[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"lyme-borreliosis-nervous-system\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:lyme-borreliosis-nervous-system":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100610626","phase-4-doxycycline-boosted-therapy-in-lyme-borreliosis-dobo-study-100610626",false,"NCT07230028","Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study.","A Monocenter, Randomized, Double Blind Pilot Study Comparing Doxycycline in Combination With Hydroxychloroquine Treatment Versus Doxycycline Monotherapy in Patients With Long-Term Complaints Attributed to Lyme Borreliosis.","DoBo","Inclusion Criteria:\n\n* Patients who are 18 years of age or older\n* Patients with probable or possible signs and symptoms attributed to Lyme borreliosis\n* Patients with probable or possible post Lyme treatment Lyme borreliosis syndrome (PTLBS)\n* Males or non-pregnant females (who must agree to use barrier methods of contraception during the study therapy period, women of childbearing age must have a negative urine pregnancy or serum test at baseline).\n\nExclusion Criteria:\n\n* Known contra-indication for used study medication.\n* Women who are pregnant or lactating","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to learn if hydroxychloroquine works to treat long-term complaints attributed to Lyme borreliosis in adults. The main questions it aims to answer are:\n\nDoes addition of hydroxychloroquine reduce physical complaints? Researchers will compare hydroxychloroquine to a placebo (a look-alike substance that contains no drug) to see if hydroxychloroquine works to treat Lyme borreliosis.\n\nParticipants will:\n\nTake hydroxychloroquine or a placebo two times a day during 28 days. Visit the clinic 4 times in one year for checkups and tests.",[27],"Lyme Borreliosis, Nervous System",[29],"Hydroxychloroquine","NOT_YET_RECRUITING","2025-11-14",{"date":33,"type":34},"2025-11-17","ACTUAL",{"date":36,"type":21},"2026-03-01",{"date":38,"type":21},"2027-11-01",{"name":40,"class":41},"Radboud University Medical Center","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":5},"100488515","effectiveness-of-an-intervention-combining-adapted-physical-activity-and-therapeutic-education-in-patients-with-chronic-symptoms-attributed-to-lyme-borreliosis-100488515","NCT05641116","Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis.","Effectiveness of an Intervention Combining Adapted Physical Activity and Therapeutic Education in Patients With Chronic Symptoms Attributed to Lyme Borreliosis. Multicenter, Controlled, Randomized Pilot Study","LyMouv'","Inclusion Criteria:\n\n* Patient referred to the reference center for tick-borne diseases by his attending physician\n* Duration of symptoms \\>6 months\n* At the end of the initial assessment, the diagnosis of functional somatic disorders is retained after consensus between the physicians\n* Patient practicing less than 150 minutes of regular physical activity per week (WHO recommendations)\n\nExclusion Criteria:\n\n* Patients with cardiac or respiratory pathologies that contraindicate the practice of physical activity physical activity\n* Important comorbidities contraindicating the practice of physical activity: associated cardiac pathologies associated cardiac pathologies (severe rhythm disorders such as rapid atrial fibrillation), respiratory pathologies respiratory pathologies (obstructive or severe restrictive respiratory insufficiency), disabling joint pathologies joint pathologies (gonarthrosis or coxarthrosis limiting training on a treadmill or on a high-intensity bicycle). intensity cycling).\n* Patients under guardianship or curatorship",{"count":51,"type":21},62,[53],"NA","Lyme borreliosis, commonly known as Lyme disease, has been clinically described for more than a century, but has been officially recognized for 40 years, with the detection of the Borrelia bacterium by W. Burgdorfer, in ticks of the Ixodes ricinus complex, identified a few years before.",[56,57,27],"Lyme Borreliosis","Physical Activity",[59,60,61,62],"sedentary time","therapeutic education of the patient","adapted physical activity","training program","RECRUITING","2025-07-02",{"date":66,"type":34},"2025-07-03",{"date":68,"type":34},"2023-09-14",{"date":70,"type":21},"2027-12",{"name":72,"class":41},"Centre Hospitalier Universitaire de Saint Etienne"]