[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-function-decreased\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-function-decreased":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,65,86,119,143,170],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100558686","cardiopulmonary-exercise-testing-and-oscillometry-for-the-evaluation-of-dyspnea-100558686",false,"NCT06554353","Cardiopulmonary Exercise Testing and Oscillometry for the Evaluation of Dyspnea","COED","Inclusion Criteria:\n\n* Willingness to perform breathing test\n* Must be able to speak and understand English\n* Referred for Cardiopulmonary Exercise Testing\n\nExclusion Criteria:\n\n* Unable to provide consent or perform oscillometry test","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on Cardiopulmonary Exercise Testing in subjects who are experiencing shortness of breath.",[24,25,26,27],"Breathing, Mouth","Lung Function Decreased","Dyspnea","Shortness of Breath","RECRUITING","2026-06-01",{"date":31,"type":32},"2026-06-03","ACTUAL",{"date":34,"type":32},"2024-10-29",{"date":36,"type":20},"2026-11-30",{"name":38,"class":39},"University of Rochester","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100640372","phase-resolved-functional-lung-mri-and-oscillometry-for-the-observation-of-healthy-lung-function-100640372","NCT07614685","Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function","PROOF","Inclusion Criteria:\n\n* Age 18 years or older\n* Ability to provide consent\n* Willingness to perform MRI and breathing test\n* Must be able to speak and understand English\n\nExclusion Criteria:\n\n* Pregnant\n* Unable or willing to provide consent or perform the required maneuvers for testing.",true,{"count":50,"type":20},20,"This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.",[53,25,54,55],"Breathing","MRI Imaging","Healthy","NOT_YET_RECRUITING","2026-05-20",{"date":59,"type":32},"2026-05-29",{"date":61,"type":20},"2026-07-01",{"date":63,"type":20},"2028-01-01",{"name":38,"class":39},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":40},"100620337","body-composition-related-evaluation-of-airway-tone-and-hyper-reactivity-using-oscillometry-100620337","NCT07356310","Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry","BREATH-OSC","Inclusion Criteria:\n\n* Willingness to perform breathing test\n* Must be able to speak and understand English\n* Referred for Methacholine Challenge Test\n\nExclusion Criteria:\n\n* Unable to provide consent or perform oscillometry test",{"count":73,"type":20},100,"This study will determine if airway resistance to airflow and pressure, measured by Oscillometry, is associated with abnormal findings on methacholine challenge testing and whether these findings are associated with body habitus,",[53,25,76,77],"Asthma (Diagnosis)","Obesity","2026-04-07",{"date":80,"type":32},"2026-04-13",{"date":82,"type":32},"2026-02-17",{"date":84,"type":20},"2027-11-01",{"name":38,"class":39},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":105,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":118},"100414454","functional-lung-avoidance-spect-guided-radiation-therapy-of-lung-cancer-100414454","NCT04676828","Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer","Functional Lung Avoidance SPECT-guided (ASPECT) Radiation Therapy for Lung Cancer Patients: Phase II Randomised Clinical Trial","ASPECT","Inclusion Criteria:\n\n* histologically verified lung cancer (small-cell and non-small cell lung cancer)\n* referred for radiotherapy with curative intent\n* radiation dose of 60-66 Gy given in 2-Gy fractions, other dose levels and fractionation schedules accepted, as per site standard\n* concurrent chemotherapy is accepted\n* patients with oligometastatic disease are allowed, where metastasis have been ablated with surgery or radiotherapy\n* receiving (chemo)-radiotherapy to the thoracic disease with curative intent\n* adults over 18, that have given oral and written informed consent before patient registration.\n\nExclusion Criteria:\n\n* concurrent immunotherapy\n* previous radiotherapy to the thorax\n* other uncontrolled malignancies; any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol",{"count":95,"type":20},90,"INTERVENTIONAL",[98],"NA","Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)\u002FCT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy. Functional avoidance implies a dose plan that takes functional distribution in the lung into account, and avoids highly functional lung volumes sparing them from radiation.",[101,102,103,104,25],"Lung Cancer","Radiation-Induced Disorder","Radiation Pneumonitis","Pulmonary Disease",[106,107,108],"radiation-induced lung toxicity","functional avoidance methodology","radiation therapy of lung cancer","2026-02-22",{"date":111,"type":32},"2026-02-24",{"date":113,"type":32},"2021-12-01",{"date":115,"type":20},"2028-12-01",{"name":117,"class":39},"University of Aarhus",2,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":126,"maxAge":127,"enrollmentInfo":128,"targetDuration":4,"studyType":96,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":40},"100581318","tubeless-surgery-with-impaired-pulmonary-function-100581318","NCT06848751","Tubeless Surgery With Impaired Pulmonary Function","Non-intubated Thoracoscopic Surgery for Lung Leision in Patients With Impaired Pulmonary Function","Inclusion Criteria:\n\n1. Patients with impaired lung function (who may require postoperative intubation and transfer to the surgical ICU after preoperative and MDT discussions).\n2. Patients requiring minimally invasive lung resection due to lung cancer, pulmonary nodules, benign lung tumors, pneumothorax, lung volume reduction surgery, etc.\n3. Patients with normal mental status who can cooperate with perioperative examinations, exercises, and physical rehabilitation measures.\n4. Patients who agree to participate in the clinical trial after communication.\n\nExclusion Criteria:\n\n1. Patients with severe impairment of cardiopulmonary function or other organ systems, who are deemed unable to tolerate any form of anesthesia or minimally invasive surgery after preoperative and MDT discussions.\n2. Patients with abnormal mental status or who are unable to adequately cooperate with perioperative examinations, exercises, and physical rehabilitation measures.\n3. Patients who refuse to participate in the clinical trial or decline the use of non-intubated anesthesia with preserved spontaneous breathing.\n4. Patients who refuse to undergo surgery.","14 Years","85 Years",{"count":129,"type":20},30,[98],"Some patients with impaired lung function require minimally invasive surgical treatment, including those with lung cancer, benign lung tumors, pneumothorax, or lung volume reduction surgery. Patients with borderline lung function often cannot be extubated immediately postoperatively under conventional treatment models. These patients typically need to be transferred to the surgical ICU for close monitoring. However, positive-pressure mechanical ventilation with an endotracheal tube carries risks of further airway injury and persistent air leakage from the lung surface, leading to a high incidence of postoperative respiratory failure.\n\nNon-intubated minimally invasive surgery (tubeless), which preserves spontaneous breathing without endotracheal intubation, avoids the physical stimulation of intubation and the airway damage caused by mechanical ventilation. This approach may reduce the incidence of postoperative airway injury and respiratory failure, potentially expanding the indications for minimally invasive lung surgery, lowering postoperative complication and mortality rates.\n\nThe aim is to further clarify the surgical indications for non-intubated single-port minimally invasive surgery in patients with impaired lung function, the decision-making criteria for postoperative ICU transfer, and the safety and feasibility of this comprehensive management approach.",[25,133],"Surgery","2025-02-22",{"date":136,"type":32},"2025-02-27",{"date":138,"type":32},"2021-04-10",{"date":140,"type":20},"2026-12-31",{"name":142,"class":39},"The Second Hospital of Shandong University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":48,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":96,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":40},"100557380","mouthpiece-with-integrated-cheek-support-vs-manual-cheek-support-during-respiratory-oscillometry-100557380","NCT06537362","Mouthpiece With Integrated Cheek Support vs. Manual Cheek Support During Respiratory Oscillometry","Comparative Evaluation of the Use of a Mouthpiece With Integrated Cheek Support vs. Manual Cheek Support During Respiratory Oscillometry Measurements","COMICUSROM","Inclusion Criteria:\n\n* subjects aged between 5 and 75 years\n\nExclusion Criteria:\n\n* Subjects unable to follow the study procedures or with any physical or mental condition deemed unsuitable by the doctor will be excluded from the study","5 Years","75 Years",{"count":154,"type":20},55,[98],"The study aims to evaluate the measurement accuracy of respiratory impedance during oscillometry (or Forced Oscillation Technique - FOT) under the following conditions: 1)The subject's cheeks are manually supported by an expert (Gold Standard method), 2) The subject's cheeks are supported by an integrated cheek support in the mouthpiece.\n\nIt is a prospective, randomized, cross-over study on Subjects who will present themselves at the offices of the participating doctors, aged between 5 and 75 years. The primary outcome is to Compare the respiratory impedance measurements under the two measurement conditions. Secondary Objectives are to: i)evaluate the patient's comfort during the measurement with the cheek support and compare this comfort to the gold standard condition; ii) assess the maximum and minimum face dimensions of the recruited subjects that allow for effective and comfortable cheek support; iii) evaluate the type and frequency of measurement errors introduced by the use of the integrated cheek support in the mouthpiece.",[158,25],"Respiratory Morbidity",[160],"Oscillometry","2024-08-26",{"date":163,"type":32},"2024-08-28",{"date":165,"type":32},"2024-03-26",{"date":167,"type":20},"2024-08",{"name":169,"class":39},"Politecnico di Milano",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":48,"sex":177,"minAge":178,"maxAge":4,"enrollmentInfo":179,"targetDuration":181,"studyType":21,"phases":4,"briefSummary":182,"conditions":183,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":40},"100518361","permian-health-womens-lung-health-study-100518361","NCT06029543","Permian Health Women's Lung Health Study","WLHS","Inclusion criteria:\n\n* Self-identified female sex\n* Age \\> 15 years: This age cutoff was chosen (as opposed to 18) because of the unique cultural norms and practices in the country where experiences and exposures occur at an earlier age than women in Western countries.\n\nExclusion criteria:\n\n* Age \\\u003C 15 years\n* Non-resident household member\n* Any acutely unwell individual\n* Pregnancy\n* Any known history of active pulmonary disease (including TB) on treatment.\n* Individuals unable or unwilling to give consent.","FEMALE","15 Years",{"count":180,"type":20},350,"3 Years","The goal of this cross-sectional observational study is to estimate the prevalence of lung function impairment as measured by spirometry in a population of Gambian women aged 15 and older. The main question\\[s\\] it aims to answer are:\n\n* What is the prevalence of lung function impairment in Gambian women\n* What is the prevalence of eosinophilic inflammation in Gambian women\n\nConsenting participants will undergo\n\n* Spirometry\n* Fractional exhaled nitric oxide (FENO) testing\n* α1-antitrypsin testing in patients with lung function impairment as assessed by spirometry",[184,25,185],"COPD","Alpha 1-Antitrypsin","2023-08-31",{"date":188,"type":32},"2023-09-08",{"date":190,"type":20},"2023-12",{"date":192,"type":20},"2026-12",{"name":194,"class":39},"Permian Health Lung Institute"]