[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-spine-instability\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-spine-instability":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100373278","the-notice-study-neurosurgery-and-orthopedics-communication-evaluation-study-following-lumbar-fusions-100373278",false,"NCT04140344","The NOTICE Study: Neurosurgery and OrThopedIcs Communication Evaluation Study Following Lumbar Fusions","NOTICE","Inclusion Criteria:\n\n1. Primary lumbar fusion 1-4 levels\n2. 18 years or older\n3. Degenerative spine diagnosis\n4. Answers YES to all the following screening questions:\n\n   * Do you own a mobile phone that is capable of sending and receiving text messages?\n   * Do you know how to text and feel comfortable texting?\n   * Are you a regular (at least once a day) text-message user?\n   * Are you agreeable to regular contact?\n\nExclusion Criteria:\n\n1. Prior lumbar fusions\n2. Tumors\u002Finfection\u002Ftrauma\n3. Prisoners or institutionalized patients\n4. Non-English speaking patients\n5. Patients who smokes or with uncontrolled diabetes\n6. Participants will be removed from study if discharged to a rehabilitation center or discharged beyond 7 days post-operatively (we are expecting \\~15% of patients to be discharged to a rehabilitation center or discharged beyond 7 days post-operatively)","ALL","18 Years",{"count":19,"type":20},224,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this single-blind, randomized, controlled study is to assess the efficacy of \"informative text messages\" vs \"traditional handouts\" provided to lumbar spine surgery patients post-operatively.",[26,27,28],"Lumbar Spine Degeneration","Lumbar Spine Instability","Lumbar Spondylosis",[30,31],"Lumbar Fusion","Text Message","RECRUITING","2026-05-05",{"date":35,"type":36},"2026-05-08","ACTUAL",{"date":38,"type":36},"2023-09-07",{"date":40,"type":20},"2027-10",{"name":42,"class":43},"Duke University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":57,"conditions":58,"keywords":67,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":44},"100441542","phase-4-regional-anesthesia-in-minimally-invasive-lumbar-spine-surgery-100441542","NCT05029726","Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery","Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age 18-80\n* Undergoing one of 3 procedure types: 1) 2 or more levels of MIS decompression (e.g., discectomy, foraminotomy, laminectomy); 2) 1-3 levels of MIS transforaminal lumbar interbody fusion (TLIF) (with or without additional levels of MIS decompression for no greater than 3 total operative levels); 3) 1-3 levels of anterior lumbar interbody fusion (ALIF) or MIS lateral lumbar interbody fusion (LLIF) accompanied by posterior percutaneous instrumentation at the same levels\n* Willing and able to give consent\n\nExclusion Criteria:\n\n* Opioid tolerant at the time of the surgical procedure--defined as consuming greater than 30mg of morphine milligram equivalents (MME) daily (https:\u002F\u002Fwww.cdc.gov\u002Fdrugoverdose\u002Fprescribing\u002Fguideline.html)\n* Presence of an indwelling pain device (e.g., intrathecal opioid pump, spinal cord stimulator, dorsal root ganglion stimulator)\n* Known allergy to bupivacaine, clonidine or similar local anesthetics\n* Indication for surgery other than degenerative disease (e.g., neoplasm, infection, trauma)\n* Chronic kidney disease (stage 3 or greater), or hepatic failure\n* Active pregnancy\n* Disease process or mental illness that would preclude accurate evaluation of pain in the perioperative period\n* Active Worker's Compensation litigation","80 Years",{"count":54,"type":20},125,[56],"PHASE4","Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.",[59,60,61,28,62,27,63,64,65,66],"Lumbar Spinal Stenosis","Lumbar Disc Herniation","Lumbar Spondylolisthesis","Lumbar Radiculopathy","Synovial Cyst","Degenerative Disc Disease","Degenerative Spondylolisthesis","Degenerative Intervertebral Discs",[68,69,70,71],"erector spinae plane block","minimally invasive spine surgery","regional anesthesia","randomized controlled trial","2026-02-11",{"date":74,"type":36},"2026-02-17",{"date":76,"type":36},"2022-02-01",{"date":78,"type":20},"2027-04-30",{"name":80,"class":43},"John O'Toole",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":21,"phases":92,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":44},"100479758","spinal-stenosis-and-listhesis-treated-with-percutaneous-interspinous-spacer-a-non-surgical-trial-100479758","NCT05527145","Spinal Stenosis and Listhesis Treated With Percutaneous Interspinous Spacer: a Non-surgical Trial","Treatment of Spinal Stenosis and Spolilolisthesis With Percutaneous Interspinous Spacers. A Phase III Trial","Inclusion Criteria:\n\n1. Age 50-85 years.\n2. Clinical symptoms of lumbar spinal stenosis (pseudoclaudication) indicating and motivating surgery. Numeric Rating Scale in lower limbs ≥3.\n3. MRI with finding of lumbar spinal stenosis at 1-3 lumbar levels. Dural sac area ≤75 mm2 or degree of stenosis C or D according to Schizas's classification.34\n4. The patient has given oral and written informed consent to participate.\n\nExclusion Criteria:\n\n1. Degenerative deformity with Cobb angle \\>20°.\n2. Symptomatic osteoarthritis in the lower limbs that affects and limits the patient's function.\n3. Arterial insufficiency (claudication intermittent).\n4. Former lumbar surgery other than disc hernia.\n5. Conditions that affect the spine, such as ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis, spondylodiscitis\u002Finfections, malignancy and neurological diseases.\n6. Heart and lung diseases presenting a significant risk for surgery or making it impossible for the patient to take part in a percutaneous arm of treatment (American Society of Anesthesiologists (ASA) score \\>3).\n7. Polyneuropathies.\n8. Psychological factors rendering the patient incapable of inclusion in the trial (eg, drug addiction, dementia).","50 Years","85 Years",{"count":91,"type":20},200,[23],"Symptomatic lumbar spinal stenosis is the most common indication for spinal surgery. However, more than one-third of the patients undergoing surgery for lumbar stenosis report dissatisfaction with the results. On the other hand, conservative treatment has shown positive results in some cases. This trial will compare the outcomes of surgical versus non-surgical treatment for lumbar stenosis.",[26,27,61,59],[96,97],"spondylolisthesis","lumbar spine stenosis","2024-02-09",{"date":100,"type":36},"2024-02-12",{"date":102,"type":20},"2024-09",{"date":104,"type":20},"2026-07",{"name":106,"class":43},"University of Roma La Sapienza"]