[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-resection-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-resection-surgery":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100643743","effect-of-individualized-positive-end-expiratory-pressure-peep-in-patients-who-have-an-intrinsic-peep-during-one-lung-ventilation-100643743",false,"NCT07638176","Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation","Effects of Individualized Positive End-expiratory Pressure (PEEP) on Intrinsic PEEP and Stroke Volume During One-lung Ventilation: a Single-center, Randomized Crossover Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists Physical Status I - III\n* The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2\n* Lung resection surgery requiring one-lung ventilation for over 60 minutes\n* Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)\n* Patient who is diagnosed with intrinsic PEEP during one-lung ventilation\n\nExclusion Criteria:\n\n* Large bullae\n* Emergency surgery\n* Mechanical ventilation before surgery\n* Hemodynamic instability before surgery\n* Surgery requiring cardiopulmonary bypass\n* Pregnancy, breastfeeding patient\n* Patient's refusal to participate\n* No intrinsic PEEP during one-lung ventilation","ALL","19 Years","100 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.",[27,28],"Pulmonary Disease (COPD), Chronic Obstructive","Lung Resection Surgery","NOT_YET_RECRUITING","2026-06-04",{"date":32,"type":33},"2026-06-10","ACTUAL",{"date":35,"type":21},"2026-06-01",{"date":37,"type":21},"2027-05-31",{"name":39,"class":40},"Samsung Medical Center","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":69},"100628449","phase-4-effect-of-oxygen-administration-in-the-non-dependent-lung-on-postoperative-complications-after-lung-surgery-100628449","NCT07461779","Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery","Impact of Continuous Oxygen Flow With or Without Airway Pressure in the Non-dependent Lung During One-lung Ventilation on Postoperative Complications in Lung Resection Surgery: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients of both genders undergoing lung resection surgery in the Thoracic Surgery Department at Hospital General Universitario Gregorio Marañón\n* Lung isolation using a double-lumen tube (DLT)\n* Scheduled surgery\n* Patients able and willing to give written informed consent\n* Patients over 18 years old and legally competent\n\nExclusion Criteria:\n\n* Patients with evidence of pulmonary bullae\n* Pregnancy or breastfeeding\n* Blood transfusion within 10 days prior to surgery\n* Treatment with immunosuppressants or corticosteroids within 3 months prior to surgery\n* Patient refusal to participate\n* Prior contralateral thoracic surgery\n* Robotic surgery\n* Pneumonectomy\n* Enrollment in another clinical trial","18 Years",{"count":50,"type":21},177,[52],"PHASE4","The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and postoperative complications. We will conduct a randomized, controlled, and blinded study in 177 patients with three arms:\n\n* Control Group: Oxygen therapy according to standard clinical practice\n* Apneic oxygenation group: A probe will be introduced through the lumen of the double-lumen tube (DLT) to administer a continuous source of oxygen without any mechanism that generates airway pressure.\n* CPAP Group: Continuous positive airway pressure with 3-5 L\u002Fmin oxygen flow and 2 cm H2O pressure delivered via a Mapleson system.\n\nInflammatory mediators in blood and in both lungs will be measured intraoperatively and 24 hours after surgery. Patients will be followed from hospital admission until discharge and again 30 days after surgery to evaluate the postoperative course, particularly the occurrence of complications according to the revised Clavien-Dindo classification for thoracic surgery, as well as other relevant clinical outcomes.",[28,55],"Anesthesia General",[57,58],"Postoperative complications","Thoracic surgery","RECRUITING","2026-03-06",{"date":62,"type":33},"2026-03-10",{"date":64,"type":33},"2025-01-27",{"date":66,"type":21},"2027-03-30",{"name":68,"class":40},"Francisco Andres de la Gala",1]