[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-protective-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-protective-ventilation":93},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,75,117,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100637399","unilateral-ventilation-on-cardiopulmonary-bypass-during-cardiac-surgery-100637399",false,"NCT07612709","Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery","Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery in Patients at Increased Risk for Severe Postoperative Pulmonary Complications","Inclusion Criteria:\n\n* Patients at increased risk for postoperative pulmonary complications\n* Major elective cardiac surgery\n* Prolonged duration of cardiopulmonary bypass\n* Patients older than 65 years of age\n* Informed consent\n\nExclusion Criteria:\n\n* Emergency\n* Urgent procedures\n* Patients with implanted pacemakers\n* Patients with internal cardioverter\u002Fdefibrillators\n* Decompensated cardiac disease\n* Pulmonary disease\n* Recent pneumonia\n* Need for temporary perioperative mechanical support\n* Patients not willing to participate\n* Treatment with inhaled nitric oxide","ALL","65 Years",{"count":19,"type":20},45,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in patients at high-risk for developing severe pulmonary complications after cardiac surgery.",[26,27,28,29,30,31,32,33,34,35,36,37],"Lung Protective Ventilation","Cardiopulmonary Bypass","High-risk Cardiac Patients","Lung Ultrasound","Lung Water Assessment","Pulmonary Complications in Surgical Patients","Single-lung Ventilation","Chest X-ray for Clinical Evaluation","Electrical Impedance Tomography (EIT)","Lung Compliance","Oxygenation Indices","Biomarkers of Vascular Endothelial Injury","NOT_YET_RECRUITING","2026-05-24",{"date":41,"type":42},"2026-05-29","ACTUAL",{"date":44,"type":20},"2026-10-01",{"date":46,"type":20},"2029-07-31",{"name":48,"class":49},"Medical University of Vienna","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":50},"100637220","intraoperative-lung-mechanics-changes-during-holep-surgery-100637220","NCT07607704","Intraoperative Lung Mechanics Changes During HoLEP Surgery","Evaluation of Intraoperative Driving Pressure and Static Lung Compliance Changes in Holmium Laser Enucleation of Prostate (HoLEP) Surgery","Inclusion Criteria:\n\n* Male patients over 18 years of age\n* Patients scheduled for elective HoLEP surgery\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Preoperative severe lung disease\n* Thoracic pathology that may affect mechanical ventilation\n* Conditions where spontaneous breathing cannot be suppressed\n* Missing data severe lung disease\n* Thoracic pathology that may affect mechanical ventilation\n* Conditions where spontaneous breathing cannot be suppressed\n* Missing data","MALE","18 Years",{"count":19,"type":20},"OBSERVATIONAL","This study aims to evaluate changes in driving pressure and static lung compliance during HoLEP surgery and to investigate their relationship with surgical and perioperative factors. This study is observational, and no changes will be made to the patients' current treatment processes.",[64,26,65],"Holmium Laser Enucleation of the Prostate","Driving Pressure","2026-05-21",{"date":68,"type":42},"2026-05-26",{"date":70,"type":20},"2026-05-15",{"date":72,"type":20},"2026-08-31",{"name":74,"class":49},"Ankara City Hospital Bilkent",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":89,"conditions":90,"keywords":95,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":50},"100602473","phase-2-pediatric-acute-respiratory-distress-syndrome-ards-management-trial-100602473","NCT07123961","Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial","Pediatric Acute Respiratory Distress Syndrome (ARDS) Management (PARMA) Trial","PARMA","Inclusion:\n\n1. age \\> 2 weeks (\\> 38 weeks corrected gestational age) and \\\u003C 18 years (not yet had 18th birthday)\n2. acute (≤ 7 days of risk factor) respiratory failure requiring invasive mechanical ventilation\n3. ventilated with endotracheal tube or tracheostomy for ≤ 7 days from risk factor onset\n4. hypoxemia defined as PaO2\u002FFIO2 (measurement of the amount of oxygen dissolved in the blood plasma\u002Fconcentration of inhaled oxygen) \\> 300 (or SpO2\u002FFIO2 (measurement of the percentage of hemoglobin in your blood that is carrying oxygen\u002Fconcentration of inhaled oxygen) \\> 315 on Positive End-Expiratory Pressure (PEEP) ≥ 5 cmH2O (rate of pressure delivery) on two consecutive measurements 4 hours apart and sustained at the time of consent and randomization\n5. bilateral opacities on chest radiograph as determined by radiologist, clinical attending, or PI\n\nExclusion:\n\n1. hypoxemia caused primarily by hydrostatic pulmonary edema from heart failure or fluid overload\n2. non-palliated or unrepaired cyanotic congenital heart disease\n3. ventilated via tracheostomy at baseline prior to acute illness\n4. obstructive airway disease determined to be the primary cause of respiratory failure\n5. severe moribund state not expected to survive \\> 72 hours\n6. any limitations of care at time of screening\n7. escalation to high frequency oscillatory ventilation or extracorporeal support (i.e., meeting PARMA protocol failure criteria) at time of screening\n8. previous enrollment in this study","2 Weeks","17 Years",{"count":86,"type":20},160,[88],"PHASE2","Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children. Currently, ventilator settings commonly used in treatment are based on approaches developed for adults, and it remains unclear whether these settings are equally effective for children. Because children's bodies respond differently than adults', it is important to determine the most effective ventilator strategies specifically for pediatric patients. This study will compare two different ventilator approaches in children with ARDS to identify which method provides the greatest benefit. The findings will also help inform the design of a larger study in the future.",[91,92,93,94],"Acute Respiratory Distress Syndrome (ARDS)","Ventilator Management","Lung-protective Ventilation","Pediatric Acute Respiratory Distress Syndrome (PARDS)",[96,97,98,99,92,100,101,102,103,104,105,106],"Acute Respiratory Distress Syndrome","ARDS","Vent","Ventilator","Pediatric ARDS","Pediatric Ventilator Management","PARDS","Pediatric ARDS Protocolized Treatment","Invasive Mechanical Ventilation","IMV","Pediatric Acute Respiratory Distress Syndrome","RECRUITING","2026-03-13",{"date":110,"type":42},"2026-03-16",{"date":112,"type":42},"2025-11-07",{"date":114,"type":20},"2030-06-30",{"name":116,"class":49},"Children's Hospital of Philadelphia",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":124,"sex":16,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":21,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":50},"100600088","driving-pressure-guided-mechanical-ventilation-versus-lung-protective-ventilation-among-patients-undergoing-elective-surgeries-100600088","NCT07092943","Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries","A Comparison of Driving Pressure Guided Mechanical Ventilation With Lung Protective Ventilation Among Patients Presenting for Elective Surgeries at a Tertiary Care Hospital; A Randomized Control Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) class: I and II.\n* Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation\n* Patients receiving neuromuscular blockade during surgery.\n* Receiving Mechanical ventilation for at least 1h.\n\nExclusion Criteria:\n\n* Pregnancy\n* Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks.\n* Body mass index \\>35 kg\u002Fm2\n* Smokers and ASA class III and above.\n* Thoracic and Cardiac surgery",true,"16 Years","80 Years",{"count":128,"type":20},70,[23],"Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient. Lung protective ventilation provides breathing at a set volume determined by patient ideal body weight, along with a set rate to maintain adequate breathing. The pressures in the lower airway are kept less than 30 cm of H20 while a pressure of 5cm of H20 is applied to prevent lung collapse. Recently to above mentioned regimen a driving pressure is added which is a difference between lower airway pressure and pressure applied to prevent lung collapse. Ventilatory settings are adjusted to keep this driving pressure less than 15 cm of H2O.",[132,26,65],"Mechanical Ventilation",[134,135],"General Anesthesia","Mechanical ventilation","2025-07-28",{"date":138,"type":42},"2025-07-30",{"date":140,"type":42},"2025-07-20",{"date":142,"type":20},"2025-10-20",{"name":144,"class":49},"Rawalpindi Medical College",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":149,"acronym":97,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":21,"phases":155,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":50},"100555601","effect-of-different-depths-of-neuromuscular-blockade-on-respiratory-mechanics-in-patients-with-moderate-severe-acute-respiratory-distress-syndrome-100555601","NCT06514209","Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome","Inclusion Criteria:\n\n1. Patients with moderate to severe ARDS requiring the use of NMBAs, as assessed by clinicians (Berlin definition 2012: PaO2\u002FFiO2 \\\u003C 150 mmHg, PEEP ≥ 5).\n2. Age: 18-85 years.\n3. Signed informed consent.\n\nExclusion Criteria:\n\n1. History of allergy to NMBAs.\n2. Open chest or abdominal injuries.\n3. Patients with pulmonary masses, lung transplantation, or lung resection.\n4. Contraindications to esophageal catheter placement.\n5. Pregnant patients.\n6. Contraindications to TOF measurement (e.g., history of neuromuscular disease, presence of a cardiac pacemaker).\n7. Severe dysfunction of other organs with an expected short-term mortality (within 7 days) or palliative care.\n8. Previous inclusion in this study.","18 Days","85 Years",{"count":154,"type":20},20,[23],"Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors, leading to refractory hypoxemia. It has high incidence and mortality rates. Neuromuscular blocking agents (NMBAs) play a crucial role as adjunctive therapy for ARDS, aiding in lung-protective ventilation by inhibiting excessive spontaneous breathing, improving patient-ventilator synchrony, and reducing barotrauma.\n\nDetermining the appropriate depth of muscle relaxation in moderate to severe ARDS patients receiving NMBAs remains a clinical challenge. Research has shown that partial neuromuscular blockade is feasible in certain ARDS patients. However, large randomized controlled trials (RCTs) and clinical practices often use higher doses of NMBAs to ensure complete cessation of spontaneous breathing. This indicates an ongoing debate regarding the optimal depth of neuromuscular blockade necessary for lung-protective ventilation in ARDS patients. It also raises the question of whether the optimal depth of neuromuscular blockade varies among patients with different severities of ARDS.\n\nThis study aims to investigate changes in respiratory mechanics and other physiological parameters in moderate to severe ARDS patients under different depths of neuromuscular blockade. The investigators will evaluate the impact of targeted neuromuscular blockade depth on lung protection in these patients.",[97,26],[97,159,160,161],"lung protective ventilation","neuromuscular blockade","respiratory mechanics","2024-07-21",{"date":164,"type":42},"2024-07-23",{"date":166,"type":42},"2024-06-28",{"date":168,"type":20},"2025-06-30",{"name":170,"class":49},"Southeast University, China"]