[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-ultrasound\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-ultrasound":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,43,77,102,133,160,185,217,246,273,309,352,377,405],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100641321","surgical-positions-and-postoperative-atelectasis-a-lung-ultrasound-study-100641321",false,"NCT07654153","Surgical Positions and Postoperative Atelectasis: A Lung Ultrasound Study","Evaluation of the Effect of Surgical Positions Under General Anesthesia on Postoperative Atelectasis Using Lung Ultrasonography","Inclusion Criteria:\n\n* Being between 18-65 years of age\n* Having ASA I-III status\n* Planning elective surgery under general anesthesia\n* Agreeing to participate in the study and signing the consent form\n\nExclusion Criteria:\n\n* Patients requiring emergency surgery\n* Patients with ASA IV or higher\n* Presence of a known serious preoperative lung disease (COPD, Asthma, Pneumonia, Pleural effusion, Pneumothorax, Interstitial lung disease, Bronchiectasis, etc.)\n* History of neuromuscular disease\n* Body Mass Index (BMI) \\> 35 kg\u002Fm² (Morbid obesity)\n* Presence of chest wall deformity or skin lesions that would obstruct LUS imaging\n* Cases with an operative duration of less than 60 minutes or more than 300 minutes\n* Patients with a history of thoracotomy, sternotomy, or prior open thoracic surgery\n* Patients with alcohol or drug dependence\n* Patients with significant anemia\n* Patients who are pregnant or lactating\n* Patients who develop laryngospasm following extubation\n* Refusal to provide consent or inability to cooperate",true,"ALL","18 Years","65 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","The aim of this study is to prospectively evaluate the effect of surgical position on the development of postoperative atelectasis in patients undergoing surgery in supine, prone, lateral decubitus, and lithotomy positions using lung ultrasonography (LUS), and to investigate whether there is a difference between these positions.",[26,27],"Lung Ultrasound","Atelectasis",[29],"lung ultrasound","NOT_YET_RECRUITING","2026-06-18",{"date":33,"type":34},"2026-06-22","ACTUAL",{"date":36,"type":22},"2026-07-20",{"date":38,"type":22},"2027-08-01",{"name":40,"class":41},"Cumhuriyet University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":42},"100637399","unilateral-ventilation-on-cardiopulmonary-bypass-during-cardiac-surgery-100637399","NCT07612709","Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery","Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery in Patients at Increased Risk for Severe Postoperative Pulmonary Complications","Inclusion Criteria:\n\n* Patients at increased risk for postoperative pulmonary complications\n* Major elective cardiac surgery\n* Prolonged duration of cardiopulmonary bypass\n* Patients older than 65 years of age\n* Informed consent\n\nExclusion Criteria:\n\n* Emergency\n* Urgent procedures\n* Patients with implanted pacemakers\n* Patients with internal cardioverter\u002Fdefibrillators\n* Decompensated cardiac disease\n* Pulmonary disease\n* Recent pneumonia\n* Need for temporary perioperative mechanical support\n* Patients not willing to participate\n* Treatment with inhaled nitric oxide",{"count":51,"type":22},45,"INTERVENTIONAL",[54],"NA","This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in patients at high-risk for developing severe pulmonary complications after cardiac surgery.",[57,58,59,26,60,61,62,63,64,65,66,67],"Lung Protective Ventilation","Cardiopulmonary Bypass","High-risk Cardiac Patients","Lung Water Assessment","Pulmonary Complications in Surgical Patients","Single-lung Ventilation","Chest X-ray for Clinical Evaluation","Electrical Impedance Tomography (EIT)","Lung Compliance","Oxygenation Indices","Biomarkers of Vascular Endothelial Injury","2026-05-24",{"date":70,"type":34},"2026-05-29",{"date":72,"type":22},"2026-10-01",{"date":74,"type":22},"2029-07-31",{"name":76,"class":41},"Medical University of Vienna",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":52,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100477083","personalized-mechanical-ventilation-guided-by-ultrasound-in-patients-with-acute-respiratory-distress-syndrome-100477083","NCT05492344","Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Admitted to a participating ICU,\n* invasively ventilated and\n* fulfil the Berlin criteria for moderate or severe ARDS.\n\nExclusion Criteria:\n\n* Age under 18,\n* participation in other interventional studies with conflicting endpoints,\n* conditions in which LUS is not feasible or possible (e.g. subcutaneous emphysema, morbid obesity or wounds),\n* mechanical ventilation for longer than 7 consecutive days in the past 30 days,\n* history of ARDS in the previous month,\n* body-mass index higher than 40 kg\u002Fm²,\n* intracranial hypertension,\n* broncho-pleural fistula,\n* chronic respiratory diseases requiring long-term oxygen therapy or respiratory support,\n* pulmonary fibrosis with a vital capacity \\\u003C 50% (severe or very severe),\n* previously randomized in the PEGASUS study\n* ECMO\n* patients who receive invasive ventilation in home setting due to a neurological disease\n* pregnant patients\n* patients who are moribund or facing end of life and\n* no informed consent.","100 Years",{"count":85,"type":22},538,[54],"Rationale Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%. The identification of ARDS phenotypes, based on focal or non-focal lung morphology, can be helpful to better target mechanical ventilation strategies of individual patients. Lung ultrasound (LUS) is a non-invasive tool that can accurately distinguish 'focal' from 'non-focal' lung morphology. The investigators hypothesize that LUS-guided personalized mechanical ventilation in ARDS patients will lead to a reduction in 90-day mortality compared to conventional mechanical ventilation.",[89,26,90],"ARDS, Human","Mechanical Ventilation","RECRUITING","2026-05-22",{"date":94,"type":34},"2026-05-27",{"date":96,"type":34},"2022-08-09",{"date":98,"type":22},"2027-11-01",{"name":100,"class":41},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",10,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":52,"phases":111,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":42},"100639824","case-based-learning-for-bedside-lung-ultrasound-teaching-in-icu-100639824","NCT07594470","Case-Based Learning for Bedside Lung Ultrasound Teaching in ICU","CBL Mode in Clinical Teaching of Bedside Lung Ultrasound in Intensive Care Unit: A Randomized Controlled Study","Inclusion Criteria:\n\n* Standardized residency trainees currently rotating in the Intensive Care Unit (ICU), specializing in Internal Medicine, Surgery, Emergency Medicine, Anesthesiology, or General Practice.\n* Have completed institutional basic ultrasound theory training or possess preliminary ultrasound knowledge.\n* Voluntarily participate and provide written informed consent.\n* Able to complete the entire teaching and evaluation schedule (including written test and OSCE).\n\nExclusion Criteria:\n\n* Prior formal training or certification in lung\u002Fcritical care ultrasound.\n* Unable to complete the study period due to rotation scheduling or absence.\n* Decline or withdraw informed consent.",{"count":110,"type":22},106,[54],"This single-center randomized controlled study aims to evaluate the effectiveness of Case-Based Learning (CBL) compared with traditional teaching in clinical training of bedside lung ultrasound (BLUE) for emergency medicine residents and medical students. The hypothesis is that CBL improves theoretical understanding, practical ultrasound skills, and clinical reasoning in emergency settings.",[114,115,116,26,117],"Medical Education","ICU","Emergency Medicine","Case-based Learning",[119,120,121,116,122,123],"Case-based learning","Bedside Lung Ultrasound (BLUE)","Case-Based Learning (CBL)","Critical ultrasonography","Intensive Care Unit","2026-05-14",{"date":126,"type":34},"2026-05-18",{"date":128,"type":22},"2026-07-01",{"date":130,"type":22},"2027-06-30",{"name":132,"class":41},"First Affiliated Hospital of Wannan Medical College",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":142,"studyType":23,"phases":4,"briefSummary":143,"conditions":144,"keywords":148,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":42},"100639257","3d-us-construct-on-volumetric-assessment-of-lung-disease--clinical-application-100639257","NCT07574255","3D-US Construct on Volumetric Assessment of Lung Disease & Clinical Application","Three-dimensional Ultrasonic Construct on Volumetric Assessment of Lung Disease and Its Clinical Application","Inclusion Criteria:\n\n* Participants suspect with lung lesions referred for ultrasound workup\n\nExclusion Criteria:\n\n* Participants aged \\\u003C 18 years\n* Participants refusal\n* Participants with implanted metal in scanning area interfering data collection\n* Participants who cannot perform breath holding for at least 1 second",{"count":141,"type":22},300,"6 Months","The goal of this observational study is to establish the three-dimensional construct of lung lesion via ultrasound in patients with peripheral lung lesions or any superficial lesion in thoracic fields. The primary question our study aims to answer is:\n\nWhether the 3D ultrasound morphology can reflect lung disease entities? Whether the 3D volumetric follow-up protocol can be standardised to reflect lung disease status?",[26,145,146,147],"Lung Cancer (Diagnosis)","Peripheral Lung Lesions","Ultrasound Assessment",[29,149,150],"three-dimensional ultrasound","peripheral lung lesions","2026-05-03",{"date":153,"type":34},"2026-05-07",{"date":155,"type":22},"2026-05-30",{"date":157,"type":22},"2031-02-28",{"name":159,"class":41},"National Taiwan University Hospital",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":169,"conditions":170,"keywords":174,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":42},"100534193","detection-of-rheumatoid-arthritis---interstitial-lung-disease-by-thoracic-ultrasound-100534193","NCT06235645","dEtection of rheumAtoid aRthritis - Interstitial Lung dIseasE by Thoracic ultRasound","EARLIER","Inclusion Criteria:\n\n* Adult patient (age \\> 18 years) followed at CHU of Tours\n* Diagnosis of rheumatoid arthritis validated according to ACR 2010 criteria, EULAR classification, regardless of time since diagnosis\n* Patient who has had or will have a thoracic CT scan and PFT performed as part of routine care in the 6 months preceding or following inclusion\n* Patient with at least two risk factors for developing RA-ILD among :\n\n  * Male sex or\n  * Active or former smoker assessed at 20 pack-year or\n  * Age \\> 60 years or\n  * Levels of RF≥3N (rheumatoid factor) and\u002For anti-CCP≥3N (antibodies against cyclic citrullinated peptides) at diagnosis or at any time during the course of the disease or\n  * High RA activity score (DAS28\\>3.2)\n\nExclusion Criteria:\n\n* Diagnosis of congenital lung disease\n* Diagnosis of another autoimmune pathology associated with RA (overlap syndrome) linked to the development of ILD (interstitial lung disease) (systemic sclerosis, myositis, dermatomyositis, mixed connectivitis, systemic lupus erythematosus or other ANCA vasculitis, with the exception of secondary Gougerot-Sjögren's syndromes).\n* Current or operated lung cancer\n* Thoracic irradiation\n* Thoracic transplant patients\n* Previous invasive thoracic procedures\n* Pathologies responsible for pleural thickening (silicosis, asbestosis, known pleural plaque, pleural sequelae of tuberculosis)\n* Pregnant or breast-feeding women\n* Patient under legal protection (guardianship, curatorship or safeguard of justice)\n* Patient who has objected to data processing\n* Parenchymal infection current or less than one month old prior to LUS examination\n* Liquid or gaseous pleural effusion",{"count":168,"type":22},280,"Rheumatoid arthritis is an autoimmune disease that can affect various organs, including the lungs, and lead to rheumatoid arthritis-interstitial lung disease (RA-ILD).\n\nRA-ILD is responsible for increased mortality in rheumatoid arthristis (RA) patients.\n\nThe prevalence of RA-ILD varies according to the screening tool used.\n\nThe current gold standard is chest CT, but this is an expensive, time-consuming and irradiating examination, and recommendations on when and how often it should be performed are not clearly established.\n\nLung ultrasound (LUS) is an emerging tool for the detection of lung parenchymal damage, particularly in systemic scleroderma and idiopathic pulmonary fibrosis (IPF).\n\nLUS is a non-irradiating, non-expensive examination that can be performed rapidly.\n\nThe aim of our study is to evaluate LUS as a screening tool for RA-ILD, in patients with risk factors for developing RA-ILD.",[171,172,173,26],"Rheumatoid Arthritis","Interstitial Lung Disease","Thoracic Ultrasound",[175,171,172],"Lung ultrasound","2026-04-29",{"date":178,"type":34},"2026-04-30",{"date":180,"type":34},"2024-11-18",{"date":182,"type":22},"2027-03",{"name":184,"class":41},"University Hospital, Tours",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":11,"sex":17,"minAge":193,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":52,"phases":197,"briefSummary":198,"conditions":199,"keywords":203,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":216},"100586946","lung-ultrasound-for-guiding-antibiotic-use-in-pediatric-pneumonia-100586946","NCT06921993","Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia","Lung Ultrasound for Antibiotic Stewardship in Community-Acquired Pneumonia: A Randomized Clinical Trial","LUSCAP","Inclusion Criteria:\n\n* Well-appearing, clinically stable patients aged 3 to 10 years, presenting to the pediatric ED with suspected pneumonia based on a combination of signs and symptoms suggestive of lower respiratory tract infection (LRTI), including:\n\n  1. Respiratory Symptoms: Cough, Tachypnea, Dyspnea (Increased work of breathing), Abnormal findings on auscultation.\n  2. Systemic Symptoms: Fever, Hypoxia, Decreased appetite.\n\n     Exclusion Criteria:\n* Neonates and children up to 3 years of age, and children older than 10 years\n* Children aged 3 to 10 years with any of the following factors:\n\n  1. Recent hospitalization (within the past 14 days)\n  2. Prior CXR or any other chest imaging (e.g. CT scan)\n  3. Ongoing antibiotic therapy\n  4. Hemodynamic instability\n  5. Respiratory failure or severe respiratory distress and\u002For hypoxemia, requiring urgent assessment for conditions such as pneumothorax, hemothorax, or other emergency respiratory conditions\n  6. History of aspiration or ab ingestis pneumonia\n  7. Underlying medical conditions predisposing to severe or recurrent pneumonia, including immunodeficiency, chronic corticosteroid use, chronic lung disease, malignancy, sickle cell disease, congenital heart disease, tracheostomy, and neuromuscular disorders affecting respiration","3 Years","10 Years",{"count":196,"type":22},659,[54],"Pneumonia is a major cause of illness and death in children, with an annual incidence of about 3.3 per 1,000 in those under five years old, many requiring hospitalization. The diagnosis is challenging due to the absence of a universally accepted gold standard, leading to variability in emergency settings. Current guidelines recommend diagnosis based on history and physical examination, which do not reliably differentiate pneumonia from other respiratory infections or identify whether it is bacterial or viral in nature. This uncertainty can lead to the unnecessary use of antibiotics.\n\nCommonly used chest X-rays have limitations such as low sensitivity, moderate interobserver reliability, and the inability to distinguish bacterial from viral pneumonia. In contrast, lung ultrasound has shown high sensitivity and specificity for diagnosing pneumonia in children. However, lung ultrasound also cannot reliably distinguish between bacterial and viral causes and might lead to increased antibiotic prescriptions by detecting minor lung consolidations not seen on chest X-rays. Despite these issues, lung ultrasound is widely used in pediatric pulmonary assessment.\n\nThe primary objective of the study is to determine if using lung ultrasound for diagnosing pneumonia in children can reduce antibiotic prescriptions compared to the standard care approach-which mainly relies on clinical diagnosis (often supplemented by chest X-ray and blood tests in selected cases). The secondary objective is to assess how frequently lung ultrasound impacts management decisions during a single clinical visit, beyond the information provided by history and physical examination. The third objective is to compare the diagnostic accuracy of lung ultrasound-supported diagnosis with existing diagnostic methods.\n\nThe study hypothesizes that lung ultrasound results can act as a decision modifier, similar to other clinical tools and examination findings. However, a lack of consensus on specific lung ultrasound parameters and their clinical correlations contributes to variability in managing suspected pneumonia, potentially leading to antibiotic overuse.\n\nEligible participants are children aged three to ten years who are in good general condition and clinically stable, presenting with signs and symptoms of lower respiratory tract infection indicative of pneumonia. Exclusion criteria include children outside the specified age range, those recently hospitalized, those who have undergone prior chest imaging, those already on antibiotic therapy, those with severe clinical instability, and those with underlying conditions predisposing them to severe or recurrent pneumonia. These criteria help ensure that the study population represents general pediatric community-acquired pneumonia cases, avoiding biases from high-risk patients.\n\nThe ultimate goal of this study is to provide evidence on whether lung ultrasound can serve as a reliable tool to guide antibiotic prescriptions, thereby reducing unnecessary antibiotic use in the management of pediatric pneumonia.",[200,201,26,202],"Pneumonia Childhood","Pneumonia","Antibiotic Stewardship",[201,204,205,175,206],"Children","Pediatrics","point-of-care ultrasound","2026-04-02",{"date":209,"type":34},"2026-04-03",{"date":211,"type":34},"2025-04-24",{"date":213,"type":22},"2028-06-30",{"name":215,"class":41},"Meyer Children's Hospital IRCCS",18,{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":223,"targetDuration":225,"studyType":23,"phases":4,"briefSummary":226,"conditions":227,"keywords":231,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":42},"100606662","concordance-and-discordance-in-the-assessment-of-volume-status-in-home-dialysis-patients-a-comparison-of-modified-medical-research-council-dyspnea-scale-physical-exam-and-point-of-care-ultrasound-pocus-100606662","NCT07178470","Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)","Inclusion Criteria:\n\n1. Age: Greater than 18 years.\n2. Diagnosis: End-stage kidney disease (ESKD).\n3. Treatment: Receiving home dialysis, either peritoneal dialysis (PD) or home hemodialysis (HHD).\n4. Duration of Home Dialysis: At least three months on home dialysis.\n\nExclusion Criteria:\n\n1. Consent: Inability to provide informed consent.\n2. Inclusion Criteria: Not meeting any of the inclusion criteria.\n3. Pregnancy.\n4. Urgent-Start PD.\n5. Any other obvious cause of shortness of breath not related to volume overload including but not limited to pneumonia, pneumothorax, advanced COPD and Interstitial lung disease.",{"count":224,"type":22},90,"1 Day","Fluid overload, which is when your body has too much fluid, is one of the reasons why people on home dialysis need to go to the hospital. Fluid overload (when body has too much fluid) commonly presents as trouble breathing and leg swelling. Traditionally, doctors check for this by asking patients if they have any symptoms like leg swelling or shortness of breath and by doing a physical exam which includes listening to the lungs or looking for swelling in legs. However, a newer, safe, and non-invasive method called point-of-care ultrasound (POCUS) has become very popular. However, we don't have a lot of research yet on how POCUS and LUS (lung ultrasound) specifically help home dialysis patients, including those on peritoneal dialysis or home hemodialysis. Peritoneal dialysis is a way to clean your blood by putting a special fluid into your belly through a small tube. The fluid uses the natural lining of your belly as a filter to remove waste and extra water. Home hemodialysis is a treatment where a machine acts like an artificial kidney to clean your blood. You get trained to do this yourself at home by connecting to the machine with a couple of needles, which cleans your blood of waste and extra fluid. POCUS, especially a (LUS), has been shown to be useful for dialysis patients in outpatient units.\n\nThis study will compare different 3 different methods of detecting fluid overload: answering various survey questions, completing a physical exam, and a LUS. The study seeks to determine which of these methods is the best method to determine fluid overload.\n\nYou were selected as a possible participant because you are over 18 years old, diagnosed with End-stage kidney disease, and have been receiving home dialysis for at least three months.",[228,229,26,230],"Fluid Overload","POCUS","Volume Status",[232,233,29,234,235,236],"pocus","fluid overload","volume status","modified Medical Research Council Dyspnea Scale","mMRC dyspnea scale","2026-02-24",{"date":239,"type":34},"2026-02-27",{"date":241,"type":34},"2026-01-09",{"date":243,"type":22},"2026-06",{"name":245,"class":41},"Indiana University",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":52,"phases":256,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":4},"100621788","ori-guided-fio-titration-in-prone-spine-surgery-impact-on-postoperative-atelectasis-assessed-by-lung-ultrasound-100621788","NCT07375173","ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Oxygen Reserve Index-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Inclusion Criteria:\n\n1. Adults aged 18 to 80 years\n2. Patients with an ASA physical status of I, II, or III\n3. Individuals with a body mass index (BMI) between 18 and 35 kg\u002Fm²\n\nExclusion Criteria:\n\n1. History of or active upper or lower respiratory tract infection within the past month\n2. Pulmonary emphysematous\u002Fbullous disease or COPD\n3. Pre-existing significant atelectasis or consolidation (Preoperative LUS showing a score of 3 consolidation or ≥2 regions with a score ≥2)\n4. Severe obstructive sleep apnea requiring CPAP therapy\n5. NYHA class III-IV heart failure, EF \\\u003C35%, or severe valvular disease\n6. Severe arrhythmia or hemodynamic instability requiring high-dose vasopressors\n7. Body mass index (BMI) \\>35 kg\u002Fm²\n8. Severe anemia (Hb \\\u003C9 g\u002FdL) or polycythemia (Hb \\>18 g\u002FdL)\n9. Non-diagnostic or unclear preoperative lung ultrasound images\n10. Preoperative SpO₂ ≤ 94%\n11. Inability to apply the sensor due to finger deformity, or inadequate signal caused by digital hypoperfusion","80 Years",{"count":255,"type":22},74,[54],"Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia. High inspiratory oxygen fractions (FiO₂) can promote absorption atelectasis, ventilation-perfusion mismatch, hemodynamic alterations, and oxidative injury.\n\nThis study evaluates the effect of two intraoperative oxygen management strategies-oxygen reserve index (ORI)-guided FiO₂ titration versus fixed 50% FiO₂-on postoperative atelectasis in patients undergoing thoracolumbar spine surgery under general anesthesia. Atelectasis severity will be assessed using lung ultrasonography (LUS), scored across 12 thoracic regions (0-3 per region, total 0-36), while respiratory function changes will be examined via preoperative and 24-hour postoperative spirometry (FVC, FEV₁, FEV₁\u002FFVC).\n\nBecause postoperative spirometry may be influenced by pain, Numeric Rating Scale (NRS) scores will be recorded to help distinguish true restrictive patterns from pain-limited respiratory effort.\n\nThe study aims to determine whether ORI-guided FiO₂ titration can reduce postoperative atelectasis and improve respiratory outcomes compared with a fixed FiO₂ approach.",[259,260,261,26,262],"Atelectases, Postoperative Pulmonary","Prone Position","Spine Surgery","Oxygen Reserve Index","2026-01-24",{"date":265,"type":34},"2026-01-29",{"date":267,"type":22},"2026-03-15",{"date":269,"type":22},"2026-11-30",{"name":271,"class":272},"Ankara Etlik City Hospital","OTHER_GOV",{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":279,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":281,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":283,"conditions":284,"keywords":289,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":42},"100594393","feasibility-study-of-novice-performed-lung-ultrasound-for-pneumothorax-detection-after-cardiac-surgery-100594393","NCT07018856","Feasibility Study of Novice-Performed Lung Ultrasound for Pneumothorax Detection After Cardiac Surgery","The CLEAR Vanguard Feasibility Study: Comparative Evaluation of Novice-Performed Lung Ultrasound Versus Chest X-Ray for Pneumothorax Detection Post-Chest Tube Removal in Cardiac Surgery Patients","CLEARVGRD","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing cardiac surgery\n* Scheduled for chest and\u002For mediastinal chest tube removal in the cardiovascular intensive care unit (CVICU)\n\nExclusion Criteria:\n\n* Severe chronic lung disease that may impair lung ultrasound interpretation, including:\n* Subcutaneous emphysema\n* COPD or emphysema with FEV₁ \\\u003C 50% predicted\n* Interstitial lung disease with FEV₁ \\\u003C 75% predicted\n* Documented history of pneumothorax prior to chest tube removal requiring intervention\n* Mechanical ventilation at the time of eligibility screening\n* Inability to undergo lung ultrasound or chest X-ray (e.g., due to hemodynamic instability or positioning limitations)",{"count":282,"type":22},120,"What is the purpose of this study? This study is being done to find out if medical trainees (such as residents and fellows) can learn to use lung ultrasound to detect a collapsed lung (pneumothorax) after heart surgery.\n\nWho is participating in the study? Adults who have recently had heart surgery and are having their chest tubes removed in the intensive care unit may be able to join.\n\nWhat will happen during the study? After chest tubes are removed, a trained medical trainee will use a small ultrasound device to check the lungs at the bedside. The patient will also have a chest X-ray, which is the usual test. The results from the ultrasound will be compared to the chest X-ray and reviewed by expert doctors.\n\nWhat is the goal of the study? The goal is to see if it is possible to train medical trainees to use lung ultrasound safely and accurately in real hospital settings. The results will help plan a larger study in the future.",[285,286,26,287,288],"Pneumothorax","Cardiac Surgery","Chest Tube Removal","Postoperative Complications (Cardiopulmonary)",[26,290,287,286,291,292,293,294,295,296,297,298,299,114],"Pneumothorax Detection","Point-of-Care Ultrasound","Postoperative Complication","Bedside Ultrasound","Novice Sonographer","Diagnostic Accuracy","Feasibility Study","Critical Care Ultrasound","Trainee-Performed Ultrasound","Chest X-Ray","2025-12-17",{"date":302,"type":34},"2025-12-24",{"date":304,"type":34},"2025-09-16",{"date":306,"type":22},"2027-02",{"name":308,"class":41},"Jacobo Moreno Garijo",{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":313,"acronym":314,"eligibilityCriteria":315,"healthyVolunteers":11,"sex":17,"minAge":316,"maxAge":317,"enrollmentInfo":318,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":320,"conditions":321,"keywords":332,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":342,"lastUpdatePostDateStruct":343,"startDateStruct":345,"completionDateStruct":347,"leadSponsor":349,"locationsCount":351},"100601977","heterogeneity-index-in-neonatologist-performed-lung-ultrasound-in-neonates-receiving-respiratory-support---a-pilot-study-100601977","NCT07117513","Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study","NPLUS HI","Inclusion Criteria:\n\n* Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neonates (\\> 37+0 weeks of gestation) admitted to the NICU\n* Presence of respiratory distress requiring respiratory support (invasive and non-invasive) at the timepoint of NPLUS 1.\n* Written informed consent obtained from the parents prior to the measurement.\n\nExclusion Criteria:\n\n* cardiopulmonary malformations\n* pleural effusion\n* pneumothorax","1 Hour","7 Days",{"count":319,"type":22},40,"Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability.\n\nThis pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.",[322,323,324,325,326,26,327,328,329,330,331],"Intensive Care Units, Neonatal","Infant, Newborn","Infant, Premature","Point-of-Care Systems","Ultrasonography","Lung Ultrasound Score","Image Interpretation, Computer Assisted","Reproducibility of Results","Respiratory Distress Neonatal","Respiratory Support",[333,26,327,334,335,336,337,338,339,340,341],"Neonatologist-Performed Lung Ultrasound","Quantitative Lung Ultrasound","Neonatal Intensive Care Unit","Observer Variability in Imaging","Ultrasound Artifact Interpretation","Respiratory Distress Syndrome in Neonates","respiratory support","preterm neonate","newborn","2025-08-05",{"date":344,"type":34},"2025-08-12",{"date":346,"type":22},"2025-08-15",{"date":348,"type":22},"2026-08-01",{"name":350,"class":41},"Medical University of Graz",2,{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":360,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":362,"conditions":363,"keywords":365,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":351},"100598336","bedside-ultrasound-to-monitor-lung-function-and-blood-flow-in-newborns-treated-with-surfactant-100598336","NCT07070167","Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant","Point-of-Care Ultrasonography for Assessing Lung Aeration and Pulmonary Vascular Resistance Dynamics After Surfactant Administration in Neonates With Respiratory Distress Syndrome","ULISSES","Inclusion Criteria:\n\n* Preterm neonates (gestational age \\\u003C37 weeks) with established Respiratory Distress Syndrome (RDS) or at risk for RDS\n* Decision of the use of surfactant by the attending physician\n\nExclusion Criteria:\n\n* Presence of major congenital abnormalities of the respiratory system\n* Infants requiring primary intubation and mechanical ventilation in the delivery room",{"count":361,"type":22},200,"The ULISSES study looks at how doctors use bedside ultrasound to help treat premature babies with breathing problems caused by Respiratory Distress Syndrome (RDS). It focuses on whether doctors decide to give a medicine called surfactant based on oxygen levels alone or if they also use lung ultrasound images to guide their decision.\n\nAround 200 babies will take part in the study in hospitals across Poland. Doctors will do ultrasound scans of the babies' lungs before and after surfactant is given. In some hospitals, heart and lung blood flow will also be checked to look for signs of high blood pressure in the lungs.\n\nThe study will see if both lungs improve equally after treatment or if one side stays worse, and whether this affects how much breathing support the baby needs. The results may help doctors improve how and when they give surfactant, leading to better care for newborns with RDS.",[26,364],"Respiratory Distress Syndrome, Newborn",[366],"surfactant","2025-07-15",{"date":369,"type":34},"2025-07-17",{"date":371,"type":22},"2025-08-30",{"date":373,"type":22},"2026-12-30",{"name":375,"class":376},"Chiesi Poland Sp. z o.o.","INDUSTRY",{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":383,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":52,"phases":387,"briefSummary":389,"conditions":390,"keywords":393,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":396,"lastUpdatePostDateStruct":397,"startDateStruct":399,"completionDateStruct":401,"leadSponsor":403,"locationsCount":42},"100476268","phase-3-lung-ultrasound-guided-hemodynamic-optimization-100476268","NCT05481723","Lung Ultrasound-guided Hemodynamic Optimization","Lung Ultrasound-guided Hemodynamic Optimization in Major Non-cardiac Surgery: a Randomized Control","POINTBAR","Inclusion Criteria:\n\n* Age\\> 18 years old\n* Abdominal, orthopaedic or vascular surgery with general anaesthesia\n* Patient of legal age ≥ 18 years.\n* ASA score ≥ II\n* Estimated duration of surgery \\> 2 hours\n* At least two of the following comorbidities (age \\> 50 years, hypertension, heart disease, electrocardiogram (ECG) abnormality, acute pulmonary oedema, smoking, stroke, peripheral arterial disease, non-insulin dependent or insulin dependent diabetes, ascites, chronic renal failure)\n* Signed consent.\n* Affiliation to a social security scheme.\n\nExclusion Criteria:\n\n* Severe untreated or unbalanced hypertension on treatment.\n* Preoperative renal failure on dialysis.\n* Acute heart failure.\n* Acute coronary insufficiency.\n* Vascular surgery with renal plasty.\n* Cardiac surgery.\n* Preoperative shock.\n* Refusal of patient participation.\n* Pregnant, parturient or breastfeeding woman.\n* Patient under guardianship or private law.\n* Acute respiratory distress syndrome according to the Berlin definition\n* respiratory distress not fully explained by cardiac failure or increased blood volume,\n* PaO2\u002FFiO2 ratio ≤ 300 mm Hg on mechanical ventilation (invasive or non-invasive)\n* Chronic respiratory failure with home oxygen therapy.\n* Chronic interstitial lung disease\n* Presence of an acoustic barrier (pneumothorax, subcutaneous emphysema, pleural calcifications, chest bandage, gunshot shrapnel...)\n* Participation in other interventional drug research.\n* Surgical fields covering the sites of investigation in lung ultrasound.",{"count":386,"type":22},350,[388],"PHASE3","The formalized expert recommendation of the French Society of Anesthesia and Intensive Care recommends guiding vascular filling by measuring the stroke volume (SV) in surgical patients considered at high risk. Vascular filling should be continued in the event of preload dependence and stopped in the event of the appearance of preload independence. The aim is to avoid vascular overload due to excessive vascular filling. The application of this recommendation has resulted in a reduction in postoperative morbidity, length of hospital stay and time to return to oral feeding. The superiority of this strategy is now being questioned and the predictive indices of response to vascular filling (static and dynamic) have many limitations. In addition, none of the cardiac output monitors are the gold standard for intraoperative use.\n\nThrough the study of artefacts, lung ultrasound has been gaining ground over the last twenty years, particularly in cardiology, nephrology and intensive care. By analogy with radiological B-lines, ultrasound B-lines result from the reverberation of ultrasound on the subpleural inter-lobular septa thickened by oedema. The Fluid Administration Limited by Lung Sonography (FALLS) protocol, described by Lichtenstein et al, is defined as the visualisation of new B lines during a vascular filling test. If a B-line appears in an area where it was not present during vascular filling, the most likely diagnosis is hydrostatic overload of the subpleural interstitial septum. This appearance of B-lines occurs at a sub-clinical stage.\n\nThe use of lung ultrasound could allow real-time assessment of vascular filling and its tolerance during the intraoperative period. The main objective of the study is to demonstrate a decrease in the incidence of postoperative complications (organ failure) (as defined by international guidelines) when using lung ultrasound-guided haemodynamic optimisation compared to standard optimisation.",[26,391,392],"Goal Directed Therapy","Non-cardiac Surgery",[29,394,395],"goal directed therapy","non-cardiac surgery","2025-05-22",{"date":398,"type":34},"2025-05-28",{"date":400,"type":34},"2022-07-28",{"date":402,"type":22},"2027-08",{"name":404,"class":41},"Centre Hospitalier Universitaire, Amiens",{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":409,"acronym":4,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":17,"minAge":411,"maxAge":412,"enrollmentInfo":413,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":415,"conditions":416,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":4},"100550165","comparison-of-lung-ultrasound-scores-with-clinical-models-for-predicting-bronchopulmonary-dysplasiaa-multi-center-prospective-cohort-study-100550165","NCT06443528","Comparison of Lung Ultrasound Scores With Clinical Models for Predicting Bronchopulmonary Dysplasia：A Multi-center Prospective Cohort Study","Inclusion Criteria:\n\n1. Preterm infants with GA \\\u003C32 weeks.\n2. Infants with enrollment within 24 hours from birth\n3. Parental written consent is obtained.\n\nExclusion Criteria:\n\n1. Complex congenital malformations or chromosomal abnormalities\n2. Congenital lung diseases or congenital heart defects\n3. Infants with enrollment after 24 hours from birth","0 Weeks","32 Weeks",{"count":414,"type":22},1620,"This study aimed to fill this knowledge gap and designed a multicentre cohort study to verify the hypothesis that LUS has good reliability to predict BPD in China and to compare the predictive value of LUS and clinical models for the development of BPD at different time points in infants born before and after 28 weeks.",[26,417],"Bronchopulmonary Dysplasia","2024-06-26",{"date":420,"type":34},"2024-06-27",{"date":422,"type":22},"2024-09-01",{"date":424,"type":22},"2029-09-30",{"name":426,"class":41},"The First Hospital of Jilin University"]