[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-injury":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,41,63,85,108,137,164,194,237,261,287,309,330,349],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100550397","functional-residual-capacity-and-alveolar-recruitment-in-single-lung-ventilation-a-randomized-study-100550397",false,"NCT06446544","Functional Residual Capacity and Alveolar Recruitment in Single-lung Ventilation: a Randomized Study","OLVEELV","* Adult patient aged 18 to 75 years inclusive\n* Patient requiring lobectomy or segmentectomy by video or robot-thoracoscopy\n* Patient having read and understood the information letter and signed the consent form\n* Patient affiliated to a social security system\n* Women :\n\n  * Of childbearing age (defined by the CTFG as a fertile woman, after menarche and until menopause, except in cases of permanent sterility (including hysterectomy, bilateral salpingectomy or bilateral oophorectomy))\n\n    * using effective contraception according to the WHO (combined hormonal contraception (containing estrogens and progestins), progestin-only contraception, intrauterine device (IUD), male or female condoms) for at least 4 weeks before inclusion and during the study And,\n    * Presenting a negative urine pregnancy test at inclusion;\n  * Menopause: menopause according to the CTFG is defined as the absence of periods for 12 months without any other medical cause. An elevated follicle-stimulating hormone (FSH) level in the postmenopausal interval can be used to confirm a postmenopausal state in women who are not using hormonal contraception or hormone replacement therapy. However, in the absence of 12 months of amenorrhea, a single FSH measurement is insufficient.\n\nExclusion Criteria:\n\n* Patients aged 76 and over\n* COPD patients (Gold stage 3 or 4 of the 2023 Gold classification)\n* Patients with a history of ischemic coronary artery disease\n* Patients with a history of pulmonary emphysema bubbles on the ventilated lung\n* Tracheostomized patient\n* Obese patients (\\>30 kg\u002Fm²)\n* Patients with a history of pulmonary resection\n* ASA patients ≥4\n* Patient benefiting from a pre-operative rehabilitation protocol with physiotherapy\n* Pregnant or parturient or breastfeeding woman or proven absence of contraception\n* Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection\u002Funder guardianship or curatorship\n* History of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol or preventing them from giving informed consent\n* Patient refusing to give consent.","ALL","18 Years","75 Years",{"count":20,"type":21},44,"ESTIMATED","INTERVENTIONAL",[24],"NA","In thoracic surgery, the incidence of postoperative pulmonary complications is higher than for other surgeries. Indeed, thoracic surgery has the specificity of being carried out with single-lung ventilation and is thus a source of intraoperative atelectasis which persists postoperatively and gives rise to pulmonary complications, particularly infectious ones. During one-lung ventilation, mediastinal and abdominal compression on the ventilated lung leads to a drop in functional residual capacity (FRC) which will in turn lead to collapse of the small airways leading to the formation of atelectasis.\n\nStrategies exist to limit the appearance of atelectasis. One of the intraoperative strategies is alveolar recruitment. Alveolar recruitment is a dynamic process that can be defined by a transient increase in transpulmonary pressure beyond the critical opening pressure. Physiologically, alveolar recruitment corresponds to the re-aeration of poorly or non-aerated lung areas. In single-lung ventilation, intraoperative alveolar recruitment maneuvers are not performed systematically to prevent the formation of atelectasis.\n\nThe General Electric Carescape R860 ventilator allows intraoperative monitoring of end-expiratory closing lung volume (EFVP), which corresponds to the CRF associated with positive expiratory pressure (PEEP). This spirometry incorporated in the ventilator continuously monitors the intraoperative variation of VPFE, thus making it possible to detect any significant decrease which would favor the formation of intraoperative atelectasis. Early detection of VPFE can therefore allow the anesthetist-resuscitator to initiate intraoperative alveolar recruitment maneuvers adapted to the patient. Alveolar recruitment maneuvers are then personalized and based on precise monitoring of the evolution of the VPFE.\n\nThe effectiveness of recruitment maneuvers can be evaluated and quantified (with the Lung Ultrasound Score (LUS)) postoperatively using pleuropulmonary ultrasound. Thus, early ultrasound detection, from the post-interventional monitoring room (SSPI), would make it possible to undertake rapid therapeutic maneuvers to combat the atelectasis observed. A patient could benefit, for example, from prophylactic NIV from the recovery room, from a stricter postural program in a seated position, or from an earlier and\u002For more intensive respiratory rehabilitation program with the physiotherapy team.",[27],"Lung Injury","NOT_YET_RECRUITING","2026-06-05",{"date":31,"type":32},"2026-06-09","ACTUAL",{"date":34,"type":21},"2026-07-01",{"date":36,"type":21},"2028-08-01",{"name":38,"class":39},"University Hospital, Rouen","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":40},"100639279","inhalational-versus-intravenous-anesthesia-on-postoperative-lung-injury-in-septic-patients-undergoing-surgery-100639279","NCT07601256","Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery","Inhalational Versus Intravenous Anesthesia on Lung Injury After Major Surgery in Patients With Sepsis","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Diagnosis of sepsis according to Sepsis-3.0 (highly suspected or confirmed infection with acute increase in SOFA score ≥ 2).\n3. Scheduled to undergo surgery under general aaesthesia for source control or sepsis-related operative management.\n\nExclusion Criteria:\n\n1. Already intubated prior to entering the operating room.\n2. Chronic home ventilator dependence (e.g., severe chronic obstructive pulmonary disease) before surgery.\n3. Personal or family history of malignant hyperthermia.\n4. Known allergy to ciprofol or sevoflurane.\n5. Known allergy to egg or soy products.\n6. Any contraindication to the planned anaesthetic agents.\n7. Pregnant women.",{"count":49,"type":21},480,[24],"This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.",[53,27],"Sepsis","2026-05-15",{"date":56,"type":32},"2026-05-22",{"date":58,"type":21},"2026-08-15",{"date":60,"type":21},"2030-12-30",{"name":62,"class":39},"Sixth Affiliated Hospital, Sun Yat-sen University",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":40},"100385235","neutrophil-phenotypic-profiling-and-acute-lung-injury-in-patients-after-cardiopulmonary-bypass-cpb-100385235","NCT04296071","Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)","Inclusion Criteria:\n\n* Are \\\u003C 12months of age\n* Scheduled for cardiac surgical needing CPB\n* Preoperative SpO2 \\> 90%\n\nExclusion Criteria:\n\n* Lack of parental (or legal guardian's) consent\n* Preoperative SpO2 \\\u003C 90%\n* Preoperative oxygen therapy","12 Months",{"count":71,"type":21},56,"OBSERVATIONAL","Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality. The objective of this study is to assess the mechanism of CPB-mediated acute lung injury in pediatric patients.",[27,75],"Cardiopulmonary Bypass","RECRUITING","2026-05-13",{"date":54,"type":32},{"date":80,"type":32},"2022-10-14",{"date":82,"type":21},"2027-12",{"name":84,"class":39},"Sophia Koutsogiannaki",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":93,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":40},"100468563","effect-on-bronchodilation-response-and-ventilation-heterogeneity-of-different-inhalation-volumes-in-copd-100468563","NCT05381415","Effect on Bronchodilation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD","Effect on Bronchodilatation Response and Ventilation Heterogeneity of Different Inhalation Volumes in COPD: the BREATH COPD Study","BREATH COPD","Inclusion Criteria:\n\n* age above 40 years old;\n* history of smoking equal or above 10 PKYs;\n* VEMS after bronchodilatation ≤ 70%,\n* medical Necessity to perform a bronchodilatation test.\n\nExclusion Criteria:\n\n* history of bronchial asthma or other chronic respiratory diseases such as pulmonary fibrosis;\n* uncontrolled cardiovascular diseases at the time of the visit;\n* current pregnancy;\n* incapacity to execute lung function tests for cognitive impairment, substance abuse or claustrophobia;\n* known hypersensitivity or intolerance to salbutamol.","40 Years",{"count":95,"type":21},30,"During bronchodilator tests, it's common to ask patients with asthma or chronic obstructive pulmonary disease (COPD) to take bronchodilator therapy by inhaling after a maximal exhalation, when the respiratory system volume equals the residual volume. The same maneuver is required for the chronic therapy.\n\nNevertheless, in patients with COPD the distribution of ventilation is more heterogeneous, especially when lung volumes are closer to residual volume . It is therefore predictable that the distribution of air volume containing bronchodilator that has been inhaled at residual volume is more heterogeneous than at higher volumes, such as at functional residual capacity. Accordingly, the bronchodilator can be preferentially distributed in more open airways than in less patent ones, with a heterogeneous distribution of the medication. Therefore, the overall bronchodilation should be greater when the drug inhalation is performed at functional residual capacity than at residual volume.\n\nIt is common knowledge that the effectiveness of bronchodilator therapy with pMDI in subjects with COPD is greatly affected by the inhalation technique, which can be difficult to perform for many patients. Therefore, in addition to the possibility that inhalation of bronchilation therapy at residual volume could lower the drug effectiveness, this maneuver complicates the sequence of actions required to the patient, enhancing the risk of errors and decreasing the aderence to treatment.\n\nThe aim of this study is to investigate whether the inhalation of a bronchodilator at different lung volumes can affect its effectiveness in terms of respiratory function, in patients with COPD.\n\nAssuming that the bronchodilator effectiveness is equal or greater when inhaled at functional residual capacity rather than at residual volume, the inhalation maneuver can be simplified for patients with COPD.",[98,27],"COPD","2026-04-28",{"date":101,"type":32},"2026-05-04",{"date":103,"type":21},"2026-12-01",{"date":105,"type":21},"2027-12-30",{"name":107,"class":39},"University of Milan",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":125,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":40},"100568824","evaluation-of-the-efficacy-of-diagnostic-support-algorithms-in-chest-x-rays--luana-trial-100568824","NCT06686251","Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial","Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays - LungAnalysis (LuAna): LuAna Stepped Wedge Trial","Inclusion Criteria:\n\n* Non-reported chest X-rays (XRts) of individuals aged over 18 years.\n* Individuals images with respiratory complaints.\n* Chest X-rays taken during the presence of these respiratory symptoms or while being followed up for respiratory disease.\n* Chest X-rays taken on any X-ray machine.\n* Chest X-rays that include at least one frontal view of the chest.\n\nExclusion Criteria:\n\n* Those whose chest X-ray was performed due to a history of trauma, pre-operative risk assessment, lung cancer screening, or exclusively for verifying the correct positioning of a peripheral intravenous catheter (PICC).\n* Chest X-rays with technical quality below the minimum required for proper interpretation and diagnosis.\n* Cases without at least one frontal view.\n* X-rays printed on regular paper.",{"count":116,"type":21},1470,[24],"This study aims to evaluate whether the use of AI as a physician support tool is associated with an increase in the detection rate of chest radiographic findings in adults with respiratory complaints, compared to diagnosis performed exclusively by doctors, without AI support. This is a cluster-randomized clinical trial, following the stepped wedge design, and adhering to the guidelines of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT). In this study, the Diagnostic Support Solution for Chest X-rays - LungAnalysis (LuAna), developed by the Hospital Israelita Albert Einstein (HIAE) within the PROADI-SUS Banco de Imagens, was used.\n\nThe clinical trial will be conducted in multiple centers with a diverse population from the public health system, to ensure that the algorithms are validated across a broad demographic profile. The expected benefits are significant, providing greater security for patients, increasing doctors' confidence in interpreting chest X-rays, promoting efficiency and cost savings for healthcare services, and offering promising prospects for other AI applications in imaging diagnostics.",[120,27,121,122,123,124],"Consolidation","Pleural Effusion","Pneumothorax","Cardiomegaly","Edema Lung",[126,127,128],"Artificial Intelligence","Chest X-ray","Stepped wedge trial","2026-01-29",{"date":131,"type":32},"2026-02-02",{"date":133,"type":32},"2026-01-05",{"date":103,"type":21},{"name":136,"class":39},"Hospital Israelita Albert Einstein",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":163},"100538848","open-lung-protective-extubation-following-general-anesthesia-100538848","NCT06296173","Open Lung Protective Extubation Following General Anesthesia","Open Lung Protective Extubation Following General Anesthesia: the OLEXT-3 Trial","OLEXT-3","Inclusion Criteria:\n\n* Adult patients (18 years of age or over)\n* Elective intra-abdominal surgery under general anesthesia.\n* Moderate or high risk of postoperative pulmonary complication according to the ARISCAT score (score of 26 or more)\n* Planned postoperative hospitalization\n\nExclusion Criteria:\n\n* Expected or known difficult intubation according to the treating anesthesiologist\n* Postoperative mechanical ventilation (planned or unplanned)\n* General anesthesia performed outside the main operating room",{"count":146,"type":21},270,[24],"Perioperative respiratory complications are a major source of morbidity and mortality. Postoperative atelectasis plays a central role in their development. Protective \"open lung\" mechanical ventilation aims to minimize the occurrence of atelectasis during the perioperative period. Randomized controlled studies have been performed comparing various \"open lung\" ventilation protocols, but these studies report varying and conflicting effects. The interpretation of these studies is complicated by the absence of imagery supporting the pulmonary impact associated with the use of different ventilation strategies. Imaging studies suggest that the gain in pulmonary gas content in \"open lung\" ventilation regimens disappears within minutes after the extubation. Thus, the potential benefits of open-lung ventilation appear to be lost if, at the time of extubation, no measures are used to keep the lungs well aerated. Recent expert recommendations on good mechanical ventilation practices in the operating room conclude that there is actually no quality study on extubation.\n\nExtubation is a very common practice for anesthesiologists as part of their daily clinical practice. It is therefore imperative to generate evidence on good clinical practice during anesthetic emergence in order to potentially identify an effective extubation strategy to reduce postoperative pulmonary complications.",[150,151,27,152,153],"Intra-abdominal Surgery","Anesthesia","Ventilator-Induced Lung Injury","Atelectasis","2026-01-19",{"date":156,"type":32},"2026-01-21",{"date":158,"type":32},"2024-10-08",{"date":160,"type":21},"2027-04-01",{"name":162,"class":39},"Centre hospitalier de l'Université de Montréal (CHUM)",4,{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":179,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":40},"100531715","the-efficacy-of-p01-guided-sedation-protocol-in-critically-ill-patients-receiving-invasive-mechanical-ventilation-a-randomized-controlled-trial-100531715","NCT06203405","The Efficacy of P0.1-guided Sedation Protocol in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Patients admitted to the medical intensive care unit at Department of Medicine, Siriraj Hospital\n2. Age ≥18 years old\n3. Receiving mechanical ventilation due to acute respiratory failure within 72 hours before enrollment (including patients receiving mechanical ventilation before ICU admission)\n\nExclusion Criteria:\n\n1. Patients receiving mechanical ventilation due to indications other than acute respiratory failure, such as postoperative procedures or airway protection in comatose patients\n2. Patients receiving mechanical ventilation for \\>72 hours before enrollment\n3. Patients receiving neuromuscular blocking agents prior to randomization\n4. Patients with impaired secretion clearance or upper airway obstruction anticipating a tracheostomy\n5. Patients with severe metabolic acidosis (arterial pH \\\u003C7.2) who do not have a plan for renal replacement therapy\n6. Patients intubated for neurological conditions, including intracranial hypertension, intracranial hemorrhage, large cerebral infarction, status epilepticus, or neuromuscular diseases\n7. Post-cardiac arrest patients\n8. Patients with severe liver dysfunction, including acute fulminant liver failure or cirrhosis with the Child-Pugh score B or C\n9. Patients who have a previous allergy to any of the opioid, sedation, or neuromuscular blocking drugs\n10. Pregnancy\n11. Patients with do-not-resuscitate (DNR) orders or decisions to withhold life-sustaining treatments\n12. Patients who refuse to participate in the study or cannot identify legally authorized representatives (LAR) within 24 hours after enrollment",{"count":171,"type":21},214,[24],"This clinical trial aims to assess the efficacy of sedation protocol targeting optimal respiratory drive using P0.1 and arousal level compared with conventional sedation strategy (targeting arousal level alone) in patients requiring mechanical ventilation in the medical intensive care unit.",[175,176,177,27,178],"Respiratory Failure","Critical Illness","Respiratory Distress Syndrome, Adult","Mechanical Ventilation Complication",[180,181,182,183,184],"acute respiratory failure","sedation","respiratory drive monitoring","mechanical ventilation","intensive care unit","2025-05-19",{"date":187,"type":32},"2025-05-22",{"date":189,"type":32},"2023-12-22",{"date":191,"type":21},"2026-06-30",{"name":193,"class":39},"Siriraj Hospital",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":201,"sex":16,"minAge":17,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":205,"conditions":206,"keywords":221,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":40},"100556693","identification-of-multiple-pulmonary-diseases-using-volatile-organic-compounds-biomarkers-in-human-exhaled-breath-100556693","NCT06528418","Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath","Exploration and Study on the Identification of Various Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled Breath","Inclusion Criteria:\n\n* Males or females, age must be 18 years old or above.\n* Patients must meet the CT imaging diagnostic criteria for different lung diseases, and patients must be able to provide electronic versions of CT image data.\n* Patients must have a clear clinical diagnosis.\n* All participants must sign a written informed consent form.\n\nExclusion Criteria:\n\n* Pregnant women.\n* Individuals with a history of cancer other than lung disease.\n* Individuals who have undergone organ transplants or non-autologous (allogeneic) bone marrow or stem cell transplants.\n* Individuals with other severe organic diseases or mental illnesses.\n* Individuals with metabolic diseases such as diabetes, hyperlipidemia, etc.\n* Any other condition that researchers deem unsuitable for participation in this clinical trial.",true,"100 Years",{"count":204,"type":21},10000,"The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) marker molecules. This model aims to accurately diagnose mutiple pulmonary diseases. The primary objectives it strives to accomplish are:\n\n1. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose several common pulmonary diseases.\n2. To assess the diagnostic accuracy of an exhaled breath VOC-assisted diagnostic artificial intelligence (AI) model in diagnose more pulmonary diseases.",[207,208,98,209,210,211,212,213,214,215,27,216,217,218,219,220],"Lung Cancer","Lung Infection","Bronchitis","Pulmonary Fibrosis","Pulmonary Embolism","Pulmonary Arterial Hypertension","Pulmonary Tuberculosis","Pulmonary Abscess","Emphysema","Cystic Fibrosis of the Lung","Bronchial Asthma","Bronchiectasis","Interstitial Lung Disease","Preserved Ratio Impaired Spirometry",[222,223,224,225,226],"Pulmonary Disease","Volatile Organic Compounds","Human Exhaled Breath","micro Gas Chromatography-photoionisation","detector (μGC-PID) system","2025-03-23",{"date":229,"type":32},"2025-03-26",{"date":231,"type":32},"2024-06-30",{"date":233,"type":21},"2027-06-30",{"name":235,"class":236},"ChromX Health","INDUSTRY",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":40},"100488647","feasibility-of-reducing-respiratory-drive-using-the-through-flow-system-100488647","NCT05642832","Feasibility of Reducing Respiratory Drive Using the Through-flow System","Feasibility of Reducing Respiratory Drive in Patients with Acute Hypoxemic Respiratory Failure Using the Through-flow System","Throughflow","Inclusion Criteria:\n\n* PaO2\u002FFiO2 less than or equal to 300 at time of screening\n* Oral endotracheal intubation with ETT 7.5 or 8.0 and on invasive mechanical ventilation\n* Bilateral airspace opacities on chest radiograph or chest CT scan\n\nExclusion Criteria:\n\n* Contraindication to esophageal catheterization (upper gastrointestinal tract surgery within preceding 6 weeks, bleeding esophageal\u002Fgastric varices)\n* Intubation for traumatic brain injury or stroke\n* Intracranial hypertension (suspected or diagnosed by medical team)\n* Anticipated liberation from mechanical ventilation within 24 hours",{"count":246,"type":21},15,[24],"Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury. Mechanical stress and strain applied by mechanical ventilation or by the patient's own respiratory muscles can also cause injury to the lungs. Diaphragm and lung injury are associated with increased morbidity and mortality. Throughflow is a novel system that can reduce dead space without the need to increase the tidal ventilation, reducing the ventilatory demands and respiratory drive.",[250,251,27],"Respiratory Insufficiency","Diaphragm Injury","2024-12-06",{"date":254,"type":32},"2024-12-11",{"date":256,"type":32},"2024-01-01",{"date":258,"type":21},"2025-08-31",{"name":260,"class":39},"University Health Network, Toronto",{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":4,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":69,"enrollmentInfo":268,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":270,"conditions":271,"keywords":276,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":278,"lastUpdatePostDateStruct":279,"startDateStruct":281,"completionDateStruct":283,"leadSponsor":285,"locationsCount":40},"100438450","comparison-of-computertomography-scan-electrical-impedance-tomography-and-ultrasound-of-the-lung-in-infants-100438450","NCT04989439","Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants","Comparison of Computertomography Scan, Electrical Impedance Tomography, and Ultrasound of the Lung in Infants - a Prospective Explorative Observational Study","Inclusion Criteria:\n\n* Patients hospitalized at the Department of Pediatrics of the Medical University of Vienna who will get a CT scan of the thorax.\n* Patients aged up to 12 months\n\nExclusion Criteria:\n\n* Unstable cardiovascular, respiratory and\u002For neurological conditions.\n* Sternotomy during the previous 15 days.\n* Thoracic skin lesions or wounds (including burns) on the thorax, where the EIT-electrode-belt would be placed.",{"count":269,"type":21},10,"The study focuses on regional lung examination, in particular on the differentiation between collapsed and hyperinflated lung areas. The purpose of the study is to elaborate common and discriminative elements between different lung imaging modalities in infants and to generate hypotheses for the bedside use of EIT and LUS in infants.",[272,273,274,275,27],"Infant ALL","Computed Tomography","Electric Impedance","Ultrasonography",[277],"CT, electrical impedance tomography, ultrasound","2024-11-18",{"date":280,"type":32},"2024-11-20",{"date":282,"type":32},"2021-07-19",{"date":284,"type":21},"2025-12-31",{"name":286,"class":39},"Medical University of Vienna",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":291,"acronym":4,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":293,"enrollmentInfo":294,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":296,"conditions":297,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":40},"100232150","effect-of-alcohol-and-drugs-of-abuse-on-immune-function-in-critically-ill-patients-with-respiratory-failure-100232150","NCT02299921","Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure","Inclusion criteria:\n\n* Specific Aim 1: Adult medical ICU patients admitted to the University of Colorado Hospital for a primary respiratory problem, and who are expected to require ICU care ≥48 hrs\n* Specific Aim 2: (1) Adult medical ICU patients with respiratory failure (due to underlying lung pathology) and who require endotracheal intubation and mechanical ventilation. (2) Adult medical and other ICU patients with respiratory failure, not related to a lung condition, and who require endotracheal intubation and mechanical ventilation. (3) Adult ICU patients previously admitted to the University of Colorado Hospital for a primary respiratory problem, and who required care ≥48 hrs.\n\nExclusion criteria, Specific Aim 1 and 2:\n\n* Patients who are expected to require ICU care \\\u003C48 hrs\n* Patients admitted to the ICU who are not ICU status (being housed for space issues)\n* Patient is unlikely to survive 48 hours\n* Patient is on comfort care (hospice measures)\n* Patients less than 18 or greater than 90 years of age\n* Patient is a prisoner\n* ICU attending declines enrollment of patient\n* Patients who are pregnant\n* Patients who have significant anemia, defined as Hgb\\\u003C8% or Hct\\\u003C24%, or who have evidence of active bleeding.\n\nFor bronchoscopy portion of Specific Aim 2.\n\n* Patients who are on either a fraction of inspired oxygen inspired oxygen fraction (FiO2)\\>80% or positive end expiratory pressure (PEEP) \\>10 cm H20\n* Patients with platelets less than 30,000(chronically)\n* Patients who are expected to undergo a spontaneous breathing trial within the next 4 hours\n* Patients with an order or plan to extubate in the next 4 hours\n* Patients who have an endotracheal tube (ETT) \\\u003C7.5 F\n* Patients who are currently dangerously agitated\n* Pregnant women\n\nExclusion criteria (outpatients ONLY for SA2 (3)):\n\n1. Patients who required ICU care \\\u003C48 hrs\n2. Patients less than 18 or greater than 90 years of age\n3. Patient is a prisoner\n4. Patients who are pregnant\n5. Residency \\> 40 miles from UCH clinics\n6. non-English or non-Spanish speaking\n7. Inability to perform study procedures (i.e. physical disability)\n8. unable to perform pulmonary function testing\n9. diagnosis of chronic pulmonary disease (e.g. COPD)\n10. diagnosis of chronic neurodegenerative disease or severe dementia\n11. history of anoxic or traumatic brain injury\n12. prior ICU hospitalization at a non-UCH facility.","90 Years",{"count":295,"type":21},300,"This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to lung infections and respiratory failure.\n\nSubjects are asked to be in this research study because they are thought to have a lung infection and may also have respiratory failure. Alcohol, tobacco, and drug use have been linked to lung infections, respiratory failure, and even death, but the reasons for this aren't known. People who use unhealthy amounts of alcohol, tobacco, and or drugs may be more at risk for lung infections, and for severe complications due to lung infection. Subject participation is important whether or not you use alcohol and or drugs.",[298,299,300,27],"Infection","Alcohol Abuse","Drugs of Abuse","2024-10-07",{"date":158,"type":32},{"date":304,"type":32},"2014-11",{"date":306,"type":21},"2029-04-30",{"name":308,"class":39},"University of Colorado, Denver",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":4,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":316,"targetDuration":4,"studyType":22,"phases":318,"briefSummary":319,"conditions":320,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":323,"startDateStruct":325,"completionDateStruct":326,"leadSponsor":328,"locationsCount":40},"100555641","the-effects-of-different-ventilation-modes-on-patients-with-pulmonary-lobe-resection-100555641","NCT06514729","The Effects of Different Ventilation Modes on Patients With Pulmonary Lobe Resection","The Effects of Different Ventilation Modes on Patients With Plasma Inflammatory Factor and Respiratory Function in Patients With Pulmonary Lobe Resection","Inclusion Criteria:\n\nComprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications\n\nAge 18-75 years old, the gender is not limited;\n\nASA grading Ⅰ \\~ III level;\n\nIt is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours\n\nExclusion Criteria:\n\nEmergency surgery;\n\nThere is a taboos on the existence of systemic anesthesia;\n\nThere is a history of acute chronic upper respiratory infections in the past January;\n\nPrevious bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure;\n\nMerge the function of important organs such as heart, liver, and kidney;\n\nThere was a history of chest surgery and the history of trauma;\n\nPreoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) \\\u003C60%);\n\nPatients refuse to participate in the clinical trial",{"count":317,"type":21},102,[24],"The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.",[27,321],"Lung Inflammation","2024-07-17",{"date":324,"type":32},"2024-07-23",{"date":256,"type":32},{"date":327,"type":21},"2025-05",{"name":329,"class":39},"Mao Enting",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":339,"conditions":340,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":348,"locationsCount":40},"100505163","respiratory-muscle-structure-and-function-in-mechanically-ventilated-patients-and-long-term-outcomes-100505163","NCT05857774","Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes","RESPIRE","Cases Inclusion Criteria:\n\n• Adult patients ≥18 years of age undergoing invasive mechanical ventilation in the ICU for any reason within 36 hours of intubation\n\nControl condition A Inclusion Criteria:\n\n• Non-invasively ventilated patients in the ICU within 36 hours of initiating non-invasive ventilation\n\nControl condition B Inclusion Criteria\n\n• Non-ventilated patients admitted to the ICU receiving no respiratory support or oxygen therapy alone, including high flow nasal cannula\n\nExclusion Criteria:\n\n* Patients expected to be extubated within 24 hours of screening for eligibility\n* Patients who have already undergone a SBT at time of screening\n* Patients with a previously diagnosed neuromuscular disorder\n* Patients receiving long-term invasive mechanical ventilation (prior to current hospitalization)\n* Patients who have required previously (during current hospitalization) a period of invasive ventilation in ICU of more than 24 hours\n* Patients who have previously been enrolled in the study\n* Patients for whom post-hospital follow-up may be challenging, e.g. those who reside overseas or who have no fixed address",{"count":338,"type":21},230,"Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain.\n\nThe RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.",[178,251,27,250,341],"Abdominal Muscle Strained","2024-05-18",{"date":344,"type":32},"2024-05-21",{"date":346,"type":32},"2023-04-27",{"date":191,"type":21},{"name":260,"class":39},{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":355,"enrollmentInfo":356,"targetDuration":4,"studyType":72,"phases":4,"briefSummary":358,"conditions":359,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":4},"100524954","polypropylene-vs-polyglactin-in-suturing-of-the-lung-100524954","NCT06115447","Polypropylene vs Polyglactin in Suturing of the Lung","Inclusion Criteria:\n\n* Patients admitted to Assiut University Hospital And will undergo surgery for lung tear repair.\n* Patients admitted to Assiut University Hospital And will undergo surgery for bullectomy or lobectomy.\n\nExclusion Criteria:\n\n* Patients with lung injury repaired with a stapler","65 Years",{"count":357,"type":21},100,"Comparative study comparing polypropylene and Polyglactin in suturing of the lung",[27,360,207],"Bleb Lung","2023-10-29",{"date":363,"type":32},"2023-11-03",{"date":365,"type":21},"2024-04-15",{"date":367,"type":21},"2028-10-30",{"name":369,"class":39},"Assiut University"]