[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-biopsy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-biopsy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100631449","robotic-assisted-versus-conventional-bronchoscopy-for-cryobiopsy-in-the-diagnosis-of-interstitial-lung-disease-100631449",false,"NCT07500818","Robotic-Assisted Versus Conventional Bronchoscopy for Cryobiopsy in the Diagnosis of Interstitial Lung Disease","Robotic-Assisted Versus Conventional Bronchoscopy for Cryobiopsy in the Diagnosis of Interstitial Lung Disease: A Randomized Controlled Trial","RAB-ILD-RCT","Inclusion Criteria:\n\n* Age ≥18 years\n* Clinical suspicion of interstitial lung disease requiring histological confirmation\n* Non-diagnostic HRCT pattern (e.g. probable UIP or indeterminate pattern)\n* Candidate for transbronchial lung cryobiopsy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Definite UIP pattern on HRCT\n* Severe pulmonary hypertension\n* Severe hypoxemia contraindicating bronchoscopy\n* Coagulopathy or contraindication to biopsy\n* Pregnancy\n* Inability to provide informed consent","ALL",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"NA","Interstitial lung disease (ILD) often requires histopathological confirmation when high-resolution computed tomography (HRCT) findings are inconclusive. Transbronchial lung cryobiopsy has emerged as a less invasive alternative to surgical lung biopsy, but diagnostic yield remains variable and dependent on biopsy location and procedural precision.\n\nRobotic-assisted bronchoscopy (RAB) combined with cone-beam computed tomography (CBCT) may allow more precise navigation to target lung segments and potentially improve biopsy quality and diagnostic yield.\n\nThis multi-center, investigator-initiated randomized controlled trial will compare conventional bronchoscopy with 2D fluoroscopy guidance versus robotic-assisted bronchoscopy with CBCT guidance for transbronchial lung cryobiopsy in patients undergoing diagnostic evaluation for suspected interstitial lung disease.\n\nParticipants will be randomized in a 1:1 ratio to undergo either conventional bronchoscopy or robotic-assisted bronchoscopy. In both groups, four cryobiopsies will be obtained from two lung lobes using a 1.7 mm cryoprobe (en-bloc removal for both study arms).\n\nThe primary endpoint is the rate of definitive histological diagnosis as determined by a blinded multidisciplinary ILD board.",[26,27],"Interstitial Lung Disease (ILD)","Lung Biopsy",[29,30,31,32,33],"Robotic-assisted Bronchoscopy","Cryobiopsy","CBCT","Interventional Pulmonology","Interstitial Lung Disease","RECRUITING","2026-03-24",{"date":37,"type":38},"2026-03-30","ACTUAL",{"date":40,"type":38},"2026-02-01",{"date":42,"type":20},"2027-09-01",{"name":44,"class":45},"University of Zurich","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":71},"100596411","a-multicenter-study-in-bronchoscopy-combining-stimulated-raman-histology-with-artificial-intelligence-for-rapid-lung-cancer-detection---the-on-site-study-100596411","NCT07045103","A Multicenter Study in Bronchoscopy Combining Stimulated Raman Histology With Artificial Intelligence for Rapid Lung Cancer Detection - The ON-SITE Study","A Multicenter Study in Bronchoscopy Combining Stimulated Raman Histology With Artificial Intelligence for Rapid Lung Cancer Detection","ON-SITE","Inclusion Criteria:\n\n1. The patient or legal guardian is willing and able to understand, sign and date the Ethics committee approved study specific Informed Consent Form.\n2. The patient is 22 years of age or older.\n3. The patient is scheduled for routinely indicated staging of the mediastinum (EBUS-TBNA) and planned peripheral lung biopsy procedure (peripheral TBBx\u002FTBNA) with an intermediate to high pretest probability of lung cancer based on clinician suspicion.\n4. The patient can tolerate the clinical procedure as indicated.\n\nExclusion Criteria:\n\n1. Patient is a prisoner.\n2. The participant, in the judgment of the Investigator, may be inappropriate for the intended study procedures","22 Years",{"count":57,"type":20},900,"OBSERVATIONAL","The ON-SITE study represents a prospective, observational study focused on the training\u002Ftuning and pivotal validation of deep learning algorithms that detect cell\u002Ftissue morphology suspicious for cancer in biopsies of peripheral lung nodules\u002Fmasses and mediastinal\u002Fhilar lymph nodes imaged with the NIO Laser Imaging System in the procedure room without requiring traditional sample processing.\n\nThe study includes four arms based on biopsy location and biopsy modality\u002Ftool:\n\n1. Transbronchial forceps biopsy of peripheral lung nodules\u002Fmasses (peripheral-TBBx)\n2. Transbronchial needle aspiration biopsy of peripheral lung nodules\u002Fmasses (peripheral TBNA)\n3. Transbronchial needle aspiration biopsy of mediastinal\u002Fhilar lymph nodes (EBUS-TBNA)\n4. Transbronchial cryo biopsy of peripheral lung nodules\u002Fmasses (peripheral-CBx)",[27],"2025-06-20",{"date":63,"type":38},"2025-07-01",{"date":65,"type":38},"2023-12-21",{"date":67,"type":20},"2026-05",{"name":69,"class":70},"Invenio Imaging Inc.","INDUSTRY",7,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":82,"studyType":58,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":94},"100559364","detection-and-prediction-of-clinically-significant-pneumothorax-after-image-guided-transthoracic-lung-biopsy-100559364","NCT06563167","Detection and Prediction of Clinically Significant Pneumothorax After Image-guided Transthoracic Lung Biopsy","Prospective Study on Detection and Prediction of Clinically Significant Pneumothorax After Image-guided Transthoracic Lung Biopsy","Inclusion Criteria:\n\n* Patients whose image-guided TTLB, including ultrasound or CT-guided, is arranged for diagnostic purposes\n* Patients who are able to sign written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients with resolution of lung lesion prior to the scheduled image-guided TTLB\n* Patients have active exacerbation of underlying diseases causing unstable respiratory conditions (e.g. exacerbation of COPD, pneumonia) which would lower the threshold for invasive interventions for iatrogenic pneumothorax\n* Patients with psychiatric disease or cognitive impairment that may limit their ability to understand or give consent to the study\n* Patients who decline to join the study","18 Years",{"count":81,"type":20},330,"1 Month","Objective: The goal of this study is to evaluate the sensitivity and specificity of the presence of pneumothorax on a 4-hour CXR after image-guided transthoracic lung biopsy (TTLB) for diagnosing subsequent clinically significant pneumothorax.\n\nHypothesis to be tested: The investigators hypothesize that an absence of pneumothorax on CXR at 4 hours can accurately predict an absence of clinically significant pneumothorax at 16 to 20 hours.\n\nDesign and subjects: This is a prospective, single-centre, diagnostic accuracy study conducted at a tertiary referral centre in Hong Kong. Patients will be recruited if an image-guided TTLB is arranged.\n\nStudy instruments: CXRs will be performed for patients at different time points. The presence and size of pneumothorax (if any) will be recorded.\n\nOutcome: The diagnostic capacity of a 4-hour CXR after image-guided TTLB will be provide evidence regarding the safety and patient selection for same-day discharge.",[27],"2025-03-08",{"date":87,"type":38},"2025-03-11",{"date":89,"type":38},"2024-09-01",{"date":91,"type":20},"2026-12-31",{"name":93,"class":45},"Chinese University of Hong Kong",1]