[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-function-tests\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-function-tests":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100617354","effects-of-expiratory-muscle-training-added-to-pulmonary-rehabilitation-in-patients-with-bronchiectasis-100617354",false,"NCT07317531","Effects of Expiratory Muscle Training Added to Pulmonary Rehabilitation in Patients With Bronchiectasis","Effects of Expiratory Muscle Training Added to Pulmonary Rehabilitation on Pulmonary Function, Respiratory Muscle Strength, and Functional Capacity in Patients With Bronchiectasis","Inclusion Criteria:\n\n* Age between 18 and 70 years\n\n  * Clinical diagnosis of non-cystic fibrosis bronchiectasis\n  * Stable disease status\n  * Follow-up at the Pulmonary Rehabilitation Unit of University of Health Sciences Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital\n  * Ability to understand and comply with the study procedures\n  * Provided written informed consent\n\nExclusion Criteria:\n\n* Acute exacerbation within the last 3 months\n* Diagnosis of cystic fibrosis-related bronchiectasis\n* Presence of severe cardiac, neurological, or orthopedic diseases that may interfere with exercise training\n* Cognitive impairment, lack of cooperation, or communication difficulties\n* Any medical condition contraindicating participation in pulmonary rehabilitation or expiratory muscle training","ALL","18 Years","70 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, single-blind, parallel-group controlled trial aims to investigate the effects of expiratory muscle training added to standard pulmonary rehabilitation on respiratory muscle strength, pulmonary function, cough effectiveness, exercise capacity, dyspnea perception, and quality of life in patients with non-cystic fibrosis bronchiectasis. Eligible patients aged 18-70 years with stable disease will be randomly assigned to either a pulmonary rehabilitation-only group or a pulmonary rehabilitation combined with expiratory muscle training group. Outcomes will be assessed at baseline and after completion of the intervention period.",[27,28,29,30,31,32],"Bronchiectasis Adult","Expiratory Muscle Training","Pulmonary Rehabilitation","Lung Function Tests","Functional Capacity","Respiratory Muscle Strength","NOT_YET_RECRUITING","2026-01-02",{"date":36,"type":37},"2026-01-05","ACTUAL",{"date":39,"type":21},"2026-02-01",{"date":41,"type":21},"2027-03-01",{"name":43,"class":44},"Istanbul Demiroglu Bilim University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":45},"100586774","early-lung-function-trajectories-comparison-between-infants-with-and-without-intrauterine-growth-restriction-100586774","NCT06919757","Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.","Early Lung Function Trajectories: Comparison Between Infants With Intrauterine Growth Restriction and Appropriately Grown Ones.","ELFIGO","Inclusion Criteria:\n\n* Fetuses and Infants born before 32 weeks of gestation, with and without fetal growth restriction\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Need for palliative care\n* Major malformations",{"count":55,"type":21},54,"2 Years","OBSERVATIONAL","During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound. Since there are currently no curative treatments for this condition, nor methods to optimize the growth of babies in the womb, the only effective strategy is intensive monitoring of fetal conditions, accompanied by early planning of delivery.\n\nThe diagnosis of early FGR (i.e. diagnosed before 32 weeks of gestation) confers a greater risk of short- and long-term respiratory problems.\n\nThe study aims to examine the association between parameters that can be assessed during pregnancy by ultrasound, such as the estimate of lung volumes, the thickness and contractility of the diaphragm, and cardiac kinetics, and any perinatal complications and respiratory function in the first years of life of premature infants, both with and without evidence of fetal growth pathology. Therefore, the study is divided into two phases: a prenatal and a postnatal phase.\n\nThe study includes two groups of patients:\n\n1. Study group: Fetuses and preterm infants with a prenatal history of FGR;\n2. Control group: Preterm infants without a prenatal history of FGR followed during neonatal follow-up.\n\nPregnant women with fetuses with FGR are followed at the Ultrasound clinics dedicated to Growth Pathology.\n\nThese pregnancies usually receive weekly ultrasound monitoring, which includes a Doppler study of the maternal and fetal circulation and an estimate of fetal weight every two weeks. Cardiotocographic monitoring is also planned once or twice a week, depending on fetal well-being.\n\nThe child will be assessed from a respiratory point of view during hospitalization and subsequently in the outpatient clinic, as required by clinical practice.\n\nHe\u002Fshe will undergo respiratory function tests. Visits are scheduled at 3, 6, 12 and 24 months of corrected age, during which at least two respiratory function tests will be performed.\n\nIn addition, routine clinical data (personal data, medical history, blood tests, biological and instrumental tests) present in the medical record of the child will be collected.\n\nData from preterm infants without fetal growth restriction will be collected after informed consent. These infants are routinely followed at our Institution and undergo clinical assessment and lung function tests in the first two years of life as previously indicated.",[60,30,61,62],"Intrauterine Growth Retardation (IUGR)","Preterm Infant","Respiratory Monitoring",[64,65,66,67,68],"lung volume measurements","pulmonary function test","preterm birth","intrauterine growth retardation","oxygen saturation\u002Fphysiology","RECRUITING","2025-08-25",{"date":72,"type":37},"2025-08-26",{"date":74,"type":37},"2025-04-20",{"date":76,"type":21},"2027-03",{"name":78,"class":44},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":45},"100595334","methacholine-challenge-test-in-school-children-withwithout-asthma-riska-100595334","NCT07031102","Methacholine Challenge Test in School Children With\u002FWithout Asthma RISKA","RISKA: Respiratory Irritability With School Kids With\u002FWithout Asthma - Assessment of Methacholine Responsiveness in Pediatric Asthma: A Comparative Study With Healthy Controls","RISKA","Inclusion Criteria: Healthy Controls\n\n* • Aged 7-15 years, both sexes\n\n  * No diagnosis of asthma in childhood\n  * No inhaled asthma medication during the previous 2 years\n  * No wheezing or shortness of breath during the previous 2 years\n  * Written informed consent from the participant and guardian\n\nInclusion Criteria: Children with Asthma\n\n* Aged 7-15 years, both sexes\n* Physician-diagnosed asthma (ICD-10 codes J45.0\u002FJ45.1\u002FJ45.9)\n* Inhaled corticosteroid treatment for at least 6 months\n* Either:\n\n  * Well-controlled asthma (c-ACT\u002FACT score ≥20) and no clinical need to intensify medication, or\n  * Poorly controlled asthma with physician-confirmed need for intensified asthma medication\n\nExclusion Criteria:\n\n* • Premature birth before 32 gestational weeks\n\n  * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)\n  * Severe underlying illness such as malignancy\n  * Beta-blocker medication\n  * Active immunological disease",true,"7 Years","15 Years",{"count":91,"type":21},260,"The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.",[94,30,95],"Asthma Bronchiale","Bronchial Hyperresponsiveness",[97,98,99,100,101],"Asthma","Lung function test","children","Methacholine challange test","Bronchial provocation test","2025-06-12",{"date":104,"type":37},"2025-06-22",{"date":106,"type":37},"2024-11-06",{"date":108,"type":21},"2027-12",{"name":110,"class":44},"Helsinki University Central Hospital"]