[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-abscess\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-abscess":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100611967","transthoracic-drainage-of-lung-abscesses-a-national-randomized-trial-100611967",false,"NCT07247461","Transthoracic Drainage of Lung Abscesses. A National Randomized Trial.","TOLA: Transthoracic Drainage of Lung Abscesses. A National Randomized Trial","TOLA","Inclusion Criteria:\n\n* Age \\>18 years.\n* Signed informed consent.\n* CT scan compatible with LA (one or more cavitating lesions with liquid content).\n* Clinical findings suggestive of ongoing infection.\n* Lung abscess size ≥ 4 cm in diameter.\n* Imaging indicates that the abscess contains fluid.\n* The abscess involves the outer one-third of the lung.\n\nExclusion Criteria:\n\n* Pregnancy. Prior to inclusion of fertile women, a negative pregnancy test must be available.\n* Brest feeding.\n* Predicted survival of less than 3 months.\n* Known tuberculosis or non-tuberculous mycobacteriosis.\n* Known chronic pulmonary aspergillosis.\n* Patients with a primary suspicion of lung cancer\n* Recent (\\\u003C3 months) contact with health facilities outside Scandinavia.\n* Patients in whom anticoagulant treatment cannot be discontinued, or in whom the treatment pause does not allow drainage within 72 hours.\n* Coagulopathy or other increased bleeding risk that cannot be corrected to allow drainage within 72 hours.\n* Hemodynamic and\u002For respiratory unstable patient.","ALL","18 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to investigate if early drainage of lung abscesses, in addition to standard antibiotic treatment, leads to shorter length of hospital stay.\n\nStudy Design\n\nThis is a randomized, controlled clinical trial. That means participants will be randomly assigned to one of two groups:\n\n1. Drainage group: Receives a chest tube (drain) inserted through the chest wall into the abscess in combination with standard intravenous antibiotics.\n2. Control group: Receives standard intravenous antibiotics only\n\nEach participant has a 50\u002F50 chance of being placed in either group.\n\nDuring Hospital Stay All participants will begin treatment with intravenous antibiotics (piperacillin\u002Ftazobactam). If assigned to the drainage group, a trained medical team will insert a small tube into the abscess to drain the pus. The tube is flushed three times a day with sterile saline.\n\nParticipants will also:\n\n* Fill out two short health questionnaires at the start and during follow-up.\n* Have relevant medical history collected from their hospital records.\n* Undergo routine scans (CT), blood tests, and lung assessments as part of standard care.\n* A cheek swab will be taken from all participants to study mouth bacteria..\n\nFor those receiving drainage the pus from the lung abscess will be collected for microbiological analysis.\n\nMicrobiology samples will be stored in a research biobank and destroyed after analysis.\n\nFollow-up after discharge\n\n* 1 week: A phone call to check symptoms and infection levels via a blood test.\n* 4 and 12 weeks later: In-person checkups at the lung clinic, including:\n\n  * 6-minute walk test\n  * Lung function test\n  * Repeat health questionnaires\n  * CT scan\n  * Blood tests (up to 20 ml in total over the study)\n* 1 years: Medical records are reviewed to asses morbidity and mortality.\n\nParticipants The study will include 84 adult patients who are hospitalized with a lung abscess larger than 4 cm, located near the outer part of the lung. Inclusion will take place at five university hospitals in Denmark\n\nWhy This Study Matters There are no official guidelines for treating lung abscesses, and research is limited. This study could offer vital new insights that help update treatment recommendations in Denmark and internationally.\n\nBecause all five Danish regions are involved, the results could quickly be implemented into daily practice, improving care for future patients with this serious condition.",[27],"Lung Abscess",[27,29,30,31],"Transthoracic drainage","Length of hospital stay","Randomized trial","RECRUITING","2026-06-09",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":36},"2026-02-16",{"date":40,"type":21},"2029-08-30",{"name":42,"class":43},"University of Aarhus","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100621634","evaluation-of-different-sizes-of-left-sided-double-lumen-tubes-for-thoracic-surgery-in-a-tertiary-level-teaching-hospital-100621634","NCT07373171","Evaluation of Different Sizes of Left-Sided Double-Lumen Tubes for Thoracic Surgery in a Tertiary Level Teaching Hospital","Inclusion Criteria:\n\n* Patient aged 18 years or older undergoing thoracic surgery requiring OLV with placement of a left-sided DLT\n\nExclusion Criteria:\n\n* Patient refusal\n* Need for rapid sequence intubation (RSI) due to increased aspiration risk\n* Anticipated difficult intubation\n* Emergency surgery\n* Patient already intubated with a single-lumen ET tube\n* DLT tube change to single lumen tube at the end and shifted with ETT in situ",{"count":52,"type":21},60,[24],"Double lumen tubes (DLT) have become standard of care for one lung ventilation in thoracic and esophageal surgeries. Selection of accurate size of DLT is important to achieve proper one lung ventilation, prevent trauma to airway, easy intubation, prevention of displacement of DLT and adequate oxygenation intraoperatively. There are no definitive guidelines to select the correct size of DLT. The aim of this study is to observe if there is any difference in the number of intubation attempts, intraoperative oxygenation and postoperative sore throat while using 35 Fr DLT size and other DLT size. The research will be conducted between Ashoj 1st 2082 to Chaitra 30 2082 at Manmohan Cardiothoracic Vascular and Transplant Center(MCVTC). Fifty patients aged more than eighteen years undergoing thoracic surgery requiring One Lung Ventilation(OLV) with left sided DLT will be selected for the study. Participants will be randomly assigned to 35 Fr DLT size group or DLT size group according to the height. Patients in both the groups will be given the samepreoperative care, intraoperative care and postoperative care. Besides patient's demography, diagnosis and operative procedure; number of intubation attempts, modified Cromack-Lehane(CL) grade, size of DLT, intraoperative oxygen saturation SpO₂ and postoperative sore throat on day of surgery and first postoperative day will be recorded. Statistical analysis will be done using t- test for independent variable, confidence interval for outcome of sore throat, significance of difference for number of male and female; rates, risk ratio and odds ratio will be calculated using 2x2 contingency table. P ≤ 0.05 will be considered statistically significant. Our expected outcome is 35 Fr DLT are easier to intubate, does not affect intraoperative oxygenation and decrease the incidence of postoperative sore throat.",[56,27],"Lung Adenocarcinoma","NOT_YET_RECRUITING","2026-01-22",{"date":60,"type":36},"2026-01-28",{"date":62,"type":21},"2026-01",{"date":64,"type":21},"2026-08",{"name":66,"class":43},"Tribhuvan University, Nepal",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":75,"maxAge":18,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":44},"100566647","complicated-pneumonia-cp-in-children-in-south-east-europe-100566647","NCT06657898","Complicated Pneumonia (CP) in Children in South-East Europe","Increasing Incidence of Complicated Pneumonia in Children in South-East Europe: a Retrospective Multi-center Analysis of Incidence, Characteristics and Outcomes","CP","Inclusion Criteria\n\n* Children aged 1 month to 18 years of age\n* Children diagnosed with complicated community acquired pneumonia (pneumonia with parapneumonic effusion, necrotizing pneumonia and lung abscess)\n* Children who were hospitalized from January 1st 2014 to April 30th 2024 and required at least 24 hours of hospital stay\n\nExclusion Criteria\n\n* Children with increased risk for severe lung infections (cystic fibrosis, primary ciliary dyskinesia, immunodeficiencies, congenital lung abnormalities, neurological conditions, chemotherapy)\n* Children with hospital-acquired pneumonia","1 Month",{"count":77,"type":21},300,"OBSERVATIONAL","This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents (viruses and bacteria) and its association to severity and outcomes of the disease. Furthermore, therapeutic approach, complications, short-term and long-term outcomes and the prevention of the disease are to be assessed. The study will encompass data from pediatric centers in the South-East Europe willing to participate in the study, encompassing ten-year period of time.",[81,27,82],"Pneumonia, Necrotizing","Empyema, Pleural",[84,85,86,87],"pneumonia in children","necrotizing pneumonia","empyema","lung abscess","2024-10-23",{"date":90,"type":36},"2024-10-26",{"date":92,"type":36},"2024-05-27",{"date":94,"type":21},"2025-10-01",{"name":96,"class":43},"Aleksandar Sovtic"]