date":487,"type":34},"2022-04-01",{"date":374,"type":20},{"name":490,"class":223},"Sklifosovsky Institute of Emergency Care",{"id":492,"slug":493,"hasResults":12,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":497,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":16,"minAge":442,"maxAge":231,"enrollmentInfo":499,"targetDuration":4,"studyType":52,"phases":501,"briefSummary":502,"conditions":503,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":71},"100522986","lumbosacral-spinal-stenosis---non-invasive-postural-therapy-for-older-adult-veterans-100522986","NCT06089746","Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans","Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans (LSS-NIPT)","LSS-NIPT","Inclusion Criteria:\n\n* Veterans receiving care at participating VA\n* Ability to read and write English and understand instructions\n* Agrees to comply with instructions\n* Symptoms for over 3 months\n* Diagnosis of Lumbar Spinal Stenosis as the cause of symptoms\n* Discomfort involving low back pain and \u002F or neurogenic claudication of legs or thighs\n* Back and\u002For leg symptoms greater than 3\u002F10 provoked by walking and \u002F or standing\n* X ray, CT, or MRI performed within the last 12 months shows Lumbar Spinal Stenosis at 1 or 2 levels\n* Prior treatment for Spinal Stenosis including therapy, medication, epidural injections, but not surgery\n* Relief of pain (standardly within 5 minutes) by sitting down\n* Ability to walk 50 feet without a cane or walker\n* General health presents ability to increase activity level if Back and \u002F or leg symptoms resolve\n* If home has stairs and patient uses multiple levels, must have steady handrail\n* Transportation routinely available by car or car service and not by bus\n* Home location allows restriction of walking to flat surfaces (lack of hills), with availability to increase ambulation on flat surfaces\n\nExclusion Criteria:\n\n* Previous Low Back Surgery for SS including decompression or fusion\n* Successful Spinal Stenosis Treatment (such as injection) over the prior 3 months\n* X ray, CT, or MRI shows Lumbar Spinal Stenosis in 3 or 4 levels\n* Prior Lumbar Fracture\n* Scoliosis with Cobb angle over 20 degrees on weight bearing AP Views\n* Inflammatory arthropathy involving the Lumbar Spine, such as RA\n* Radiculopathy attributed to herniated disc\n* Suspected or confirmed moderate to severe large fiber neuropathy\n* Failure of relief of back or leg pain brought on by standing or walking, within 5 minutes, by sitting down\n* Rapid increase in symptoms with lumbar flexion such as sitting, Increase in symptoms brought on by leaning on grocery cart or walker\n* Reduced symptoms by lumbo-sacral extension\n* Vascular Claudication with ABI less than 60 or over 140\n* Prior bypass or stent surgery for PAD\n* Current foot, ankle, leg, or thigh infection or open ulcer\n* Current use of a Brace for foot, ankle, or knee pathology,\n* Moderate to severe arthritis of the Hip, knee, ankle or foot preventing pain free ambulation greater than 1 block\n* Neurologic or neurodegenerative induced gait pathology such as CVA, Parkinson's, NPH, Cervical Myelopathy\n* Current Medico Legal issues, active substance use, SI, HI, or other factors that may interfere with completion of six-week treatment trial\n* Planned surgery or procedure in the 6-week study period",{"count":500,"type":20},20,[54],"Lumbosacral spinal stenosis (LSS) is a leading cause of limited mobility, reduced independence, and poor health outcomes in older adults, and is very common in older adult Veterans. Several years ago, major research studies indicated that surgery for LSS was more effective than usual (medical) management. Nonetheless, there are many patients for whom surgery is not the ideal therapy. There have been reports that modifications in daily activities including temporary use of a modified rolling walker and changes in sleep positioning may help relieve LSS. The investigators have assembled a VA team to study this carefully. The investigators will recruit a small group of older adult Veterans with LSS to try out this program; the investigators will monitor them closely for relief of their symptoms and improvements in walking. The investigators will, as part of this small study, try to understand potential barriers to use of this therapy. The investigators will interview the Veterans and healthcare providers to identify problems that may arise in trying this therapy. If this small study works, the investigators plan to expand the effort.",[24],"2025-12-08",{"date":506,"type":34},"2025-12-16",{"date":508,"type":34},"2024-11-15",{"date":510,"type":20},"2026-11-30",{"name":512,"class":513},"VA Office of Research and Development","FED",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":4,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":16,"minAge":521,"maxAge":442,"enrollmentInfo":522,"targetDuration":4,"studyType":52,"phases":524,"briefSummary":525,"conditions":526,"keywords":527,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":71},"100614594","early-phase-1-decompressive-laminectomy-versus-laminectomy-with-transpedicular-fixation-in-lumbar-spinal-stenosis-100614594","NCT07281625","Decompressive Laminectomy Versus Laminectomy With Transpedicular Fixation in Lumbar Spinal Stenosis","A Randomized Controlled Trial Comparing Surgical Outcomes of Decompressive Laminectomy Versus Decompressive Laminectomy With Transpedicular Screw Fixation in Multilevel Lumbar Spinal Stenosis","Inclusion Criteria:\n\n* Age 30-60 years\n* Diagnosis of lumbar spinal stenosis based on MRI criteria (anteroposterior canal diameter \\\u003C10-15 mm or cross-sectional area \\\u003C75-145 mm²)\n* Multilevel disc herniation\n* Degenerative disc disease with Pfirrmann grade 3-5 on T2-weighted MRI\n* Failure of at least six weeks of conservative treatment\n\nExclusion Criteria:\n\n* Previous history of lumbar spine surgery\n* Spinal malignancy\n* Congenital lumbar spinal stenosis, scoliosis, or kyphoscoliosis\n* Lumbar spondylolisthesis grade 3-5\n* Significant comorbidities including diabetes mellitus or ischemic heart disease","30 Years",{"count":523,"type":20},60,[315],"Lumbar spinal stenosis is a condition where the spinal canal becomes narrowed and can cause symptoms such as back pain, numbness, leg pain, and difficulty walking. Surgery is often considered when symptoms do not improve with medical treatment.\n\nThis study will compare two types of surgery used to treat lumbar spinal stenosis: decompressive laminectomy alone and decompressive laminectomy with transpedicular screw fixation. Patients will be randomly assigned to one of the two surgical options.\n\nThe purpose of this study is to determine which approach provides better pain relief, improved function, fewer complications, and better spinal stability after surgery.",[24],[528,529,479,530],"laminectomy","spinal stenosis","VAS pain score","2025-12-02",{"date":453,"type":34},{"date":534,"type":34},"2025-10-01",{"date":536,"type":20},"2025-12-31",{"name":538,"class":70},"Punjab Health Care Commission",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":545,"eligibilityCriteria":546,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":547,"targetDuration":4,"studyType":52,"phases":548,"briefSummary":549,"conditions":550,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":122},"100543432","post-market-clinical-study-of-functional-motion-outcomes-in-subjects-treated-with-the-minuteman-device-100543432","NCT06355791","Post-Market Clinical Study of Functional Motion Outcomes in Subjects Treated With the Minuteman Device","The Stability Study: Open-Label, Multi-Center, Post-Market Study of Functional Motion Outcomes In Subjects Treated With the Spinal Simplicity Minuteman G5 Fusion Plate","STABILITY","Inclusion Criteria\n\nA subject must MEET ALL of the following inclusion criteria:\n\n1. Be a candidate for Spinal Simplicity Minuteman G5 Fusion Plate device per labeled indication\n2. Be willing and capable of giving written consent to participate in this clinical study based on voluntary agreement after a thorough explanation of the subject's participation has been provided\n3. Be willing and capable of subjective evaluation, read and understand written questionnaires, and read, understand the written informed consent\n4. Be 18 years of age or older at the time of enrollment\n5. Have been diagnosed with degenerative conditions of the lumbar spine resulting in chronic low back pain with lower extremity symptoms and concurrent neurogenic claudication\n6. Received at least 3 months of non-operative or conservative treatment without significant benefit in the opinion of the Investigator\n7. Be willing and able to comply with study-related requirements, procedures and visits\n8. Be on a stable pain medication regimen, as determined by the Investigator, for at least 30 days prior to enrolling in this study.\n9. Must disclose any unresolved major issues of secondary gain (e.g., social, financial, legal), as determined by the Investigator. Including being involved in an injury claim under current litigation or has a pending or approved worker's compensation claim. Subjects will not be excluded due to secondary gain, but it should be disclosed at Enrollment.\n\nExclusion Criteria\n\nA subject must NOT MEET ANY of the following exclusion criteria:\n\n1. Had previous spinal surgery at the level of intervention (e.g. lumbar fusion, discectomy, Laminectomy) MILD procedure is not considered an exclusion.\n2. Patient physically unable to perform the Gait and\u002For Balance tests.\n3. Current systemic infection or local infection increasing the risk of surgery\n4. History of medications decreasing bone quality or soft tissue healing in the opinion of the Investigator\n5. Grade II-V spondylolisthesis\n6. Significant scoliosis with Cobb angle \\>10 degrees\n7. Unremitting back pain in a spinal flexion position\n8. Active systemic disease that may affect the welfare of the subject in the opinion of the Investigator\n9. Be concurrently participating in another clinical drug and\u002For device study that may alter or confound the results of the assessment (investigational device, investigational drug, new indication for a device or drug, or additional testing beyond standard of care procedures) as determined by the investigator.\n10. Vertebral osteoporosis or history of vertebral fracture\n11. Be pregnant\u002F lactating or plan to become pregnant from study enrollment through 3 months post-operatively. (determined by urine testing unless female subject is surgical sterile or post-menopausal). If female, sexually active and childbearing age, subject must be willing to use a reliable form of birth control through the 3-month visit.\n12. Malformation or dysplasia of spinous process\n13. Severe osteoporosis with T score \\\u003C-2.5 SD",{"count":257,"type":20},[54],"This is a prospective, multi-center open-label single arm post-market study where the purpose is to evaluate the effectiveness and safety of the market approved Spinal Simplicity Minuteman G5 MIS Fusion Plate and bone graft material in patients with degenerative conditions of the lumbar spine resulting in chronic low back pain with lower extremity symptoms and concurrent neurogenic claudication. The indication for the device under study is degenerative conditions of the lumbar spine resulting in back pain with lower extremity symptoms and neurogenic claudication.",[551,24,552],"Degenerative Conditions of the Lumbar Spine","Spondylolisthesis",{"date":554,"type":34},"2025-10-03",{"date":556,"type":34},"2024-05-29",{"date":558,"type":20},"2030-12",{"name":560,"class":41},"Spinal Simplicity LLC",{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":570,"conditions":571,"keywords":575,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":71},"100599116","artificial-intelligence-ai-based-prediction-of-treatment-response-in-sciatica-patients-receiving-transforaminal-epidural-steroid-injection-100599116","NCT07080307","Artificial Intelligence (AI)-Based Prediction of Treatment Response in Sciatica Patients Receiving Transforaminal Epidural Steroid Injection","Artificial Intelligence-Based Predictive Models for Estimating Treatment Response in Sciatica Patients Treated With Transforaminal Epidural Steroid Injection (TFESI)","Inclusion Criteria:\n\n* Age 18 years or older\n* Presence of clinical and radiological radiculopathy findings consistent with L4, L5, or S1 nerve root involvement\n* Symptoms present for at least 3 months\n* Resistant to conservative treatment\n* Scheduled for transforaminal epidural steroid injection (TFESI) by a pain medicine specialist\n* Being willing to participate in the study and having signed a consent form\n\nExclusion Criteria:\n\n* Malignancy\n* Coagulation disorders\n* Pregnancy\n* History of allergic reaction to the injected substances\n* History of major psychiatric disorders\n* Presence of known coagulopathy\n* Receiving systemic steroid treatment for any reason\n* Having received an epidural steroid injection within the last 3 months",{"count":569,"type":20},1500,"This prospective observational study aims to develop artificial intelligence (AI)-based predictive models to estimate treatment response in patients with sciatica undergoing transforaminal epidural steroid injection (TFESI). Approximately 1500 adult patients diagnosed with sciatica and scheduled for TFESI at Marmara University Training and Research Hospital Algology Clinic will be enrolled. Clinical, radiological, laboratory, and psychological data will be systematically collected before the procedure and at multiple follow-up points (1 hour, 3 weeks, 3 months, and 6 months post-treatment). Pain relief, measured by a 50% or greater reduction in the Numeric Rating Scale (NRS), will be the primary outcome. The study will use these comprehensive data sets to train and validate AI algorithms, aiming to create a decision-support system that can predict individual patient responses to TFESI and improve personalized treatment planning.",[572,573,24,574,415],"Sciatica","Low Back Pain","Radiculopathy",[576],"sciatica, radiculopathy, lumbar disc herniation, spinal stenosis, low back pain","2025-07-15",{"date":579,"type":34},"2025-07-23",{"date":581,"type":20},"2025-07",{"date":583,"type":20},"2026-10",{"name":194,"class":70},{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":16,"minAge":103,"maxAge":4,"enrollmentInfo":592,"targetDuration":4,"studyType":52,"phases":593,"briefSummary":594,"conditions":595,"keywords":598,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":603,"lastUpdatePostDateStruct":604,"startDateStruct":606,"completionDateStruct":608,"leadSponsor":609,"locationsCount":71},"100594965","is-it-really-necessary-going-all-over-the-top-in-patients-with-symptomatic-lumbar-spinal-stenosis-100594965","NCT07026305","Is it Really Necessary Going All Over the Top in Patients With Symptomatic Lumbar Spinal Stenosis?","Non-inferiority of Osseous Decompression of the Lumbar Canal Until Normalization of Epidural Pressure Compared to Conventional Open Laminectomy in Patients With Symptomatic Lumbar Spinal Stenosis.","Inclusion Criteria:\n\n* Surgical indication determined by:\n\n  * Lower back pain and\u002For lower extremity pain for more than 3 months.\n  * Pain refractory to conservative medical management (analgesics, physical therapy, epidural block).\n  * Clinical criterion of neurogenic claudication defined as a score ≥11 on the N-CLASS scale.\n  * Preoperative magnetic resonance imaging (MRI) showing lumbar canal stenosis.\n* Patient consents to the proposed surgical intervention.\n* Patient agrees to participate in the study by signing the informed consent form.\n\nExclusion Criteria:\n\n* Foraminal or lateral recess stenosis.\n* Symptomatic disc herniation at the segment to be treated.\n* Spondylolisthesis \\> Grade I (Meyerding) (translation \\>25% of the vertebra) or spondylolysis.\n* Radiological instability defined as \\>5 mm of anteroposterior translation on dynamic flexion-extension spine X-rays.\n* Scoliosis with Cobb angle \\>30°.\n* Compression fracture at the level to be treated.\n* Prior surgery at the same segment to be treated.\n* Prior infection at the segment to be treated.\n* Contraindication for MRI.\n* Diagnosis of major depressive disorder or dysthymia according to DSM-V criteria.",{"count":247,"type":20},[54],"The goal of this clinical trial is to evaluate the theory of epidural pressure by comparing a surgical procedure that aims to perform less bone resection compared to conventional surgery in patients with lumbar spinal stenosis.\n\nThe main questions it aims to answer is:\n\nIs bony decompression of the lumbar canal performed until normalization of epidural pressure not inferior to conventional surgery in achieving clinical improvement in patients with symptomatic lumbar canal stenosis?\n\nResearchers will:\n\nCompare conventional open laminectomy to bony decompression of the lumbar canal until normalization of epidural pressure is achieved.\n\nParticipants will:\n\n* Be randomized to one of the two surgical interventions: laminectomy guided by epidural pressure measure or conventional laminectomy.\n* Visit the clinic for checkups and tests until 1 year of follow-up.",[596,24,597],"Lumbar Canal Stenosis","Lumbar Spinal Stenosis (LSS)",[599,600,601,602],"lumbar canal stenosis","spinal epidural pressure","lumbar spinal stenosis","LSS","2025-06-18",{"date":605,"type":34},"2025-06-24",{"date":607,"type":34},"2025-04-21",{"date":583,"type":20},{"name":610,"class":70},"Universidad Complutense de Madrid",{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":16,"minAge":173,"maxAge":231,"enrollmentInfo":618,"targetDuration":4,"studyType":52,"phases":620,"briefSummary":621,"conditions":622,"keywords":624,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":636,"locationsCount":4},"100595103","a-study-on-the-clinical-use-of-a-new-expandable-olif-cage-with-posterior-bone-grafting-in-lumbar-spine-surgery-100595103","NCT07028099","A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery","Multi-Center Randomized Controlled Clinical Study on the Application of a Novel Expandable Posterior Bone Grafting OLIF Cage","Inclusion Criteria:1: Age between 40 and 80 years (inclusive)\n\n2: Clinically diagnosed with lumbar spondylolisthesis or lumbar spinal stenosis\n\n3: Confirmed single-level lumbar degenerative disease\n\n4: Affected level located at L2\u002F3, L3\u002F4, or L4\u002F5\n\n5: Failure of conservative treatment for at least 6 months\n\nExclusion Criteria:1: Patients requiring direct decompression of the spinal canal\n\n2: History of prior lumbar or retroperitoneal surgery\n\n3: Abnormal anatomy between the iliac vascular sheath and the psoas major muscle\n\n4: Presence of active infection or other significant systemic diseases\n\n5: Inability to complete surgical treatment or comply with follow-up due to various limitations\n\n\\-",{"count":619,"type":20},340,[54],"This clinical trial aims to evaluate the safety and effectiveness of a novel expandable OLIF (Oblique Lateral Interbody Fusion) cage with posterior bone grafting in patients with lumbar degenerative diseases. OLIF is a minimally invasive spinal surgery technique that restores intervertebral height and relieves nerve compression by placing a cage into the disc space.\n\nThe new device allows surgeons to adjust the height of the cage during surgery and deliver bone grafts through a special channel after expansion. This study compares the outcomes of patients receiving the new cage versus those treated with a conventional OLIF cage.\n\nThe trial will assess pain relief, functional improvement, spinal stability, fusion success, and potential complications. Radiological images and patient-reported scores (like VAS and ODI) will be collected over 12 months. The study includes patients aged 40 to 80 with single-level lumbar spine disease who have not improved after at least 6 months of conservative treatment.\n\nThis study will help determine whether the new expandable cage offers clinical advantages and better long-term outcomes for patients undergoing OLIF surgery.",[212,623,415,24],"Degenerative Lumbar Scoliosis",[625,626,627,628],"Expandable OLIF Cage","Minimally Invasive Spine Surgery","Prospective Multicenter Randomized Controlled Trial","Degenerative Lumbar Disease","2025-06-17",{"date":631,"type":34},"2025-06-19",{"date":633,"type":20},"2025-06-10",{"date":635,"type":20},"2027-05-31",{"name":637,"class":70},"The Affiliated Hospital of Qingdao University",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":4,"eligibilityCriteria":644,"healthyVolunteers":12,"sex":16,"minAge":103,"maxAge":231,"enrollmentInfo":645,"targetDuration":646,"studyType":21,"phases":4,"briefSummary":647,"conditions":648,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":656,"locationsCount":71},"100546373","effect-of-degenerative-spondylolisthesis-on-the-clinical-outcome-of-unilateral-biportal-endoscopy-for-lumbar-spinal-stenosis-study-protocol-100546373","NCT06394089","Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: Study Protocol","Effect of Degenerative Spondylolisthesis on the Clinical Outcome of Unilateral Biportal Endoscopy for Lumbar Spinal Stenosis: a Single-center, Prospective Cohort Trial Protocol","Inclusion Criteria:\n\n* Age range: 50-80 years\n* Diagnosis of LSS affecting 1-2 vertebral levels\n* Predominant manifestation of neurogenic intermittent claudication, with ineffective conservative treatment for at least 3 months\n* Presence of lumbar DS of less than grade II and absence of spine instability\n* Willingness to participate in the study and complete follow-up assessments.\n\nExclusion Criteria:\n\n* Diagnosis of isthmic lumbar spondylolisthesis or lumbar DS of grade ≥II\n* Evidence of instability at the affected vertebral level (intervertebral angle change \\> 15° and\u002For vertebral translation ≥ 4.5 mm in standing flexion-extension radiographs of the lumbar spine)\n* History of prior surgery at the affected vertebral level\n* Presence of scoliosis with a Cobb angle \\>20º\n* Presence of other conditions affecting the lumbar spine (infection, tumor, fracture, neurological diseases, and others)\n* Medical disorders that preclude surgical tolerance\n* Participation in other clinical research projects related to the treatment of lumbar spinal stenosis.",{"count":257,"type":20},"2 Years","A single-center, prospective cohort trial aims to provide stronger evidence regarding the impact of degenerative spondylolisthesis on the clinical outcome of unilateral biportal endoscopy for lumbar spinal stenosis",[86,24],"2025-06-03",{"date":651,"type":34},"2025-06-06",{"date":653,"type":34},"2024-03-01",{"date":655,"type":20},"2027-02-28",{"name":657,"class":70},"Beijing Friendship Hospital"]