[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-function":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,75,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100601896","cost-effective-air-filtration-intervention-in-low-income-housing-to-reduce-asthma-morbidity-100601896",false,"NCT07116460","Cost Effective Air Filtration Intervention in Low-Income Housing to Reduce Asthma Morbidity","Cost Effective Air Filtration Intervention and Particulate Matter Monitoring in Low-Income Housing to Reduce Asthma Morbidity","Inclusion Criteria:\n\n* Age 7-18 years\n* Asthma symptoms in the past 4 weeks\n* Resident in lower-income housing in NYC Northern Manhattan and South Bronx\n\nExclusion Criteria:\n\n* Inability to successfully perform spirometry maneuver or FeNO test\n* Family planning to move in the next year","ALL","7 Years","18 Years",{"count":20,"type":21},55,"ESTIMATED","INTERVENTIONAL",[24],"NA","This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC). The study will be conducted over a 2-year period.\n\nColumbia University and Little Sisters of the Assumption Family Health Service (LSAFHS) will conduct an intervention study to evaluate the efficacy of using a cost-effective high-capacity high efficiency particulate air (HEPA) filter air cleaner to reduce airborne particulate matter (PM) in the homes of children with asthma and to reduce their asthma morbidity. The study will take place in East Harlem, a low-income neighborhood with high asthma prevalence. It will build on findings from prior Housing and Urban Development Lead and Healthy Homes Technical Studies (HUD LHHTS)-funded research, the experience of LSAFHS installing air cleaners in the homes of asthmatic children, and recent findings demonstrating the effectiveness of home air cleaners in reducing asthma morbidity. The investigators hypothesize that the cost-effective single air cleaner will substantially reduce PM exposure in the homes of asthmatic children and reduce airway inflammation and asthma morbidity. This study will use cutting-edge air sampling technology to continuously quantify and characterize indoor air pollutants in the home for one year, verify and incentivize compliance, and conduct repeated exhaled nitric oxide and pulmonary function tests before and throughout the year after the intervention. This cost-effective intervention can be easily and quickly implemented in homes in low-income, urban communities and easily transferred between homes if families move.",[27,28,29],"Asthma Attack","Lung Function","Airway Inflammation",[31,32,33,34,35,36,37],"asthma","air cleaner","particulate matter","pm2.5","lung function","airway inflammation","children","RECRUITING","2026-05-29",{"date":41,"type":42},"2026-06-02","ACTUAL",{"date":44,"type":42},"2026-01-30",{"date":46,"type":21},"2028-04",{"name":48,"class":49},"Columbia University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":5},"100521101","early-life-mri-biomarkers-of-longer-term-respiratory-morbidity-in-infants-born-extremely-preterm-emblem-100521101","NCT06065215","Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)","EMBLEM","Inclusion Criteria:\n\n1. Infants born at \\\u003C29 weeks gestation;\n2. currently \\\u003C36 weeks PMA.\n\nExclusion Criteria:\n\n1. Known interstitial lung disease, congenital lung anomaly, ciliary dysfunction, immunodeficiency, cystic fibrosis, neuromuscular disease, or structural heart disease (other than atrial septal defect\u002Fhemodynamically insignificant ventricular septal defect\u002Fpatent ductus arteriosus);\n2. genetic syndrome or congenital anomaly;\n3. contraindications for MRI or transport;\n4. invasive or non-invasive ventilation that cannot be safely removed for MRI;\n5. current respiratory infection;\n6. family cannot speak English\u002FFrench;\n7. transferred to another hospital prior to baseline study visit\n8. not receiving follow-up at one of the study centres.","35 Weeks","21 Months",{"count":61,"type":21},319,"OBSERVATIONAL","Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood. Prediction of who will have these problems is challenging using traditional definitions of disease. It is believed that underdevelopment and injury occur in both lung tissue and the blood vessels in the lungs, with a sophisticated interplay between them that contributes to lung disease seen in prematurity. New magnetic resonance imaging (MRI) techniques can delineate tissue structure with unprecedented granularity, assessing lung tissue, blood vessels, and their interplay. The ability to identify, at an early stage, those infants destined for chronic lung disease with greater certainty will be useful in counseling families and critical for the effective introduction of promising new BPD therapies. 319 infants born less than 29 weeks gestation will be recruited from 4 centres, including 5 babies who received stem cell therapy in a clinical trial. Babies will be evaluated at 36 weeks post-conception with lung MRI, oscillometry (lung function), echocardiogram (heart ultrasound), and oscillometry. Lung health will be assessed every 3 months by phone questionnaire and chart review. At 18-21 months post-conception, babies will undergo neurodevelopmental assessment and lung function testing. The investigators will look at how well baseline MRI markers predict subsequent lung health and development, independently and combined with echocardiogram, lung ultrasound, and traditional markers of BPD. The investigators anticipate that these new MRI markers will measure lung health safely and longitudinally in babies born extremely preterm. By identifying predictors of longer-term lung disease, clinicians will be able to allocate resources to babies at the highest risk of severe disease. Further, The investigators envision that MRI will help identify babies who would benefit most from interventions like stem cell therapy and be useful for evaluation of future treatments.",[28,65],"BPD - Bronchopulmonary Dysplasia","2025-02-21",{"date":68,"type":42},"2025-02-24",{"date":70,"type":42},"2024-03-30",{"date":72,"type":21},"2027-06-30",{"name":74,"class":49},"Children's Hospital of Eastern Ontario",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100571112","manual-diaphragmatic-release-on-ventilatory-functions-in-women-with-rheumatoid-arthritis-100571112","NCT06716008","Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis","Effect of Manual Diaphragmatic Release on Ventilatory Functions in Women With Rheumatoid Arthritis","Inclusion Criteria:\n\n* All women will have rheumatoid arthritis for more than 2 years with low-to-moderate disease activity.\n* Normal to mildly restrictive lung pattern.\n* Their ages will be ranged from 40 to 60 years old.\n* Their body mass index will be less than 30 Kg\u002Fm2.\n\nExclusion Criteria:\n\n* Chronic chest diseases.\n* Recent parenteral steroid administration.\n* Cardiovascular disorders (coronary heart disease, heart failure, cardiac arrhythmia, peripheral arterial disease, uncontrolled hypertension).\n* Smokers.\n* Joint surgery (in the preceding 6 months).\n* Musculoskeletal\u002F neurological limitations to exercise.\n* Pregnancy.","FEMALE","40 Years","60 Years",{"count":86,"type":21},60,[24],"Evaluate the effect of manual diaphragmatic release on ventilatory functions in women with rheumatoid arthritis",[90,28],"Rheumatic Arthritis","NOT_YET_RECRUITING","2024-12-04",{"date":94,"type":42},"2024-12-09",{"date":96,"type":21},"2024-12-03",{"date":98,"type":21},"2025-04-01",{"name":100,"class":49},"Middle East University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":50},"100409419","lung-function-exercise-capacity-and-serology-responses-in-patients-with-covid-19-100409419","NCT04611243","Lung Function, Exercise Capacity, and Serology Responses in Patients With COVID-19","Inclusion Criteria: Patients who have been discharged from hospital following treatment for COVID-19 -\n\nExclusion Criteria: Unwilling to be follow up\n\n\\-",{"count":108,"type":21},700,"(a) Objectives\n\n1. To assess the full lung function, exercise capacity, quality of life in patients with COVID-19 over 2 years.\n2. To assess the longevity of the serology response to SARS-CoV2.\n3. To investigate the association of the neutralization titer in plasma from different vaccinated cohorts to its protection of infection using in vivo model\n4. To investigate the SARS-CoV-2 specific cellular and humoral immunities as well as their determinant factors from community subjects who have received different types of COVID-19 vaccines.\n5. To assess the third booster dose for subjects who have poor antibody response despite having received two doses of CoronaVac (Sinovac)",[28,111,112,113],"Exercise Capacity","Quality of Life","Covid19","2024-08-19",{"date":116,"type":42},"2024-08-21",{"date":118,"type":42},"2020-05-22",{"date":120,"type":21},"2026-02-17",{"name":122,"class":49},"Chinese University of Hong Kong"]