[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lung-volume\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lung-volume":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,83,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":27,"conditions":28,"keywords":39,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100630322","phase-1-influence-of-lung-volume-optimization-maneuver-on-cardiac-output-and-lung-compliance-in-ventilated-children-with-congenital-heart-disease-undergoing-surgical-repair-100630322",false,"NCT07486167","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Mechanics in Children With Congenital Heart Disease","ILOCO-CHD","Inclusion Criteria:\n\n* Inclusion Criteria\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.","ALL","0 Days","18 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25,26],"PHASE1","PHASE2","The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.\n\nThe primary hypothesis is that optimizing end-expiratory lung volume through a standardized PEEP titration maneuver improves cardiac performance and lung function.\n\nSecondary objectives are to evaluate whether this strategy reduces duration of mechanical ventilation, improves hemodynamics and ventilation-perfusion matching, and decreases the need for vasopressor support.",[29,30,31,32,33,34,35,36,37,38],"Congenital Heart Disease","Cardiopulmonary Bypass","Mechanical Ventilation","Peep Titration in Lung Protective Ventilation","Positive End-expiratory Pressure (PEEP)","Lung Volume","Lung Mechanics","Children","Hemodynamic Changes","Cardiac Surgery",[40,41,42,43],"cardiopulmonary interactions","end-expiratory lung volume","electrical impedance tomography","PEEP titration","NOT_YET_RECRUITING","2026-04-26",{"date":47,"type":48},"2026-04-30","ACTUAL",{"date":50,"type":22},"2026-09-01",{"date":52,"type":22},"2028-12-31",{"name":54,"class":55},"Charite University, Berlin, Germany","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":19,"enrollmentInfo":66,"targetDuration":4,"studyType":23,"phases":67,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":56},"100607835","phase-1-influence-of-personalized-lung-volume-optimization-maneuver-on-lung-function-and-cardiac-performance-in-children-100607835","NCT07193719","Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children","Influence of a Personalized Lung Volume Optimization Maneuver on Lung Aeration and Cardiac Performance in Mechanically Ventilated Children","ILOCO","CHD study:\n\nInclusion Criteria\n\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.\n\nECMO study Inclusion Criteria\n\n* patients with respiratory failure on ECMO or at risk for ECMO\n* invasive ventilation\n\nExclusion Criteria:\n\n\\- severe lung hypoplasia or interstitial lung disease","0 Years",{"count":21,"type":22},[25,26],"The goal of this randomized interventional clinical trial is to learn if a standardized lung volume optimization maneuver (LVOM) is beneficial in\n\n1. study) children undergoing biventricular repair of their congenital heart disease (CHD) with cardiopulmonary bypass and\n2. study) in children with severe respiratory failure at risk for or need for ECMO.\n\nThe main questions it aims to answer are:\n\nMain hypotheses of CHD study: Does a standardized PEEP-Titration maneuver, to optimize end-expiratory lung volume improve:\n\n* cardiac performance\n* lung function\n\nDoes it make a difference in:\n\n* length of ventilation\n* ventilation\u002Fperfusion mismatch of the lung\n* need for vasopressor support?\n\nMain hypotheses of ECMO study:\n\nDoes a LVOM in children\u002Finfants with severe respiratory failure \u002FARDS\n\n* improve lung compliance and gas exchange\n* facilitate lung protective ventilation according to PALICC-2 guidelines\n* improve lung aeration and V\u002FQ-matching assessed with EIT\n\nDoes it make a difference in\n\n* need for ECMO\n* duration of ECMO runs\n* hemodynamics stability",[29,30,38,31,33,34,35,37,36,70,71],"ARDS","ECMO",[40,41,43,70,71,73],"cardiopulmonary bypass","RECRUITING","2026-04-05",{"date":77,"type":48},"2026-04-09",{"date":79,"type":48},"2025-12-05",{"date":81,"type":22},"2027-12-20",{"name":54,"class":55},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":56},"100624575","combined-acupressure-effects-on-post-thoracotomy-pain-and-lung-volume-100624575","NCT07411417","Combined Acupressure Effects on Post-Thoracotomy Pain and Lung Volume","The Effects of Acupressure Combination on Post-Thoracotomy Pain and Lung Volume During Rest, Breathing-Coughing Exercises: A Randomized Controlled Study","Inclusion Criteria:\n\n* Underwent thoracotomy\n* Undergoing thoracic surgery for the first time\n* Classified as ASA (American Society of Anesthesiology) physical status I, II and III\n* Presence of a drain upon admission to the intensive care unit\n* Conscious, oriented, and cooperative\n* Provided verbal and written informed consent after receiving information about the study\n\nExclusion Criteria:\n\n* Intubated\n* Persistent anxiety before the surgery\n* Diagnosed with panic disorder\n* Chemotherapy within the last 6 months\n* Diagnosed psychiatric illness or mental health problems\n* Presence of edema\n* Intraoperative or postoperative complications\n* Non-Turkish speaking, or presence of hearing or visual impairment\n* Body mass index (BMI) greater than 30\n* Participation in another clinical trial during the study period",{"count":21,"type":22},[92],"NA","Pain is a subjective, sensory and emotionally unpleasant experience resulting from real or hidden injuries in tissues. The pain experience is a subjective and unique experience in physiological and psychological terms and is the first negative sensory experience of the patient after the surgical procedure. Thoracotomy is an invasive surgical incision that causes severe postoperative pain due to the negative effect on the ribs, muscles and peripheral nerves. During thoracic surgery, anatomical lung resection is performed through posterolateral thoracotomy. Surgical incision during thoracotomy surgery is the most severe cause of postoperative pain. Epidural analgesia, peripheral nerve block and systematic treatment methods are used in post-thoracotomy pain management. Opioid use is frequently preferred in post-thoracotomy pain management. Although thoracotomy pain can mostly be controlled with opioid analgesics, excessive use of opioids may lead to respiratory suppression, constipation, suppression of cough, nausea, vomiting and many other possible side effects. Ineffective postoperative pain management may lead to postoperative complications such as increased cardiac workload, prolonged pulmonary rehabilitation and delayed wound healing. The use of holistic non-drug pain relief methods is vital in reducing the need for opioid analgesics and the risk of possible side effects in early postoperative pain management.",[95,96,97,98,34],"Pain, Acute","Breathing, Mouth","Relaxation; Diaphragm","Cough",[100,101,102,34],"Thoracotomy after Pain","Acupressure","Pain","2026-02-11",{"date":105,"type":48},"2026-02-13",{"date":107,"type":48},"2025-01-06",{"date":109,"type":22},"2027-01-06",{"name":111,"class":55},"Özgül Aydemir",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":123,"phases":4,"briefSummary":124,"conditions":125,"keywords":131,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":56},"100611173","pulmonary-volume-changes-during-synchonized-noninvasive-positive-pressure-ventilation-100611173","NCT07237139","Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation","Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants","INSPIRE","Inclusion Criteria:\n\n* Written informed consent by one or both parents or legal guardians\n* Gestational age at birth \\\u003C 30 0\u002F7 weeks\n* Infants on sNIPPV respiratory support\n* Below 4 weeks chronological age\n\nExclusion Criteria:\n\n* Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)\n* Too ill\u002Funstable in the opinion of the treating physician.","4 Weeks",{"count":122,"type":22},27,"OBSERVATIONAL","Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.",[126,127,128,129,130,34],"Infant, Preterm","Respiratory Distress Syndrome (Neonatal)","Chronic Lung Disease of Newborn","Respiratory Support","Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)",[132,133,134,135],"Synchronized noninvasive positive pressure ventilation (SNIPPV)","Lung volume","Electrical Impedance Tomography (EIT)","infant, preterm","2025-12-08",{"date":138,"type":48},"2025-12-09",{"date":140,"type":48},"2025-11-17",{"date":142,"type":22},"2027-01-30",{"name":144,"class":55},"University of Zurich"]