[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-recruitment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-recruitment":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100570285","peep-for-lung-recruitment-in-preterm-infants-eit-study-100570285",false,"NCT06705257","PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY","EFFECT OF VARYING LEVELS OF PEEP ON PRETERM LUNG RECRUITMENT USING ELECTRICAL IMPEDANCE TOMOGRAPHY- FEASIBILITY STUDY","[PEOPLE]","Inclusion criteria\n\n1. Gestational age \\\u003C32 weeks based on mother's last menstrual period or first trimester ultrasound dating.\n2. Receiving either CPAP or mechanical ventilation respiratory support.\n3. Informed written consent from one of the parents.\n4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life.\n\nExclusion criteria\n\n1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team.\n2. Infants diagnosed with pneumothorax i.\n3. Receiving high frequency mechanical ventilation.\n4. Infants with concerns of skin integrity.","ALL","22 Weeks","32 Weeks",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP\u002FCPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as \"continuous distending pressure (CDP)\".\n\nThose babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung injury . Preterm infants who are already on breathing machine, providing sub optimal PEEP\u002FCPAP could also lead to lung damage. Providing optimal PEEP\u002FCPAP could prevent these negative outcomes. Currently there is not enough evidence to suggest optimal PEEP\u002FCPAP in preterm infants. Neonatal units all around the world uses PEEP\u002FCPAP ranging from 4 to 10cm H20 based on their unit practice. Currently available investigations provide limited one time information (e.g. Chest X-ray) regarding whether baby is receiving optimal PEEP\u002FCPAP. Electrical Impedance Tomography (EIT) is a new technology which could provide better information regarding the pressure delivered. Also, this device would provide continuous information as if the clinicians are doing continuous chest X-ray but without any radiation. In this study, the team will assess the effect of different levels of PEEP\u002FCPAP (4 to 10cm H20) on prevention of lung collapse using EIT. This would be studied in premature infants who are on breathing machine support and CPAP machine support.",[28,29,30,31],"PreTerm Neonate","Positive End Expiratory Pressure (PEEP)","Lung Recruitment","Electrical Impedance Tomography (EIT)",[33,34,35],"positive end expiratory pressure","PRETERM","Electrical Impedance Tomography","RECRUITING","2026-05-01",{"date":39,"type":40},"2026-05-06","ACTUAL",{"date":42,"type":40},"2025-06-15",{"date":44,"type":22},"2026-12-31",{"name":46,"class":47},"South Tees Hospitals NHS Foundation Trust","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":5},"100495084","integrated-echocardiography-and-chest-ultrasound-assessment-of-lung-recruitment-in-preterm-infants-100495084","NCT05726578","Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants","Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants Using High Frequency Ventilation","Inclusion Criteria:\n\n* Infants will be enrolled if they are 32 to 37 weeks of gestational age, have respiratory distress (RD) in the first 24 h of life, intubated and have invasive respiratory support using HFOV. Signs of RD are tachypnea (respiratory rate \\> 60\u002Fmin), grunting, nasal flaring, chest retraction, and need of oxygen supplementation or other respiratory support.\n\nExclusion Criteria:\n\n1. Known major congenital anomalies including congenital heart diseases.\n2. Fetal hydrops.\n3. Babies with congenital heart diseases","1 Hour","3 Days",{"count":59,"type":22},72,[25],"The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.",[63,64,65,66,30],"Ventilator Lung","Echocardiography","Chest Ultrasound","High Frequency Ventilation",[68],"Premature infants","2025-05-24",{"date":71,"type":40},"2025-05-28",{"date":73,"type":40},"2024-07-01",{"date":75,"type":22},"2025-07-01",{"name":77,"class":47},"Alexandria University"]