[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbar-spine-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbar-spine-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,81,107,134,161,185],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100624235","rehabilitation-with-empowered-strategies-to-optimize-recovery-100624235",false,"NCT07406997","Rehabilitation With Empowered STrategies to Optimize REcovery","Rehabilitation With Empowered STrategies to Optimize REcovery After Spine Surgery","RESTORE","Inclusion Criteria:\n\n* Surgical treatment of a lumbar degenerative condition using a laminectomy with or without fusion procedure\n* English speaking\n* Age between 18-85 years\n\nExclusion Criteria:\n\n* Surgery due to trauma, fracture, tumor, infection, or spinal deformity\n* Revision surgery\n* Prior history of lumbar spine surgery in last 12 months\n* Involved in litigation or a workers' compensation claim due to injury\n* Currently undergoing treatment for cancer\n* Unable to access a reliable internet connection\n* Unable to provide a stable telephone or physical address\n* Unable to participate in follow-up assessment for 6 months after surgery","ALL","18 Years","85 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","The main goal of this clinical trial is to understand the benefits of remotely delivered Empowered Relief in patients undergoing lumbar spine surgery. The main question the trial aims to answer is:\n\nDoes a postoperative behavioral intervention, Empowered Relief, performed early after back surgery have a measurable impact on postoperative outcomes?\n\nAdditional questions are whether changes in pain catastrophizing are related to improvements in outcomes and whether preoperative pain catastrophizing is a moderator of response to treatment.\n\nResearchers will compare remotely delivered Empowered Relief to remotely delivered education to see if Empowered Relief helps patients manage their pain and functional limitations after back surgery.\n\nParticipants will:\n\n* Complete one group session of remotely delivered Empowered Relief or Education after back surgery\n* Complete surveys before surgery and 3- and 6-months after surgery",[28,29],"Lumbar Spine Degenerative Changes","Lumbar Spine Surgery",[31,32,33,34],"behavioral research","Patient Reported Outcomes Measures","Pain","Pain Catastrophizing","RECRUITING","2026-05-27",{"date":38,"type":39},"2026-06-01","ACTUAL",{"date":41,"type":39},"2026-02-24",{"date":43,"type":22},"2029-08-31",{"name":45,"class":46},"Vanderbilt University Medical Center","OTHER",4,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100638726","sevoflurane-vs-propofol-anesthesia-in-obese-patients-undergoing-lumbar-surgery-100638726","NCT07611240","Sevoflurane vs Propofol Anesthesia in Obese Patients Undergoing Lumbar Surgery","Comparison of the Immunomodulatory Effects of Sevoflurane and Propofol Anesthesia on Pentraxin-3 and Serum Amyloid A Levels in Obese Patients Undergoing Lumbar Instrumentation Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Patients scheduled for elective lumbar instrumentation surgery\n* Body mass index between 30 and 34.9 kg\u002Fm²\n* Patients who provided written informed consent\n\nExclusion Criteria:\n\n* Known allergy to inhalational or intravenous anesthetic agents\n* Acute or chronic infectious disease\n* Autoimmune disease or immunodeficiency\n* Surgery within the last 3 months\n* Chronic anti-inflammatory or immunomodulatory drug use\n* Morbid obesity, defined as BMI \\>35 kg\u002Fm²\n* History of malignancy or active cancer treatment\n* Renal failure, defined as GFR \\\u003C60 mL\u002Fmin\n* Liver failure, defined as AST or ALT greater than 2 times the upper limit of normal\n* Diabetes mellitus, metabolic syndrome, or insulin resistance\n* Pregnancy or lactation\n* Neurological disease, including epilepsy, multiple sclerosis, or Parkinson's disease\n* Alcohol or substance abuse\n* Inability to comply with the study protocol or provide informed consent\n* Known allergy to study drugs (propofol, sevoflurane, remifentanil)\n* Emergency surgery","65 Years",{"count":57,"type":22},70,[25],"This randomized, single-center, single-masked clinical trial aims to compare the immunomodulatory effects of sevoflurane-based inhalational anesthesia and propofol-based total intravenous anesthesia in obese patients undergoing elective lumbar instrumentation surgery. Seventy patients will be randomized into two groups: a propofol group and a sevoflurane group. Blood samples will be collected preoperatively, at postoperative 6 hours, and at postoperative 24 hours. Pentraxin-3 and serum amyloid A levels will be evaluated as primary inflammatory biomarkers together with IL-6, TNF-α, CRP, glucose, and complete blood count parameters.",[61,29],"Obesity & Overweight",[63,64,65,66,67,68,69,70],"Propofol","Sevoflurane","Pentraxin-3","Serum Amyloid A","Immunomodulation","Total Intravenous Anesthesia","Volatile Anesthesia","Inflammatory Response","2026-05-20",{"date":73,"type":39},"2026-05-28",{"date":75,"type":39},"2025-06-15",{"date":77,"type":22},"2026-06-16",{"name":79,"class":46},"Ataturk University",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100635167","ivc-collapsibility-index-in-lumbar-stabilization-surgery-100635167","NCT07549165","IVC Collapsibility Index in Lumbar Stabilization Surgery","Hemodynamic Assessment Using the Inferior Vena Cava Collapsibility Index in Patients Undergoing Lumbar Stabilization Surgery","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients classified as ASA physical status I-II-III\n* Patients scheduled for elective lumbar spine stabilization surgery under general anesthesia\n* Ability to obtain adequate inferior vena cava (IVC) ultrasonographic imaging\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n\n  * Emergency surgery\n  * American Society of Anesthesiologists (ASA) physical status IV\n  * Patients undergoing revision lumbar stabilization surgery\n  * Baseline systolic blood pressure \\>180 mmHg or \\\u003C90 mmHg\n  * Heart failure with ejection fraction (EF) \\\u003C40%\n  * Pulmonary artery pressure (PAP) \\>40 mmHg\n  * Presence of intra-abdominal mass, ascites, or increased intra-abdominal pressure\n  * Body mass index (BMI) \\>30 kg\u002Fm²\n  * Pregnancy\n  * Patients with neurological or psychiatric disorders\n  * Inability to obtain adequate inferior vena cava (IVC) ultrasonographic imaging\n  * Refusal to provide written informed consent",{"count":89,"type":22},128,"OBSERVATIONAL","This study aims to evaluate perioperative hemodynamic changes using the inferior vena cava (IVC) collapsibility index in patients undergoing lumbar stabilization surgery under general anesthesia. The IVC diameter and collapsibility index will be measured using ultrasonography at predefined perioperative time points. Hemodynamic parameters such as blood pressure and heart rate will also be recorded. The study seeks to determine whether the IVC collapsibility index can be used as a non-invasive indicator of intravascular volume status and hemodynamic changes during lumbar spine surgery.",[29,93,94],"Hemodynamic Changes","Intravascular Volume Status",[96],"Inferior Vena Cava • IVC Collapsibility Index • Lumbar Stabilization Surgery • Hemodynamic Monitoring","2026-04-17",{"date":99,"type":39},"2026-04-23",{"date":101,"type":39},"2026-02-15",{"date":103,"type":22},"2026-07-15",{"name":105,"class":46},"Trabzon Kanuni Education and Research Hospital",2,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":80},"100627971","postoperative-pain-monitoring-with-ani-in-lumbar-spine-surgery-100627971","NCT07455565","Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery","Comparison Of Postoperative Analgesic Efficacy Using Analgesia Nociception Index Monitoring In Patients Undergoing Elective Lumbar Spine Surgery: A Randomized Parallel-Group Study","SPINE-ANI","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-II\n* Scheduled for elective lumbar spine surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known allergy to study medications\n* Coagulation disorders\n* Infection at the block site\n* Severe cardiovascular disease\n* Pregnancy\n* Inability to understand the study protocol",{"count":21,"type":22},[25],"This study aims to compare two different pain management methods in patients undergoing elective lumbar spine surgery. Patients are randomly assigned to receive either an ultrasound-guided erector spinae plane block (ESPB) or intravenous multimodal analgesia.\n\nPostoperative pain will be assessed using both clinical pain scores and the Analgesia Nociception Index (ANI), a non-invasive monitoring system that evaluates pain-related responses based on heart rate variability. The goal of this study is to determine which method provides better postoperative pain control.",[119,29],"Postoperative Pain",[121,122,119,29,123,124],"Analgesia Nociception Index","Erector Spinae Plane Block","Multimodal Analgesia","Randomized Controlled Trial","2026-03-03",{"date":127,"type":39},"2026-03-06",{"date":129,"type":39},"2025-12-16",{"date":131,"type":22},"2026-12",{"name":133,"class":46},"Akdeniz University Hospital",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":55,"enrollmentInfo":141,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":143,"conditions":144,"keywords":146,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":80},"100618065","effect-of-ultrasound-guided-quadro-iliac-plane-block-on-postoperative-analgesia-after-lumbar-spinal-surgery-100618065","NCT07326774","Effect of Ultrasound-Guided Quadro-Iliac Plane Block on Postoperative Analgesia After Lumbar Spinal Surgery","Evaluation of the Effect of Ultrasound-Guided Quadro-Iliac Plane Block on Postoperative Analgesia in Patients Undergoing Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Scheduled for elective posterior lumbar spinal instrumentation surgery under general anesthesia\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Emergency surgery\n* Local infection or hematoma at the block application site\n* Previous surgery at the block application site\n* Presence of coagulopathy\n* Known allergy or toxicity to local anesthetics\n* History of hematological, renal, or hepatic disease, or advanced respiratory or cardiac failure\n* Chronic analgesic use, chronic alcohol consumption, or substance abuse\n* Inability to speak Turkish or presence of language\u002Fcommunication barriers",{"count":142,"type":22},60,"This prospective observational study aims to evaluate the effect of ultrasound-guided Quadro-Iliac Plane Block (QIPB) on postoperative analgesia in patients undergoing lumbar spinal surgery. Lumbar spinal procedures are commonly associated with significant postoperative pain, which may impair early mobilization and increase opioid consumption. In routine clinical practice, QIPB is increasingly used as part of multimodal analgesia to improve pain control and reduce opioid-related adverse effects.\n\nAdult patients scheduled for elective lumbar spinal surgery under general anesthesia will be followed according to routine clinical care. Postoperative analgesia will be managed with intravenous patient-controlled analgesia (PCA) using tramadol, with or without the addition of ultrasound-guided QIPB, based on the preference of the attending anesthesiologist. No intervention or treatment assignment will be performed by the investigators.\n\nPostoperative pain scores at rest and during movement, opioid consumption, need for rescue analgesics, incidence of nausea and vomiting, and patient satisfaction will be recorded during the first 24 hours after surgery. The findings of this study are expected to provide further clinical evidence regarding the effectiveness of QIPB as part of multimodal analgesia in lumbar spinal surgery.",[119,29,145],"Postoperative Analgesia",[147,148,149,150,145,151],"Quadro-Iliac Plane Block","QIPB","Ultrasound-Guided Regional Anesthesia","Lumbar Spinal Surgery","Patient-Controlled Analgesia","2026-02-19",{"date":154,"type":39},"2026-02-23",{"date":156,"type":39},"2026-01-05",{"date":158,"type":22},"2026-10",{"name":160,"class":46},"Fatih Sultan Mehmet Training and Research Hospital",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":168,"sex":17,"minAge":18,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":172,"conditions":173,"keywords":174,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":80},"100517666","lumoptik-brightpoint-reflectometer-device-for-lumbar-epidural-placement-100517666","NCT06020508","Lumoptik BRIGHTPOINT Reflectometer Device for Lumbar Epidural Placement","Pilot Study for Human Clinical Trial to Evaluate the BRIGHTPOINT Reflectometer Device as Secondary Confirmation to Loss of Resistance in Lumbar Epidural Placement","Inclusion Criteria:\n\n* Any patient undergoing a lumbar neuraxial procedure requiring epidural needle\n* Age 18-99\n\nExclusion Criteria:\n\n* Previous lumbar spine surgery\n* Any known spinal abnormality that would interfere with successfully advancing a needle into the epidural space\n* Any patient requiring epidural needle longer than 4 inches\n* Any contraindication to neuraxial anesthesia\n* Tattoo at the site of epidural insertion",true,"99 Years",{"count":171,"type":22},36,"The goal of this clinical trial is to test the BrightPoint Epidural device as the first system to use multispectral reflectometry to find the epidural space in lumbar neuraxial procedures requiring epidural needle. The main questions it aims to answer are:\n\n1. Is the device a qualitatively effective secondary confirmation of Loss of Resistance?\n2. Is the device a qualitatively effective training tool for educating trainees in how to perform lumbar epidurals?\n\nParticipants will undergo a neuraxial procedure in which the attending anesthesiologist will use the BrightPoint epidural device to form an opinion on its effectiveness in confirming epidural space access.",[29],[175,176],"epidural","neuraxial","2025-12-09",{"date":129,"type":39},{"date":180,"type":39},"2023-09-12",{"date":182,"type":22},"2026-07",{"name":184,"class":46},"Hospital for Special Surgery, New York",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":200,"leadSponsor":202,"locationsCount":80},"100597636","affection-of-symptoms-duration-on-outcomes-of-lumbar-spine-surgery-100597636","NCT07061067","Affection of Symptoms Duration on Outcomes of Lumbar Spine Surgery","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Both sexes.\n* Patients undergoing lumbar spine surgery\n* Presenting symptoms include lumbar back pain, lumbar radiculopathy, neurogenic claudication, lower-extremity weakness, bowel or bladder symptoms, and duration of symptoms.\n\nExclusion Criteria:\n\n* Previous spinal surgery.\n* Vascular claudication.\n* Comorbid pathology affecting walking ability.\n* Severe comorbidities that may impact surgery outcomes (e.g., uncontrolled diabetes, cardiovascular disease).\n* Bony metastases.\n* Unfit for general anaesthesia.",{"count":142,"type":22},"This study aims to evaluate the affection of symptoms duration on outcomes of lumbar spine surgery.",[194,195,29],"Symptom Duration","Outcomes","2025-07-19",{"date":198,"type":39},"2025-07-22",{"date":196,"type":39},{"date":201,"type":22},"2026-01-01",{"name":203,"class":46},"Kafrelsheikh University"]