[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lumbosacral-radiculopathy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lumbosacral-radiculopathy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,71,98,131,166,205,231,260,285],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100631243","procedural-framing-and-epidural-steroid-injection-outcomes-100631243",false,"NCT07498140","Procedural Framing and Epidural Steroid Injection Outcomes","PEACE Study: Psychophysical Enhancement to Augment Conservative and Epidural Steroid Injection Outcomes: A Multi-Center International Randomized Trial","PEACE","Inclusion Criteria:\n\n* Age \\> 18\n* Lumbosacral radicular pain based on history and physical exam (e.g. pain radiating into one or both lower extremities, sensory loss, muscle weakness, positive straight leg raising test etc.)\n* Duration of pain \\>6 weeks\n* NRS leg pain score \\> 4 (or if 3\u002F10, greater or equal to back pain)\n* MRI evidence of spinal pathology consistent with symptoms\n* Candidates for ESI and pharmacotherapy\n\nExclusion Criteria:\n\n* Untreated coagulopathy\n* Previous spine surgery\n* No MRI or non-concordant MRI study\n* Leg pain \\> 15 years duration\n* Epidural steroid injection within past 2 years\n* Signs or symptoms of cauda equina syndrome\n* Previous failed trials with gabapentin and pregabalin and tricyclic antidepressants and duloxetine\n* Allergic reactions to contrast dye prohibiting injection (e.g., tranforaminal ESI), gabapentinoids, tricyclic antidepressants or duloxetine, and contraindications to all of the above medications\n* Referrals from surgery for diagnostic injections for surgical evaluation\n* Serious medical (e.g. congestive heart failure) or psychiatric (untreated depression) condition that might preclude optimal outcome\n* Pregnancy\n* Inability to understand basic English","ALL",{"count":19,"type":20},210,"ESTIMATED","INTERVENTIONAL",[23],"NA","Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world.\n\nThere is strong evidence that the placebo effect for all pain treatments, including ESI, is greater than the intrinsic effect. The placebo effect is highly dependent on a patient's 'expectations', and therefore how the procedure is framed.\n\nThis study aims to compare ESI when the procedure is framed very positively- as is often done in clinical practice vs. more neutrally (which is less commonly done in clinical practice but consistent with evidence). The placebo effect is also stronger for procedures than medications. The evidence on the benefits of ESI is highly dependent on whether it is compiled by interventional doctors who perform the procedure or non-interventional researchers.\n\nIn order to determine how 'framing' a treatment affects pain outcomes, the investigative team will conduct a 3-arm randomized trial comparing positive framing of ESI, neutral framing of ESI, and medications, in patients with lumbosacral radiculopathy.",[26],"Lumbosacral Radiculopathy",[28,29,30,31,32,33],"Back pain","Lumbar radiculopathy","Epidural steroid injection","Placebo effect","Sciatica","Positive framing","RECRUITING","2026-06-22",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":38},"2026-03-30",{"date":42,"type":20},"2028-06-30",{"name":44,"class":45},"Northwestern University","OTHER",4,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":63,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100589561","phase-3-efficacy-and-safety-of-ver-01-in-the-treatment-of-participants-with-chronic-painful-lumbosacral-radiculopathy-100589561","NCT06956014","Efficacy and Safety of VER-01 in the Treatment of Participants With Chronic Painful Lumbosacral Radiculopathy","Multicenter, Double-blind, Randomized, Placebo-controlled Phase III Trial to Evaluate the Efficacy and Safety of the Full-spectrum Cannabis Extract VER-01 in Participants With Chronic Painful Lumbosacral Radiculopathy","EXPAND","Inclusion Criteria:\n\n* Participants ≥ 18 years of age, all sexes\n* Participant voluntarily provided written informed consent\n* Participant is willing and able to comply with scheduled visits, treatment plan, eDiary, and other trial-related procedures throughout trial participation\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding female patients\n* Known history of previous or current severe psychiatric disorder as per DSM-5 (e.g., schizophrenia, bipolar disorder, severe anxiety disorder, psychotic disorder, post-traumatic stress disorder), or currently taking antipsychotic medication\n* Cardiovascular event or clinically significant cardiac dysfunction (e.g., congestive heart failure, myocardial ischemia, arrhythmias, poorly controlled high blood pressure, congenital long QT syndrome) within 12 months or a cardiac disorder that, in the opinion of the investigator, would put the patient at risk of a clinically significant arrhythmia or myocardial infarction","18 Years",{"count":57,"type":20},810,[59],"PHASE3","The aim of the trial is to prove the efficacy and safety of VER-01 compared to placebo in patients with chronic painful lumbosacral radiculopathy (PLSR) for whom drug treatment is indicated and previous optimized treatments with non-opioid analgesics have not led to sufficient pain relief or were unsuitable due to contraindications or intolerance.",[26],"NOT_YET_RECRUITING",{"date":37,"type":38},{"date":65,"type":20},"2026-09",{"date":67,"type":20},"2028-09",{"name":69,"class":70},"Vertanical GmbH","INDUSTRY",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100637353","us-vs-fl-guided-lumbar-nerve-root-injections-100637353","NCT07627308","US vs FL-Guided Lumbar Nerve Root Injections","Ultrasound-Guided Versus Fluoroscopy-Guided Selective Lumbar Nerve Root Injections for Lumbosacral Radiculopathy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 75 years.\n* Clinical diagnosis of lumbar radiculopathy characterized by radicular pain, paresthesia, or weakness in a dermatomal distribution.\n* Magnetic Resonance Imaging (MRI)-confirmed nerve root compression due to disc herniation or foraminal stenosis.\n* Failure to respond to at least 3 months of conservative medical treatment.\n* Radiculopathy affecting the L4, L5, or combined L5-S1 levels (where the primary symptomatic level can be reliably targeted)\n\nExclusion Criteria:\n\n* Isolated S1 radiculopathy.\n* Significant spinal deformities, including scoliosis \\>20° or spondylolisthesis \\>Grade II.\n* History of prior lumbar spine surgery.\n* Bleeding disorders (International Normalized Ratio \\[INR\\] \\>2.5).\n* Severe uncontrolled diabetes mellitus (HbA1c \\>8%).\n* Advanced cardiac, renal, or hepatic disease.\n* Active systemic infection or localized infection at the injection site.\n* Known allergies to corticosteroids or local anesthetics.\n* Presence of progressive neurological deficits or cauda equina syndrome.\n* Peripheral neuropathies mimicking radiculopathy.\n* Pregnancy or breastfeeding.\n* Severe psychiatric illness or cognitive impairment affecting study compliance.","75 Years",{"count":80,"type":20},64,[23],"The goal of this clinical trial is to learn if ultrasound-guided nerve root injections work as well as fluoroscopy (X-ray)-guided injections to treat lower back and leg pain caused by irritated nerves (lumbosacral radiculopathy) in adults aged 18 to 75 years old.\n\nThe main questions it aims to answer are:\n\n* Does ultrasound guidance lower pain as effectively as fluoroscopy guidance after 3 months?\n* Does one method help participants recover their ability to do daily activities better than the other?\n* Are ultrasound-guided injections as fast and safe for participants as fluoroscopy-guided injections? Researchers will compare ultrasound-guided nerve root injections to fluoroscopy-guided nerve root injections to see if ultrasound works to treat the pain just as well while allowing participants to avoid radiation exposure.\n\nParticipants will:\n\n* Receive one targeted nerve injection of medication (a steroid and numbing medicine) in their lower back using either ultrasound or fluoroscopy to guide the needle.\n* Stay at the clinic for 30 to 60 minutes after the procedure so researchers can check their safety.\n* Attend checkups at 1 week, 1 month, and 3 months to answer survey questions about their pain levels and daily functioning.",[26],[26,85,86,87],"Radicular Pain","Ultrasound-Guided","Fluoroscopy-Guided","2026-05-31",{"date":90,"type":38},"2026-06-04",{"date":92,"type":38},"2026-06-01",{"date":94,"type":20},"2026-10-30",{"name":96,"class":45},"Tanta University",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":4},"100632663","clinical-and-mri-findings-in-lumbar-disc-disease-100632663","NCT07516613","Clinical and MRI Findings in Lumbar Disc Disease","Correlation Between Clinical Parameters and MRI Imaging Findings in Lumbar Disc Disease","Inclusion Criteria:\n\n* Adult patients aged 18-70 years presenting with clinical symptoms suggestive of lumbar disc disease (low back pain with or without radiculopathy).\n* Patients with MRI-confirmed lumbar disc pathology (disc bulge, protrusion, extrusion, or sequestration) at one or more levels.\n* Patients who have had lumbar MRI performed within 3 months prior to enrollment.\n* Patients able to communicate clearly and complete assessment questionnaires.\n* Patients providing written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with previous lumbar spine surgery.\n* Patients with spinal fractures, tumors, infections, or inflammatory spondyloarthropathies (e.g., ankylosing spondylitis).\n* Patients with severe psychiatric disorders that interfere with assessment.\n* Patients with contraindications to MRI (e.g., pacemakers, metallic implants).\n* Patients with cauda equina syndrome requiring emergency surgical intervention.\n* Patients with peripheral neuropathy from systemic causes (e.g., diabetes mellitus with confirmed neuropathy, renal failure).\n* Pregnant women.\n* Patients who refuse to participate or provide informed consent.","70 Years",{"count":107,"type":20},96,"OBSERVATIONAL","Low back pain related to lumbar disc disease is a very common condition. Doctors frequently use Magnetic Resonance Imaging (MRI) to look at the spine and diagnose these problems. However, it is not always clear how well the severity of the damage seen on an MRI matches the actual symptoms a patient is experiencing. Sometimes, patients with severe MRI findings have mild symptoms, and vice versa.\n\nThe purpose of this observational study is to understand the relationship between a patient's clinical symptoms and their MRI results. Researchers want to see if the severity of the spinal damage shown on an MRI can accurately predict how much pain or disability a patient has.\n\nParticipants in this study are adults (ages 18-70) who are already experiencing symptoms of lumbar disc disease and have recently had an MRI. During the study, participants will:\n\n* Complete a questionnaire about the intensity of their back and leg pain.\n* Fill out a survey about how their back pain affects their daily activities.\n* Undergo a standard physical and neurological examination by a doctor to check their reflexes, muscle strength, and sensation.\n\nResearchers will then compare these physical examination and questionnaire results with the detailed findings from the patient's MRI scans. The goal of this research is to improve diagnostic accuracy and help doctors make better, more personalized treatment decisions for future patients with lower back pain.",[111,112,113,26],"Lumbar Disc Disease","Low Back Pain","Lumbar Disc Herniation",[115,116,117,118,119,120,121],"Magnetic Resonance Imaging (MRI)","Visual Analog Scale (VAS)","Oswestry Disability Index (ODI)","Pfirrmann Grading System","Nerve Root Compression","Spinal Canal Stenosis","Disc Degeneration","2026-04-01",{"date":124,"type":38},"2026-04-08",{"date":126,"type":20},"2026-04",{"date":128,"type":20},"2027-05",{"name":130,"class":45},"Assiut University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":141,"briefSummary":143,"conditions":144,"keywords":149,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":165},"100613260","phase-1-study-to-evaluate-safety-of-c-1101-versus-sterile-saline-in-adults-with-chronic-painful-lumbosacral-radiculopathy-100613260","NCT07264270","Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy","Inclusion Criteria:\n\n* Diagnosis of painful LSR (sciatica) radiating to or below the knee, with an inadequate response to conservative care\n* Body mass index \\\u003C 35 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Presence of clinically significant disease or any other painful condition that may interfere with assessments.\n* Any condition that currently requires blood or platelet transfusions.\n* Diagnosed with schizophrenia, bipolar disorder, or major depressive disorder.\n* Increased risk of bleeding or is taking anticoagulants or platelet aggregation inhibitors.\n* History or presence of autonomic neuropathy, diabetic neuropathy, or other peripheral neuropathies.\n* History of myocardial infarction within the last 6 months or congestive heart failure.\n* The presence of an active malignancy or tumor.\n* Have undergone a surgical procedure for back pain.\n* Recent use of immunosuppressants, oral steroids, or intravenous steroids.","65 Years",{"count":140,"type":20},24,[142],"PHASE1","The purpose of this study is to evaluate the safety and tolerability of C-1101 administered as a single dose, transforaminal epidural injection compared to sterile saline",[145,146,147,32,148,26],"Lumbosacral Radicular Pain","Sciatic Radiculopathy","Sciatic Leg Pain","Lumbosacral Radicular Syndrome",[32,150,151,152,26,153,154,155],"Sciatic Nerve Pain","LSR","back pain","Chronic Painful Lumbosacral Radiculopathy","non-opioid pain medication","transforaminal epidural injection","2026-03-16",{"date":158,"type":38},"2026-03-17",{"date":160,"type":38},"2025-12-03",{"date":162,"type":20},"2026-12-01",{"name":164,"class":70},"Consano Bio",3,{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":21,"phases":176,"briefSummary":177,"conditions":178,"keywords":182,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":97},"100602554","a-multicomponent-intervention-for-patients-with-lumbosacral-radiculopathy-move-more-100602554","NCT07125027","A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE","Move-MORE","Inclusion Criteria:\n\n* ● Adults age 18-65 years at the time of enrollment\n\n  * Ability to stand for 10 minutes\n  * Presence of lumbosacral radicular pain within the past week that extends below the knee (i.e., pain radiating from the low back into the leg in a nerve root distribution) with or without accompanying low back pain, of at least 12 weeks' duration, AND\n  * Tampa Scale of Kinesiophobia score ≥ 23\n  * At least one positive physical examination finding consistent with lumbosacral radiculopathy, including at least one of the following:\n\n    * Positive straight leg raise test (eliciting radicular pain below the knee at ≤70 degrees of elevation);\n    * Positive Valsalva maneuver (eliciting radiculcar pain below the knee);\n    * Positive slump test;\n    * Neurological deficit in a lumbar nerve root distribution, including at least one of the following:\n\n      * Dermatomal sensory loss,\n      * Myotomal weakness, or\n      * Reduced or absent deep tendon reflexes (e.g., patellar or Achilles reflex) corresponding to the affected nerve root.\n  * Daily access to the internet via cell phone, tablet, or computer\n  * Willing to engage with Move-MORE 4-5 times per week on your own\n  * Willing to attend a two-hour-long virtual Zoom meeting once per week for eight weeks\n  * Willing to attend two in-person study visits and a follow-up visit\n  * Willing to complete 18 questionnaires pertaining to your pain symptoms, quality of life, psychosocial experiences, and your experiences in the trial\n  * Willing to wear an actigraphy device all day, every day, and while sleeping, for the duration of study participation and willing to keep it charged\n  * Willing to respond to a daily online survey for the duration of study participation\n  * Able to speak, read, and understand the English language\n  * Able to provide written informed consent\n  * Moderately motivated to participate as reported on a numeric rating scale (≥ 4\u002F10)\n\nExclusion Criteria:\n\n* ● Participants will be excluded if they have clinical signs or symptoms of lumbosacral radiculopathy with progressive neurologic deficits (loss of motor or sensory function) or intolerable pain.\n\n  * Participants with lumbosacral radiculopathy with progressive neurologic deficits will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n    ● Participants will be excluded if they have clinical signs or symptoms suggestive of cauda equina syndrome, including any of the following:\n  * New-onset urinary retention or overflow incontinence not attributable to other known causes;\n  * Fecal incontinence;\n  * New onset of saddle anesthesia (loss of sensation in the buttocks, perineum, and inner thighs);\n  * Severe or progressive bilateral lower extremity weakness;\n\n    * Participants with suspected cauda equina syndrome will be referred for immediate medical attention, and are not eligible for participation in this study.\n\n      * Presence of moderate to severe foot drop, defined as noticeable weakness in ankle dorsiflexion that interferes with walking or requires the use of an assistive device (e.g., ankle-foot orthosis). Participants with suspected or worsening foot drop will be referred for further evaluation and are not eligible for study participation.\n      * Current use of a spinal cord stimulator\n      * Have received epidural steroid injection in the prior 3 months\n      * Have received a surgical intervention for low back pain or lumbosacral radiculopathy in the previous 6 months\n      * Current active mindfulness meditation practice 1 time\u002Fweek or more, and\u002For history of formal training in mindfulness\u002Fmeditation practice\n      * Concurrent diagnosis of cancer\n      * Current unmanaged or uncontrolled mental illness known to cause psychosis: schizophrenia, schizotypal disorders, bipolar I disorder with psychosis, major depressive disorder with psychosis\n      * Diagnosis of Borderline Personality Disorder or score \\>6 on the McLean Screening Instrument for Borderline Personality Disorder\n      * Initiation of or changes to an exercise regimen within 2 weeks prior to screening and\u002For enrollment\n      * Major medical or surgical event requiring hospitalization (for any reason other than a minor scheduled medical procedure) within 3 months prior to screening; or, scheduled or will be scheduled to occur within the 20 weeks (i.e., five months) after enrollment\n      * Currently participating in another interventional research study or participated in another interventional study within 2 weeks prior to screening\n      * Any reason the Clinical Investigator or Principal Investigator believes confers increased risk to the potential participant, if they were to enroll in the study","66 Years",{"count":175,"type":20},32,[23],"The Move-MORE study is designed to evaluate a multicomponent mindfulness and movement program for patients with lumbosacral radiculopathy. The program brings together mindfulness training to help participants develop awareness of their body and manage pain-related stress, gentle movement practice to improve comfort with physical activity and support function, and motivational interviewing to strengthen motivation, confidence, and the ability to make healthy changes.\n\nThe main objectives are to determine whether it is feasible for participants to use each component of the program when delivered online, to assess how acceptable and engaging each component is, and to evaluate the impact on pain, physical function, and daily activity levels. The study intervention will be conducted entirely remotely. Participants will complete online surveys, brief daily check-ins on their phone, and wear a small activity monitor on the hip to measure movement. They will also undergo quantitative sensory testing to evaluate pain sensitivity. At the end of the program, participants will share feedback about their experiences via qualitative interviews.\n\nThe findings will help identify which parts of the program provide the greatest benefit, with the ultimate goal of developing a more targeted and effective digital program for people with this condition.",[26,32,179,180,181],"Chronic Low Back Pain With a Neuropathic Component","Radiculopathy Lumbar","Chronic Pain (Back \u002F Neck)",[183,184,185,186,187,188,189,190,191,26,192,193,194,195],"Mindfulness","Physical Activity","Motivational Interviewing","Meditation","Tai Chi\u002FQi Gong","Movement","Mindfulness-Oriented Recovery Enhancement","Mindfulness-Based Interventions","Radiculopathy","Lumbar Radiculopathy","Chronic low back pain","Low back pain","Back Pain","2025-11-10",{"date":198,"type":38},"2025-11-12",{"date":200,"type":38},"2025-08-15",{"date":202,"type":20},"2026-11",{"name":204,"class":45},"National University of Natural Medicine",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":21,"phases":217,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":4},"100599031","effect-of-kinetic-control-in-lumbosacral-radiculopathy-100599031","NCT07079202","Effect of Kinetic Control in Lumbosacral Radiculopathy.","EFFECT OF KINETIC CONTROL RETRAINING ON ELECTROMYOGRAPHIC ACTIVITY OF TRUNK MUSCLES IN PATIENTS WITH LUMBOSACRAL RADICULOPATHY.","KC","Inclusion Criteria:\n\n1. Patients will be from both sexes.\n2. The age of patients will range from 35- 50 years old.\n3. The Body Mass Index (BMI) of patients will be less than 30Kg\u002Fm2\n4. All patients represent chronic low back pain (at least 3 months).\n5. Patients with unilateral lumbosacral radiculopathy (L4-5, L5-S1) due to Posterolateral disc prolapse.\n6. Patients have been diagnosed by MRI.\n7. Patients with sufficient cognitive abilities that enables them to understand and follow instructions (Mini-Mental State Examination (MMSE) scale \\>24).\n\nExclusion Criteria:\n\n1. Previous spinal surgeries\n2. Another Causes of the lumbosacral radiculopathy\n3. Pain that persists less than 3 months\n4. Spinal tumors\n5. Lumbar instability due to structural problems, for example: ligament tear or spondylolythesis.\n6. Cognitive impairment (a score less than 24 according to MMSE).","35 Years","50 Years",{"count":216,"type":20},50,[23],"-This study would answer the following question: Is there an effect of kinetic control retraining on electromyographic activity of trunk and lumbar proprioception in patients with lumbosacral radiculopathy?\n\nThe aims of this study are:\n\n1. To investigate the effect of kinetic control retraining on electromyographic activity of trunk in patients with lumbosacral radiculopathy\n2. To investigate the effect of kinetic control retraining on lumbar proprioception in patients with lumbosacral radiculopathy.\n3. To investigate the effect of kinetic control retraining on trunk Range of motion (ROM) in patients with lumbosacral radiculopathy.\n4. To investigate the effect of kinetic control retraining on pain intensity in patients with lumbosacral radiculopathy. 5 -To investigate the effect of kinetic control retraining on functional disability in patients with lumbosacral radiculopathy.",[220,221],"LUMBOSACRAL RADICULOPATHY","Chronic Low Back Pain","2025-07-13",{"date":224,"type":38},"2025-07-22",{"date":226,"type":20},"2025-07-17",{"date":228,"type":20},"2025-08-31",{"name":230,"class":45},"Madonna Maher Ezzat Yassa",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":105,"enrollmentInfo":238,"targetDuration":4,"studyType":21,"phases":240,"briefSummary":242,"conditions":243,"keywords":244,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100566020","phase-2-safety-and-efficacy-study-on-afa-281-for-the-treatment-of-low-back-pain-100566020","NCT06649747","Safety and Efficacy Study on AFA-281 for the Treatment of Low Back Pain","A Double-blind, Placebo-controlled, Multi-center Phase II Study of the Safety, Tolerability, Efficacy and Pharmacokinetics of Oral AFA-281 in Patients With Painful Lumbosacral Radiculopathy","Inclusion Criteria:\n\n1. Signed informed consent form (ICF) indicating that the subject has been informed of the procedures to be followed, the experimental nature of the therapy, potential benefits, side effects, risks, and discomforts\n2. Men or nonpregnant, non-breastfeeding women 18 to 65 years of age who can read and understand written and spoken local language\n3. Clinical diagnosis of CLBP due to LSR in a dermatomal pattern (L4, L5, or S1) that has been present for at least 3 months at the time of screening.\n4. MRI imaging is done within 12 months before screening that does not provide evidence of exclusionary pathology (see exclusion criteria). CT is acceptable for subjects with contra-indications for MRI.\n5. Willing to discontinue current pain medications from 2 weeks before randomization until the end of the clinical study (treatment).\n6. Numeric rating scale (NRS) ≥4 and ≤9 at screening based on the Patient's Global Impression of Severity (PGI-S)\n\nExclusion Criteria:\n\n1. Neuropathic pain due to other causes rather than LSR (e.g. painful diabetic neuropathy, other neuropathy, spinal abscess, infection, hematoma or malignancy; phantom limb pain)\n2. Has a history of peripheral neuropathy (e.g., due to diabetes, alcohol consumption, other causes, or idiopathic) or evidence of peripheral neuropathy upon neurological examination\n3. History of surgical intervention for LSR at the radicular level of the current pain episode.\n4. Current indication for neurosurgery (e.g. progressive motor loss due to compression) or planned surgical intervention for LSR within the duration of the study\n5. Has planned surgical intervention for PLSR within the duration of the study. (Subjects with persistent radicular pain after prior surgery are eligible.)\n6. Spinal stenosis with neurogenic claudication (pain present during walking and signs of significant lumbar stenosis on existing MRI or CT scan)\n7. Presence of spinal cord stimulator.\n8. Hypersensitivity\u002Fallergic reaction to other T-type calcium agents, such as (but not limited to) ethosuximide, zonisamide, and the mixed sodium and T-type calcium channel blocker lamotrigine and .\n9. Patients who failed a relatively adequate treatment with a tricyclic antidepressants (TAC), selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs)\n10. Concurrent illnesses that would be a contraindication to trial participation, including, but not limited to:\n\n    1. Severe arterial thromboembolic events (myocardial infarction, unstable angina pectoris, stroke) less than 6 months before screening\n    2. New York Heart Association (NYHA) Class III or IV congestive heart failure, ventricular arrhythmias or uncontrolled hypertension\n    3. Clinically significant electrocardiographic (ECG) abnormality per the investigator assessment\n    4. Has a history or risk of seizures or a history of epilepsy, clinically significant head injury, or related neurological disorders",{"count":239,"type":20},408,[241],"PHASE2","The goal of this clinical trial is to evaluate if the drug candidate AFA-281 works to treat chronic low back and leg pain caused by painful lumbosacral radiculopathy (PLSR) in adults. This trial will also evaluate the safety of AFA-281. The main questions it aims to answer are:\n\n* Does AFA-281 mitigate pain?\n* What are the side effects (if any)? Researchers will compare AFA-281 to a placebo (a look-alike substance that contains no drug) to see if AFA-281 works to treat chronic low back and leg pain.\n\nParticipants will:\n\n* Take drug AFA-281 or a placebo three times every day for 4 weeks\n* Visit the clinic once every 2 weeks for checkups and tests\n* Keep a diary of their pain scores and about mood and sleep questionnaires, and the number of times they use a rescue pain medicines.",[26],[245,246,247,248,249,250],"Analgesics","Inflammatory pain","Neurologic Diseases","Neuromuscular Diseases","Neuropathic pain,","Peripheral Nervous System Diseases","2025-06-21",{"date":253,"type":38},"2025-06-26",{"date":255,"type":20},"2027-04-01",{"date":257,"type":20},"2032-03-31",{"name":259,"class":70},"Afasci Inc",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":105,"enrollmentInfo":266,"targetDuration":4,"studyType":21,"phases":268,"briefSummary":269,"conditions":270,"keywords":271,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":4},"100594979","evaluation-of-the-effect-of-music-therapy-on-fear-of-needle-electromyography-100594979","NCT07026487","Evaluation of The Effect of Music Therapy on Fear of Needle Electromyography","Inclusion Criteria:\n\n1. Patients aged 18-70 years referred to the Electroneuromyography Unit with a prediagnosis of lumbosacral radiculopathy\n2. Patients whose cognitive status is sufficient to complete the study and who can be co-operated with\n\nExclusion Criteria:\n\n1. Individuals with hearing impairment and\u002For the use of hearing aids\n2. Patients with a history of significant neurological or psychiatric illness.\n3. Patients with cognitive impairment\n4. Patients with a diagnosis of polyneuropathy.\n5. Patients receiving pharmacological agents that affect the pain state, including analgesics, antidepressants, and other medications.\n6. Individuals who have previously undergone electrodiagnostic studies.\n7. Individuals with contraindications for needle EMG, including those with bleeding disorders, anticoagulant use, or active infection.",{"count":267,"type":20},58,[23],"Electroneuromyography (ENMG) is a frequently employed methodology in the diagnosis and monitoring of neuromuscular disorders. It encompasses two principal components: nerve conduction studies (NCS) and needle electromyography (EMG). While NST is conducted with the application of electrical stimulation, which may result in mild discomfort, needle EMG is employed for the examination of muscle electrical activity. It is acknowledged that the procedure may cause discomfort, anxiety and fear in patients, which may have an adverse effect on the test results. A variety of methods have been proposed to mitigate discomfort, including oral ibuprofen, cognitive therapy, and topical agents. Music therapy has demonstrated efficacy in alleviating anxiety and pain during numerous medical procedures; however, its impact on pain and anxiety during needle EMG remains unexplored. This study aims to examine the influence of music therapy on pain and anxiety in individuals undergoing needle EMG. To this end, the effects of needle EMG and music therapy on pain and anxiety will be contrasted in two distinct groups.",[26],[272,273,274,275],"needle emg","music therapy","electromyography","fear of needle EMG","2025-06-17",{"date":278,"type":38},"2025-06-18",{"date":280,"type":20},"2025-06-25",{"date":282,"type":20},"2025-10-15",{"name":284,"class":45},"TC Erciyes University",{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":17,"minAge":213,"maxAge":292,"enrollmentInfo":293,"targetDuration":4,"studyType":21,"phases":295,"briefSummary":296,"conditions":297,"keywords":299,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":97},"100532706","effect-of-combined-lumbar-traction-and-repetitive-back-extension-exercise-on-h-reflex-in-lumbosacral-radiculopathy-100532706","NCT06216288","Effect of Combined Lumbar Traction and Repetitive Back Extension Exercise on H-reflex in Lumbosacral Radiculopathy","The Effects of Combined Lumbar Traction and Repeated Back Extension Exercise on H-Reflex, Pain, and Disability in Patients With Lumbosacral Radiculopathy","Inclusion Criteria:\n\n1. Patient with chronic unilateral lumbosacral radiculopathy (more than 3 months duration)\n2. Age:35- 60 years\n3. Both male and female\n4. People with L5-S1 postero-lateral disc herniation or protrusion.\n5. people with positive straight leg raise\n\nExclusion Criteria:\n\n1. Subjects with lumbosacral Surgery.\n2. Subjects with stenosis or scoliosis.\n3. Subjects with cardiac problem or cancer.\n4. Subjects with peripheral neuropathy.\n5. Subjects with upper motor neuron injury.","60 Years",{"count":294,"type":20},60,[23],"The aim of the study is to investigate the effect of performing combined lumbar traction and repeated back extension exercise (McKenzie) on soleus H-reflex, pain, and disability in patients with lumbosacral radiculopathy. The main question that it aims to answer is:\n\nDoes the combination of lumbar traction and back extension exercise (McKenzie) improves soleus H-reflex, pain, and function in patient with lumbosacral radiculopathy? participants will be randomized into 2 groups: one group will include repeated back extension exercise (McKenzie Approach) without mechanical traction and the other group will include the same but in combination with mechanical traction.",[26,298],"McKenzie Derangement Syndrome",[300,301,302,303],"H-reflex","radiculopathy","McKenzie","Lumbar traction","2024-08-19",{"date":306,"type":38},"2024-08-21",{"date":308,"type":38},"2024-01-20",{"date":310,"type":20},"2024-10",{"name":312,"class":45},"Cairo University"]